{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:09:21Z","timestamp":1791425361162,"version":"4.3.3"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,1,21]],"date-time":"2010-01-21T00:00:00Z","timestamp":1264032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,1,21]],"date-time":"2010-01-21T00:00:00Z","timestamp":1264032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1038\/leu.2009.287","type":"journal-article","created":{"date-parts":[[2010,1,21]],"date-time":"2010-01-21T05:45:25Z","timestamp":1264052725000},"page":"512-520","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":188,"title":["Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management"],"prefix":"10.1038","volume":"24","author":[{"given":"T D","family":"Shanafelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Lanasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Landgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C","family":"Rawstron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,21]]},"reference":[{"key":"BFleu2009287_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3322\/caac.20006","volume":"59","author":"A Jemal","year":"2009","unstructured":"Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ . Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225\u2013249.","journal-title":"CA Cancer J Clin"},{"key":"BFleu2009287_CR2","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/j.1365-2141.2007.06861.x","volume":"139","author":"RF Vogt","year":"2007","unstructured":"Vogt RF, Shim YK, Middleton DC, Buffler PA, Campolucci SS, Lybarger JA et al. Monoclonal B-cell lymphocytosis as a biomarker in environmental health studies. Br J Haematol 2007; 139: 690\u2013700.","journal-title":"Br J Haematol"},{"key":"BFleu2009287_CR3","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/cyto.b.20174","volume":"72","author":"YK Shim","year":"2007","unstructured":"Shim YK, Vogt RF, Middleton D, Abbasi F, Slade B, Lee KY et al. Prevalence and natural history of monoclonal and polyclonal B-cell lymphocytosis in a residential adult population. Cytometry B Clin Cytom 2007; 72: 344\u2013353.","journal-title":"Cytometry B Clin Cytom"},{"key":"BFleu2009287_CR4","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1182\/blood.V100.2.635","volume":"100","author":"A Rawstron","year":"2002","unstructured":"Rawstron A, Green M, Kuzmicki A, Kennedy B, Fenton J, Evans P et al. Monoclonal B lymphocytes with the characteristics of \u2018indolent\u2019 chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood 2002; 100: 635\u2013639.","journal-title":"Blood"},{"key":"BFleu2009287_CR5","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1182\/blood-2003-09-3277","volume":"103","author":"P Ghia","year":"2004","unstructured":"Ghia P, Prato G, Scielzo C, Stella S, Geuna M, Guida G et al. Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 2004; 103: 2337\u20132342.","journal-title":"Blood"},{"key":"BFleu2009287_CR6","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1365-2141.2005.05550.x","volume":"130","author":"GE Marti","year":"2005","unstructured":"Marti GE, Rawstron AC, Ghia P, Hillmen P, Houlston RS, Kay N et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol 2005; 130: 325\u2013332.","journal-title":"Br J Haematol"},{"key":"BFleu2009287_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1182\/blood.V98.1.29","volume":"98","author":"AC Rawstron","year":"2001","unstructured":"Rawstron AC, Kennedy B, Evans PA, Davies FE, Richards SJ, Haynes AP et al. Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy. Blood 2001; 98: 29\u201335.","journal-title":"Blood"},{"key":"BFleu2009287_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1182\/blood-2008-09-176933","volume":"114","author":"A Dagklis","year":"2009","unstructured":"Dagklis A, Fazi C, Sala C, Cantarelli V, Scielzo C, Massacane R et al. The immunoglobulin gene repertoire of population CLL-like MBL is different from CLL: diagnostic implications for clinical monitoring. Blood 2009; 114: 26\u201332.","journal-title":"Blood"},{"key":"BFleu2009287_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1182\/blood-2009-01-197368","volume":"114","author":"WG Nieto","year":"2009","unstructured":"Nieto WG, Almeida J, Romero A, Teodosio C, Lopez A, Henriques AF et al. Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. Blood 2009; 114: 33\u201337.","journal-title":"Blood"},{"key":"BFleu2009287_CR10","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1182\/blood-2004-01-0341","volume":"104","author":"L Goldin","year":"2004","unstructured":"Goldin L, Pfeiffer R, X XL, Hemminki K . Familial risk of lymphoproliferative tuors in families of patients with chronic lymphocytic leukemia: results from the swedish family-cancer database. Blood 2004; 104: 1850\u20131854.","journal-title":"Blood"},{"key":"BFleu2009287_CR11","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3324\/haematol.2008.003632","volume":"94","author":"LR Goldin","year":"2009","unstructured":"Goldin LR, Bjorkholm M, Kristinsson SY, Turesson I, Landgren O . Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia. Haematologica 2009; 94: 647\u2013653.","journal-title":"Haematologica"},{"key":"BFleu2009287_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cyto.b.10013","volume":"52B","author":"G Marti","year":"2003","unstructured":"Marti G, Carter P, Abbasi F, Washington G, Jain N, Zenger V et al. B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia. Cytometry 2003; 52B: 1\u201312.","journal-title":"Cytometry"},{"key":"BFleu2009287_CR13","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1182\/blood-2002-03-0892","volume":"100","author":"A Rawstron","year":"2002","unstructured":"Rawstron A, Yuille M, Fuller J, Cullen M, Kennedy B, Richards S et al. Inherited predispoition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion. Blood 2002; 100: 2289\u20132290.","journal-title":"Blood"},{"key":"BFleu2009287_CR14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1365-2141.2009.07861.x","volume":"147","author":"DM Matos","year":"2009","unstructured":"Matos DM, Ismael SJ, Scrideli CA, de Oliveira FM, Rego EM, Falcao RP . Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic (non-familial) chronic lymphocytic leukaemia. Br J Haematol 2009; 147: 339\u2013346.","journal-title":"Br J Haematol"},{"key":"BFleu2009287_CR15","doi-asserted-by":"crossref","unstructured":"Lanasa MD, Allgood SD, Volkheimer AD, Gockerman JP, Whitesides JF, Goodman BK et al. Single cell analysis reveals oligoclonality among \u2018low count\u2019 monoclonal B cell lymphocytosis. Leukemia 2009, e-pub ahead of print 15 October 2009.","DOI":"10.1038\/leu.2009.192"},{"key":"BFleu2009287_CR16","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/j.1365-2141.2007.06863.x","volume":"139","author":"AC Rawstron","year":"2007","unstructured":"Rawstron AC, Bennett F, Hillmen P . The biological and clinical relationship between CD5+23+ monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia. Br J Haematol 2007; 139: 724\u2013729.","journal-title":"Br J Haematol"},{"key":"BFleu2009287_CR17","doi-asserted-by":"crossref","first-page":"338a","DOI":"10.1182\/blood.V110.11.1113.1113","volume":"110","author":"BA McCarthy","year":"2007","unstructured":"McCarthy BA, Tipping M, Wang XP, Bennet F, Li W, Lesser M et al. Expression levels of a single gene, lymphoid enhancer binding factor 1, discriminates CLL B-Cells from other B-cell malignancies. Blood 2007; 110: 338a.","journal-title":"Blood"},{"key":"BFleu2009287_CR18","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1056\/NEJMoa075290","volume":"359","author":"AC Rawstron","year":"2008","unstructured":"Rawstron AC, Bennett FL, O\u2032Connor SJ, Kwok M, Fenton JA, Plummer M et al. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med 2008; 359: 575\u2013583.","journal-title":"N Engl J Med"},{"key":"BFleu2009287_CR19","doi-asserted-by":"publisher","first-page":"3959","DOI":"10.1200\/JCO.2008.21.2704","volume":"27","author":"T Shanafelt","year":"2009","unstructured":"Shanafelt T, Kay N, Rabe K, Call T, Zent CS, Maddocks K et al. Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis (MBL) compared to patients with Rai 0 chronic lymphocytic leukemia (CLL). J Clin Oncol 2009; 27: 3959\u20133963.","journal-title":"J Clin Oncol"},{"key":"BFleu2009287_CR20","doi-asserted-by":"publisher","first-page":"4188","DOI":"10.1182\/blood-2008-09-176149","volume":"113","author":"TD Shanafelt","year":"2009","unstructured":"Shanafelt TD, Kay NE, Jenkins G, Call TG, Zent CS, Jelinek DF et al. B-cell count and survival: differentiating chronic lymphocytic leukemia (CLL) from monoclonal B-cell lymphocytosis (MBL) based on clinical outcome. Blood 2009; 113: 4188\u20134196.","journal-title":"Blood"},{"key":"BFleu2009287_CR21","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","volume":"94","author":"TJ Hamblin","year":"1999","unstructured":"Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK . Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848\u20131854.","journal-title":"Blood"},{"key":"BFleu2009287_CR22","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","volume":"94","author":"RN Damle","year":"1999","unstructured":"Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94: 1840\u20131847.","journal-title":"Blood"},{"key":"BFleu2009287_CR23","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1182\/blood-2006-03-012948","volume":"109","author":"K Stamatopoulos","year":"2007","unstructured":"Stamatopoulos K, Belessi C, Moreno C, Boudjograh M, Guida G, Smilevska T et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007; 109: 259\u2013270.","journal-title":"Blood"},{"key":"BFleu2009287_CR24","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1182\/blood-2007-07-099564","volume":"111","author":"F Murray","year":"2008","unstructured":"Murray F, Darzentas N, Hadzidimitriou A, Tobin G, Boudjogra M, Scielzo C et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 2008; 111: 1524\u20131533.","journal-title":"Blood"},{"key":"BFleu2009287_CR25","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1056\/NEJMc086211","volume":"359","author":"CS Mulligan","year":"2008","unstructured":"Mulligan CS, Thomas ME, Mulligan SP . Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med 2008; 359: 2065\u20132066 .","journal-title":"N Engl J Med"},{"key":"BFleu2009287_CR26","doi-asserted-by":"publisher","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","volume":"111","author":"M Hallek","year":"2008","unstructured":"Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Dohner H et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008; 111: 5446\u20135456.","journal-title":"Blood"},{"key":"BFleu2009287_CR27","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1365-2141.2009.07711.x","volume":"146","author":"D Rossi","year":"2009","unstructured":"Rossi D, Sozzi E, Puma A, De Paoli L, Rasi S, Spina V et al. The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. Br J Haematol 2009; 146: 64\u201375.","journal-title":"Br J Haematol"},{"key":"BFleu2009287_CR28","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1056\/NEJMoa0806122","volume":"360","author":"O Landgren","year":"2009","unstructured":"Landgren O, Albitar M, Ma W, Abbasi F, Hayes RB, Ghia P et al. B-cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med 2009; 360: 659\u2013667.","journal-title":"N Engl J Med"},{"key":"BFleu2009287_CR29","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/ajh.2830290307","volume":"29","author":"BD Cheson","year":"1988","unstructured":"Cheson BD, Bennett JM, Rai KR, Grever MR, Kay NE, Schiffer CA et al. Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group. Am J Hematol 1988; 29: 152\u2013163.","journal-title":"Am J Hematol"},{"key":"BFleu2009287_CR30","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1182\/blood.V87.12.4990.bloodjournal87124990","volume":"87","author":"BD Cheson","year":"1996","unstructured":"Cheson BD, Bennett JM, Grever M, Kay NE, Keating M, O\u2032Brien O et al. National cancer institute-sponsored working group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996; 87: 4990\u20134997.","journal-title":"Blood"},{"key":"BFleu2009287_CR31","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1016\/j.leukres.2007.11.030","volume":"32","author":"TD Shanafelt","year":"2008","unstructured":"Shanafelt TD, Kay NE, Call TG, Zent CS, Jelinek DF, Laplant B et al. MBL or CLL: which classification best categorizes the clinical course of patients with an absolute lymphocyte count &gt;\/=5 \u00d7 10(9)L(-1) but a B-cell lymphocyte count &lt;5 \u00d7 10(9)L(-1)? Leuk Res 2008; 32: 1458\u20131461.","journal-title":"Leuk Res"},{"key":"BFleu2009287_CR32","unstructured":"Hanson CA, Herrick JL, Morice WG, Rabe KG, Slager SL, Van Dyke DL et al. Bone marrow involvement in monoclonal B-cell lymphoctyosis (MBL). Eur Soc Hematol 2008. Abstract #1173."},{"key":"BFleu2009287_CR33","doi-asserted-by":"publisher","first-page":"776","DOI":"10.4065\/83.7.776","volume":"83","author":"WG Morice","year":"2008","unstructured":"Morice WG, Kurtin PJ, Hodnefield JM, Shanafelt TD, Hoyer JD, Remstein ED et al. Predictive value of blood and bone marrow flow cytometry in B-cell lymphoma classification: comparative analysis of flow cytometry and tissue biopsy in 252 patients. Mayo Clin Proc 2008; 83: 776\u2013785.","journal-title":"Mayo Clin Proc"},{"key":"BFleu2009287_CR34","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1200\/JCO.2008.19.6121","volume":"27","author":"P Martin","year":"2009","unstructured":"Martin P, Chadburn A, Christos P, Weil K, Furman RR, Ruan J et al. Outcome of deferred initial therapy in mantle-cell lymphoma. J Clin Oncol 2009; 27: 1209\u20131213.","journal-title":"J Clin Oncol"},{"key":"BFleu2009287_CR35","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1001\/jama.298.3.317","volume":"298","author":"AJ Einstein","year":"2007","unstructured":"Einstein AJ, Henzlova MJ, Rajagopalan S . Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography. JAMA 2007; 298: 317\u2013323.","journal-title":"JAMA"},{"key":"BFleu2009287_CR36","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/j.1365-2141.2007.06862.x","volume":"139","author":"NM Hardy","year":"2007","unstructured":"Hardy NM, Grady C, Pentz R, Stetler-Stevenson M, Raffeld M, Fontaine LS et al. Bioethical considerations of monoclonal B-cell lymphocytosis: donor transfer after haematopoietic stem cell transplantation. Br J Haematol 2007; 139: 824\u2013831.","journal-title":"Br J Haematol"},{"key":"BFleu2009287_CR37","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1001\/jama.283.20.2701","volume":"283","author":"EJ Emanuel","year":"2000","unstructured":"Emanuel EJ, Wendler D, Grady C . What makes clinical research ethical? JAMA 2000; 283: 2701\u20132711.","journal-title":"JAMA"},{"key":"BFleu2009287_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1365-2141.2007.06791.x","volume":"39","author":"TD Shanafelt","year":"2007","unstructured":"Shanafelt TD, Bowen D, Venkat C, Slager SL, Zent CS, Kay N et al. Quality of life in chronic lymphocytic leukemia: an international survey of 1482 patients. Br J Haematol 2007; 39: 255\u2013264.","journal-title":"Br J Haematol"},{"key":"BFleu2009287_CR39","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.leukres.2008.06.019","volume":"33","author":"TD Shanafelt","year":"2009","unstructured":"Shanafelt TD, Bowen DA, Venkat C, Slager SL, Zent CS, Kay NE et al. The physician-patient relationship and quality of life: lessons from chronic lymphocytic leukemia. Leuk Res 2009; 33: 263\u2013270.","journal-title":"Leuk Res"},{"key":"BFleu2009287_CR40","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.leukres.2006.07.006","volume":"31","author":"A Victor Hoffbrand","year":"2007","unstructured":"Victor Hoffbrand A, Hamblin TJ . Is \u2033leukemia\u2033 an appropriate label for all patients who meet the diagnostic criteria of chronic lymphocytic leukemia? Leuk Res 2007; 31: 273\u2013275.","journal-title":"Leuk Res"},{"key":"BFleu2009287_CR41","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/j.1365-2141.2007.06870.x","volume":"139","author":"JM Rachel","year":"2007","unstructured":"Rachel JM, Zucker ML, Fox CM, Plapp FV, Menitove JE, Abbasi F et al. Monoclonal B-cell lymphocytosis in blood donors. Br J Haematol 2007; 139: 832\u2013836.","journal-title":"Br J Haematol"},{"key":"BFleu2009287_CR42","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1182\/blood-2009-05-206821","volume":"114","author":"J Delgado","year":"2009","unstructured":"Delgado J, Milligan DW, Dreger P . Allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: ready for primetime? Blood 2009; 114: 2581\u20132588.","journal-title":"Blood"},{"key":"BFleu2009287_CR43","doi-asserted-by":"publisher","first-page":"4912","DOI":"10.1200\/JCO.2007.15.4757","volume":"26","author":"ML Sorror","year":"2008","unstructured":"Sorror ML, Storer BE, Sandmaier BM, Maris M, Shizuru J, Maziarz R et al. Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol 2008; 26: 4912\u20134920.","journal-title":"J Clin Oncol"},{"key":"BFleu2009287_CR44","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/sj.leu.2404441","volume":"21","author":"P Dreger","year":"2007","unstructured":"Dreger P, Corradini P, Kimby E, Michallet M, Milligan D, Schetelig J et al. Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia 2007; 21: 12\u201317.","journal-title":"Leukemia"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2009287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2009287","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2009287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T08:05:13Z","timestamp":1648713913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2009287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,21]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["BFleu2009287"],"URL":"https:\/\/doi.org\/10.1038\/leu.2009.287","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,21]]},"assertion":[{"value":"30 September 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}