{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:57:55Z","timestamp":1792094275785,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1038\/leu.2009.3","type":"journal-article","created":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T05:49:05Z","timestamp":1233812945000},"page":"1139-1151","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":181,"title":["Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies"],"prefix":"10.1038","volume":"23","author":[{"given":"J","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kucuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"deLeeuw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Klinkebiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J K","family":"Christman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Dybkaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I F L","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Y","family":"Au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W L","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W C","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"BFleu20093_CR1","volume-title":"Pathology and Genetics of Tumors of the Haematopoietic and Lymphoid Tissues","author":"NL Harris","year":"2001","unstructured":"Harris NL, Stein H, Vardiman JW (eds). Pathology and Genetics of Tumors of the Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumors Lyon: International Agency for Research on Cancer, 2001."},{"key":"BFleu20093_CR2","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1038\/sj.leu.2403955","volume":"19","author":"YL Kwong","year":"2005","unstructured":"Kwong YL . Natural killer-cell malignancies: diagnosis and treatment. Leukemia 2005; 19: 2186\u20132194.","journal-title":"Leukemia"},{"key":"BFleu20093_CR3","first-page":"77","volume":"3","author":"JK Chan","year":"1998","unstructured":"Chan JK . Natural killer cell neoplasms. Anat Pathol 1998; 3: 77\u2013145.","journal-title":"Anat Pathol"},{"key":"BFleu20093_CR4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/cyto.1069","volume":"46","author":"YH Ko","year":"2001","unstructured":"Ko YH, Choi KE, Han JH, Kim JM, Ree HJ . Comparative genomic hybridization study of nasal-type NK\/T-cell lymphoma. Cytometry 2001; 46: 85\u201391.","journal-title":"Cytometry"},{"key":"BFleu20093_CR5","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S0145-2126(02)00055-3","volume":"26","author":"RA MacLeod","year":"2002","unstructured":"MacLeod RA, Nagel S, Kaufmann M, Greulich-Bode K, Drexler HG . Multicolor-FISH analysis of a natural killer cell line (NK-92). Leuk Res 2002; 26: 1027\u20131033.","journal-title":"Leuk Res"},{"key":"BFleu20093_CR6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/gcc.20245","volume":"44","author":"Y Nakashima","year":"2005","unstructured":"Nakashima Y, Tagawa H, Suzuki R, Karnan S, Karube K, Ohshima K et al. Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma\/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk\/T-cell lymphoma, nasal type. Genes Chromosomes Cancer 2005; 44: 247\u2013255.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu20093_CR7","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1016\/S0002-9440(10)64818-3","volume":"157","author":"LL Siu","year":"2000","unstructured":"Siu LL, Chan V, Chan JK, Wong KF, Liang R, Kwong YL . Consistent patterns of allelic loss in natural killer cell lymphoma. Am J Pathol 2000; 157: 1803\u20131809.","journal-title":"Am J Pathol"},{"key":"BFleu20093_CR8","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/S0002-9440(10)65454-5","volume":"155","author":"LL Siu","year":"1999","unstructured":"Siu LL, Wong KF, Chan JK, Kwong YL . Comparative genomic hybridization analysis of natural killer cell lymphoma\/leukemia. Recognition of consistent patterns of genetic alterations. Am J Pathol 1999; 155: 1419\u20131425.","journal-title":"Am J Pathol"},{"key":"BFleu20093_CR9","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/S0145-2126(02)00065-6","volume":"26","author":"KF Wong","year":"2002","unstructured":"Wong KF . Genetic changes in natural killer cell neoplasms. Leuk Res 2002; 26: 977\u2013978.","journal-title":"Leuk Res"},{"key":"BFleu20093_CR10","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1046\/j.1365-2141.1997.3223139.x","volume":"98","author":"KF Wong","year":"1997","unstructured":"Wong KF, Chan JK, Kwong YL . Identification of del(6)(q21q25) as a recurring chromosomal abnormality in putative NK cell lymphoma\/leukaemia. Br J Haematol 1997; 98: 922\u2013926.","journal-title":"Br J Haematol"},{"key":"BFleu20093_CR11","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1080\/1042819031000123410","volume":"44","author":"J Yoon","year":"2003","unstructured":"Yoon J, Ko YH . Deletion mapping of the long arm of chromosome 6 in peripheral T and NK cell lymphomas. Leuk Lymphoma 2003; 44: 2077\u20132082.","journal-title":"Leuk Lymphoma"},{"key":"BFleu20093_CR12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3960\/jslrt.45.51","volume":"45","author":"R Suzuki","year":"2005","unstructured":"Suzuki R . Leukemia and Lymphoma of Natural Killer Cells. J Clin Exp Hematopathol 2005; 45: 51\u201370.","journal-title":"J Clin Exp Hematopathol"},{"key":"BFleu20093_CR13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/ng754","volume":"29","author":"AM Snijders","year":"2001","unstructured":"Snijders AM, Nowak N, Segraves R, Blackwood S, Brown N, Conroy J et al. Assembly of microarrays for genome-wide measurement of DNA copy number. Nat Genet 2001; 29: 263\u2013264.","journal-title":"Nat Genet"},{"key":"BFleu20093_CR14","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/ng1307","volume":"36","author":"AS Ishkanian","year":"2004","unstructured":"Ishkanian AS, Malloff CA, Watson SK, DeLeeuw RJ, Chi B, Coe BP et al. A tiling resolution DNA microarray with complete coverage of the human genome. Nat Genet 2004; 36: 299\u2013303.","journal-title":"Nat Genet"},{"key":"BFleu20093_CR15","volume-title":"Molecular Cloning: A Laboratory Manual","author":"J Sambrook","year":"2001","unstructured":"Sambrook J, Russell DW . Molecular Cloning: A Laboratory Manual, 3rd edn, vol. 1. CSHL Press: Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York, 2001."},{"key":"BFleu20093_CR16","first-page":"6","volume":"5","author":"SK Watson","year":"2004","unstructured":"Watson SK, deLeeuw RJ, Ishkanian AS, Malloff CA, Lam WL . Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays. BMC Genomics [Electronic Resource] 2004; 5: 6.","journal-title":"BMC Genomics [Electronic Resource]"},{"key":"BFleu20093_CR17","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1093\/hmg\/ddh195","volume":"13","author":"RJ de Leeuw","year":"2004","unstructured":"de Leeuw RJ, Davies JJ, Rosenwald A, Bebb G, Gascoyne RD, Dyer MJ et al. Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes. Hum Mol Genet 2004; 13: 1827\u20131837.","journal-title":"Hum Mol Genet"},{"key":"BFleu20093_CR18","first-page":"54","volume-title":"Applications of Evolutionary Computing. EvoBIO: Evolutionary Computation and Bioinformatics","author":"K Jong","year":"2003","unstructured":"Jong K, Marchori E, van der Vaart A, Ylstra B, Weiss M, Meijer G (eds). Chromosomal breakpoint detection in human cancer. In Applications of Evolutionary Computing. EvoBIO: Evolutionary Computation and Bioinformatics. Springer LNCS: Springer Berlin\/Heidelberg, 2003, pp 54\u201365."},{"key":"BFleu20093_CR19","first-page":"230","volume":"8","author":"K Dybkaer","year":"2007","unstructured":"Dybkaer K, Iqbal J, Zhou G, Geng H, Xiao L, Schmitz A et al. Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways. BMC Genomics [Electronic Resource] 2007; 8: 230.","journal-title":"BMC Genomics [Electronic Resource]"},{"key":"BFleu20093_CR20","unstructured":"Simon R, Peng A . BRB-ArrayTools User Guide, version 3.6.0. Biometric Research Branch, National Cancer Institute. [cited; Available from: http:\/\/linus.nci.nih.gov\/BRB-ArrayTools.html:Year 2008]."},{"key":"BFleu20093_CR21","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/10428190290006062","volume":"43","author":"K Ohshima","year":"2002","unstructured":"Ohshima K, Haraokaa S, Ishihara S, Ohgami A, Yoshioka S, Suzumiya J et al. Analysis of chromosome 6q deletion in EBV-associated NK cell leukaemia\/lymphoma. Leuk Lymphoma 2002; 43: 293\u2013300.","journal-title":"Leuk Lymphoma"},{"key":"BFleu20093_CR22","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1182\/blood-2005-09-3778","volume":"107","author":"W Tam","year":"2006","unstructured":"Tam W, Gomez M, Chadburn A, Lee JW, Chan WC, Knowles DM . Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. Blood 2006; 107: 4090\u20134100.","journal-title":"Blood"},{"key":"BFleu20093_CR23","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1016\/j.biocel.2008.02.014","volume":"40","author":"P Radhakrishnan","year":"2008","unstructured":"Radhakrishnan P, Basma H, Klinkebiel D, Christman J, Cheng PW . Cell type-specific activation of the cytomegalovirus promoter by dimethylsulfoxide and 5-aza-2\u2032-deoxycytidine. Int J Biochem Cell Biol 2008; 40: 1944\u20131955.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFleu20093_CR24","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1016\/j.biocel.2008.02.014","volume":"40","author":"P Radhakrishnan","year":"2008","unstructured":"Radhakrishnan P, Basma H, Klinkebiel D, Christman J, Cheng PW . Cell type-specific activation of the cytomegalovirus promoter by dimethylsulfoxide and 5-Aza-2\u2032-deoxycytidine. Int J Biochem Cell Biol 2008; 40: 1944\u20131955.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFleu20093_CR25","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1182\/blood-2007-09-111385","volume":"111","author":"W Tam","year":"2008","unstructured":"Tam W, Gomez M, Nie K . Significance of PRDM1beta expression as a prognostic marker in diffuse large B-cell lymphomas. Blood 2008; 111: 2488\u20132489; author reply 2489\u20132490.","journal-title":"Blood"},{"key":"BFleu20093_CR26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1086\/510560","volume":"80","author":"KK Wong","year":"2007","unstructured":"Wong KK, Deleeuw RJ, Dosanjh NS, Kimm LR, Cheng Z, Horsman DE et al. A comprehensive analysis of common copy-number variations in the human genome. Am J Hum Genet 2007; 80: 91\u2013104.","journal-title":"Am J Hum Genet"},{"key":"BFleu20093_CR27","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1038\/sj.onc.1202684","volume":"18","author":"S Wang","year":"1999","unstructured":"Wang S, Nath N, Adlam M, Chellappan S . Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function. Oncogene 1999; 18: 3501\u20133510.","journal-title":"Oncogene"},{"key":"BFleu20093_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1158\/1535-7163.MCT-05-0310","volume":"5","author":"IF Chen","year":"2006","unstructured":"Chen IF, Ou-Yang F, Hung JY, Liu JC, Wang H, Wang SC et al. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol Cancer Ther 2006; 5: 1\u20137.","journal-title":"Mol Cancer Ther"},{"key":"BFleu20093_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/01.pap.0000151318.34752.80","volume":"12","author":"VE Nava","year":"2005","unstructured":"Nava VE, Jaffe ES . The pathology of NK-cell lymphomas and leukemias. Adv Anat Pathol 2005; 12: 27\u201334.","journal-title":"Adv Anat Pathol"},{"key":"BFleu20093_CR30","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1053\/hupa.2000.7625","volume":"31","author":"N Wong","year":"2000","unstructured":"Wong N, Wong KF, Chan JK, Johnson PJ . Chromosomal translocations are common in natural killer-cell lymphoma\/leukemia as shown by spectral karyotyping. Hum Pathol 2000; 31: 771\u2013774.","journal-title":"Hum Pathol"},{"key":"BFleu20093_CR31","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3109\/10428199909050949","volume":"34","author":"KF Wong","year":"1999","unstructured":"Wong KF, Zhang YM, Chan JK . Cytogenetic abnormalities in natural killer cell lymphoma\/leukaemia\u2014is there a consistent pattern? Leuk Lymphoma 1999; 34: 241\u2013250.","journal-title":"Leuk Lymphoma"},{"key":"BFleu20093_CR32","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0002-9440(10)65298-4","volume":"154","author":"BM Ghadimi","year":"1999","unstructured":"Ghadimi BM, Schrock E, Walker RL, Wangsa D, Jauho A, Meltzer PS et al. Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas. Am J Pathol 1999; 154: 525\u2013536.","journal-title":"Am J Pathol"},{"key":"BFleu20093_CR33","first-page":"141","volume":"59","author":"M Macville","year":"1999","unstructured":"Macville M, Schrock E, Padilla-Nash H, Keck C, Ghadimi BM, Zimonjic D et al. Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping. Cancer Res 1999; 59: 141\u2013150.","journal-title":"Cancer Res"},{"key":"BFleu20093_CR34","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/35008115","volume":"404","author":"RH Medema","year":"2000","unstructured":"Medema RH, Kops GJ, Bos JL, Burgering BM . AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000; 404: 782\u2013787.","journal-title":"Nature"},{"key":"BFleu20093_CR35","first-page":"2339","volume":"58","author":"GH Su","year":"1998","unstructured":"Su GH, Hilgers W, Shekher MC, Tang DJ, Yeo CJ, Hruban RH et al. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Res 1998; 58: 2339\u20132342.","journal-title":"Cancer Res"},{"key":"BFleu20093_CR36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0092-8674(02)00809-7","volume":"110","author":"SH Baek","year":"2002","unstructured":"Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG . Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 2002; 110: 55\u201367.","journal-title":"Cell"},{"key":"BFleu20093_CR37","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S1097-2765(02)00468-9","volume":"9","author":"J Zhang","year":"2002","unstructured":"Zhang J, Kalkum M, Chait BT, Roeder RG . The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell 2002; 9: 611\u2013623.","journal-title":"Mol Cell"},{"key":"BFleu20093_CR38","first-page":"4177","volume":"57","author":"DH Teng","year":"1997","unstructured":"Teng DH, Perry III WL, Hogan JK, Baumgard M, Bell R, Berry S et al. Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Cancer Res 1997; 57: 4177\u20134182.","journal-title":"Cancer Res"},{"key":"BFleu20093_CR39","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1046\/j.1365-2141.2003.04419.x","volume":"122","author":"HS Sun","year":"2003","unstructured":"Sun HS, Su IJ, Lin YC, Chen JS, Fang SY . A 2.6\u2009Mb interval on chromosome 6q25.2\u2013q25.3 is commonly deleted in human nasal natural killer\/T-cell lymphoma. Br J Haematol 2003; 122: 590\u2013599.","journal-title":"Br J Haematol"},{"key":"BFleu20093_CR40","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1073\/pnas.94.7.3229","volume":"94","author":"ME Ray","year":"1997","unstructured":"Ray ME, Wistow G, Su YA, Meltzer PS, Trent JM . AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma. Pro Natl Acad Sci USA 1997; 94: 3229\u20133234.","journal-title":"Pro Natl Acad Sci USA"},{"key":"BFleu20093_CR41","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1172\/JCI20039","volume":"112","author":"X Qu","year":"2003","unstructured":"Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112: 1809\u20131820.","journal-title":"J Clin Invest"},{"key":"BFleu20093_CR42","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/nature03029","volume":"432","author":"A Kuma","year":"2004","unstructured":"Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432: 1032\u20131036.","journal-title":"Nature"},{"key":"BFleu20093_CR43","doi-asserted-by":"publisher","first-page":"9349","DOI":"10.1158\/0008-5472.CAN-06-1597","volume":"66","author":"MM Hippert","year":"2006","unstructured":"Hippert MM, O'Toole PS, Thorburn A . Autophagy in cancer: good, bad, or both? Cancer Res 2006; 66: 9349\u20139351.","journal-title":"Cancer Res"},{"key":"BFleu20093_CR44","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0092-8674(94)90321-2","volume":"77","author":"CA Turner Jr","year":"1994","unstructured":"Turner Jr CA, Mack DH, Davis MM . Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 1994; 77: 297\u2013306.","journal-title":"Cell"},{"key":"BFleu20093_CR45","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/ni1321","volume":"7","author":"A Kallies","year":"2006","unstructured":"Kallies A, Hawkins ED, Belz GT, Metcalf D, Hommel M, Corcoran LM et al. Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol 2006; 7: 466\u2013474.","journal-title":"Nat Immunol"},{"key":"BFleu20093_CR46","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1084\/jem.20052204","volume":"203","author":"L Pasqualucci","year":"2006","unstructured":"Pasqualucci L, Compagno M, Houldsworth J, Monti S, Grunn A, Nandula SV et al. Inactivation of the PRDM1\/BLIMP1 gene in diffuse large B cell lymphoma. J Exp Med 2006; 203: 311\u2013317.","journal-title":"J Exp Med"},{"key":"BFleu20093_CR47","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1101\/gad.3.5.612","volume":"3","author":"SM Iguchi-Ariga","year":"1989","unstructured":"Iguchi-Ariga SM, Schaffner W . CpG methylation of the cAMP-responsive enhancer\/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Genes Dev 1989; 3: 612\u2013619.","journal-title":"Genes Dev"},{"key":"BFleu20093_CR48","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1128\/MCB.23.6.1946-1960.2003","volume":"23","author":"H Maier","year":"2003","unstructured":"Maier H, Colbert J, Fitzsimmons D, Clark DR, Hagman J . Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site. Mol Cell Biol 2003; 23: 1946\u20131960.","journal-title":"Mol Cell Biol"},{"key":"BFleu20093_CR49","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1073\/pnas.85.7.2066","volume":"85","author":"MA Harrington","year":"1988","unstructured":"Harrington MA, Jones PA, Imagawa M, Karin M . Cytosine methylation does not affect binding of transcription factor Sp1. Pro Natl Acad Sci USA 1988; 85: 2066\u20132070.","journal-title":"Pro Natl Acad Sci USA"},{"key":"BFleu20093_CR50","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1101\/gad.2.9.1127","volume":"2","author":"M Holler","year":"1988","unstructured":"Holler M, Westin G, Jiricny J, Schaffner W . Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated. Genes Dev 1988; 2: 1127\u20131135.","journal-title":"Genes Dev"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu20093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu20093","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu20093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T08:35:17Z","timestamp":1648715717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu20093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,5]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["BFleu20093"],"URL":"https:\/\/doi.org\/10.1038\/leu.2009.3","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,5]]},"assertion":[{"value":"23 September 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2009","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}