{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:02:13Z","timestamp":1761919333873},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T00:00:00Z","timestamp":1275523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T00:00:00Z","timestamp":1275523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1038\/leu.2010.101","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T09:44:20Z","timestamp":1275558260000},"page":"1445-1449","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["BCR and BCR-ABL regulation during myeloid differentiation in healthy donors and in chronic phase\/blast crisis CML patients"],"prefix":"10.1038","volume":"24","author":[{"given":"M","family":"Marega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pirola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mogavero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Iacobucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Meneghetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Parma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M","family":"Pogliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Gambacorti-Passerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,6,3]]},"reference":[{"key":"BFleu2010101_CR1","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/243290a0","volume":"243","author":"JD Rowley","year":"1973","unstructured":"Rowley JD . Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973; 243: 290\u2013293.","journal-title":"Nature"},{"key":"BFleu2010101_CR2","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/300765a0","volume":"300","author":"A de Klein","year":"1982","unstructured":"de Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 1982; 300: 765\u2013767.","journal-title":"Nature"},{"key":"BFleu2010101_CR3","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1056\/NEJMoa040258","volume":"351","author":"CH Jamieson","year":"2004","unstructured":"Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 2004; 351: 657\u2013667.","journal-title":"N Engl J Med"},{"key":"BFleu2010101_CR4","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/sj.emboj.7601485","volume":"26","author":"AM Coluccia","year":"2007","unstructured":"Coluccia AM, Vacca A, Dunach M, Mologni L, Redaelli S, Bustos VH et al. Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J 2007; 26: 1456\u20131466.","journal-title":"EMBO J"},{"key":"BFleu2010101_CR5","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1182\/blood-2007-03-078303","volume":"110","author":"JS Chang","year":"2007","unstructured":"Chang JS, Santhanam R, Trotta R, Neviani P, Eiring AM, Briercheck E et al. High levels of the BCR-ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C\/EBPalpha-driven myeloid differentiation. Blood 2007; 110: 994\u20131003.","journal-title":"Blood"},{"key":"BFleu2010101_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/ng791","volume":"30","author":"D Perrotti","year":"2002","unstructured":"Perrotti D, Cesi V, Trotta R, Guerzoni C, Santilli G, Campbell K et al. BCR-ABL suppresses C\/EBPalpha expression through inhibitory action of hnRNP E2. Nat Genet 2002; 30: 48\u201358.","journal-title":"Nat Genet"},{"key":"BFleu2010101_CR7","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ccr.2008.04.018","volume":"13","author":"MJ Bueno","year":"2008","unstructured":"Bueno MJ, Perez de Castro I, Gomez de Cedron M, Santos J, Calin GA, Cigudosa JC et al. Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell 2008; 13: 496\u2013506.","journal-title":"Cancer Cell"},{"key":"BFleu2010101_CR8","doi-asserted-by":"publisher","first-page":"7119","DOI":"10.1093\/nar\/18.23.7119","volume":"18","author":"QS Zhu","year":"1990","unstructured":"Zhu QS, Heisterkamp N, Groffen J . Unique organization of the human BCR gene promoter. Nucleic Acids Res 1990; 18: 7119\u20137125.","journal-title":"Nucleic Acids Res"},{"key":"BFleu2010101_CR9","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1128\/MCB.11.4.1854","volume":"11","author":"NP Shah","year":"1991","unstructured":"Shah NP, Witte ON, Denny CT . Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines. Mol Cell Biol 1991; 11: 1854\u20131860.","journal-title":"Mol Cell Biol"},{"key":"BFleu2010101_CR10","doi-asserted-by":"publisher","first-page":"11872","DOI":"10.1073\/pnas.172384399","volume":"99","author":"MG Manz","year":"2002","unstructured":"Manz MG, Miyamoto T, Akashi K, Weissman IL . Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci USA 2002; 99: 11872\u201311877.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2010101_CR11","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.leukres.2006.07.021","volume":"31","author":"J Rulcova","year":"2007","unstructured":"Rulcova J, Zmekova V, Zemanova Z, Klamova H, Moravcova J . The effect of total-ABL, GUS and B2M control genes on BCR-ABL monitoring by real-time RT-PCR. Leuk Res 2007; 31: 483\u2013491.","journal-title":"Leuk Res"},{"key":"BFleu2010101_CR12","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","volume":"17","author":"J Gabert","year":"2003","unstructured":"Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N et al. Standardization and quality control studies of \u2018real-time\u2019 quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia\u2014a Europe Against Cancer program. Leukemia 2003; 17: 2318\u20132357.","journal-title":"Leukemia"},{"key":"BFleu2010101_CR13","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1073\/pnas.0900189106","volume":"106","author":"AE Abrahamsson","year":"2009","unstructured":"Abrahamsson AE, Geron I, Gotlib J, Dao KH, Barroga CF, Newton IG et al. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci USA 2009; 106: 3925\u20133929.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2010101_CR14","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1002\/jcb.21505","volume":"102","author":"N Gavert","year":"2007","unstructured":"Gavert N, Ben-Ze'ev A . beta-Catenin signaling in biological control and cancer. J Cell Biochem 2007; 102: 820\u2013828.","journal-title":"J Cell Biochem"},{"key":"BFleu2010101_CR15","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1182\/blood-2005-09-3732","volume":"107","author":"M Notari","year":"2006","unstructured":"Notari M, Neviani P, Santhanam R, Blaser BW, Chang JS, Galietta A et al. A MAPK\/HNRPK pathway controls BCR-ABL oncogenic potential by regulating MYC mRNA translation. Blood 2006; 107: 2507\u20132516.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2010101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2010101","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2010101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T13:34:01Z","timestamp":1648733641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2010101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,3]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["BFleu2010101"],"URL":"https:\/\/doi.org\/10.1038\/leu.2010.101","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,3]]},"assertion":[{"value":"11 January 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}