{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:03:30Z","timestamp":1791169410768,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T00:00:00Z","timestamp":1281571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T00:00:00Z","timestamp":1281571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1038\/leu.2010.174","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T09:42:50Z","timestamp":1281606170000},"page":"1742-1750","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Analysis of genomic breakpoints in p190 and p210 BCR\u2013ABL indicate distinct mechanisms of formation"],"prefix":"10.1038","volume":"24","author":[{"given":"J","family":"Score","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Calasanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Ottman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Pane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R F","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Sobrinho-Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kreil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Hidalgo-Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J V","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wiemels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Nadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N C P","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F H","family":"Grand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,12]]},"reference":[{"key":"BFleu2010174_CR1","first-page":"421","volume":"58","author":"MW Deininger","year":"1998","unstructured":"Deininger MW, Bose S, Gora-Tybor J, Yan XH, Goldman JM, Melo JV . Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation. Cancer Res 1998; 58: 421\u2013425.","journal-title":"Cancer Res"},{"key":"BFleu2010174_CR2","first-page":"4070","volume":"17","author":"M Stanulla","year":"1997","unstructured":"Stanulla M, Wang J, Chervinsky DS, Thandla S, Aplan PD . DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. MolCell Biol 1997; 17: 4070\u20134079.","journal-title":"MolCell Biol"},{"key":"BFleu2010174_CR3","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1182\/blood.V93.4.1197","volume":"93","author":"H Neves","year":"1999","unstructured":"Neves H, Ramos C, da Silva MG, Parreira A, Parreira L . The nuclear topography of ABL, BCR, PML, and RARalpha genes: evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation. Blood 1999; 93: 1197\u20131207.","journal-title":"Blood"},{"key":"BFleu2010174_CR4","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/gcc.10154","volume":"36","author":"A Reiter","year":"2003","unstructured":"Reiter A, Saussele S, Grimwade D, Wiemels JL, Segal MR, Lafage-Pochitaloff M et al. Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia. Genes Chromosomes Cancer 2003; 36: 175\u2013188.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2010174_CR5","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/gcc.20568","volume":"47","author":"E Mattarucchi","year":"2008","unstructured":"Mattarucchi E, Guerini V, Rambaldi A, Campiotti L, Venco A, Pasquali F et al. Microhomologies and interspersed repeat elements at genomic breakpoints in chronic myeloid leukemia. Genes Chromosomes Cancer 2008; 47: 625\u2013632.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2010174_CR6","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0950-3536(97)80003-0","volume":"10","author":"JV Melo","year":"1997","unstructured":"Melo JV . BCR-ABL gene variants. Baillieres Clin Haematol 1997; 10: 203\u2013222.","journal-title":"Baillieres Clin Haematol"},{"key":"BFleu2010174_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/17.1.1","volume":"17","author":"MJ van der Feltz","year":"1989","unstructured":"van der Feltz MJ, Shivji MK, Allen PB, Heisterkamp N, Groffen J, Wiedemann LM . Nucleotide sequence of both reciprocal translocation junction regions in a patient with Ph positive acute lymphoblastic leukaemia, with a breakpoint within the first intron of the BCR gene. Nucleic Acids Res 1989; 17: 1\u201310.","journal-title":"Nucleic Acids Res"},{"key":"BFleu2010174_CR8","doi-asserted-by":"publisher","first-page":"7631","DOI":"10.1093\/nar\/17.19.7631","volume":"17","author":"SJ Chen","year":"1989","unstructured":"Chen SJ, Chen Z, Font MP, d\u2019Auriol L, Larsen CJ, Berger R . Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation. Nucleic Acids Res 1989; 17: 7631\u20137642.","journal-title":"Nucleic Acids Res"},{"key":"BFleu2010174_CR9","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/hmg\/7.5.767","volume":"7","author":"AR Jeffs","year":"1998","unstructured":"Jeffs AR, Benjes SM, Smith TL, Sowerby SJ, Morris CM . The BCR gene recombines preferentially with Alu elements in complex BCR-ABL translocations of chronic myeloid leukaemia. Hum Mol Genet 1998; 7: 767\u2013776.","journal-title":"Hum Mol Genet"},{"key":"BFleu2010174_CR10","first-page":"195","volume":"4","author":"SJ Chen","year":"1989","unstructured":"Chen SJ, Chen Z, d\u2019Auriol L, Le Coniat M, Grausz D, Berger R . Ph1+bcr- acute leukemias: implication of Alu sequences in a chromosomal translocation occurring in the new cluster region within the BCR gene. Oncogene 1989; 4: 195\u2013202.","journal-title":"Oncogene"},{"key":"BFleu2010174_CR11","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.cell.2008.09.062","volume":"135","author":"DF Robbiani","year":"2008","unstructured":"Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S et al. AID is required for the chromosomal breaks in c-myc that lead to c-myc\/IgH translocations. Cell 2008; 135: 1028\u20131038.","journal-title":"Cell"},{"key":"BFleu2010174_CR12","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/j.cell.2008.10.035","volume":"135","author":"AG Tsai","year":"2008","unstructured":"Tsai AG, Lu H, Raghavan SC, Muschen M, Hsieh CL, Lieber MR . Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell 2008; 135: 1130\u20131142.","journal-title":"Cell"},{"key":"BFleu2010174_CR13","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.dnarep.2006.05.015","volume":"5","author":"R Marculescu","year":"2006","unstructured":"Marculescu R, Vanura K, Montpellier B, Roulland S, Le T, Navarro JM et al. Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures. DNA Repair (Amst) 2006; 5: 1246\u20131258.","journal-title":"DNA Repair (Amst)"},{"key":"BFleu2010174_CR14","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/nri1152","volume":"3","author":"DB Roth","year":"2003","unstructured":"Roth DB . Restraining the V(D)J recombinase. Nat Rev Immunol 2003; 3: 656\u2013666.","journal-title":"Nat Rev Immunol"},{"key":"BFleu2010174_CR15","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/978-1-4419-0296-2_3","volume":"650","author":"VL Brandt","year":"2009","unstructured":"Brandt VL, Roth DB . Recent insights into the formation of RAG-induced chromosomal translocations. Adv Exp Med Biol 2009; 650: 32\u201345.","journal-title":"Adv Exp Med Biol"},{"key":"BFleu2010174_CR16","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1126\/science.2255914","volume":"250","author":"PD Aplan","year":"1990","unstructured":"Aplan PD, Lombardi DP, Ginsberg AM, Cossman J, Bertness VL, Kirsch IR . Disruption of the human SCL locus by \u2018illegitimate\u2019 V-(D)-J recombinase activity. Science 1990; 250: 1426\u20131429.","journal-title":"Science"},{"key":"BFleu2010174_CR17","doi-asserted-by":"publisher","first-page":"5904","DOI":"10.1128\/MCB.25.14.5904-5919.2005","volume":"25","author":"SC Raghavan","year":"2005","unstructured":"Raghavan SC, Swanson PC, Ma Y, Lieber MR . Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro. Mol Cell Biol 2005; 25: 5904\u20135919.","journal-title":"Mol Cell Biol"},{"key":"BFleu2010174_CR18","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1172\/JCI109193","volume":"62","author":"PJ Fialkow","year":"1978","unstructured":"Fialkow PJ, Denman AM, Jacobson RJ, Lowenthal MN . Chronic myelocytic leukemia. Origin of some lymphocytes from leukemic stem cells. J Clin Invest 1978; 62: 815\u2013823.","journal-title":"J Clin Invest"},{"key":"BFleu2010174_CR19","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1182\/blood.V95.3.1007.003k35_1007_1013","volume":"95","author":"C Cobaleda","year":"2000","unstructured":"Cobaleda C, Gutierrez-Cianca N, Perez-Losada J, Flores T, Garcia-Sanz R, Gonzalez M et al. A primitive hematopoietic cell is the target for the leukemic transformation in human philadelphia-positive acute lymphoblastic leukemia. Blood 2000; 95: 1007\u20131013.","journal-title":"Blood"},{"key":"BFleu2010174_CR20","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/sj.leu.2400986","volume":"12","author":"TM Schenk","year":"1998","unstructured":"Schenk TM, Keyhani A, Bottcher S, Kliche KO, Goodacre A, Guo JQ et al. Multilineage involvement of Philadelphia chromosome positive acute lymphoblastic leukemia. Leukemia 1998; 12: 666\u2013674.","journal-title":"Leukemia"},{"key":"BFleu2010174_CR21","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1038\/leu.2008.386","volume":"23","author":"M Zaliova","year":"2009","unstructured":"Zaliova M, Fronkova E, Krejcikova K, Muzikova K, Mejstrikova E, Stary J et al. Quantification of fusion transcript reveals a subgroup with distinct biological properties and predicts relapse in BCR\/ABL-positive ALL: implications for residual disease monitoring. Leukemia 2009; 23: 944\u2013951.","journal-title":"Leukemia"},{"key":"BFleu2010174_CR22","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.cancergencyto.2004.06.011","volume":"157","author":"U Bacher","year":"2005","unstructured":"Bacher U, Haferlach T, Hiddemann W, Schnittger S, Kern W, Schoch C . Additional clonal abnormalities in Philadelphia-positive ALL and CML demonstrate a different cytogenetic pattern at diagnosis and follow different pathways at progression. Cancer Genet Cytogenet 2005; 157: 53\u201361.","journal-title":"Cancer Genet Cytogenet"},{"key":"BFleu2010174_CR23","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1182\/blood.V71.5.1495.1495","volume":"71","author":"AG Turhan","year":"1988","unstructured":"Turhan AG, Eaves CJ, Kalousek DK, Eaves AC, Humphries RK . Molecular analysis of clonality and bcr rearrangements in Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 1988; 71: 1495\u20131498.","journal-title":"Blood"},{"key":"BFleu2010174_CR24","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1158\/0008-5472.CAN-04-1356","volume":"65","author":"M Hotfilder","year":"2005","unstructured":"Hotfilder M, Rottgers S, Rosemann A, Schrauder A, Schrappe M, Pieters R et al. Leukemic stem cells in childhood high-risk ALL\/t(9;22) and t(4;11) are present in primitive lymphoid-restricted CD34+. Cancer Res 2005; 65: 1442\u20131449.","journal-title":"Cancer Res"},{"key":"BFleu2010174_CR25","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nm1253","volume":"11","author":"A Castor","year":"2005","unstructured":"Castor A, Nilsson L, Astrand-Grundstrom I, Buitenhuis M, Ramirez C, Anderson K et al. Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med 2005; 11: 630\u2013637.","journal-title":"Nat Med"},{"key":"BFleu2010174_CR26","first-page":"208","volume":"8","author":"JV Melo","year":"1994","unstructured":"Melo JV, Myint H, Galton DA, Goldman JM . P190BCR-ABL chronic myeloid leukaemia: the missing link with chronic myelomonocytic leukaemia? Leukemia 1994; 8: 208\u2013211.","journal-title":"Leukemia"},{"key":"BFleu2010174_CR27","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1084\/jem.189.9.1399","volume":"189","author":"S Li","year":"1999","unstructured":"Li S, Ilaria Jr RL, Million RP, Daley GQ, Van Etten RA . The P190, P210, and P230 forms of the BCR\/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med 1999; 189: 1399\u20131412.","journal-title":"J Exp Med"},{"key":"BFleu2010174_CR28","first-page":"186","volume":"8","author":"NCP Cross","year":"1994","unstructured":"Cross NCP, Melo JV, Feng L, Goldman JM . An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders. Leukemia 1994; 8: 186\u2013189.","journal-title":"Leukemia"},{"key":"BFleu2010174_CR29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1046\/j.1365-2141.2003.04051.x","volume":"120","author":"EJ Baxter","year":"2003","unstructured":"Baxter EJ, Kulkarni S, Vizmanos JL, Jaju R, Martinelli G, Testoni N et al. Novel translocations that disrupt the platelet-derived growth factor receptor beta (PDGFRB) gene in BCR-ABL-negative chronic myeloproliferative disorders. Br J Haematol 2003; 120: 251\u2013256.","journal-title":"Br J Haematol"},{"key":"BFleu2010174_CR30","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1182\/blood-2007-02-074252","volume":"110","author":"S Kreil","year":"2007","unstructured":"Kreil S, Pfirrmann M, Haferlach C, Waghorn K, Chase A, Hehlmann R et al. Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia. Blood 2007; 110: 1283\u20131290.","journal-title":"Blood"},{"key":"BFleu2010174_CR31","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1198\/016214502753479239","volume":"97","author":"MR Segal","year":"2002","unstructured":"Segal MR, Wiemels JL . Clustering of translocation breakpoints. Journal of the American Statistical Association 2002; 97: 66\u201376.","journal-title":"Journal of the American Statistical Association"},{"key":"BFleu2010174_CR32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1146\/annurev.biochem.71.090501.150203","volume":"71","author":"M Gellert","year":"2002","unstructured":"Gellert M . V(D)J recombination: RAG proteins, repair factors, and regulation. Annu Rev Biochem 2002; 71: 101\u2013132.","journal-title":"Annu Rev Biochem"},{"key":"BFleu2010174_CR33","doi-asserted-by":"publisher","first-page":"15101","DOI":"10.1073\/pnas.222481199","volume":"99","author":"JL Wiemels","year":"2002","unstructured":"Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT et al. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2002; 99: 15101\u201315106.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2010174_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1084\/jem.20011578","volume":"195","author":"R Marculescu","year":"2002","unstructured":"Marculescu R, Le T, Simon P, Jaeger U, Nadel B . V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites. J Exp Med 2002; 195: 85\u201398.","journal-title":"J Exp Med"},{"key":"BFleu2010174_CR35","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1128\/MCB.26.1.131-139.2006","volume":"26","author":"DM Weinstock","year":"2006","unstructured":"Weinstock DM, Jasin M . Alternative pathways for the repair of RAG-induced DNA breaks. Mol Cell Biol 2006; 26: 131\u2013139.","journal-title":"Mol Cell Biol"},{"key":"BFleu2010174_CR36","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/ncb1624","volume":"9","author":"DM Weinstock","year":"2007","unstructured":"Weinstock DM, Brunet E, Jasin M . Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat Cell Biol 2007; 9: 978\u2013981.","journal-title":"Nat Cell Biol"},{"key":"BFleu2010174_CR37","first-page":"85","volume":"25","author":"PC Nowell","year":"1960","unstructured":"Nowell PC, Hungerford DA . Chromosome studies on normal and leukemic human leukocytes. J NatlCancer Inst 1960; 25: 85\u2013109.","journal-title":"J NatlCancer Inst"},{"key":"BFleu2010174_CR38","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1038\/sj.onc.1202229","volume":"17","author":"M Reichel","year":"1998","unstructured":"Reichel M, Gillert E, Nilson I, Siegler G, Greil J, Fey GH et al. Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation. Oncogene 1998; 17: 3035\u20133044.","journal-title":"Oncogene"},{"key":"BFleu2010174_CR39","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1365-2141.1995.tb03392.x","volume":"90","author":"JG Zhang","year":"1995","unstructured":"Zhang JG, Goldman JM, Cross NCP . Characterization of genomic BCR-ABL breakpoints in chronic myeloid leukaemia by PCR. BrJ Haematol 1995; 90: 138\u2013146.","journal-title":"BrJ Haematol"},{"key":"BFleu2010174_CR40","first-page":"1","volume":"2","author":"B Tycko","year":"1990","unstructured":"Tycko B, Sklar J . Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase model. Cancer Cells 1990; 2: 1\u20138.","journal-title":"Cancer Cells"},{"key":"BFleu2010174_CR41","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature02355","volume":"428","author":"SC Raghavan","year":"2004","unstructured":"Raghavan SC, Swanson PC, Wu X, Hsieh CL, Lieber MR . A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature 2004; 428: 88\u201393.","journal-title":"Nature"},{"key":"BFleu2010174_CR42","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/ng.2007.35","volume":"40","author":"L Pasqualucci","year":"2008","unstructured":"Pasqualucci L, Bhagat G, Jankovic M, Compagno M, Smith P, Muramatsu M et al. AID is required for germinal center-derived lymphomagenesis. Nat Genet 2008; 40: 108\u2013112.","journal-title":"Nat Genet"},{"key":"BFleu2010174_CR43","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1182\/blood.V73.5.1312.1312","volume":"73","author":"SJ Chen","year":"1989","unstructured":"Chen SJ, Chen Z, Hillion J, Grausz D, Loiseau P, Flandrin G et al. Ph1-positive, bcr-negative acute leukemias: clustering of breakpoints on chromosome 22 in the 3\u2032 end of the BCR gene first intron. Blood 1989; 73: 1312\u20131315.","journal-title":"Blood"},{"key":"BFleu2010174_CR44","doi-asserted-by":"publisher","first-page":"7631","DOI":"10.1093\/nar\/17.19.7631","volume":"17","author":"SJ Chen","year":"1989","unstructured":"Chen SJ, Chen Z, Font MP, d\u2019Auriol L, Larsen CJ, Berger R . Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation. Nucleic Acids Res 1989; 17: 7631\u20137642.","journal-title":"Nucleic Acids Res"},{"key":"BFleu2010174_CR45","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1182\/blood.V81.10.2488.2488","volume":"81","author":"JV Melo","year":"1993","unstructured":"Melo JV, Gordon DE, Tuszynski A, Dhut S, Young BD, Goldman JM . Expression of the ABL-BCR fusion gene in Philadelphia-positive acute lymphoblastic leukemia. Blood 1993; 81: 2488\u20132491.","journal-title":"Blood"},{"key":"BFleu2010174_CR46","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/sj.leu.2402829","volume":"17","author":"G Specchia","year":"2003","unstructured":"Specchia G, Albano F, Anelli L, Storlazzi CT, Zagaria A, Mancini M et al. Deletions on der(9) chromosome in adult Ph-positive acute lymphoblastic leukemia occur with a frequency similar to that observed in chronic myeloid leukemia. Leukemia 2003; 17: 528\u2013531.","journal-title":"Leukemia"},{"key":"BFleu2010174_CR47","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1182\/blood.V98.6.1732","volume":"98","author":"BJ Huntly","year":"2001","unstructured":"Huntly BJ, Reid AG, Bench AJ, Campbell LJ, Telford N, Shepherd P et al. Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia. Blood 2001; 98: 1732\u20131738.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2010174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2010174","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2010174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T13:33:24Z","timestamp":1648733604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2010174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,12]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["BFleu2010174"],"URL":"https:\/\/doi.org\/10.1038\/leu.2010.174","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,12]]},"assertion":[{"value":"12 May 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}