{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:34:31Z","timestamp":1791293671451,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T00:00:00Z","timestamp":1310083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T00:00:00Z","timestamp":1310083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1038\/leu.2011.166","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T13:30:34Z","timestamp":1310131834000},"page":"1849-1856","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["E\u03bc\/miR-125b transgenic mice develop lethal B-cell malignancies"],"prefix":"10.1038","volume":"25","author":[{"given":"Y","family":"Enomoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kitaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Hatakeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Watanuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Akasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Shimanuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Taniwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Haferlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J S","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Asou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Aburatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Nakakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sonoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,7,8]]},"reference":[{"key":"BFleu2011166_CR1","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1182\/blood.V96.3.808","volume":"96","author":"TG Willis","year":"2000","unstructured":"Willis TG, Dyer MJ . The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies. Blood 2000; 96: 808\u2013822.","journal-title":"Blood"},{"key":"BFleu2011166_CR2","doi-asserted-by":"publisher","first-page":"5580","DOI":"10.1038\/sj.onc.1204640","volume":"20","author":"R K\u00fcppers","year":"2001","unstructured":"K\u00fcppers R, Dalla-Favera R . Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 2001; 20: 5580\u20135594.","journal-title":"Oncogene"},{"key":"BFleu2011166_CR3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V Ambros","year":"2004","unstructured":"Ambros V . The functions of animal microRNAs. Nature 2004; 431: 350\u2013355.","journal-title":"Nature"},{"key":"BFleu2011166_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"D Bartel","year":"2004","unstructured":"Bartel D . MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281\u2013297.","journal-title":"Cell"},{"key":"BFleu2011166_CR5","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.4161\/cc.7.16.6453","volume":"7","author":"PP Medina","year":"2008","unstructured":"Medina PP, Slack FJ . microRNAs and cancer: an overview. Cell Cycle 2008; 7: 2485\u20132492.","journal-title":"Cell Cycle"},{"key":"BFleu2011166_CR6","doi-asserted-by":"publisher","first-page":"5848","DOI":"10.1200\/JCO.2009.24.0317","volume":"27","author":"MV Iorio","year":"2009","unstructured":"Iorio MV, Croce CM . MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol 2009; 27: 5848\u20135856.","journal-title":"J Clin Oncol"},{"key":"BFleu2011166_CR7","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1038\/sj.leu.2403938","volume":"19","author":"T Sonoki","year":"2005","unstructured":"Sonoki T, Iwanaga E, Mitsuya H, Asou N . Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia. Leukemia 2005; 19: 2009\u20132010.","journal-title":"Leukemia"},{"key":"BFleu2011166_CR8","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1084\/jem.20080285","volume":"205","author":"M Bousquet","year":"2008","unstructured":"Bousquet M, Quelen C, Rosati R, Mansat-De Mas V, La Starza R, Bastard C et al. Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med 2008; 205: 2499\u20132506.","journal-title":"J Exp Med"},{"key":"BFleu2011166_CR9","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1038\/leu.2010.93","volume":"24","author":"E Chapiro","year":"2010","unstructured":"Chapiro E, Russell L, Struski S, Cav\u00e9 H, Radford-Weiss I, Valle V et al. A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia. Leukemia 2010; 24: 1362\u20131364.","journal-title":"Leukemia"},{"key":"BFleu2011166_CR10","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/gcc.20776","volume":"49","author":"E Tassano","year":"2010","unstructured":"Tassano E, Acquila M, Tavella E, Micalizzi C, Panarello C, Morerio C . MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer 2010; 49: 682\u2013687.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2011166_CR11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/leu.2009.208","volume":"24","author":"N Gefen","year":"2010","unstructured":"Gefen N, Binder V, Zaliova M, Linka Y, Morrow M, Novosel A et al. Hsa-mir-125b-2 is highly expressed in childhood ETV6\/RUNX1 (TEL\/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53. Leukemia 2010; 24: 89\u201396.","journal-title":"Leukemia"},{"key":"BFleu2011166_CR12","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1101\/gad.1856210","volume":"24","author":"J Klusmann","year":"2010","unstructured":"Klusmann J, Li Z, B\u00f6hmer K, Maroz A, Koch M, Emmrich S et al. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev 2010; 24: 478\u2013490.","journal-title":"Genes Dev"},{"key":"BFleu2011166_CR13","doi-asserted-by":"publisher","first-page":"14235","DOI":"10.1073\/pnas.1009798107","volume":"107","author":"R O'Connell","year":"2010","unstructured":"O'Connell R, Chaudhuri A, Rao D, Gibson W, Balazs A, Baltimore D . MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci USA 2010; 107: 14235\u201314240.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2011166_CR14","doi-asserted-by":"publisher","first-page":"21558","DOI":"10.1073\/pnas.1016611107","volume":"107","author":"M Bousquet","year":"2010","unstructured":"Bousquet M, Harris MH, Zhou B, Lodish HF . MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci USA 2010; 107: 21558\u201321563.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2011166_CR15","doi-asserted-by":"publisher","first-page":"21505","DOI":"10.1073\/pnas.1016218107","volume":"107","author":"AG Ooi","year":"2010","unstructured":"Ooi AG, Sahoo D, Adorno M, Wang Y, Weissman IL, Park CY . MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc Natl Acad Sci USA 2010; 107: 21505\u201321510.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2011166_CR16","doi-asserted-by":"publisher","first-page":"37722","DOI":"10.1074\/jbc.M301979200","volume":"278","author":"R Tomasini","year":"2003","unstructured":"Tomasini R, Samir A, Carrier A, Isnardon D, Cecchinelli B, Soddu S et al. TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. J Biol Chem 2003; 278: 37722\u201337729.","journal-title":"J Biol Chem"},{"key":"BFleu2011166_CR17","doi-asserted-by":"publisher","first-page":"44185","DOI":"10.1074\/jbc.M105647200","volume":"276","author":"R Tomasini","year":"2001","unstructured":"Tomasini R, Samir A, Vaccaro M, Pebusque M, Dagorn J, Iovanna J et al. Molecular and functional characterization of the stress-induced protein (SIP) gene and its two transcripts generated by alternative splicing. SIP induced by stress and promotes cell death. J Biol Chem 2001; 276: 44185\u201344192.","journal-title":"J Biol Chem"},{"key":"BFleu2011166_CR18","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1078\/0171-9335-00248","volume":"81","author":"R Tomasini","year":"2002","unstructured":"Tomasini R, Samir A, Pebusque M, Calvo E, Totaro S, Dagorn J et al. P53-dependent expression of the stress-induced protein (SIP). Eur J Cell Biol 2002; 81: 294\u2013301.","journal-title":"Eur J Cell Biol"},{"key":"BFleu2011166_CR19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S1097-2765(01)00284-2","volume":"8","author":"S Okamura","year":"2001","unstructured":"Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y et al. p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell 2001; 8: 85\u201394.","journal-title":"Mol Cell"},{"key":"BFleu2011166_CR20","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1182\/blood-2006-08-041012","volume":"109","author":"T Akasaka","year":"2007","unstructured":"Akasaka T, Balasas T, Russell LJ, Sugimoto KJ, Majid A, Walewska R et al. Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood 2007; 109: 3451\u20133461.","journal-title":"Blood"},{"key":"BFleu2011166_CR21","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1182\/blood-2010-02-270181","volume":"117","author":"N Kato","year":"2011","unstructured":"Kato N, Kitaura J, Doki N, Komeno Y, Watanabe-Okochi N, Togami K et al. Two types of C\/EBP\u03b1 mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models. Blood 2011; 117: 221\u2013233.","journal-title":"Blood"},{"key":"BFleu2011166_CR22","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s12185-009-0299-0","volume":"89","author":"N Watanabe-Okochi","year":"2009","unstructured":"Watanabe-Okochi N, Oki T, Komeno Y, Kato N, Yuji K, Ono R et al. Possible involvement of RasGRP4 in leukemogenesis. Int J Hematol 2009; 89: 470\u2013481.","journal-title":"Int J Hematol"},{"key":"BFleu2011166_CR23","doi-asserted-by":"publisher","first-page":"35274","DOI":"10.1074\/jbc.M110.137166","volume":"285","author":"Y Enomoto","year":"2010","unstructured":"Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takahashi M, Maehara A et al. Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)\/CLM-3 as an activating receptor: its similarities to and differences from LMIR4\/CLM-5. J Biol Chem 2010; 285: 35274\u201335283.","journal-title":"J Biol Chem"},{"key":"BFleu2011166_CR24","doi-asserted-by":"publisher","first-page":"17997","DOI":"10.1074\/jbc.M701100200","volume":"282","author":"K Izawa","year":"2007","unstructured":"Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Oki T, Shibata F et al. Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3. J Biol Chem 2007; 282: 17997\u201318008.","journal-title":"J Biol Chem"},{"key":"BFleu2011166_CR25","doi-asserted-by":"publisher","first-page":"925","DOI":"10.4049\/jimmunol.0900552","volume":"183","author":"K Izawa","year":"2009","unstructured":"Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M et al. An activating and inhibitory signal from an inhibitory receptor LMIR3\/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J Immunol 2009; 183: 925\u2013936.","journal-title":"J Immunol"},{"key":"BFleu2011166_CR26","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1182\/blood-2007-04-085787","volume":"111","author":"Y Yamanishi","year":"2008","unstructured":"Yamanishi Y, Kitaura J, Izawa K, Matsuoka T, Oki T, Lu Y et al. Analysis of mouse LMIR5\/CLM-7 as an activating receptor: differential regulation of LMIR5\/CLM-7 in mouse versus human cells. Blood 2008; 111: 688\u2013698.","journal-title":"Blood"},{"key":"BFleu2011166_CR27","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1172\/JCI200522725","volume":"115","author":"R Ono","year":"2005","unstructured":"Ono R, Nakajima H, Ozaki K, Kumagai H, Kawashima T, Taki T et al. Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis. J Clin Invest 2005; 115: 919\u2013929.","journal-title":"J Clin Invest"},{"key":"BFleu2011166_CR28","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/leu.2010.40","volume":"24","author":"Y Komeno","year":"2010","unstructured":"Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F et al. AID-induced T-lymphoma or B-leukemia\/lymphoma in a mouse BMT model. Leukemia 2010; 24: 1018\u20131024.","journal-title":"Leukemia"},{"key":"BFleu2011166_CR29","doi-asserted-by":"publisher","first-page":"7024","DOI":"10.1073\/pnas.0602266103","volume":"103","author":"S Costinean","year":"2006","unstructured":"Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, Heerema N et al. Pre-B cell proliferation and lymphoblastic leukemia\/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA 2006; 103: 7024\u20137029.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2011166_CR30","doi-asserted-by":"publisher","first-page":"16170","DOI":"10.1073\/pnas.0703942104","volume":"104","author":"M Gironella","year":"2007","unstructured":"Gironella M, Seux M, Xie M, Cano C, Tomasini R, Gommeaux J et al. Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. Proc Natl Acad Sci USA 2007; 104: 16170\u201316175.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2011166_CR31","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1128\/MCB.01454-06","volume":"27","author":"J Gommeaux","year":"2007","unstructured":"Gommeaux J, Cano C, Garcia S, Gironella M, Pietri S, Culcasi M et al. Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1. Mol Cell Biol 2007; 27: 2215\u20132228.","journal-title":"Mol Cell Biol"},{"key":"BFleu2011166_CR32","doi-asserted-by":"publisher","first-page":"14229","DOI":"10.1073\/pnas.0913574107","volume":"107","author":"S Guo","year":"2010","unstructured":"Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC et al. MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci USA 2010; 107: 14229\u201314234.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2011166_CR33","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/nature09284","volume":"467","author":"PP Medina","year":"2010","unstructured":"Medina PP, Nolde M, Slack FJ . OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 2010; 467: 86\u201390.","journal-title":"Nature"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2011166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2011166","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2011166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T14:17:00Z","timestamp":1648736220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2011166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,8]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["BFleu2011166"],"URL":"https:\/\/doi.org\/10.1038\/leu.2011.166","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,8]]},"assertion":[{"value":"4 March 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}