{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:11:52Z","timestamp":1791277912398,"version":"4.1.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T00:00:00Z","timestamp":1312502400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T00:00:00Z","timestamp":1312502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1038\/leu.2011.187","type":"journal-article","created":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T08:57:12Z","timestamp":1312534632000},"page":"172-177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients"],"prefix":"10.1038","volume":"26","author":[{"given":"F X","family":"Gruber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Porkka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Engh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Mikkola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hochhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,5]]},"reference":[{"key":"BFleu2011187_CR1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1126\/science.1099480","volume":"305","author":"NP Shah","year":"2004","unstructured":"Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL . Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305: 399\u2013401.","journal-title":"Science"},{"key":"BFleu2011187_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ccr.2005.01.007","volume":"7","author":"E Weisberg","year":"2005","unstructured":"Weisberg E, Manley PW, Breitenstein W, Br\u00fcggen J, Cowan-Jacob SW, Ray A et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005; 7: 129\u2013141.","journal-title":"Cancer Cell"},{"key":"BFleu2011187_CR3","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1182\/blood-2007-03-066936","volume":"110","author":"T O\u2019Hare","year":"2007","unstructured":"O\u2019Hare T, Eide CA, Deininger MW . Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood 2007; 110: 2242\u20132249.","journal-title":"Blood"},{"key":"BFleu2011187_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1200\/JCO.2008.19.8853","volume":"27","author":"S Radaelli","year":"2009","unstructured":"Radaelli S, Piazza R, Rostagno R, Magistroni V, Perini P, Marega M et al. Activity of bosutinib, dasatinib and nilotinib against 18 imatinib resistant BCR\/ABL mutants. J Clin Oncol 2009; 27: 469\u2013471.","journal-title":"J Clin Oncol"},{"key":"BFleu2011187_CR5","doi-asserted-by":"publisher","first-page":"6041","DOI":"10.1200\/JCO.2009.25.0779","volume":"27","author":"M Baccarani","year":"2009","unstructured":"Baccarani M, Cortes J, Pane F, Niederwieser D, Saglio G, Apperley J et al. European Leukemia Net. J Clin Oncol 2009; 27: 6041\u20136051.","journal-title":"J Clin Oncol"},{"key":"BFleu2011187_CR6","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.3324\/haematol.2009.006981","volume":"94","author":"T Ernst","year":"2009","unstructured":"Ernst T, Gruber FX, Pelz-Ackermann O, Maier J, Pfirrmann M, M\u00fcller MC et al. A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib. Haematologica 2009; 94: 1227\u20131235.","journal-title":"Haematologica"},{"key":"BFleu2011187_CR7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3109\/10428199309047861","volume":"11","author":"NC Cross","year":"1993","unstructured":"Cross NC, Feng L, Bungey J, Goldman JM . Minimal residual disease after bone marrow transplant for chronic myeloid leukaemia detected by the polymerase chain reaction. Leuk Lymphoma 1993; 11: 39\u201343.","journal-title":"Leuk Lymphoma"},{"key":"BFleu2011187_CR8","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1038\/sj.leu.2401566","volume":"13","author":"M Emig","year":"1999","unstructured":"Emig M, Saussele S, Wittor H, Weisser A, Reiter A, Willer A et al. Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR. Leukemia 1999; 13: 1825\u20131832.","journal-title":"Leukemia"},{"key":"BFleu2011187_CR9","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1038\/sj.leu.2403983","volume":"19","author":"FX Gruber","year":"2005","unstructured":"Gruber FX, Lamark T, Anonli A, Sovershaev MA, Olsen M, Gedde-Dahl T et al. Selecting and deselecting imatinib-resistant clones: observations made by longitudinal, quantitative monitoring of mutated BCR-ABL. Leukemia 2005; 19: 2159\u20132165.","journal-title":"Leukemia"},{"key":"BFleu2011187_CR10","doi-asserted-by":"crossref","unstructured":"Gruber FX, Ernst T, Kiselev Y, Hochhaus A, Mikkola I . Detection of drug-resistant clones in chronicmyelogenous leukemia patients during dasatinib and nilotinib treatment. Clin Chem 2010 Mar; 56:469\u201356:473.","DOI":"10.1373\/clinchem.2009.133843"},{"key":"BFleu2011187_CR11","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/nm1487","volume":"12","author":"I Roeder","year":"2006","unstructured":"Roeder I, Horn M, Glauche I, Hochhaus A, Mueller MC, Loeffler M . Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nat Med 2006; 12: 1181\u20131184.","journal-title":"Nat Med"},{"key":"BFleu2011187_CR12","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1038\/nature03669","volume":"435","author":"F Michor","year":"2005","unstructured":"Michor F, Hughes TP, Iwasa Y, Branford S, Shah NP, Sawyers CL et al. Dynamics of chronic myeloid leukaemia. Nature 2005; 435: 1267\u20131270.","journal-title":"Nature"},{"key":"BFleu2011187_CR13","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1055\/s-2002-34939","volume":"127","author":"MC M\u00fcller","year":"2002","unstructured":"M\u00fcller MC, Lahaye T, Hochhaus A . Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells. Dtsch Med Wochenschr 2002; 127: 2205\u20132207.","journal-title":"Dtsch Med Wochenschr"},{"key":"BFleu2011187_CR14","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3324\/haematol.2010.030999","volume":"96","author":"B Hanfstein","year":"2011","unstructured":"Hanfstein B, Mueller MC, Kreil S, Schenk T, Lorentz U, Schwindel A et al. Dynamics of mutant BCR-ABL positive clones after cessation of tyrosine kinase therapy. Haematologica 2011; 96: 360\u2013366.","journal-title":"Haematologica"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2011187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2011187","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2011187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T14:25:31Z","timestamp":1648736731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2011187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,5]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["BFleu2011187"],"URL":"https:\/\/doi.org\/10.1038\/leu.2011.187","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,5]]},"assertion":[{"value":"5 August 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}