{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:31:22Z","timestamp":1790602282375,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T00:00:00Z","timestamp":1334793600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1038\/leu.2012.108","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T08:18:06Z","timestamp":1334823486000},"page":"2343-2352","source":"Crossref","is-referenced-by-count":89,"title":["Differential regulation of miR-21 and miR-146a by Epstein\u2013Barr virus-encoded EBNA2"],"prefix":"10.1038","volume":"26","author":[{"given":"P","family":"Rosato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Anastasiadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Lenze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Boccellato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Vincenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Severa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E M","family":"Coccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cirone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A F","family":"Campese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hummel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Frati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Presutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Faggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,19]]},"reference":[{"key":"BFleu2012108_CR1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.semcancer.2009.07.004","volume":"19","author":"M Rowe","year":"2009","unstructured":"Rowe M, Kelly GL, Bell AI, Rickinson AB . Burkitt's lymphoma: the Rosetta Stone deciphering Epstein-Barr virus biology. Semin Cancer Biol 2009; 19: 377\u2013388.","journal-title":"Semin Cancer Biol"},{"key":"BFleu2012108_CR2","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1128\/JVI.44.3.834-844.1982","volume":"44","author":"M Rabson","year":"1982","unstructured":"Rabson M, Gradoville L, Heston L, Miller G . Non-immortalizing P3J-HR-1 Epstein-Barr virus: a deletion mutant of its transforming parent, Jijoye. J Virol 1982; 44: 834\u2013844.","journal-title":"J Virol"},{"key":"BFleu2012108_CR3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/JVI.67.1.606-609.1993","volume":"67","author":"A Marchini","year":"1993","unstructured":"Marchini A, Kieff E, Longnecker R . Marker rescue of a transformation-negative Epstein-Barr virus recombinant from an infected Burkitt lymphoma cell line: a method useful for analysis of genes essential for transformation. J Virol 1993; 67: 606\u2013609.","journal-title":"J Virol"},{"key":"BFleu2012108_CR4","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/j.1460-2075.1996.tb00367.x","volume":"15","author":"N Jochner","year":"1996","unstructured":"Jochner N, Eick D, Zimber-Strobl U, Pawlita M, Bornkamm GW, Kempkes B . Epstein-Barr virus nuclear antigen 2 is a transcriptional suppressor of the immunoglobulin mu gene: implications for the expression of the translocated c-myc gene in Burkitt's lymphoma cells. EMBO J 1996; 15: 375\u2013382.","journal-title":"EMBO J"},{"key":"BFleu2012108_CR5","first-page":"1397","volume":"60","author":"G Brady","year":"2007","unstructured":"Brady G, MacArthur GJ, Farrell PJ . Epstein-Barr virus and Burkitt lymphoma. J Clin Pathol 2007; 60: 1397\u20131402.","journal-title":"J Clin Pathol"},{"key":"BFleu2012108_CR6","doi-asserted-by":"publisher","first-page":"7568","DOI":"10.1073\/pnas.91.16.7568","volume":"91","author":"SR Grossman","year":"1994","unstructured":"Grossman SR, Johannsen E, Tong X, Yalamanchili R, Kieff E . The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein. Proc Natl Acad Sci USA 1994; 91: 7568\u20137572.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012108_CR7","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1128\/JVI.68.11.6947-6958.1994","volume":"68","author":"G Laux","year":"1994","unstructured":"Laux G, Dugrillon F, Eckert C, Adam B, Zimber-Strobl U, Bornkamm GW . Identification and characterization of an Epstein-Barr virus nuclear antigen 2-responsive cis element in the bidirectional promoter region of latent membrane protein and terminal protein 2 genes. J Virol 1994; 68: 6947\u20136958.","journal-title":"J Virol"},{"key":"BFleu2012108_CR8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1128\/JVI.69.1.253-262.1995","volume":"69","author":"E Johannsen","year":"1995","unstructured":"Johannsen E, Koh E, Mosialos G, Tong X, Kieff E, Grossman SR . Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1. J Virol 1995; 69: 253\u2013262.","journal-title":"J Virol"},{"key":"BFleu2012108_CR9","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1073\/pnas.97.1.430","volume":"97","author":"L Wang","year":"2000","unstructured":"Wang L, Grossman SR, Kieff E . Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter. Proc Natl Acad Sci USA 2000; 97: 430\u2013435.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012108_CR10","doi-asserted-by":"publisher","first-page":"7456","DOI":"10.1128\/JVI.00223-08","volume":"82","author":"W Lucchesi","year":"2008","unstructured":"Lucchesi W, Brady G, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ . Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2. J Virol 2008; 82: 7456\u20137466.","journal-title":"J Virol"},{"key":"BFleu2012108_CR11","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1128\/JVI.01822-06","volume":"81","author":"F Boccellato","year":"2007","unstructured":"Boccellato F, Anastasiadou E, Rosato P, Kempkes B, Frati L, Faggioni A et al. EBNA2 interferes with the germinal center phenotype by downregulating BCL6 and TCL1 in non-Hodgkin's lymphoma cells. J Virol 2007; 81: 2274\u20132283.","journal-title":"J Virol"},{"key":"BFleu2012108_CR12","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1073\/pnas.0510612103","volume":"103","author":"B Zhao","year":"2006","unstructured":"Zhao B, Maruo S, Cooper AR, Chase M, Johannsen E, Kieff E et al. RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines. Proc Natl Acad Sci USA 2006; 103: 1900\u20131905.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012108_CR13","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1172\/JCI32577","volume":"117","author":"GA Calin","year":"2007","unstructured":"Calin GA, Croce CM . Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications. J Clin Invest 2007; 117: 2059\u20132066.","journal-title":"J Clin Invest"},{"key":"BFleu2012108_CR14","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1126\/science.1096781","volume":"304","author":"S Pfeffer","year":"2004","unstructured":"Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J et al. Identification of virus-encoded microRNAs. Science 2004; 304: 734\u2013736.","journal-title":"Science"},{"key":"BFleu2012108_CR15","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1038\/sj.onc.1210147","volume":"26","author":"J Kluiver","year":"2007","unstructured":"Kluiver J, van den Berg A, de Jong D, Blokzijl T, Harms G, Bouwman E et al. Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma. Oncogene 2007; 26: 3769\u20133776.","journal-title":"Oncogene"},{"key":"BFleu2012108_CR16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/gcc.20273","volume":"45","author":"J Kluiver","year":"2006","unstructured":"Kluiver J, Haralambieva E, de Jong D, Blokzijl T, Jacobs S, Kroesen BJ et al. Lack of BIC and microRNA miR-155 expression in primary cases of Burkitt lymphoma. Genes Chromosomes Cancer 2006; 45: 147\u2013153.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2012108_CR17","doi-asserted-by":"publisher","first-page":"10436","DOI":"10.1128\/JVI.00752-08","volume":"82","author":"F Lu","year":"2008","unstructured":"Lu F, Weidmer A, Liu CG, Volinia S, Croce CM, Lieberman PM . Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence. J Virol 2008; 82: 10436\u201310443.","journal-title":"J Virol"},{"key":"BFleu2012108_CR18","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1128\/JVI.02136-07","volume":"82","author":"JE Cameron","year":"2008","unstructured":"Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X et al. The Epstein-Barr Virus latent membrane protein 1 (LMP1) induces cellular microRNA-146a, a modulator of lymphocyte signaling pathways. J Virol 2008; 82: 1946\u20131958.","journal-title":"J Virol"},{"key":"BFleu2012108_CR19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4161\/rna.4.3.5206","volume":"4","author":"N Motsch","year":"2007","unstructured":"Motsch N, Pfuhl T, Mrazek J, Barth S, Grasser FA . Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a. RNA Biol 2007; 4: 131\u2013137.","journal-title":"RNA Biol"},{"key":"BFleu2012108_CR20","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1038\/onc.2009.439","volume":"29","author":"E Anastasiadou","year":"2010","unstructured":"Anastasiadou E, Boccellato F, Vincenti S, Rosato P, Bozzoni I, Frati L et al. Epstein-Barr virus encoded LMP1 downregulates TCL1 oncogene through miR-29b. Oncogene 2010; 29: 1316\u20131328.","journal-title":"Oncogene"},{"key":"BFleu2012108_CR21","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0014-5793(95)00889-H","volume":"371","author":"M Shimakage","year":"1995","unstructured":"Shimakage M, Kurata A, Inoue H, Okamoto Y, Yutsudo M, Hakura A . Tumorigenicity of EBNA2-transfected cells. FEBS Lett 1995; 371: 245\u2013248.","journal-title":"FEBS Lett"},{"key":"BFleu2012108_CR22","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1093\/carcin\/bgn291","volume":"30","author":"SH Pan","year":"2009","unstructured":"Pan SH, Tai CC, Lin CS, Hsu WB, Chou SF, Lai CC et al. Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability. Carcinogenesis 2009; 30: 366\u2013375.","journal-title":"Carcinogenesis"},{"key":"BFleu2012108_CR23","first-page":"1521","volume":"12","author":"J Tornell","year":"1996","unstructured":"Tornell J, Farzad S, Espander-Jansson A, Matejka G, Isaksson O, Rymo L . Expression of Epstein-Barr nuclear antigen 2 in kidney tubule cells induce tumors in transgenic mice. Oncogene 1996; 12: 1521\u20131528.","journal-title":"Oncogene"},{"key":"BFleu2012108_CR24","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1080\/1042819021000032917","volume":"43","author":"RM Amini","year":"2002","unstructured":"Amini RM, Berglund M, Rosenquist R, Von Heideman A, Lagercrantz S, Thunberg U et al. A novel B-cell line (U-2932) established from a patient with diffuse large B-cell lymphoma following Hodgkin lymphoma. Leuk Lymphoma 2002; 43: 2179\u20132189.","journal-title":"Leuk Lymphoma"},{"key":"BFleu2012108_CR25","first-page":"505","volume":"113","author":"P Trivedi","year":"1995","unstructured":"Trivedi P, Zhang QJ, Chen F, Minarovits J, Ekman M, Biberfeld P et al. Parallel existence of Epstein-Barr virus (EBV) positive and negative cells in a sporadic case of Burkitt lymphoma. Oncogene 1995; 113: 505\u2013510.","journal-title":"Oncogene"},{"key":"BFleu2012108_CR26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/j.1460-2075.1995.tb06978.x","volume":"14","author":"B Kempkes","year":"1995","unstructured":"Kempkes B, Spitkovsky D, Jansen-Durr P, Ellwart JW, Kremmer E, Delecluse HJ et al. B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2. EMBO J 1995; 14: 88\u201396.","journal-title":"EMBO J"},{"key":"BFleu2012108_CR27","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1099\/0022-1317-82-10-2373","volume":"82","author":"S Maruo","year":"2001","unstructured":"Maruo S, Yang L, Takada K . Roles of Epstein-Barr virus glycoproteins gp350 and gp25 in the infection of human epithelial cells. J Gen Virol 2001; 82: 2373\u20132383.","journal-title":"J Gen Virol"},{"key":"BFleu2012108_CR28","doi-asserted-by":"publisher","first-page":"12481","DOI":"10.1073\/pnas.0605298103","volume":"103","author":"KD Taganov","year":"2006","unstructured":"Taganov KD, Boldin MP, Chang KJ, Baltimore D . NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 2006; 103: 12481\u201312486.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012108_CR29","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1182\/blood-2009-06-222794","volume":"114","author":"Y Yamanaka","year":"2009","unstructured":"Yamanaka Y, Tagawa H, Takahashi N, Watanabe A, Guo YM, Iwamoto K et al. Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma\/leukemia. Blood 2009; 114: 3265\u20133275.","journal-title":"Blood"},{"key":"BFleu2012108_CR30","doi-asserted-by":"publisher","first-page":"10983","DOI":"10.1073\/pnas.211430998","volume":"98","author":"JR Testa","year":"2001","unstructured":"Testa JR, Bellacosa A . AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 2001; 98: 10983\u201310985.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012108_CR31","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.4161\/cc.7.22.7120","volume":"7","author":"S Godshalk","year":"2008","unstructured":"Godshalk S, Bhaduri-McIntosh ES, Slack FJ . Epstein-Barr virus-mediated dysregulation of human microRNA expression. Cell Cycle 2008; 7: 3595\u20133600.","journal-title":"Cell Cycle"},{"key":"BFleu2012108_CR32","doi-asserted-by":"publisher","first-page":"6029","DOI":"10.1158\/0008-5472.CAN-05-0137","volume":"65","author":"JA Chan","year":"2005","unstructured":"Chan JA, Krichevsky AM, Kosik KS . MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005; 65: 6029\u20136033.","journal-title":"Cancer Res"},{"key":"BFleu2012108_CR33","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1073\/pnas.0510565103","volume":"103","author":"S Volinia","year":"2006","unstructured":"Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006; 103: 2257\u20132261.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012108_CR34","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1158\/1078-0432.CCR-07-0666","volume":"14","author":"TS Wong","year":"2008","unstructured":"Wong TS, Liu XB, Wong BY, Ng RW, Yuen AP, Wei WI . Mature miR-184 as Potential Oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res 2008; 14: 2588\u20132592.","journal-title":"Clin Cancer Res"},{"key":"BFleu2012108_CR35","doi-asserted-by":"publisher","first-page":"7065","DOI":"10.1158\/0008-5472.CAN-05-1783","volume":"65","author":"MV Iorio","year":"2005","unstructured":"Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005; 65: 7065\u20137070.","journal-title":"Cancer Res"},{"key":"BFleu2012108_CR36","doi-asserted-by":"publisher","first-page":"4944","DOI":"10.1182\/blood-2006-12-062398","volume":"109","author":"V Fulci","year":"2007","unstructured":"Fulci V, Chiaretti S, Goldoni M, Azzalin G, Carucci N, Tavolaro S et al. Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. Blood 2007; 109: 4944\u20134951.","journal-title":"Blood"},{"key":"BFleu2012108_CR37","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/nature09284","volume":"467","author":"PP Medina","year":"2010","unstructured":"Medina PP, Nolde M, Slack FJ . Oncomir addiction in an in vivo model of microRNa-21 induced pre-B cell lymphoma. Nature 2010; 467: 86\u201390.","journal-title":"Nature"},{"key":"BFleu2012108_CR38","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1038\/sj.onc.1210083","volume":"26","author":"ML Si","year":"2007","unstructured":"Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY . miR-21-mediated tumor growth. Oncogene 2007; 26: 2799\u20132803.","journal-title":"Oncogene"},{"key":"BFleu2012108_CR39","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/cr.2008.24","volume":"18","author":"S Zhu","year":"2008","unstructured":"Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY . MicroRNA-21 targets tumorsuppressor genes in invasion and metastasis. Cell Res 2008; 18: 350\u2013359.","journal-title":"Cell Res"},{"key":"BFleu2012108_CR40","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.virol.2008.09.018","volume":"382","author":"JE Cameron","year":"2008","unstructured":"Cameron JE, Fewell C, Yin Q, McBride J, Wang X, Lin Z et al. Epstein-Barr virus growth\/latency III program alters cellular microRNA expression. Virology 2008b; 382: 257\u2013266.","journal-title":"Virology"},{"key":"BFleu2012108_CR41","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1038\/sj.onc.1210856","volume":"27","author":"IA Asangani","year":"2008","unstructured":"Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008; 27: 2128\u20132136.","journal-title":"Oncogene"},{"key":"BFleu2012108_CR42","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature07242","volume":"455","author":"D Baek","year":"2008","unstructured":"Baek D, Villon J, Shin C, Camargo FD, Gygi SP, Bartel DP 2008 The impact of microRNAs on protein output. Nature 455: 64\u201371.","journal-title":"Nature"},{"key":"BFleu2012108_CR43","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.1073\/pnas.84.13.4567","volume":"84","author":"MG Masucci","year":"1987","unstructured":"Masucci MG, Torsteindottir S, Colombani J, Brautbar C, Klein E, Klein G . Down-regulation of class I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma lines. Proc Natl Acad Sci USA 1987; 84: 4567\u20134571.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012108_CR44","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.4049\/jimmunol.0900707","volume":"183","author":"J Hou","year":"2009","unstructured":"Hou J, Wang P, Lin L, Liu X, Ma F, An H et al. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol 2009; 183: 2150\u20132158.","journal-title":"J Immunol"},{"key":"BFleu2012108_CR45","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1002\/art.24436","volume":"60","author":"Y Tang","year":"2009","unstructured":"Tang Y, Luo X, Cui H, Ni X, Yuan M, Guo Y et al. MicroRNA-146A contributes to a normal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum 2009; 60: 1065\u20131075.","journal-title":"Arthritis Rheum"},{"key":"BFleu2012108_CR46","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1515\/BC.1999.029","volume":"380","author":"K Kanda","year":"1999","unstructured":"Kanda K, Kempkes B, Bornkamm GW, von Gabain A, Decker T . The Epstein-Barr virus nuclear antigen 2 (EBNA2), a protein required for B lymphocyte immortalization, induces the synthesis of type I interferon in Burkitt's lymphomacell lines. Biol Chem 1999; 380: 213\u2013221.","journal-title":"Biol Chem"},{"key":"BFleu2012108_CR47","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1128\/MCB.8.8.3397","volume":"8","author":"J Hiscott","year":"1988","unstructured":"Hiscott J, Wong A, Alper D, Xanthoudakis S . Transactivation of type 1 interferon promoters by simian virus 40 T antigen. Mol Cell Biol 1988; 8: 3397\u20133405.","journal-title":"Mol Cell Biol"},{"key":"BFleu2012108_CR48","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1128\/JVI.66.4.1884-1890.1992","volume":"66","author":"U Nielsch","year":"1992","unstructured":"Nielsch U, Pine R, Zimmer SG, Babiss LE . Induced expression of the endogenous beta interferon gene in adenovirus type 5-transformed rat fibroblasts. J Virol 1992; 66: 1884\u20131890.","journal-title":"J Virol"},{"key":"BFleu2012108_CR49","doi-asserted-by":"publisher","first-page":"4930","DOI":"10.1128\/MCB.12.11.4930","volume":"12","author":"K Kanda","year":"1992","unstructured":"Kanda K, Decker T, Aman P, Wahlstrom M, von Gabain A, Kallin B . The EBNA2-related resistance towards alpha interferon (IFN-alpha) in Burkitt's lymphoma cells effects induction of IFN-induced genes but not the activation of transcription factor ISGF-3. Mol Cell Biol 1992; 12: 4930\u20134936.","journal-title":"Mol Cell Biol"},{"key":"BFleu2012108_CR50","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.1038\/onc.2008.171","volume":"27","author":"D Bhaumik","year":"2008","unstructured":"Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, Benz CC . Expression of microRNA-146 suppresses NF-kB actitivity with redution of metastatic potential in breast cancer cells. Oncogene 2008; 27: 5643\u20135647.","journal-title":"Oncogene"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/leu2012108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/leu2012108","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/leu2012108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:03:33Z","timestamp":1684433013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2012108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,19]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["BFleu2012108"],"URL":"https:\/\/doi.org\/10.1038\/leu.2012.108","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,19]]}}}