{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:15:53Z","timestamp":1759601753244},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T00:00:00Z","timestamp":1327881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T00:00:00Z","timestamp":1327881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1038\/leu.2012.19","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T09:35:31Z","timestamp":1327916131000},"page":"1555-1563","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Gfi-1 inhibits proliferation and colony formation of p210BCR\/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1"],"prefix":"10.1038","volume":"26","author":[{"given":"A R","family":"Soliera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Audia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Lidonnici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Addya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Ferrari-Amorotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Cattelani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Manzotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Fragliasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Perini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T L","family":"Holyoake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Calabretta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,1,30]]},"reference":[{"key":"BFleu201219_CR1","doi-asserted-by":"publisher","first-page":"6816","DOI":"10.1038\/sj.onc.1210764","volume":"26","author":"AD Friedman","year":"2007","unstructured":"Friedman AD . Transcriptional control of granulocyte and monocyte development. Oncogene 2007; 26: 6816\u20136828.","journal-title":"Oncogene"},{"key":"BFleu201219_CR2","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.cell.2006.06.052","volume":"126","author":"P Laslo","year":"2006","unstructured":"Laslo P, Spooner CJ, Warmflash A, Lancki DN, Lee HS, Sciammes R et al. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell 2006; 126: 755\u2013766.","journal-title":"Cell"},{"key":"BFleu201219_CR3","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1182\/blood-2009-03-207944","volume":"114","author":"ST Chou","year":"2009","unstructured":"Chou ST, Khandros E, Baley LC, Nichols KE, Vakoc CR, Yao Y et al. Graded expression of PU1\/Sfp1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood 2009; 114: 983\u2013994.","journal-title":"Blood"},{"key":"BFleu201219_CR4","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1182\/blood-2005-09-3846","volume":"108","author":"H Sakamoto","year":"2006","unstructured":"Sakamoto H, Dai G, Tsujino K, Huang X, Fujimoto T, Mucenski M et al. Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development. Blood 2006; 108: 896\u2013903.","journal-title":"Blood"},{"key":"BFleu201219_CR5","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.immuni.2004.11.006","volume":"21","author":"P Zhang","year":"2004","unstructured":"Zhang P, Iwasaki-Arai J, Iwasaki H, Fenyus ML, Dayaram T, Owens BM et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C\/EBPalpha. Immunity 2004; 21: 853\u2013863.","journal-title":"Immunity"},{"key":"BFleu201219_CR6","doi-asserted-by":"publisher","first-page":"6829","DOI":"10.1038\/sj.onc.1210765","volume":"26","author":"T Pabst","year":"2007","unstructured":"Pabst T, Mueller BU . Transcriptional dysregulation during myeloid transformation in AML. Oncogene 2007; 26: 6829\u20136837.","journal-title":"Oncogene"},{"key":"BFleu201219_CR7","doi-asserted-by":"publisher","first-page":"4301","DOI":"10.1128\/MCB.18.7.4301","volume":"18","author":"HS Radomska","year":"1998","unstructured":"Radomska HS, Huettner CS, Zhang P, Chen T, Scadden DT, Tenen DG . CCAAT\/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol 1998; 18: 4301\u20134314.","journal-title":"Mol Cell Biol"},{"key":"BFleu201219_CR8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrc989","volume":"3","author":"DG Tenen","year":"2003","unstructured":"Tenen DG . Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer 2003; 3: 89\u2013101.","journal-title":"Nat Rev Cancer"},{"key":"BFleu201219_CR9","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nrc1363","volume":"4","author":"C Nerlov","year":"2004","unstructured":"Nerlov C . C\/EBP\u03b1 mutations in acute myeloid leukemias. Nat Rev Cancer 2004; 4: 394\u2013400.","journal-title":"Nat Rev Cancer"},{"key":"BFleu201219_CR10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/ng791","volume":"30","author":"D Perrotti","year":"2002","unstructured":"Perrotti D, Cesi V, Trotta R, Guerzoni C, Santilli G, Campbell K et al. BCR-ABL suppresses C\/EBP\u03b1 expression through inhibitory action of hnRNP E2. Nat Genet 2002; 30: 48\u201358.","journal-title":"Nat Genet"},{"key":"BFleu201219_CR11","doi-asserted-by":"publisher","first-page":"52651","DOI":"10.1074\/jbc.M307077200","volume":"278","author":"S Tavor","year":"2003","unstructured":"Tavor S, Park DJ, Gery S, Vuong PT, Gombart AF, Koeffler HP . Restoration of C\/EBP\u03b1 exression in BCR-ABL+ cell line induces terminal granulocytic differentiation. J Biol Chem 2003; 278: 52651\u201352659.","journal-title":"J Biol Chem"},{"key":"BFleu201219_CR12","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/86515","volume":"7","author":"T Pabst","year":"2001","unstructured":"Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, Behre G et al. AML1-ETO downregulates the granulocytic differentiation factor C\/EBPalpha in t (8;21) myeloid leukemia. Nat Med 2001; 7: 444\u2013451.","journal-title":"Nat Med"},{"key":"BFleu201219_CR13","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1182\/blood-2006-01-011833","volume":"108","author":"G Ferrari-Amorotti","year":"2006","unstructured":"Ferrari-Amorotti G, Keeshan K, Zattoni M, Guerzoni C, Iotti G, Donato N et al. Leukemogenesis induced by wild-type and ST1571-resistant BCR\/ABL is potently suppressed by C\/EBP\u03b1. Blood 2006; 108: 1353\u20131362.","journal-title":"Blood"},{"key":"BFleu201219_CR14","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1182\/blood-2003-02-0477","volume":"102","author":"K Keeshan","year":"2003","unstructured":"Keeshan K, Santilli G, Corradini F, Perrotti D, Calabretta B . Transcription activation function of C\/EBP\u03b1 is required for induction of granulocytic differentiation. Blood 2003; 102: 1267\u20131275.","journal-title":"Blood"},{"key":"BFleu201219_CR15","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S1097-2765(01)00366-5","volume":"8","author":"H Wang","year":"2001","unstructured":"Wang H, Iakova P, Wilde M, Welm A, Goode T, Roesler WJ et al. C\/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell 2001; 8: 817\u2013828.","journal-title":"Mol Cell"},{"key":"BFleu201219_CR16","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0092-8674(01)00516-5","volume":"107","author":"X Xu","year":"2001","unstructured":"Xu X, Lindberg B, Wewer UM, Friis-Hansen L, Nerlov C . E2F repression by C\/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell 2001; 107: 247\u2013258.","journal-title":"Cell"},{"key":"BFleu201219_CR17","doi-asserted-by":"publisher","first-page":"7353","DOI":"10.1074\/jbc.M312709200","volume":"279","author":"C M\u00fcller","year":"2004","unstructured":"M\u00fcller C, Calkhoven CF, Sha X, Leutz A . The CCAAT enhancer-binding protein alpha (C\/EBPalpha) requires a SWI\/SNF complex for proliferation arrest. J Biol Chem 2004; 279: 7353\u20137358.","journal-title":"J Biol Chem"},{"key":"BFleu201219_CR18","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1182\/blood-2003-02-0479","volume":"102","author":"F D\u2019Alo","year":"2003","unstructured":"D\u2019Alo F, Johansen LM, Nelson EA, Radomska HS, Evans EK, Zhang P et al. The amino terminal of E 2F interaction domains are critical for C\/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells. Blood 2003; 102: 3163\u20133171.","journal-title":"Blood"},{"key":"BFleu201219_CR19","doi-asserted-by":"publisher","first-page":"7949","DOI":"10.1158\/0008-5472.CAN-10-1667","volume":"70","author":"MR Lidonnici","year":"2010","unstructured":"Lidonnici MR, Audia A, Soliera AR, Prisco M, Ferrari-Amorotti G, waldron et al. Expression of the transcription repressor Gfi-1 is regulated by C\/EBP(alpha) and is involved in its proliferation and colony formation-inhibitory effects in p210BCR\/ABL-expressing cells. Cancer Res 2010; 70: 7949\u20137959.","journal-title":"Cancer Res"},{"key":"BFleu201219_CR20","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/nature02994","volume":"431","author":"H Hock","year":"2004","unstructured":"Hock H, Haniblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y et al. Gfi-1 restricts proliferation and preserves functional integrity of hematopoietic stem cells. Nature 2004; 431: 1002\u20131007.","journal-title":"Nature"},{"key":"BFleu201219_CR21","doi-asserted-by":"publisher","first-page":"4116","DOI":"10.1038\/sj.emboj.7600419","volume":"23","author":"H Zeng","year":"2004","unstructured":"Zeng H, Yucel R, Kosan C, Klein-Hitpass L, Moroy T . Transcription factor Gfi-1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 2004; 23: 4116\u20134125.","journal-title":"EMBO J"},{"key":"BFleu201219_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.stem.2008.11.006","volume":"4","author":"Y Liu","year":"2009","unstructured":"Liu Y, Elf SE, Miyata Y, Sashida G, Liu Y, Huang G et al. P53 regulates hematopoietic stem cell quiescence. Cell Stem Cell 2009; 4: 37\u201348.","journal-title":"Cell Stem Cell"},{"key":"BFleu201219_CR23","doi-asserted-by":"publisher","first-page":"6473","DOI":"10.1074\/jbc.M607613200","volume":"282","author":"R Dahl","year":"2007","unstructured":"Dahl R, Iyer SR, Owens KS, Cuylear DD, Simon MC . The transcriptional repressor GFI-1 antagonizes PU 1 activity through protein-protein interaction. J Biol Chem 2007; 282: 6473\u20136483.","journal-title":"J Biol Chem"},{"key":"BFleu201219_CR24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S1074-7613(02)00501-0","volume":"18","author":"H Hock","year":"2003","unstructured":"Hock H, Hamblen MJ, Rooke HM, Trover D, Bronson RT, Cameron S et al. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity 2003; 18: 109\u2013120.","journal-title":"Immunity"},{"key":"BFleu201219_CR25","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1084\/jem.20041024","volume":"200","author":"JJ Schuringa","year":"2004","unstructured":"Schuringa JJ, Chung KY, Morrone G, Moore MA . Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation. J Exp Med 2004; 200: 623\u2013635.","journal-title":"J Exp Med"},{"key":"BFleu201219_CR26","doi-asserted-by":"publisher","first-page":"6668","DOI":"10.1128\/MCB.01025-08","volume":"28","author":"ATJ Wierenga","year":"2008","unstructured":"Wierenga ATJ, Vellenga E, Schuringa JJ . Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels. Mol Cell Biol 2008; 28: 6668\u20136680.","journal-title":"Mol Cell Biol"},{"key":"BFleu201219_CR27","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1126\/science.1106114","volume":"307","author":"JT Opferman","year":"2005","unstructured":"Opferman JT, Iwasaki H, Ong CC, Suh H, Mizuno S, Akashi K et al. Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science 2005; 307: 1101\u20131104.","journal-title":"Science"},{"key":"BFleu201219_CR28","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1182\/blood-2009-12-258095","volume":"116","author":"CJV Campbell","year":"2010","unstructured":"Campbell CJV, Lee JB, Levadoux-Martin M, Wynder T, Xenocostas A, Leber B et al. The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity. Blood 2010; 116: 1433\u20131442.","journal-title":"Blood"},{"key":"BFleu201219_CR29","doi-asserted-by":"publisher","first-page":"3871","DOI":"10.1128\/MCB.18.7.3871","volume":"18","author":"M Onishi","year":"1998","unstructured":"Onishi M, Nosaka T, Misawa ALF, Gorman DM, McMahon M, Miyajima A et al. Identification and characterization of a constitutively active STAT 5 mutant that promotes cell proliferation. Mol Cell Biol 1998; 18: 3871\u20133879.","journal-title":"Mol Cell Biol"},{"key":"BFleu201219_CR30","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nature03579","volume":"435","author":"T Oltersdorf","year":"2005","unstructured":"Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435: 677\u2013681.","journal-title":"Nature"},{"key":"BFleu201219_CR31","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ccr.2006.10.006","volume":"10","author":"M Konopleva","year":"2006","unstructured":"Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 2006; 10: 375\u2013388.","journal-title":"Cancer Cell"},{"key":"BFleu201219_CR32","doi-asserted-by":"publisher","first-page":"19512","DOI":"10.1073\/pnas.0709443104","volume":"104","author":"M Nguyen","year":"2007","unstructured":"Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madirayan SR et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci USA 2007; 104: 19512\u201319517.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu201219_CR33","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1158\/0008-5472.CAN-07-1919","volume":"68","author":"M Konopleva","year":"2008","unstructured":"Konopleva M, Watt J, Contractor R, Tsao T, Harris D, Estrov Z et al. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-07 (obatoclax). Cancer Res 2008; 68: 3413\u20133420.","journal-title":"Cancer Res"},{"key":"BFleu201219_CR34","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1182\/blood-2009-11-255232","volume":"117","author":"EA Nelson","year":"2011","unstructured":"Nelson EA, Walker SR, Weisberg E, Bar-Natan M, Barrett R, Gashin LB et al. The STAT 5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood 2011; 117: 3421\u20133429.","journal-title":"Blood"},{"key":"BFleu201219_CR35","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1182\/blood-2008-02-138339","volume":"112","author":"MA Kerenyi","year":"2008","unstructured":"Kerenyi MA, Grebien F, Gehart H, Schirfer M, Artaker M, Kovacic B et al. Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood 2008; 112: 3878\u20133888.","journal-title":"Blood"},{"key":"BFleu201219_CR36","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.1182\/blood-2004-02-0749","volume":"105","author":"KJ Aichberger","year":"2005","unstructured":"Aichberger KJ, Mayerhofer M, Ktauth M-T, Skvana H, Florian S, Sonneck K et al. Identification of mcl-1 as a BCR\/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides. Blood 2005; 105: 3303\u20133311.","journal-title":"Blood"},{"key":"BFleu201219_CR37","doi-asserted-by":"publisher","first-page":"5466","DOI":"10.1182\/blood-2008-09-179747","volume":"113","author":"SR Horman","year":"2009","unstructured":"Horman SR, Velu SC, Chaubey A, Bourdeau T, Zhu J, Paul WE et al. Gfi-1 integrates progenitor versus granulocytic transcriptional programming. Blood 2009; 113: 5466\u20135475.","journal-title":"Blood"},{"key":"BFleu201219_CR38","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1124\/mol.106.033308","volume":"72","author":"M Rahmani","year":"2007","unstructured":"Rahmani M, Nguyen TK, Dent P, Grant S . The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcf\/abl+ human leukemia cells in association with signal transducer and activation of transcription 5 innhibition and myeloid cell leukemia-1 downregulation. Mol Pharmacol 2007; 72: 788\u2013795.","journal-title":"Mol Pharmacol"},{"key":"BFleu201219_CR39","doi-asserted-by":"publisher","first-page":"5024","DOI":"10.1182\/blood-2008-12-196055","volume":"114","author":"G Yoshimoto","year":"2009","unstructured":"Yoshimoto G, Miyamoto T, Jabbarzadeh-Tabrizi S, Iino T, Rocnick JL et al. FLT3-ITD upregulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT 5 activation. Blood 2009; 114: 5024\u20135043.","journal-title":"Blood"},{"key":"BFleu201219_CR40","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/leu.2011.55","volume":"25","author":"EK Allan","year":"2011","unstructured":"Allan EK, Holyoake TL, Craig AR, Jorgensen HG . Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem\/progenitor cells. Leukemia 2011; 25: 985\u2013994.","journal-title":"Leukemia"},{"key":"BFleu201219_CR41","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.1158\/1078-0432.CCR-10-1565","volume":"16","author":"S Cheng","year":"2010","unstructured":"Cheng S, Gao N, Zhang Z, Chen G, Budhraja A, Ke Z et al. Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax. Clin Cancer Res 2010; 16: 5679\u20135691.","journal-title":"Clin Cancer Res"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu201219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu201219","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu201219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T15:15:54Z","timestamp":1648739754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu201219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,30]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["BFleu201219"],"URL":"https:\/\/doi.org\/10.1038\/leu.2012.19","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,30]]},"assertion":[{"value":"2 November 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}