{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:49:42Z","timestamp":1790272182513,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1038\/leu.2012.213","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T06:39:13Z","timestamp":1343198353000},"page":"464-472","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":210,"title":["Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma"],"prefix":"10.1038","volume":"27","author":[{"given":"H","family":"Tamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Tanosaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hyodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Shinya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"key":"BFleu2012213_CR1","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/70932","volume":"5","author":"H Dong","year":"1999","unstructured":"Dong H, Zhu G, Tamada K, Chen L . B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999; 5: 1365\u20131369.","journal-title":"Nat Med"},{"key":"BFleu2012213_CR2","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1182\/blood.V97.6.1809","volume":"97","author":"H Tamura","year":"2001","unstructured":"Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K et al. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001; 97: 1809\u20131816.","journal-title":"Blood"},{"key":"BFleu2012213_CR3","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1084\/jem.20021752","volume":"197","author":"S Wang","year":"2003","unstructured":"Wang S, Bajorath J, Flies DB, Dong H, Honjo T, Chen L . Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J Exp Med 2003; 197: 1083\u20131091.","journal-title":"J Exp Med"},{"key":"BFleu2012213_CR4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/BF02983556","volume":"78","author":"H Tamura","year":"2003","unstructured":"Tamura H, Ogata K, Dong H, Chen L . Immunology of B7-H1 and its roles in human diseases. Int J Hematol 2003; 78: 321\u2013328.","journal-title":"Int J Hematol"},{"key":"BFleu2012213_CR5","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","volume":"192","author":"GJ Freeman","year":"2000","unstructured":"Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000; 192: 1027\u20131034.","journal-title":"J Exp Med"},{"key":"BFleu2012213_CR6","doi-asserted-by":"publisher","first-page":"3887","DOI":"10.1002\/j.1460-2075.1992.tb05481.x","volume":"11","author":"Y Ishida","year":"1992","unstructured":"Ishida Y, Agata Y, Shibahara K, Honjo T . Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992; 11: 3887\u20133895.","journal-title":"EMBO J"},{"key":"BFleu2012213_CR7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.immuni.2007.05.016","volume":"27","author":"MJ Butte","year":"2007","unstructured":"Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ . Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007; 27: 111\u2013122.","journal-title":"Immunity"},{"key":"BFleu2012213_CR8","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.1016\/j.molimm.2008.05.014","volume":"45","author":"MJ Butte","year":"2008","unstructured":"Butte MJ, Pena-Cruz V, Kim MJ, Freeman GJ, Sharpe AH . Interaction of human PD-L1 and B7-1. Mol Immunol 2008; 45: 3567\u20133572.","journal-title":"Mol Immunol"},{"key":"BFleu2012213_CR9","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nm730","volume":"8","author":"H Dong","year":"2002","unstructured":"Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002; 8: 793\u2013800.","journal-title":"Nat Med"},{"key":"BFleu2012213_CR10","doi-asserted-by":"publisher","first-page":"17174","DOI":"10.1073\/pnas.0406351101","volume":"101","author":"RH Thompson","year":"2004","unstructured":"Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, Webster WS et al. Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci USA 2004; 101: 17174\u201317179.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012213_CR11","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1593\/neo.05733","volume":"8","author":"H Ghebeh","year":"2006","unstructured":"Ghebeh H, Mohammed S, Al-Omair A, Qattan A, Lehe C, Al-Qudaihi G et al. The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia 2006; 8: 190\u2013198.","journal-title":"Neoplasia"},{"key":"BFleu2012213_CR12","doi-asserted-by":"publisher","first-page":"5094","DOI":"10.1158\/1078-0432.CCR-04-0428","volume":"10","author":"J Konishi","year":"2004","unstructured":"Konishi J, Yamazaki K, Azuma M, Kinoshita I, Dosaka-Akita H, Nishimura M . B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res 2004; 10: 5094\u20135100.","journal-title":"Clin Cancer Res"},{"key":"BFleu2012213_CR13","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1111\/j.1349-7006.2009.01302.x","volume":"100","author":"R Yamamoto","year":"2009","unstructured":"Yamamoto R, Nishikori M, Tashima M, Sakai T, Ichinohe T, Takaori-Kondo A et al. B7-H1 expression is regulated by MEK\/ERK signaling pathway in anaplastic large cell lymphoma and Hodgkin lymphoma. Cancer Sci 2009; 100: 2093\u20132100.","journal-title":"Cancer Sci"},{"key":"BFleu2012213_CR14","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1182\/blood-2009-12-255125","volume":"116","author":"A Kondo","year":"2010","unstructured":"Kondo A, Yamashita T, Tamura H, Zhao W, Tsuji T, Shimizu M et al. Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes. Blood 2010; 116: 1124\u20131131.","journal-title":"Blood"},{"key":"BFleu2012213_CR15","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.ejca.2005.12.025","volume":"42","author":"CS Mitsiades","year":"2006","unstructured":"Mitsiades CS, Mitsiades NS, Munshi NC, Richardson PG, Anderson KC . The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions. Eur J Cancer 2006; 42: 1564\u20131573.","journal-title":"Eur J Cancer"},{"issue":"Suppl 1","key":"BFleu2012213_CR16","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/S0268-960X(10)70003-5","volume":"24","author":"A Mahindra","year":"2010","unstructured":"Mahindra A, Hideshima T, Anderson KC . Multiple myeloma: biology of the disease. Blood Rev 2010; 24 (Suppl 1): S5\u201311.","journal-title":"Blood Rev"},{"key":"BFleu2012213_CR17","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/j.1365-2141.2004.05084.x","volume":"126","author":"F Silvestris","year":"2004","unstructured":"Silvestris F, Cafforio P, Calvani N, Dammacco F . Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells. Br J Haematol 2004; 126: 475\u2013486.","journal-title":"Br J Haematol"},{"key":"BFleu2012213_CR18","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1182\/blood-2006-10-051482","volume":"110","author":"J Liu","year":"2007","unstructured":"Liu J, Hamrouni A, Wolowiec D, Coiteux V, Kuliczkowski K, Hetuin D et al. Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-gamma and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood 2007; 110: 296\u2013304.","journal-title":"Blood"},{"key":"BFleu2012213_CR19","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.exphem.2009.11.008","volume":"38","author":"K Kuranda","year":"2010","unstructured":"Kuranda K, Berthon C, Dupont C, Wolowiec D, Leleu X, Polakowska R et al. A subpopulation of malignant CD34+CD138+B7-H1+ plasma cells is present in multiple myeloma patients. Exp Hematol 2010; 38: 124\u2013131.","journal-title":"Exp Hematol"},{"key":"BFleu2012213_CR20","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1158\/1078-0432.CCR-08-0501","volume":"15","author":"T Yamashita","year":"2009","unstructured":"Yamashita T, Tamura H, Satoh C, Shinya E, Takahashi H, Chen L et al. Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage. Clin Cancer Res 2009; 15: 770\u2013777.","journal-title":"Clin Cancer Res"},{"key":"BFleu2012213_CR21","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1182\/blood.V85.4.997.bloodjournal854997","volume":"85","author":"BA Roecklein","year":"1995","unstructured":"Roecklein BA, Torok-Storb B . Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6\/E7 genes. Blood 1995; 85: 997\u20131005.","journal-title":"Blood"},{"key":"BFleu2012213_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/leu.2008.291","volume":"23","author":"RA Kyle","year":"2009","unstructured":"Kyle RA, Rajkumar SV . Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia 2009; 23: 3\u20139.","journal-title":"Leukemia"},{"key":"BFleu2012213_CR23","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U","volume":"36","author":"BG Durie","year":"1975","unstructured":"Durie BG, Salmon SE . A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 1975; 36: 842\u2013854.","journal-title":"Cancer"},{"key":"BFleu2012213_CR24","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1200\/JCO.2005.04.242","volume":"23","author":"PR Greipp","year":"2005","unstructured":"Greipp PR, San Miguel J, Durie BG, Crowley JJ, Barlogie B, Blade J et al. International staging system for multiple myeloma. J Clin Oncol 2005; 23: 3412\u20133420.","journal-title":"J Clin Oncol"},{"key":"BFleu2012213_CR25","doi-asserted-by":"publisher","first-page":"5708","DOI":"10.1158\/1078-0432.CCR-04-2672","volume":"11","author":"H Tamura","year":"2005","unstructured":"Tamura H, Dan K, Tamada K, Nakamura K, Shioi Y, Hyodo H et al. Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Clin Cancer Res 2005; 11: 5708\u20135717.","journal-title":"Clin Cancer Res"},{"key":"BFleu2012213_CR26","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.leukres.2008.07.006","volume":"33","author":"C Satoh","year":"2009","unstructured":"Satoh C, Tamura H, Yamashita T, Tsuji T, Dan K, Ogata K . Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic syndromes. Leuk Res 2009; 33: 326\u2013331.","journal-title":"Leuk Res"},{"key":"BFleu2012213_CR27","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1182\/blood-2009-05-220285","volume":"114","author":"Y Zheng","year":"2009","unstructured":"Zheng Y, Cai Z, Wang S, Zhang X, Qian J, Hong S et al. Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis. Blood 2009; 114: 3625\u20133628.","journal-title":"Blood"},{"key":"BFleu2012213_CR28","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1182\/blood-2002-03-0940","volume":"100","author":"Y Dai","year":"2002","unstructured":"Dai Y, Landowski TH, Rosen ST, Dent P, Grant S . Combined treatment with the checkpoint abrogator UCN-01 and MEK1\/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism. Blood 2002; 100: 3333\u20133343.","journal-title":"Blood"},{"key":"BFleu2012213_CR29","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1182\/blood.V87.10.4149.bloodjournal87104149","volume":"87","author":"C Selleri","year":"1996","unstructured":"Selleri C, Maciejewski JP, Sato T, Young NS . Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition. Blood 1996; 87: 4149\u20134157.","journal-title":"Blood"},{"key":"BFleu2012213_CR30","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/CJI.0b013e31821ca6ce","volume":"34","author":"J Rosenblatt","year":"2011","unstructured":"Rosenblatt J, Glotzbecker B, Mills H, Vasir B, Tzachanis D, Levine JD et al. PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell\/myeloma fusion vaccine. J Immunother 2011; 34: 409\u2013418.","journal-title":"J Immunother"},{"key":"BFleu2012213_CR31","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.bbmt.2011.03.011","volume":"17","author":"WH Hallett","year":"2011","unstructured":"Hallett WH, Jing W, Drobyski WR, Johnson BD . Immunosuppressive effects of multiple myeloma are overcome by PD-L1 blockade. Biol Blood Marrow Transplant 2011; 17: 1133\u20131145.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFleu2012213_CR32","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1182\/blood-2010-02-271874","volume":"116","author":"DM Benson","year":"2010","unstructured":"Benson DM, Bakan CE, Mishra A, Hofmeister CC, Efebera Y, Becknell B et al. The PD-1\/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood 2010; 116: 2286\u20132294.","journal-title":"Blood"},{"key":"BFleu2012213_CR33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/hon.685","volume":"20","author":"BC Baliga","year":"2002","unstructured":"Baliga BC, Kumar S . Role of Bcl-2 family of proteins in malignancy. Hematol Oncol 2002; 20: 63\u201374.","journal-title":"Hematol Oncol"},{"key":"BFleu2012213_CR34","doi-asserted-by":"publisher","first-page":"931","DOI":"10.7326\/0003-4819-115-12-931","volume":"115","author":"MA Dimopoulos","year":"1991","unstructured":"Dimopoulos MA, Barlogie B, Smith TL, Alexanian R . High serum lactate dehydrogenase level as a marker for drug resistance and short survival in multiple myeloma. Ann Intern Med 1991; 115: 931\u2013935.","journal-title":"Ann Intern Med"},{"key":"BFleu2012213_CR35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-0609.2010.01466.x","volume":"85","author":"E Terpos","year":"2010","unstructured":"Terpos E, Katodritou E, Roussou M, Pouli A, Michalis E, Delimpasi S et al. High serum lactate dehydrogenase adds prognostic value to the international myeloma staging system even in the era of novel agents. Eur J Haematol 2010; 85: 114\u2013119.","journal-title":"Eur J Haematol"},{"key":"BFleu2012213_CR36","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1182\/blood-2002-01-0102","volume":"100","author":"M Chatterjee","year":"2002","unstructured":"Chatterjee M, Honemann D, Lentzsch S, Bommert K, Sers C, Herrmann P et al. In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6\/gp130\/STAT3 pathway. Blood 2002; 100: 3311\u20133318.","journal-title":"Blood"},{"key":"BFleu2012213_CR37","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nrc2189","volume":"7","author":"T Hideshima","year":"2007","unstructured":"Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC . Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 2007; 7: 585\u2013598.","journal-title":"Nat Rev Cancer"},{"key":"BFleu2012213_CR38","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1182\/blood.V96.4.1274","volume":"96","author":"B Pope","year":"2000","unstructured":"Pope B, Brown RD, Gibson J, Yuen E, Joshua D . B7-2-positive myeloma: incidence, clinical characteristics, prognostic significance, and implications for tumor immunotherapy. Blood 2000; 96: 1274\u20131279.","journal-title":"Blood"},{"key":"BFleu2012213_CR39","doi-asserted-by":"publisher","first-page":"5002","DOI":"10.1182\/blood-2006-03-012542","volume":"109","author":"NJ Bahlis","year":"2007","unstructured":"Bahlis NJ, King AM, Kolonias D, Carlson LM, Liu HY, Hussein MA et al. CD28-mediated regulation of multiple myeloma cell proliferation and survival. Blood 2007; 109: 5002\u20135010.","journal-title":"Blood"},{"key":"BFleu2012213_CR40","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.leukres.2003.12.008","volume":"28","author":"Y Matsuo","year":"2004","unstructured":"Matsuo Y, Drexler HG, Harashima A, Okochi A, Hasegawa A, Kojima K et al. Induction of CD28 on the new myeloma cell line MOLP-8 with t(11;14)(q13;q32) expressing delta\/lambda type immunoglobulin. Leuk Res 2004; 28: 869\u2013877.","journal-title":"Leuk Res"},{"key":"BFleu2012213_CR41","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.1182\/blood-2007-11-123141","volume":"111","author":"T Azuma","year":"2008","unstructured":"Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L . B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 2008; 111: 3635\u20133643.","journal-title":"Blood"},{"key":"BFleu2012213_CR42","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1126\/science.276.5320.1851","volume":"276","author":"MB Rettig","year":"1997","unstructured":"Rettig MB, Ma HJ, Vescio RA, Pold M, Schiller G, Belson D et al. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 1997; 276: 1851\u20131854.","journal-title":"Science"},{"key":"BFleu2012213_CR43","first-page":"409","volume":"84","author":"DB Flies","year":"2011","unstructured":"Flies DB, Sandler BJ, Sznol M, Chen L . Blockade of the B7-H1\/PD-1 pathway for cancer immunotherapy. Yale J Biol Med 2011; 84: 409\u2013421.","journal-title":"Yale J Biol Med"},{"key":"BFleu2012213_CR44","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1182\/blood-2010-03-275446","volume":"116","author":"Q Zhou","year":"2010","unstructured":"Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M et al. Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood 2010; 116: 2484\u20132493.","journal-title":"Blood"},{"key":"BFleu2012213_CR45","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1200\/JCO.2009.26.7609","volume":"28","author":"JR Brahmer","year":"2010","unstructured":"Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacody namics, and immunologic correlates. J Clin Oncol 2010; 28: 3167\u20133175.","journal-title":"J Clin Oncol"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2012213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2012213","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2012213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T12:31:56Z","timestamp":1714221116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2012213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,25]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["BFleu2012213"],"URL":"https:\/\/doi.org\/10.1038\/leu.2012.213","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,25]]},"assertion":[{"value":"26 April 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}