{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:39:00Z","timestamp":1791247140383,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T00:00:00Z","timestamp":1343952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T00:00:00Z","timestamp":1343952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1038\/leu.2012.220","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T06:48:13Z","timestamp":1343976493000},"page":"409-415","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Transcriptional suppression of BACH2 by the Bcr-Abl oncoprotein is mediated by PAX5"],"prefix":"10.1038","volume":"27","author":[{"given":"D A","family":"Casolari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Makri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Muto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J V","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,3]]},"reference":[{"key":"BFleu2012220_CR1","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","volume":"96","author":"MW Deininger","year":"2000","unstructured":"Deininger MW, Goldman JM, Melo JV . The molecular biology of chronic myeloid leukemia. Blood 2000; 96: 3343\u20133356.","journal-title":"Blood"},{"key":"BFleu2012220_CR2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0950-3536(97)80007-8","volume":"10","author":"J Cortes","year":"1997","unstructured":"Cortes J, Kantarjian HM, Giralt S, Talpaz M . Natural history and staging of chronic myelogenous leukaemia. Baillieres Clin Haematol 1997; 10: 277\u2013290.","journal-title":"Baillieres Clin Haematol"},{"key":"BFleu2012220_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.cancergencyto.2004.06.011","volume":"157","author":"U Bacher","year":"2005","unstructured":"Bacher U, Haferlach T, Hiddemann W, Schnittger S, Kern W, Schoch C . Additional clonal abnormalities in Philadelphia-positive ALL and CML demonstrate a different cytogenetic pattern at diagnosis and follow different pathways at progression. Cancer Genet Cytogenet 2005; 157: 53\u201361.","journal-title":"Cancer Genet Cytogenet"},{"key":"BFleu2012220_CR4","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev.immunol.22.012703.104753","volume":"22","author":"S Wong","year":"2004","unstructured":"Wong S, Witte ON . The BCR-ABL story: bench to bedside and back. Annu Rev Immunol 2004; 22: 247\u2013306.","journal-title":"Annu Rev Immunol"},{"key":"BFleu2012220_CR5","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000065655","volume":"108","author":"DJ Barnes","year":"2002","unstructured":"Barnes DJ, Melo JV . Cytogenetic and molecular genetic aspects of chronic myeloid leukaemia. Acta Haematol 2002; 108: 180\u2013202.","journal-title":"Acta Haematol"},{"key":"BFleu2012220_CR6","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1182\/blood-2002-10-3207","volume":"102","author":"Y Canitrot","year":"2003","unstructured":"Canitrot Y, Falinski R, Louat T, Laurent G, Cazaux C, Hoffmann JS et al. p210 BCR\/ABL kinase regulates nucleotide excision repair (NER) and resistance to ultraviolet (UV) radiation. Blood 2003; 102: 2632\u20132637.","journal-title":"Blood"},{"key":"BFleu2012220_CR7","doi-asserted-by":"publisher","first-page":"3746","DOI":"10.1182\/blood-2004-05-1941","volume":"104","author":"MO Nowicki","year":"2004","unstructured":"Nowicki MO, Falinski R, Koptyra M, Slupianek A, Stoklosa T, Gloc E et al. BCR\/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. Blood 2004; 104: 3746\u20133753.","journal-title":"Blood"},{"key":"BFleu2012220_CR8","first-page":"2049","volume":"60","author":"MW Deininger","year":"2000","unstructured":"Deininger MW, Vieira S, Mendiola R, Schultheis B, Goldman JM, Melo JV . BCR-ABL tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic myeloid leukemia. Cancer Res 2000; 60: 2049\u20132055.","journal-title":"Cancer Res"},{"key":"BFleu2012220_CR9","first-page":"8005","volume":"61","author":"MW Deininger","year":"2001","unstructured":"Deininger MW, Vieira SA, Parada Y, Banerji L, Lam EW, Peters G et al. Direct relation between BCR-ABL tyrosine kinase activity and cyclin D2 expression in lymphoblasts. Cancer Res 2001; 61: 8005\u20138013.","journal-title":"Cancer Res"},{"key":"BFleu2012220_CR10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/gcc.1200","volume":"32","author":"SA Vieira","year":"2001","unstructured":"Vieira SA, Deininger MW, Sorour A, Sinclair P, Foroni L, Goldman JM et al. Transcription factor BACH2 is transcriptionally regulated by the BCR\/ABL oncogene. Genes Chromosomes Cancer 2001; 32: 353\u2013363.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2012220_CR11","doi-asserted-by":"publisher","first-page":"6083","DOI":"10.1128\/MCB.16.11.6083","volume":"16","author":"T Oyake","year":"1996","unstructured":"Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M et al. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol 1996; 16: 6083\u20136095.","journal-title":"Mol Cell Biol"},{"key":"BFleu2012220_CR12","doi-asserted-by":"publisher","first-page":"5734","DOI":"10.1093\/emboj\/17.19.5734","volume":"17","author":"A Muto","year":"1998","unstructured":"Muto A, Hoshino H, Madisen L, Yanai N, Obinata M, Karasuyama H et al. Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J 1998; 17: 5734\u20135743.","journal-title":"EMBO J"},{"key":"BFleu2012220_CR13","doi-asserted-by":"publisher","first-page":"20724","DOI":"10.1074\/jbc.M112003200","volume":"277","author":"A Muto","year":"2002","unstructured":"Muto A, Tashiro S, Tsuchiya H, Kume A, Kanno M, Ito E et al. Activation of Maf\/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies. J Biol Chem 2002; 277: 20724\u201320733.","journal-title":"J Biol Chem"},{"key":"BFleu2012220_CR14","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nature02596","volume":"429","author":"A Muto","year":"2004","unstructured":"Muto A, Tashiro S, Nakajima O, Hoshino H, Takahashi S, Sakoda E et al. The transcriptional programme of antibody class switching involves the repressor Bach2. Nature 2004; 429: 566\u2013571.","journal-title":"Nature"},{"key":"BFleu2012220_CR15","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1182\/blood-2005-12-040972","volume":"109","author":"C Yoshida","year":"2007","unstructured":"Yoshida C, Yoshida F, Sears DE, Hart SM, Ikebe D, Muto A et al. Bcr-Abl signaling through the PI-3\/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. Blood 2007; 109: 1211\u20131219.","journal-title":"Blood"},{"key":"BFleu2012220_CR16","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/ni1454","volume":"8","author":"C Cobaleda","year":"2007","unstructured":"Cobaleda C, Schebesta A, Delogu A, Busslinger M . Pax5: the guardian of B cell identity and function. Nat Immunol 2007; 8: 463\u2013470.","journal-title":"Nat Immunol"},{"key":"BFleu2012220_CR17","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1084\/jem.179.4.1099","volume":"179","author":"Y Wakatsuki","year":"1994","unstructured":"Wakatsuki Y, Neurath MF, Max EE, Strober W . The B cell-specific transcription factor BSAP regulates B cell proliferation. J Exp Med 1994; 179: 1099\u20131108.","journal-title":"J Exp Med"},{"key":"BFleu2012220_CR18","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.4049\/jimmunol.161.6.2906","volume":"161","author":"G Qiu","year":"1998","unstructured":"Qiu G, Stavnezer J . Overexpression of BSAP\/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line. J Immunol 1998; 161: 2906\u20132918.","journal-title":"J Immunol"},{"key":"BFleu2012220_CR19","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.4049\/jimmunol.158.7.3197","volume":"158","author":"T Usui","year":"1997","unstructured":"Usui T, Wakatsuki Y, Matsunaga Y, Kaneko S, Koseki H, Kita T . Overexpression of B cell-specific activator protein (BSAP\/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype. J Immunol 1997; 158: 3197\u20133204.","journal-title":"J Immunol"},{"key":"BFleu2012220_CR20","doi-asserted-by":"publisher","first-page":"10058","DOI":"10.1128\/MCB.24.22.10058-10071.2004","volume":"24","author":"dM Fernandez","year":"2004","unstructured":"Fernandez dM, Essafi A, Soeiro I, Pietersen AM, Birkenkamp KU, Edwards CS et al. FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5\/BCL6-dependent mechanism. Mol Cell Biol 2004; 24: 10058\u201310071.","journal-title":"Mol Cell Biol"},{"key":"BFleu2012220_CR21","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1182\/blood-2002-05-1570","volume":"101","author":"JB Rance","year":"2003","unstructured":"Rance JB, Follows GA, Cockerill PN, Bonifer C, Lane DA, Simmonds RE . Regulation of the human endothelial cell protein C receptor gene promoter by multiple Sp1 binding sites. Blood 2003; 101: 4393\u20134401.","journal-title":"Blood"},{"key":"BFleu2012220_CR22","doi-asserted-by":"publisher","first-page":"6704","DOI":"10.4049\/jimmunol.166.11.6704","volume":"166","author":"H Sato","year":"2001","unstructured":"Sato H, Wang D, Kudo A . Dissociation of Pax-5 from KI and KII sites during kappa-chain gene rearrangement correlates with its association with the underphosphorylated form of retinoblastoma. J Immunol 2001; 166: 6704\u20136710.","journal-title":"J Immunol"},{"key":"BFleu2012220_CR23","doi-asserted-by":"publisher","first-page":"10226","DOI":"10.1073\/pnas.181344198","volume":"98","author":"T Sawado","year":"2001","unstructured":"Sawado T, Igarashi K, Groudine M . Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter. Proc Natl Acad Sci USA 2001; 98: 10226\u201310231.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012220_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/47412","volume":"403","author":"BD Strahl","year":"2000","unstructured":"Strahl BD, Allis CD . The language of covalent histone modifications. Nature 2000; 403: 41\u201345.","journal-title":"Nature"},{"key":"BFleu2012220_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.immuni.2007.05.019","volume":"27","author":"A Schebesta","year":"2007","unstructured":"Schebesta A, McManus S, Salvagiotto G, Delogu A, Busslinger GA, Busslinger M . Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity 2007; 27: 49\u201363.","journal-title":"Immunity"},{"key":"BFleu2012220_CR26","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1038\/sj.onc.1208421","volume":"24","author":"A Essafi","year":"2005","unstructured":"Essafi A, Fernandez dM, Hassen YA, Soeiro I, Mufti GJ, Thomas NS et al. Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene 2005; 24: 2317\u20132329.","journal-title":"Oncogene"},{"key":"BFleu2012220_CR27","doi-asserted-by":"publisher","first-page":"14907","DOI":"10.1073\/pnas.0606176103","volume":"103","author":"J Kuroda","year":"2006","unstructured":"Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC et al. Bim and Bad mediate imatinib-induced killing of Bcr\/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci USA 2006; 103: 14907\u201314912.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012220_CR28","doi-asserted-by":"publisher","first-page":"8577","DOI":"10.1038\/sj.onc.1206085","volume":"21","author":"D Perrotti","year":"2002","unstructured":"Perrotti D, Calabretta B . Post-transcriptional mechanisms in BCR\/ABL leukemogenesis: role of shuttling RNA-binding proteins. Oncogene 2002; 21: 8577\u20138583.","journal-title":"Oncogene"},{"key":"BFleu2012220_CR29","doi-asserted-by":"publisher","first-page":"3222","DOI":"10.1038\/sj.onc.1207543","volume":"23","author":"D Perrotti","year":"2004","unstructured":"Perrotti D, Calabretta B . Translational regulation by the p210 BCR\/ABL oncoprotein. Oncogene 2004; 23: 3222\u20133229.","journal-title":"Oncogene"},{"key":"BFleu2012220_CR30","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1128\/MCB.22.7.2255-2266.2002","volume":"22","author":"A Iervolino","year":"2002","unstructured":"Iervolino A, Santilli G, Trotta R, Guerzoni C, Cesi V, Bergamaschi A et al. hnRNP A1 nucleocytoplasmic shuttling activity is required for normal myelopoiesis and BCR\/ABL leukemogenesis. Mol Cell Biol 2002; 22: 2255\u20132266.","journal-title":"Mol Cell Biol"},{"key":"BFleu2012220_CR31","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/ng791","volume":"30","author":"D Perrotti","year":"2002","unstructured":"Perrotti D, Cesi V, Trotta R, Guerzoni C, Santilli G, Campbell K et al. BCR-ABL suppresses C\/EBPalpha expression through inhibitory action of hnRNP E2. Nat Genet 2002; 30: 48\u201358.","journal-title":"Nat Genet"},{"key":"BFleu2012220_CR32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0378-1119(00)00580-1","volume":"263","author":"M Rahman","year":"2001","unstructured":"Rahman M, Hirabayashi Y, Ishii T, Kodera T, Watanabe M, Takasawa N et al. A repressor element in the 5'-untranslated region of human Pax5 exon 1A. Gene 2001; 263: 59\u201366.","journal-title":"Gene"},{"key":"BFleu2012220_CR33","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1038\/emboj.2011.140","volume":"30","author":"S McManus","year":"2011","unstructured":"McManus S, Ebert A, Salvagiotto G, Medvedovic J, Sun Q, Tamir I et al. The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. EMBO J 2011; 30: 2388\u20132404.","journal-title":"EMBO J"},{"key":"BFleu2012220_CR34","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1046\/j.1365-2141.1998.00842.x","volume":"102","author":"T Hamada","year":"1998","unstructured":"Hamada T, Yonetani N, Ueda C, Maesako Y, Akasaka H, Akasaka T et al. Expression of the PAX5\/BSAP transcription factor in haematological tumour cells and further molecular characterization of the t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma. Br J Haematol 1998; 102: 691\u2013700.","journal-title":"Br J Haematol"},{"key":"BFleu2012220_CR35","first-page":"207","volume":"1","author":"ET Stuart","year":"1995","unstructured":"Stuart ET, Kioussi C, Aguzzi A, Gruss P . PAX5 expression correlates with increasing malignancy in human astrocytomas. Clin Cancer Res 1995; 1: 207\u2013214.","journal-title":"Clin Cancer Res"},{"key":"BFleu2012220_CR36","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.1038\/onc.2011.511","volume":"31","author":"X Li","year":"2012","unstructured":"Li X, Cheung KF, Ma X, Tian L, Zhao J, Go MY et al. Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients. Oncogene 2012; 31: 3419\u20133430.","journal-title":"Oncogene"},{"key":"BFleu2012220_CR37","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.3324\/haematol.2009.020792","volume":"95","author":"I Iacobucci","year":"2010","unstructured":"Iacobucci I, Lonetti A, Paoloni F, Papayannidis C, Ferrari A, Storlazzi CT et al. The PAX5 gene is frequently rearranged in BCR-ABL1-positive acute lymphoblastic leukemia but is not associated with outcome. A report on behalf of the GIMEMA Acute Leukemia Working Party. Haematologica 2010; 95: 1683\u20131690.","journal-title":"Haematologica"},{"key":"BFleu2012220_CR38","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nature05690","volume":"446","author":"CG Mullighan","year":"2007","unstructured":"Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758\u2013764.","journal-title":"Nature"},{"key":"BFleu2012220_CR39","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/onc.2011.291","volume":"31","author":"N Kawamata","year":"2012","unstructured":"Kawamata N, Pennella MA, Woo JL, Berk AJ, Koeffler HP . Dominant-negative mechanism of leukemogenic PAX5 fusions. Oncogene 2012; 31: 966\u2013977.","journal-title":"Oncogene"},{"key":"BFleu2012220_CR40","doi-asserted-by":"publisher","first-page":"17050","DOI":"10.1073\/pnas.0803494105","volume":"105","author":"Q An","year":"2008","unstructured":"An Q, Wright SL, Konn ZJ, Matheson E, Minto L, Moorman AV et al. Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer. Proc Natl Acad Sci USA 2008; 105: 17050\u201317054.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012220_CR41","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1182\/blood-2003-01-0338","volume":"102","author":"ME Ross","year":"2003","unstructured":"Ross ME, Zhou X, Song G, Shurtleff SA, Girtman K, Williams WK et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 2003; 102: 2951\u20132959.","journal-title":"Blood"},{"key":"BFleu2012220_CR42","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1200\/JCO.2007.14.4519","volume":"26","author":"D Bhojwani","year":"2008","unstructured":"Bhojwani D, Kang H, Menezes RX, Yang W, Sather H, Moskowitz NP et al. Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected]. J Clin Oncol 2008; 26: 4376\u20134384.","journal-title":"J Clin Oncol"},{"key":"BFleu2012220_CR43","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ccr.2009.07.030","volume":"16","author":"L Klemm","year":"2009","unstructured":"Klemm L, Duy C, Iacobucci I, Kuchen S, von Levetzow G, Feldhahn N et al. The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell 2009; 16: 232\u2013245.","journal-title":"Cancer Cell"},{"key":"BFleu2012220_CR44","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3346\/jkms.2003.18.6.804","volume":"18","author":"X Zhang","year":"2003","unstructured":"Zhang X, Lin Z, Kim I . Pax5 expression in non-Hodgkin's lymphomas and acute leukemias. J Korean Med Sci 2003; 18: 804\u2013808.","journal-title":"J Korean Med Sci"},{"key":"BFleu2012220_CR45","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1073\/pnas.87.5.1908","volume":"87","author":"PA Scherle","year":"1990","unstructured":"Scherle PA, Dorshkind K, Witte ON . Clonal lymphoid progenitor cell lines expressing the BCR\/ABL oncogene retain full differentiative function. Proc Natl Acad Sci USA 1990; 87: 1908\u20131912.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2012220_CR46","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4049\/jimmunol.153.2.730","volume":"153","author":"MF Neurath","year":"1994","unstructured":"Neurath MF, Strober W, Wakatsuki Y . The murine Ig 3' alpha enhancer is a target site with repressor function for the B cell lineage-specific transcription factor BSAP (NF-HB, S alpha-BP). J Immunol 1994; 153: 730\u2013742.","journal-title":"J Immunol"},{"key":"BFleu2012220_CR47","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1182\/blood.V73.6.1402.1402","volume":"73","author":"H Griesser","year":"1989","unstructured":"Griesser H, Tkachuk D, Reis MD, Mak TW . Gene rearrangements and translocations in lymphoproliferative diseases. Blood 1989; 73: 1402\u20131415.","journal-title":"Blood"},{"key":"BFleu2012220_CR48","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/gcc.20214","volume":"44","author":"B Poppe","year":"2005","unstructured":"Poppe B, De Paepe P, Michaux L, Dastugue N, Bastard C, Herens C et al. PAX5\/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements. Genes Chromosomes Cancer 2005; 44: 218\u2013223.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2012220_CR49","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1182\/blood-2002-12-3656","volume":"102","author":"T Kamio","year":"2003","unstructured":"Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K et al. The B cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. Blood 2003; 102: 3317\u20133322.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2012220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2012220","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2012220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T03:31:26Z","timestamp":1687663886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2012220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,3]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["BFleu2012220"],"URL":"https:\/\/doi.org\/10.1038\/leu.2012.220","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,3]]},"assertion":[{"value":"15 February 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}