{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:33:50Z","timestamp":1789986830768,"version":"4.0.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:00:00Z","timestamp":1345075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:00:00Z","timestamp":1345075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1038\/leu.2012.232","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T11:28:20Z","timestamp":1345548500000},"page":"515-516","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Single-nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma"],"prefix":"10.1038","volume":"27","author":[{"given":"A J","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Serie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S K","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Cerhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Liebow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D R","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C L","family":"Colby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Kyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S V","family":"Rajkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R B","family":"Diasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S L","family":"Slager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Vachon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,16]]},"reference":[{"key":"BFleu2012232_CR1","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1056\/NEJMoa01133202","volume":"346","author":"RA Kyle","year":"2002","unstructured":"Kyle RA, Therneau TM, Rajkumar SV, Offord JR, Larson DR, Plevak MF et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med 2002; 346: 564\u2013569.","journal-title":"N Engl J Med"},{"key":"BFleu2012232_CR2","doi-asserted-by":"publisher","first-page":"5412","DOI":"10.1182\/blood-2008-12-194241","volume":"113","author":"O Landgren","year":"2009","unstructured":"Landgren O, Kyle RA, Pfeiffer RM, Katzmann JA, Caporaso NE, Hayes RB et al. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood 2009; 113: 5412\u20135417.","journal-title":"Blood"},{"key":"BFleu2012232_CR3","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1182\/blood-2008-12-192575","volume":"114","author":"CM Vachon","year":"2009","unstructured":"Vachon CM, Kyle RA, Therneau TM, Foreman BJ, Larson DR, Colby CL et al. Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance. Blood 2009; 114: 785\u2013790.","journal-title":"Blood"},{"key":"BFleu2012232_CR4","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1182\/blood-2008-12-191676","volume":"114","author":"O Landgren","year":"2009","unstructured":"Landgren O, Kristinsson SY, Goldin LR, Caporaso NE, Blimark C, Mellqvist UH et al. Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden. Blood 2009; 114: 791\u2013795.","journal-title":"Blood"},{"key":"BFleu2012232_CR5","doi-asserted-by":"publisher","first-page":"5359","DOI":"10.1182\/blood-2011-11-387324","volume":"119","author":"AJ Greenberg","year":"2012","unstructured":"Greenberg AJ, Rajkumar SV, Vachon CM . Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics. Blood 2012; 119: 5359\u20135366.","journal-title":"Blood"},{"key":"BFleu2012232_CR6","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/ng.993","volume":"44","author":"P Broderick","year":"2012","unstructured":"Broderick P, Chubb D, Johnson DC, Weinhold N, Forsti A, Lloyd A et al. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Nat Genet 2012; 44: 58\u201361.","journal-title":"Nat Genet"},{"key":"BFleu2012232_CR7","first-page":"95","volume":"2","author":"JR Cerhan","year":"2011","unstructured":"Cerhan JR, Fredericksen ZS, Wang AH, Habermann TM, Kay NE, Macon WR et al. Design and validity of a clinic-based case-control study on the molecular epidemiology of lymphoma. Int J Mol Epidemiol Genet 2011; 2: 95\u2013113.","journal-title":"Int J Mol Epidemiol Genet"},{"key":"BFleu2012232_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/HJH.0b013e3283406927","volume":"29","author":"JE Ho","year":"2011","unstructured":"Ho JE, Levy D, Rose L, Johnson AD, Ridker PM, Chasman DI . Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study. J Hypertens 2011; 29: 62\u201369.","journal-title":"J Hypertens"},{"key":"BFleu2012232_CR9","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/jhg.2010.31","volume":"55","author":"KW Hong","year":"2010","unstructured":"Hong KW, Jin HS, Lim JE, Kim S, Go MJ, Oh B . Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. J Hum Genet 2010; 55: 336\u2013341.","journal-title":"J Hum Genet"},{"key":"BFleu2012232_CR10","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/S0140-6736(10)60482-5","volume":"375","author":"A Dispenzieri","year":"2010","unstructured":"Dispenzieri A, Katzmann JA, Kyle RA, Larson DR, Melton LJ, Colby CL et al. Prevalence and risk of progression of light-chain monoclonal gammopathy of undetermined significance: a retrospective population-based cohort study. Lancet 2010; 375: 1721\u20131728.","journal-title":"Lancet"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2012232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2012232","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2012232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T15:22:47Z","timestamp":1648740167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2012232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,16]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["BFleu2012232"],"URL":"https:\/\/doi.org\/10.1038\/leu.2012.232","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,16]]},"assertion":[{"value":"16 August 2012","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}