{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:44:35Z","timestamp":1792791875349,"version":"4.5.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1038\/leu.2013.135","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T06:41:04Z","timestamp":1367304064000},"page":"2165-2176","source":"Crossref","is-referenced-by-count":369,"title":["The MLL recombinome of acute leukemias in 2013"],"prefix":"10.1038","volume":"27","author":[{"given":"C","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Burmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Gr\u00f6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T S","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Emerenciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pombo de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Renneville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Villarese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Macintyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Cav\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Clappier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Mass-Malo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Trka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"De Braekeleer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"De Braekeleer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Tsaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Fechina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V H J","family":"van der Velden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J M","family":"van Dongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Delabesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Binato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L M","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kustanovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Aleinikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Lund-Aho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Juvonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Heidenreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Vormoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W W L","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jarosova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kolenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Menendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Wehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Talmant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Tondeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Lippert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Launay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ballerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Lapillone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Callanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Cayuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Herbaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Cazzaniga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P M","family":"Kakadiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bohlander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ahlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Gameiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Krauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Cornillet-Lefebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Te Kronnie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B W","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kubetzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C N","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"zur Stadt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N C","family":"Venn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Izraeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Trakhtenbrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H O","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Cerveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Lo Nigro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"M\u00f6ricke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Stanulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Schrappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Sed\u00e9k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Szczepa\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Zwaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"Coenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M M","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Strehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dworzak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Panzer-Gr\u00fcmayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Dingermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Klingebiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Marschalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"BFleu2013135_CR1","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/S0140-6736(02)08782-2","volume":"359","author":"CH Pui","year":"2002","unstructured":"Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W et al. Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region. Lancet 2002; 359: 1909\u20131915.","journal-title":"Lancet"},{"key":"BFleu2013135_CR2","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/sj.leu.2402883","volume":"17","author":"CH Pui","year":"2003","unstructured":"Pui CH, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM et al. Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements. Leukemia 2003; 17: 700\u2013706.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR3","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1182\/blood-2009-04-215152","volume":"114","author":"BV Balgobind","year":"2009","unstructured":"Balgobind BV, Raimondi SC, Harbott J, Zimmermann M, Alonzo TA, Auvrignon A et al. Novel prognostic subgroups in childhood 11q23\/MLL-rearranged acute myeloid leukemia: results of an International Retrospective Sstudy. Blood 2009; 114: 2489\u20132496.","journal-title":"Blood"},{"key":"BFleu2013135_CR4","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/S1470-2045(09)70369-9","volume":"11","author":"T Szczepa\u0144ski","year":"2010","unstructured":"Szczepa\u0144ski T, Harrison CJ, van Dongen JJ . Genetic aberrations in paediatric acute leukaemias and implications for management of patients. Lancet Oncol 2010; 11: 880\u2013889.","journal-title":"Lancet Oncol"},{"key":"BFleu2013135_CR5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/sj.leu.2404082","volume":"20","author":"T Burmeister","year":"2006","unstructured":"Burmeister T, Marschalek R, Schneider B, Meyer C, G\u00f6kbuget N, Schwartz S et al. Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrations. Leukemia 2006; 20: 451\u2013457.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR6","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/leu.2009.17","volume":"23","author":"VH van der Velden","year":"2009","unstructured":"van der Velden VH, Corral L, Valsecchi MG, Jansen MW, De Lorenzo P, Cazzaniga G et al. Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant-99 protocol. Leukemia 2009; 23: 1073\u20131079.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR7","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1200\/JCO.2011.40.5936","volume":"30","author":"AE Yeoh","year":"2012","unstructured":"Yeoh AE, Ariffin H, Chai EL, Kwok CS, Chan YH, Ponnudurai K et al. Minimal residual disease-guided treatment deintensification for children with acute lymphoblastic leukemia: results from the Malaysia\u2013Singapore acute lymphoblastic leukemia 2003 study. J Clin Oncol 2012; 30: 2384\u20132392.","journal-title":"J Clin Oncol"},{"key":"BFleu2013135_CR8","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/sj.leu.2401019","volume":"12","author":"B Johansson","year":"1998","unstructured":"Johansson B, Moorman AV, Secker-Walker LM . Derivative chromosomes of 11q23-translocations in hematologic malignancies. European 11q23 Workshop participants. Leukemia 1998; 12: 828\u2013833.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR9","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/sj.leu.2401413","volume":"13","author":"NA Heerema","year":"1999","unstructured":"Heerema NA, Sather HN, Ge J, Arthur DC, Hilden JM, Trigg ME et al. Cytogenetic studies of infant acute lymphoblastic leukemia: poor prognosis of infants with t(4;11)\u2014a report of the Children's Cancer Group. Leukemia 1999; 13: 679\u2013686.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR10","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1038\/sj.leu.2401595","volume":"13","author":"M Van der Burg","year":"1999","unstructured":"Van der Burg M, Beverloo HB, Langerak AW, Wijsman J, van Drunen E, Slater R et al. Rapid and sensitive detection of all types of MLL gene translocations with a single FISH probe set. Leukemia 1999; 13: 2107\u20132113.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR11","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/sj.leu.2403340","volume":"18","author":"M van der Burg","year":"2004","unstructured":"van der Burg M, Poulsen TS, Hunger SP, Beverloo HB, Smit EM, Vang-Nielsen K et al. Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia. Leukemia 2004; 18: 895\u2013908.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR12","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1365-2141.2005.05497.x","volume":"129","author":"CJ Harrison","year":"2005","unstructured":"Harrison CJ, Moorman AV, Barber KE, Broadfield ZJ, Cheung KL, Harris RL et al. Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study. Br J Haematol 2005; 129: 520\u2013530.","journal-title":"Br J Haematol"},{"key":"BFleu2013135_CR13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1073\/pnas.0406994102","volume":"102","author":"C Meyer","year":"2005","unstructured":"Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S et al. Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci USA 2005; 102: 449\u2013454.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2013135_CR14","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/sj.leu.2404150","volume":"20","author":"C Meyer","year":"2006","unstructured":"Meyer C, Schneider B, Jakob S, Strehl S, Schnittger S, Schoch C et al. The MLL recombinome of acute leukemias. Leukemia 2006; 20: 777\u2013784.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR15","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1038\/leu.2009.33","volume":"23","author":"C Meyer","year":"2009","unstructured":"Meyer C, Kowarz E, Hofmann J, Renneville A, Zuna J, Trka J et al. New insights into the MLL recombinome of acute leukemias. Leukemia 2009; 23: 1490\u20131499.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.semcancer.2005.01.007","volume":"15","author":"A Daser","year":"2005","unstructured":"Daser A, Rabbitts TH . The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis. Semin Cancer Biol 2005; 15: 175\u2013188.","journal-title":"Semin Cancer Biol"},{"key":"BFleu2013135_CR17","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nrc2253","volume":"7","author":"AV Krivtsov","year":"2007","unstructured":"Krivtsov AV, Armstrong SA . MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 2007; 7: 823\u2013833.","journal-title":"Nat Rev Cancer"},{"key":"BFleu2013135_CR18","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/bjh.12250","volume":"161","author":"M Emerenciano","year":"2013","unstructured":"Emerenciano M, Meyer C, Mansur MB, Marschalek R, Pombo-de-Oliveira MS, The Brazilian Collaborative Study Group of Infant Acute Leukaemia. The distribution of MLL breakpoints correlates with outcome in infant acute leukaemia. Br J Haematol 2013; 161: 224\u2013236.","journal-title":"Br J Haematol"},{"key":"BFleu2013135_CR19","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1006\/jmbi.2000.3766","volume":"299","author":"B Linder","year":"2000","unstructured":"Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P et al. Biochemical analyses of the AF10 protein: the extended LAP\/PHD-finger mediates oligomerisation. J Mol Biol 2000; 299: 369\u2013378.","journal-title":"J Mol Biol"},{"key":"BFleu2013135_CR20","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1128\/MCB.21.10.3589-3597.2001","volume":"21","author":"K Fair","year":"2001","unstructured":"Fair K, Anderson M, Bulanova E, Mi H, Tropschug M, Diaz MO . Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells. Mol Cell Biol 2001; 21: 3589\u20133597.","journal-title":"Mol Cell Biol"},{"key":"BFleu2013135_CR21","doi-asserted-by":"publisher","first-page":"8342","DOI":"10.1073\/pnas.1436338100","volume":"100","author":"ZB Xia","year":"2003","unstructured":"Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ . MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. Proc Natl Acad Sci USA 2003; 100: 8342\u20138347.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2013135_CR22","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jmb.2010.05.005","volume":"400","author":"PY Chang","year":"2010","unstructured":"Chang PY, Hom RA, Musselman CA, Zhu L, Kuo A, Gozani O et al. Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. J Mol Biol 2010; 400: 137\u2013144.","journal-title":"J Mol Biol"},{"key":"BFleu2013135_CR23","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.cell.2010.05.016","volume":"141","author":"Z Wang","year":"2010","unstructured":"Wang Z, Song J, Milne TA, Wang GG, Li H, Allis CD et al. Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell 2010; 141: 1183\u20131194.","journal-title":"Cell"},{"key":"BFleu2013135_CR24","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1182\/blood-2011-06-362079","volume":"119","author":"J Wang","year":"2012","unstructured":"Wang J, Muntean AG, Hess JL . ECSASB2 mediates MLL degradation during hematopoietic differentiation. Blood 2012; 119: 1151\u20131161.","journal-title":"Blood"},{"key":"BFleu2013135_CR25","doi-asserted-by":"publisher","first-page":"43410","DOI":"10.1074\/jbc.M112.423855","volume":"287","author":"J Wang","year":"2012","unstructured":"Wang J, Muntean AG, Wu L, Hess JL . A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity. J Biol Chem 2012; 287: 43410\u201343416.","journal-title":"J Biol Chem"},{"key":"BFleu2013135_CR26","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.cell.2010.06.013","volume":"141","author":"EJ Grow","year":"2010","unstructured":"Grow EJ, Wysocka J . Flipping MLL1\u2019s switch one proline at a time. Cell 2010; 141: 1108\u20131010.","journal-title":"Cell"},{"key":"BFleu2013135_CR27","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1182\/blood.V92.10.3793","volume":"92","author":"PL Strissel","year":"1998","unstructured":"Strissel PL, Strick R, Rowley JD, Zeleznik-Le NJ . An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region. Blood 1998; 92: 3793\u20133803.","journal-title":"Blood"},{"key":"BFleu2013135_CR28","doi-asserted-by":"publisher","first-page":"4070","DOI":"10.1128\/MCB.17.7.4070","volume":"17","author":"M Stanulla","year":"1997","unstructured":"Stanulla M, Wang J, Chervinsk DS, Thandla S, Aplan PD . DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. Mol Cell Biol 1997; 17: 4070\u20134079.","journal-title":"Mol Cell Biol"},{"key":"BFleu2013135_CR29","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1038\/sj.onc.1209948","volume":"26","author":"S Scharf","year":"2007","unstructured":"Scharf S, Zech J, Bursen A, Schraets D, Oliver PL, Kliem S et al. Transcription linked to recombination: a gene-internal promoter coincides with the recombination hot spot II of the human MLL gene. Oncogene 2007; 26: 1361\u20131371.","journal-title":"Oncogene"},{"key":"BFleu2013135_CR30","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/mpo.1125","volume":"36","author":"CA Felix","year":"2001","unstructured":"Felix CA . Leukemias related to treatment with DNA topoisomerase II inhibitors. Med Pediatr Oncol 2001; 36: 525\u2013535.","journal-title":"Med Pediatr Oncol"},{"key":"BFleu2013135_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1023\/A:1020918411532","volume":"41","author":"S Wang","year":"2003","unstructured":"Wang S, Zhang Z, Ying K, Chen JZ, Meng XF, Yang QS et al. Cloning, expression, and genomic structure of a novel human Rap2 interacting gene (RPIP9). Biochem Genet 2003; 41: 13\u201325.","journal-title":"Biochem Genet"},{"key":"BFleu2013135_CR32","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/hmg\/ddm301","volume":"17","author":"S Raychaudhuri","year":"2008","unstructured":"Raychaudhuri S, Sinha M, Mukhopadhyay D, Bhattacharyya NP . HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity. Hum Mol Genet 2008; 17: 240\u2013255.","journal-title":"Hum Mol Genet"},{"key":"BFleu2013135_CR33","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1128\/MCB.01505-09","volume":"30","author":"M Grote","year":"2010","unstructured":"Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, Schomburg A et al. Molecular architecture of the human Prp19\/CDC5L complex. Mol Cell Biol 2010; 30: 2105\u20132119.","journal-title":"Mol Cell Biol"},{"key":"BFleu2013135_CR34","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1021\/bi051787e","volume":"45","author":"CW Vander Kooi","year":"2006","unstructured":"Vander Kooi CW, Ohi MD, Rosenberg JA, Oldham ML, Newcomer ME, Gould KL et al. The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases. Biochemistry 2006; 45: 121\u2013130.","journal-title":"Biochemistry"},{"key":"BFleu2013135_CR35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.bbrc.2007.02.134","volume":"356","author":"CR Sihn","year":"2007","unstructured":"Sihn CR, Cho SY, Lee JH, Lee TR, Kim SH . Mouse homologue of yeast Prp19 interacts with mouse SUG1, the regulatory subunit of 26S proteasome. Biochem Biophys Res Commun 2007; 356: 175\u2013180.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFleu2013135_CR36","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1042\/BJ20041517","volume":"388","author":"M L\u00f6scher","year":"2005","unstructured":"L\u00f6scher M, Fortschegger K, Ritter G, Wostry M, Voglauer R, Schmid JA et al. Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20S proteasome. Biochem J 2005; 388: 593\u2013603.","journal-title":"Biochem J"},{"key":"BFleu2013135_CR37","doi-asserted-by":"publisher","first-page":"655","DOI":"10.4161\/cc.8.4.7844","volume":"8","author":"YR Pan","year":"2009","unstructured":"Pan YR, Lee EY . UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity. Cell Cycle 2009; 8: 655\u2013664.","journal-title":"Cell Cycle"},{"key":"BFleu2013135_CR38","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1101\/gad.1627708","volume":"22","author":"S Sivasubramaniam","year":"2008","unstructured":"Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY . Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev 2008; 22: 587\u2013600.","journal-title":"Genes Dev"},{"key":"BFleu2013135_CR39","doi-asserted-by":"publisher","first-page":"28232","DOI":"10.1074\/jbc.M109.054668","volume":"284","author":"L Baisamy","year":"2009","unstructured":"Baisamy L, Cavin S, Jurisch N, Diviani D . The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-Lbc. J Biol Chem 2009; 284: 28232\u201328242.","journal-title":"J Biol Chem"},{"key":"BFleu2013135_CR40","doi-asserted-by":"publisher","first-page":"35308","DOI":"10.1074\/jbc.M704426200","volume":"282","author":"O Shibolet","year":"2007","unstructured":"Shibolet O, Giallourakis C, Rosenberg I, Mueller T, Xavier RJ, Podolsky DK . AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling. J Biol Chem 2007; 282: 35308\u201335317.","journal-title":"J Biol Chem"},{"key":"BFleu2013135_CR41","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1038\/ncb2130","volume":"12","author":"FD Smith","year":"2010","unstructured":"Smith FD, Langeberg LK, Cellurale C, Pawson T, Morrison DK, Davis RJ et al. AKAP-Lbc enhances cyclic AMP control of the ERK1\/2 cascade. Nat Cell Biol 2010; 12: 1242\u20131249.","journal-title":"Nat Cell Biol"},{"key":"BFleu2013135_CR42","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1126\/science.8351518","volume":"261","author":"P Liu","year":"1993","unstructured":"Liu P, Tarl\u00e9 SA, Hajra A, Claxton DF, Marlton P, Freedman M et al. Fusion between transcription factor CBF beta\/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 1993; 261: 1041\u20131044.","journal-title":"Science"},{"key":"BFleu2013135_CR43","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1038\/sj.onc.1202229","volume":"17","author":"M Reichel","year":"1998","unstructured":"Reichel M, Gillert E, Nilson I, Siegler G, Greil J, Fey GH et al. Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation. Oncogene 1998; 17: 3035\u20133044.","journal-title":"Oncogene"},{"key":"BFleu2013135_CR44","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/35015097","volume":"405","author":"C Richardson","year":"2000","unstructured":"Richardson C, Jasin M . Frequent chromosomal translocations induced by DNA double-strand breaks. Nature 2000; 405: 697\u2013700.","journal-title":"Nature"},{"key":"BFleu2013135_CR45","doi-asserted-by":"publisher","first-page":"6236","DOI":"10.1073\/pnas.91.13.6236","volume":"91","author":"SA Schichman","year":"1994","unstructured":"Schichman SA, Caligiuri MA, Gu Y, Strout MP, Canaani E, Bloomfield CD et al. ALL-1 partial duplication in acute leukemia. Proc Natl Acad Sci USA 1994; 91: 6236\u20136239.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2013135_CR46","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S1535-6108(03)00214-9","volume":"4","author":"ME Martin","year":"2003","unstructured":"Martin ME, Milne TA, Bloyer S, Galoian K, Shen W, Gibbs D et al. Dimerization of MLL fusion proteins immortalizes hematopoietic cells. Cancer Cell 2003; 4: 197\u2013207.","journal-title":"Cancer Cell"},{"key":"BFleu2013135_CR47","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/j.1365-2141.2006.06301.x","volume":"135","author":"J B\u00e4secke","year":"2006","unstructured":"B\u00e4secke J, Whelan JT, Griesinger F, Bertrand FE . The MLL partial tandem duplication in acute myeloid leukaemia. Br J Haematol 2006; 135: 438\u2013449.","journal-title":"Br J Haematol"},{"key":"BFleu2013135_CR48","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/sj.leu.2404542","volume":"21","author":"C Meyer","year":"2007","unstructured":"Meyer C, Burmeister T, Strehl S, Schneider B, Hubert D, Zach O et al. Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia. Leukemia 2007; 21: 588\u2013590.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR49","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1038\/nm.2988","volume":"18","author":"AJ Holland","year":"2012","unstructured":"Holland AJ, Cleveland DW . Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements. Nat Med 2012; 18: 1630\u20131638.","journal-title":"Nat Med"},{"key":"BFleu2013135_CR50","doi-asserted-by":"publisher","first-page":"3570","DOI":"10.1182\/blood-2009-06-229542","volume":"115","author":"A Bursen","year":"2010","unstructured":"Bursen A, Schwabe K, R\u00fcster B, Henschler R, Ruthardt M, Dingermann T et al. AF4-MLL is capable of inducing ALL in mice without requirement of MLL-AF4. Blood 2010; 115: 3570\u20133579.","journal-title":"Blood"},{"key":"BFleu2013135_CR51","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.canlet.2012.12.023","volume":"332","author":"M Emerenciano","year":"2013","unstructured":"Emerenciano M, Kowarz E, Karl K, de Almeida Lopes B, Scholz B, Bracharz S et al. Functional analysis of the two reciprocal fusion genes MLL-NEBL and NEBL-MLL reveal their oncogenic potential. Cancer Lett 2013; 332: 30\u201334.","journal-title":"Cancer Lett"},{"key":"BFleu2013135_CR52","doi-asserted-by":"publisher","first-page":"5525","DOI":"10.1038\/sj.onc.1208699","volume":"24","author":"DT Zeisig","year":"2005","unstructured":"Zeisig DT, Bittner CB, Zeisig BB, Garc\u00eda-Cu\u00e9llar MP, Hess JL, Slany RK . The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin. Oncogene 2005; 24: 5525\u20135532.","journal-title":"Oncogene"},{"key":"BFleu2013135_CR53","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/hmg\/ddl444","volume":"16","author":"E Bitoun","year":"2007","unstructured":"Bitoun E, Oliver PL, Davies KE . The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum Mol Genet 2007; 16: 192\u2013106.","journal-title":"Hum Mol Genet"},{"key":"BFleu2013135_CR54","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cell.2005.02.020","volume":"121","author":"Y Okada","year":"2005","unstructured":"Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM et al. hDOT1L links histone methylation to leukemogenesis. Cell 2005; 121: 167\u2013178.","journal-title":"Cell"},{"key":"BFleu2013135_CR55","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1101\/gad.927301","volume":"15","author":"Y Zhang","year":"2001","unstructured":"Zhang Y, Reinberg D . Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev 2001; 15: 2343\u20132360.","journal-title":"Genes Dev"},{"key":"BFleu2013135_CR56","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/leu.2010.249","volume":"25","author":"A Benedikt","year":"2011","unstructured":"Benedikt A, Baltruschat S, Scholz B, Bursen A, Arrey TN, Meyer B et al. The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures. Leukemia 2011; 25: 135\u2013144.","journal-title":"Leukemia"},{"key":"BFleu2013135_CR57","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ccr.2008.10.001","volume":"14","author":"AV Krivtsov","year":"2008","unstructured":"Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 2008; 14: 355\u2013368.","journal-title":"Cancer Cell"},{"key":"BFleu2013135_CR58","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.celrep.2012.12.016","volume":"3","author":"AC Wilkinson","year":"2013","unstructured":"Wilkinson AC, Ballabio E, Geng H, North P, Tapia M, Kerry J et al. RUNX1 Is a key target in t(4;11) leukemias that contributes to gene activation through an AF4\u2013MLL complex interaction. Cell Rep 2013; 3: 116\u2013127.","journal-title":"Cell Rep"},{"key":"BFleu2013135_CR59","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ccr.2011.06.009","volume":"20","author":"SR Daigle","year":"2011","unstructured":"Daigle SR, Olhava EJ, Therkelsen CA, Majer CR, Sneeringer CJ, Song J et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 2011; 20: 53\u201365.","journal-title":"Cancer Cell"},{"key":"BFleu2013135_CR60","doi-asserted-by":"publisher","first-page":"6237","DOI":"10.1038\/sj.onc.1207837","volume":"23","author":"A Bursen","year":"2004","unstructured":"Bursen A, Moritz S, Gaussmann A, Dingermann T, Marschalek R . Interaction of AF4 wildtype and AF4\u2022MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology? Oncogene 2004; 23: 6237\u20136249.","journal-title":"Oncogene"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/leu2013135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/leu2013135","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/leu2013135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:03:51Z","timestamp":1684433031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2013135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,30]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["BFleu2013135"],"URL":"https:\/\/doi.org\/10.1038\/leu.2013.135","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,30]]}}}