{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:42:27Z","timestamp":1790628147996,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1038\/leu.2014.177","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T13:39:33Z","timestamp":1401889173000},"page":"58-65","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Evolutionary trajectories of hyperdiploid ALL in monozygotic twins"],"prefix":"10.1038","volume":"29","author":[{"given":"C M","family":"Bateman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Alpar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Colman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kearney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Greaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"BFleu2014177_CR1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"SHCE Swerdlow","year":"2008","unstructured":"Swerdlow SH CE, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. IARC Press: Lyon, France, 2008."},{"key":"BFleu2014177_CR2","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1365-2141.2010.08314.x","volume":"151","author":"CJ Harrison","year":"2010","unstructured":"Harrison CJ, Haas O, Harbott J, Biondi A, Stanulla M, Trka J et al. Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfurt-Munster study group. Br J Haematol 2010; 151: 132\u2013142.","journal-title":"Br J Haematol"},{"key":"BFleu2014177_CR3","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0165-4608(81)90016-9","volume":"4","author":"Y Kaneko","year":"1981","unstructured":"Kaneko Y, Hayashi Y, Sakurai M . Chromosomal findings and their correlation to prognosis in acute lymphocytic leukemia. Cancer Genet Cytogenet 1981; 4: 227\u2013235.","journal-title":"Cancer Genet Cytogenet"},{"key":"BFleu2014177_CR4","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1182\/blood.V73.7.1963.1963","volume":"73","author":"CH Pui","year":"1989","unstructured":"Pui CH, Raimondi SC, Dodge RK, Rivera GK, Fuchs LA, Abromowitch M et al. Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia. Blood 1989; 73: 1963\u20131967.","journal-title":"Blood"},{"key":"BFleu2014177_CR5","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1182\/blood-2012-06-437681","volume":"121","author":"N Dastugue","year":"2013","unstructured":"Dastugue N, Suciu S, Plat G, Speleman F, Cave H, Girard S et al. Hyperdiploidy with 58-66 chromosomes in childhood B-acute lymphoblastic leukemia is highly curable: 58951 CLG-EORTC results. Blood 2013; 121: 2415\u20132423.","journal-title":"Blood"},{"key":"BFleu2014177_CR6","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1182\/blood-2003-04-1128","volume":"102","author":"AV Moorman","year":"2003","unstructured":"Moorman AV, Richards SM, Martineau M, Cheung KL, Robinson HM, Jalali GR et al. Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia. Blood 2003; 102: 2756\u20132762.","journal-title":"Blood"},{"key":"BFleu2014177_CR7","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.3324\/haematol.2013.085852","volume":"98","author":"K Paulsson","year":"2013","unstructured":"Paulsson K, Forestier E, Andersen MK, Autio K, Barbany G, Borgstrom G et al. High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992\/2000 protocols. Haematologica 2013; 98: 1424\u20131432.","journal-title":"Haematologica"},{"key":"BFleu2014177_CR8","doi-asserted-by":"publisher","first-page":"21719","DOI":"10.1073\/pnas.1006981107","volume":"107","author":"K Paulsson","year":"2010","unstructured":"Paulsson K, Forestier E, Lilljebjorn H, Heldrup J, Behrendtz M, Young BD et al. Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2010; 107: 21719\u201321724.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2014177_CR9","doi-asserted-by":"crossref","unstructured":"Balatzenko G, Guenova M, Kalinova I, Belcheva M, Hristozova H, Kaleva V . Simultaneous occurrence of ETV6-RUNX1 and BCR-ABL1 (e1a2) transcripts in a child with B-cell acute lymphoblastic leukemia. Cancer Genet 2013.","DOI":"10.1016\/j.cancergen.2013.01.004"},{"key":"BFleu2014177_CR10","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1200\/JCO.2000.18.9.1876","volume":"18","author":"NA Heerema","year":"2000","unstructured":"Heerema NA, Sather HN, Sensel MG, Zhang T, Hutchinson RJ, Nachman JB et al. Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (&gt; 50 chromosomes). J Clin Oncol 2000; 18: 1876\u20131887.","journal-title":"J Clin Oncol"},{"key":"BFleu2014177_CR11","doi-asserted-by":"publisher","first-page":"6708","DOI":"10.1073\/pnas.0800408105","volume":"6105","author":"K Paulsson","year":"2008","unstructured":"Paulsson K, Cazier JB, Macdougall F, Stevens J, Stasevich I, Vrcelj N et al. Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: unexpected similarities with pediatric disease. Proc Natl Acad Sci USA 2008; 6105: 6708\u20136713.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2014177_CR12","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/leu.2010.39","volume":"24","author":"J Davidsson","year":"2010","unstructured":"Davidsson J, Paulsson K, Lindgren D, Lilljebjorn H, Chaplin T, Forestier E et al. Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations. Leukemia 2010; 24: 924\u2013931.","journal-title":"Leukemia"},{"key":"BFleu2014177_CR13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/gcc.20502","volume":"47","author":"K Paulsson","year":"2008","unstructured":"Paulsson K, Horvat A, Strombeck B, Nilsson F, Heldrup J, Behrendtz M et al. Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer 2008; 47: 26\u201333.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2014177_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bcmd.2010.07.007","volume":"45","author":"JL Wiemels","year":"2010","unstructured":"Wiemels JL, Kang M, Chang JS, Zheng L, Kouyoumji C, Zhang L et al. Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia. Blood Cells Mol Dis 2010; 45: 186\u2013191.","journal-title":"Blood Cells Mol Dis"},{"key":"BFleu2014177_CR15","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1038\/leu.2012.60","volume":"26","author":"A Inthal","year":"2012","unstructured":"Inthal A, Zeitlhofer P, Zeginigg M, Morak M, Grausenburger R, Fronkova E et al. CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemia. Leukemia 2012; 26: 1797\u20131803.","journal-title":"Leukemia"},{"key":"BFleu2014177_CR16","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1182\/blood-2002-12-3817","volume":"1102","author":"MF Greaves","year":"2003","unstructured":"Greaves MF, Maia AT, Wiemels JL, Ford AM . Leukemia in twins: lessons in natural history. Blood 2003; 1102: 2321\u20132333.","journal-title":"Blood"},{"key":"BFleu2014177_CR17","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1182\/blood-2009-10-251413","volume":"115","author":"CM Bateman","year":"2010","unstructured":"Bateman CM, Colman SM, Chaplin T, Young BD, Eden TO, Bhakta M et al. Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia. Blood 2010; 115: 3553\u20133558.","journal-title":"Blood"},{"key":"BFleu2014177_CR18","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1002\/cncr.11664","volume":"198","author":"S Faderl","year":"2003","unstructured":"Faderl S, Jeha S, Kantarjian HM . The biology and therapy of adult acute lymphoblastic leukemia. Cancer 2003; 198: 1337\u20131354.","journal-title":"Cancer"},{"key":"BFleu2014177_CR19","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/gcc.20010","volume":"40","author":"AT Maia","year":"2004","unstructured":"Maia AT, Tussiwand R, Cazzaniga G, Rebulla P, Colman S, Biondi A et al. Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood. Genes Chromosomes Cancer 2004; 40: 38\u201343.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2014177_CR20","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/978-1-59745-418-6_9","volume":"538","author":"M Gupta","year":"2009","unstructured":"Gupta M, Young BD . Application of SNP genotype arrays to determine somatic changes in cancer. Methods Mol Biol 2009; 538: 179\u2013206.","journal-title":"Methods Mol Biol"},{"key":"BFleu2014177_CR21","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","volume":"17","author":"JJ van Dongen","year":"2003","unstructured":"van Dongen JJ, Langerak AW, Bruggemann M, Evans PA, Hummel M, Lavender FL et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17: 2257\u20132317.","journal-title":"Leukemia"},{"key":"BFleu2014177_CR22","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1038\/leu.2012.246","volume":"26","author":"AW Langerak","year":"2012","unstructured":"Langerak AW, Groenen PJ, Bruggemann M, Beldjord K, Bellan C, Bonello L et al. EuroClonality\/BIOMED-2 guidelines for interpretation and reporting of Ig\/TCR clonality testing in suspected lymphoproliferations. Leukemia 2012; 26: 2159\u20132171.","journal-title":"Leukemia"},{"key":"BFleu2014177_CR23","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/sj.leu.2404586","volume":"21","author":"VH van der Velden","year":"2007","unstructured":"van der Velden VH, Cazzaniga G, Schrauder A, Hancock J, Bader P, Panzer-Grumayer ER et al. Analysis of minimal residual disease by Ig\/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data. Leukemia 2007; 21: 604\u2013611.","journal-title":"Leukemia"},{"key":"BFleu2014177_CR24","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/path.4247","volume":"231","author":"IY Chong","year":"2013","unstructured":"Chong IY, Cunningham D, Barber LJ, Campbell J, Chen L, Kozarewa I et al. The genomic landscape of oesophagogastric junctional adenocarcinoma. J Pathol 2013; 231: 301\u2013310.","journal-title":"J Pathol"},{"key":"BFleu2014177_CR25","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 2010; 20: 1297\u20131303.","journal-title":"Genome Res"},{"key":"BFleu2014177_CR26","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.cell.2012.06.023","volume":"150","author":"JS Welch","year":"2012","unstructured":"Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 2012; 150: 264\u2013278.","journal-title":"Cell"},{"key":"BFleu2014177_CR27","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nature05690","volume":"446","author":"CG Mullighan","year":"2007","unstructured":"Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758\u2013764.","journal-title":"Nature"},{"key":"BFleu2014177_CR28","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/leu.2008.390","volume":"23","author":"E Csinady","year":"2009","unstructured":"Csinady E, van der Velden VH, Joas R, Fischer S, de Vries JF, Beverloo HB et al. Chromosome 14 copy number-dependent IGH gene rearrangement patterns in high hyperdiploid childhood B-cell precursor ALL: implications for leukemia biology and minimal residual disease analysis. Leukemia 2009; 23: 870\u2013876.","journal-title":"Leukemia"},{"key":"BFleu2014177_CR29","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/sj.leu.2402206","volume":"15","author":"T Szczepanski","year":"2001","unstructured":"Szczepanski T, Willemse MJ, van Wering ER, van Weerden JF, Kamps WA, van Dongen JJ . Precursor-B-ALL with D(H)-J(H) gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14. Leukemia 2001; 15: 1415\u20131423.","journal-title":"Leukemia"},{"key":"BFleu2014177_CR30","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1126\/science.1150648","volume":"18319","author":"D Hong","year":"2008","unstructured":"Hong D, Gupta R, Ancliff P, Atzberger A, Brown J, Soneji S et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 2008; 18319: 336\u2013339.","journal-title":"Science"},{"key":"BFleu2014177_CR31","doi-asserted-by":"publisher","first-page":"5559","DOI":"10.1182\/blood-2011-07-366542","volume":"118","author":"G Cazzaniga","year":"2011","unstructured":"Cazzaniga G, van Delft FW, Lo Nigro L, Ford AM, Score J, Iacobucci I et al. Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia. Blood 2011; 118: 5559\u20135564.","journal-title":"Blood"},{"key":"BFleu2014177_CR32","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/gcc.20671","volume":"48","author":"K Paulsson","year":"2009","unstructured":"Paulsson K, Johansson B . High hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer 2009; 48: 637\u2013660.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2014177_CR33","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/ni.1891","volume":"11","author":"YC Lin","year":"2010","unstructured":"Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R et al. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol 2010; 11: 635\u2013643.","journal-title":"Nat Immunol"},{"key":"BFleu2014177_CR34","doi-asserted-by":"publisher","first-page":"7429","DOI":"10.1073\/pnas.1221099110","volume":"110","author":"Y Ma","year":"2013","unstructured":"Ma Y, Dobbins SE, Sherborne AL, Chubb D, Galbiati M, Cazzaniga G et al. Developmental timing of mutations revealed by whole-genome sequencing of twins with acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2013; 110: 7429\u20137433.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2014177_CR35","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1182\/blood-2002-01-0144","volume":"100","author":"ER Panzer-Grumayer","year":"2002","unstructured":"Panzer-Grumayer ER, Fasching K, Panzer S, Hettinger K, Schmitt K, Stockler-Ipsiroglu S et al. Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis. Blood 2002; 100: 347\u2013349.","journal-title":"Blood"},{"key":"BFleu2014177_CR36","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1038\/sj.onc.1206406","volume":"22","author":"A Matsuda","year":"2003","unstructured":"Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 2003; 22: 3307\u20133318.","journal-title":"Oncogene"},{"key":"BFleu2014177_CR37","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nature09650","volume":"469","author":"K Anderson","year":"2011","unstructured":"Anderson K, Lutz C, van Delft FW, Bateman CM, Guo Y, Colman SM et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 2011; 469: 356\u2013361.","journal-title":"Nature"},{"key":"BFleu2014177_CR38","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1101\/gr.159913.113","volume":"23","author":"NE Potter","year":"2013","unstructured":"Potter NE, Ermini L, Papaemmanuil E, Cazzaniga G, Vijayaraghavan G, Titley I et al. Single-cell mutational profiling and clonal phylogeny in cancer. Genome Res 2013; 23: 2115\u20132125.","journal-title":"Genome Res"},{"key":"BFleu2014177_CR39","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1038\/sj.leu.2403101","volume":"17","author":"AT Maia","year":"2003","unstructured":"Maia AT, van der Velden VH, Harrison CJ, Szczepanski T, Williams MD, Griffiths MJ et al. Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins. Leukemia 2003; 17: 2202\u20132206.","journal-title":"Leukemia"},{"key":"BFleu2014177_CR40","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1182\/blood.V99.8.2992","volume":"99","author":"JW Taub","year":"2002","unstructured":"Taub JW, Konrad MA, Ge Y, Naber JM, Scott JS, Matherly LH et al. High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia. Blood 2002; 99: 2992\u20132996.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2014177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2014177","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2014177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T16:31:58Z","timestamp":1648744318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2014177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["BFleu2014177"],"URL":"https:\/\/doi.org\/10.1038\/leu.2014.177","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,4]]},"assertion":[{"value":"3 March 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}