{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:44:47Z","timestamp":1789454687488,"version":"build-2803163510"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1038\/leu.2015.108","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T08:13:55Z","timestamp":1430295235000},"page":"2266-2269","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy"],"prefix":"10.1038","volume":"29","author":[{"given":"N","family":"Lachmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Czarnecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Brennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Phaltane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Heise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kempf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Dilloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Kaever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Schambach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Heuser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,29]]},"reference":[{"key":"BFleu2015108_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1080\/14653240152584640","volume":"3","author":"T Moritz","year":"2001","unstructured":"Moritz T, Williams DA . Marrow protection - transduction of hematopoietic cells with drug resistance genes. Cytotherapy 2001; 3: 67\u201384.","journal-title":"Cytotherapy"},{"key":"BFleu2015108_CR2","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1172\/JCI76739","volume":"124","author":"JE Adair","year":"2014","unstructured":"Adair JE, Johnston SK, Mrugala MM, Beard BC, Guyman LA, Baldock AL et al. Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients. J Clin Invest 2014; 124: 4082\u20134092.","journal-title":"J Clin Invest"},{"key":"BFleu2015108_CR3","first-page":"133ra157","volume":"4","author":"JE Adair","year":"2012","unstructured":"Adair JE, Beard BC, Trobridge GD, Neff T, Rockhill JK, Silbergeld DL et al. Extended survival of glioblastoma patients after chemoprotective HSC gene therapy. Sci Transl Med 2012; 4: 133ra157.","journal-title":"Sci Transl Med"},{"key":"BFleu2015108_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/1476-4598-13-159","volume":"13","author":"M Klanova","year":"2014","unstructured":"Klanova M, Lorkova L, Vit O, Maswabi B, Molinsky J, Pospisilova J et al. Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents. Mol Cancer 2014; 13: 159.","journal-title":"Mol Cancer"},{"key":"BFleu2015108_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1593\/neo.121954","volume":"15","author":"N Lachmann","year":"2013","unstructured":"Lachmann N, Brennig S, Phaltane R, Flasshove M, Dilloo D, Moritz T . Myeloprotection by cytidine deaminase gene transfer in antileukemic therapy. Neoplasia 2013; 15: 239\u2013248.","journal-title":"Neoplasia"},{"key":"BFleu2015108_CR6","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/gt.2012.40","volume":"20","author":"N Lachmann","year":"2013","unstructured":"Lachmann N, Brennig S, Pfaff N, Schermeier H, Dahlmann J, Phaltane R et al. Efficient in vivo regulation of cytidine deaminase expression in the haematopoietic system using a doxycycline-inducible lentiviral vector system. Gene Ther 2013; 20: 298\u2013307.","journal-title":"Gene Ther"},{"key":"BFleu2015108_CR7","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1038\/sj.leu.2403977","volume":"19","author":"W Bardenheuer","year":"2005","unstructured":"Bardenheuer W, Lehmberg K, Rattmann I, Brueckner A, Schneider A, Sorg UR et al. Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells. Leukemia 2005; 19: 2281\u20132288.","journal-title":"Leukemia"},{"key":"BFleu2015108_CR8","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1182\/blood-2006-03-011734","volume":"108","author":"I Rattmann","year":"2006","unstructured":"Rattmann I, Kleff V, Sorg UR, Bardenheuer W, Brueckner A, Hilger RA et al. Gene transfer of cytidine deaminase protects myelopoiesis from cytidine analogs in an in vivo murine transplant model. Blood 2006; 108: 2965\u20132971.","journal-title":"Blood"},{"key":"BFleu2015108_CR9","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.1128\/JVI.72.12.9873-9880.1998","volume":"72","author":"R Zufferey","year":"1998","unstructured":"Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L et al. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 1998; 72: 9873\u20139880.","journal-title":"J Virol"},{"key":"BFleu2015108_CR10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.exphem.2014.03.004","volume":"42","author":"OS Kustikova","year":"2014","unstructured":"Kustikova OS, Stahlhut M, Ha TC, Scherer R, Schambach A, Baum C . Dose response and clonal variability of lentiviral tetracycline-regulated vectors in murine hematopoietic cells. Exp Hematol 2014; 42: 505\u2013515.e7.","journal-title":"Exp Hematol"},{"key":"BFleu2015108_CR11","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1182\/blood-2005-06-2335","volume":"107","author":"T Neff","year":"2006","unstructured":"Neff T, Beard BC, Kiem HP . Survival of the fittest: in vivo selection and stem cell gene therapy. Blood 2006; 107: 1751\u20131760.","journal-title":"Blood"},{"key":"BFleu2015108_CR12","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1056\/NEJM200012143432402","volume":"343","author":"KR Rai","year":"2000","unstructured":"Rai KR, Peterson BL, Appelbaum FR, Kolitz J, Elias L, Shepherd L et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1750\u20131757.","journal-title":"N Engl J Med"},{"key":"BFleu2015108_CR13","doi-asserted-by":"publisher","first-page":"3360","DOI":"10.1200\/JCO.2012.47.4874","volume":"31","author":"AK Burnett","year":"2013","unstructured":"Burnett AK, Russell NH, Hills RK, Hunter AE, Kjeldsen L, Yin J et al. Optimization of chemotherapy for younger patients with acute myeloid leukemia: results of the medical research council AML15 trial. J Clin Oncol 2013; 31: 3360\u20133368.","journal-title":"J Clin Oncol"},{"key":"BFleu2015108_CR14","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/leu.2009.30","volume":"23","author":"JE Rubnitz","year":"2009","unstructured":"Rubnitz JE, Crews KR, Pounds S, Yang S, Campana D, Gandhi VV et al. Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: results of the St Jude AML97 trial. Leukemia 2009; 23: 1410\u20131416.","journal-title":"Leukemia"},{"key":"BFleu2015108_CR15","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1073\/pnas.0913900107","volume":"107","author":"G Toy","year":"2010","unstructured":"Toy G, Austin WR, Liao H-I, Cheng D, Singh A, Campbell DO et al. Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci 2010; 107: 5551\u20135556.","journal-title":"Proc Natl Acad Sci"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2015108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2015108","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2015108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T16:28:26Z","timestamp":1648744106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2015108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,29]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["BFleu2015108"],"URL":"https:\/\/doi.org\/10.1038\/leu.2015.108","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,29]]},"assertion":[{"value":"29 April 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}