{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:25:25Z","timestamp":1761765925200},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1038\/leu.2015.193","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T06:41:54Z","timestamp":1437633714000},"page":"955-958","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Independent development of lymphoid and histiocytic malignancies from a shared early precursor"],"prefix":"10.1038","volume":"30","author":[{"given":"E","family":"Waanders","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"Hebeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E J","family":"Kamping","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J T A","family":"Groenen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Simons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Hoischen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C J","family":"Jongmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Hoogerbrugge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F N","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R P","family":"Kuiper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M W M","family":"te Loo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"BFleu2015193_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2559.2002.01418.x","volume":"41","author":"SA Pileri","year":"2002","unstructured":"Pileri SA, Grogan TM, Harris NL, Banks P, Campo E, Chan JK et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 2002; 41: 1\u201329.","journal-title":"Histopathology"},{"key":"BFleu2015193_CR2","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/modpathol.3800346","volume":"18","author":"JA Vos","year":"2005","unstructured":"Vos JA, Abbondanzo SL, Barekman CL, Andriko JW, Miettinen M, Aguilera NS . Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163. Mod Pathol 2005; 18: 693\u2013704.","journal-title":"Mod Pathol"},{"key":"BFleu2015193_CR3","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1002\/pbc.20246","volume":"45","author":"S Weitzman","year":"2005","unstructured":"Weitzman S, Jaffe R . Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses. Pediatr Blood Cancer 2005; 45: 256\u2013264.","journal-title":"Pediatr Blood Cancer"},{"key":"BFleu2015193_CR4","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/leu.2014.87","volume":"28","author":"F Pagni","year":"2014","unstructured":"Pagni F, Fazio G, Zannella S, Spinelli M, De Angelis C, Cusi C et al. The role of PAX5 and C\/EBP alpha\/beta in atypical non-Langerhans cell histiocytic tumor post acute lymphoblastic leukemia. Leukemia 2014; 28: 1377\u20131379.","journal-title":"Leukemia"},{"key":"BFleu2015193_CR5","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S1470-2045(04)01428-7","volume":"5","author":"AL Feldman","year":"2004","unstructured":"Feldman AL, Minniti C, Santi M, Downing JR, Raffeld M, Jaffe ES . Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. Lancet Oncol 2004; 5: 248\u2013250.","journal-title":"Lancet Oncol"},{"key":"BFleu2015193_CR6","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/pbc.22810","volume":"56","author":"R Kumar","year":"2011","unstructured":"Kumar R, Khan SP, Joshi DD, Shaw GR, Ketterling RP, Feldman AL . Pediatric histiocytic sarcoma clonally related to precursor B-cell acute lymphoblastic leukemia with homozygous deletion of CDKN2A encoding p16INK4A. Pediatr Blood Cancer 2011; 56: 307\u2013310.","journal-title":"Pediatr Blood Cancer"},{"key":"BFleu2015193_CR7","doi-asserted-by":"publisher","first-page":"e71","DOI":"10.1016\/j.leukres.2009.08.020","volume":"34","author":"R McClure","year":"2010","unstructured":"McClure R, Khoury J, Feldman A, Ketterling R . Clonal relationship between precursor B-cell acute lymphoblastic leukemia and histiocytic sarcoma: a case report and discussion in the context of similar cases. Leuk Res 2010; 34: e71\u2013e73.","journal-title":"Leuk Res"},{"key":"BFleu2015193_CR8","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1038\/leu.2014.167","volume":"28","author":"P Brunner","year":"2014","unstructured":"Brunner P, Rufle A, Dirnhofer S, Lohri A, Willi N, Cathomas G et al. Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor. Leukemia 2014; 28: 1937\u20131940.","journal-title":"Leukemia"},{"key":"BFleu2015193_CR9","doi-asserted-by":"publisher","first-page":"406796","DOI":"10.1155\/2012\/406796","volume":"2012","author":"E Dorantes-Acosta","year":"2012","unstructured":"Dorantes-Acosta E, Pelayo R . Lineage switching in acute leukemias: a consequence of stem cell plasticity? Bone Marrow Res 2012; 2012: 406796.","journal-title":"Bone Marrow Res"},{"key":"BFleu2015193_CR10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1600-065X.2010.00959.x","volume":"238","author":"H Kawamoto","year":"2010","unstructured":"Kawamoto H, Ikawa T, Masuda K, Wada H, Katsura Y . A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model. Immunol Rev 2010; 238: 23\u201336.","journal-title":"Immunol Rev"},{"key":"BFleu2015193_CR11","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/leu.2013.354","volume":"28","author":"L Slamova","year":"2014","unstructured":"Slamova L, Starkova J, Fronkova E, Zaliova M, Reznickova L, van Delft FW et al. CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage. Leukemia 2014; 28: 609\u2013620.","journal-title":"Leukemia"},{"key":"BFleu2015193_CR12","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nature06159","volume":"449","author":"C Cobaleda","year":"2007","unstructured":"Cobaleda C, Jochum W, Busslinger M . Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 2007; 449: 473\u2013477.","journal-title":"Nature"},{"key":"BFleu2015193_CR13","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S0092-8674(04)00419-2","volume":"117","author":"H Xie","year":"2004","unstructured":"Xie H, Ye M, Feng R, Graf T . Stepwise reprogramming of B cells into macrophages. Cell 2004; 117: 663\u2013676.","journal-title":"Cell"},{"key":"BFleu2015193_CR14","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1182\/blood-2002-06-1797","volume":"101","author":"D Yu","year":"2003","unstructured":"Yu D, Allman D, Goldschmidt MH, Atchison ML, Monroe JG, Thomas-Tikhonenko A . Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing\/reactivation of the EBF\/Pax5 pathway. Blood 2003; 101: 1950\u20131955.","journal-title":"Blood"},{"key":"BFleu2015193_CR15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ccr.2006.03.028","volume":"9","author":"DR Carrasco","year":"2006","unstructured":"Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ et al. The PTEN and INK4A\/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell 2006; 9: 379\u2013390.","journal-title":"Cancer Cell"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2015193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2015193","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2015193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T16:15:31Z","timestamp":1648743331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2015193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,23]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["BFleu2015193"],"URL":"https:\/\/doi.org\/10.1038\/leu.2015.193","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,23]]},"assertion":[{"value":"23 July 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}