{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:59:35Z","timestamp":1791280775699,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1038\/leu.2016.211","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T13:19:36Z","timestamp":1470057576000},"page":"382-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Differentiation stage of myeloma plasma cells: biological and clinical significance"],"prefix":"10.1038","volume":"31","author":[{"given":"B","family":"Paiva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Cedena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B G","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Rapado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Martinez-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Cordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Alignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"van Zelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J M","family":"Van Dongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Agirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Prosper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Mart\u00edn-Subero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-B","family":"Vidriales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N C","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Oriol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Echeveste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S K","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Barlogie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G J","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Orfao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Blade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M V","family":"Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J","family":"Lahuerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"San-Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of GEM (Grupo Espa\u00f1ol de MM)\/PETHEMA (Programa para el Estudio de la Terap\u00e9utica en Hemopat\u00edas Malignas) cooperative study groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"BFleu2016211_CR1","doi-asserted-by":"publisher","first-page":"4701","DOI":"10.1182\/blood-2010-10-299529","volume":"117","author":"M Dimopoulos","year":"2011","unstructured":"Dimopoulos M, Kyle R, Fermand JP, Rajkumar SV, San Miguel J, Chanan-Khan A et al. Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3. Blood 2011; 117: 4701\u20134705.","journal-title":"Blood"},{"key":"BFleu2016211_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/cyto.b.21265","volume":"90","author":"J Flores-Montero","year":"2015","unstructured":"Flores-Montero J, de Tute R, Paiva B, Perez JJ, Bottcher S, Wind H et al. Immunophenotype of normal vs. myeloma plasma cells: Toward antibody panel specifications for MRD detection in multiple myeloma. Cytometry B Clin Cytom 2015; 90: 61\u201372.","journal-title":"Cytometry B Clin Cytom"},{"key":"BFleu2016211_CR3","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1200\/JCO.2007.15.4120","volume":"26","author":"G Mateo","year":"2008","unstructured":"Mateo G, Montalban MA, Vidriales MB, Lahuerta JJ, Mateos MV, Gutierrez N et al. Prognostic value of immunophenotyping in multiple myeloma: a study by the PETHEMA\/GEM cooperative study groups on patients uniformly treated with high-dose therapy. J Clin Oncol 2008; 26: 2737\u20132744.","journal-title":"J Clin Oncol"},{"key":"BFleu2016211_CR4","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1038\/leu.2012.42","volume":"26","author":"B Paiva","year":"2012","unstructured":"Paiva B, Gutierrez NC, Chen X, Vidriales MB, Montalban MA, Rosinol L et al. Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patients. Leukemia 2012; 26: 1862\u20131869.","journal-title":"Leukemia"},{"key":"BFleu2016211_CR5","first-page":"1234","volume":"91","author":"R Bataille","year":"2006","unstructured":"Bataille R, Jego G, Robillard N, Barille-Nion S, Harousseau JL, Moreau P et al. The phenotype of normal, reactive and malignant plasma cells. Identification of \u2018many and multiple myelomas\u2019 and of new targets for myeloma therapy. Haematologica 2006; 91: 1234\u20131240.","journal-title":"Haematologica"},{"key":"BFleu2016211_CR6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/cyto.b.20512","volume":"78","author":"B Paiva","year":"2010","unstructured":"Paiva B, Almeida J, Perez-Andres M, Mateo G, Lopez A, Rasillo A et al. Utility of flow cytometry immunophenotyping in multiple myeloma and other clonal plasma cell-related disorders. Cytometry B Clin Cytom 2010; 78: 239\u2013252.","journal-title":"Cytometry B Clin Cytom"},{"key":"BFleu2016211_CR7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3324\/haematol.11080","volume":"93","author":"AC Rawstron","year":"2008","unstructured":"Rawstron AC, Orfao A, Beksac M, Bezdickova L, Brooimans RA, Bumbea H et al. Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders. Haematologica 2008; 93: 431\u2013438.","journal-title":"Haematologica"},{"key":"BFleu2016211_CR8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nri1572","volume":"5","author":"M Shapiro-Shelef","year":"2005","unstructured":"Shapiro-Shelef M, Calame K . Regulation of plasma-cell development. Nat Rev Immunol 2005; 5: 230\u2013242.","journal-title":"Nat Rev Immunol"},{"key":"BFleu2016211_CR9","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/ni1454","volume":"8","author":"C Cobaleda","year":"2007","unstructured":"Cobaleda C, Schebesta A, Delogu A, Busslinger M . Pax5: the guardian of B cell identity and function. Nat Immunol 2007; 8: 463\u2013470.","journal-title":"Nat Immunol"},{"key":"BFleu2016211_CR10","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1128\/MCB.12.6.2662","volume":"12","author":"Z Kozmik","year":"1992","unstructured":"Kozmik Z, Wang S, Dorfler P, Adams B, Busslinger M . The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol Cell Biol 1992; 12: 2662\u20132672.","journal-title":"Mol Cell Biol"},{"key":"BFleu2016211_CR11","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.4049\/jimmunol.1103720","volume":"189","author":"M Cocco","year":"2012","unstructured":"Cocco M, Stephenson S, Care MA, Newton D, Barnes NA, Davison A et al. In vitro generation of long-lived human plasma cells. J Immunol 2012; 189: 5773\u20135785.","journal-title":"J Immunol"},{"key":"BFleu2016211_CR12","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.immuni.2015.06.016","volume":"43","author":"JL Halliley","year":"2015","unstructured":"Halliley JL, Tipton CM, Liesveld J, Rosenberg AF, Darce J, Gregoretti IV et al. Long-lived plasma cells are contained within the CD19(-)CD38(hi)CD138(+) subset in human bone marrow. Immunity 2015; 43: 132\u2013145.","journal-title":"Immunity"},{"key":"BFleu2016211_CR13","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1182\/blood-2014-02-555169","volume":"125","author":"HE Mei","year":"2015","unstructured":"Mei HE, Wirries I, Frolich D, Brisslert M, Giesecke C, Grun JR et al. A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow. Blood 2015; 125: 1739\u20131748.","journal-title":"Blood"},{"key":"BFleu2016211_CR14","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1172\/JCI39748","volume":"120","author":"MC van Zelm","year":"2010","unstructured":"van Zelm MC, Smet J, Adams B, Mascart F, Schandene L, Janssen F et al. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest 2010; 120: 1265\u20131274.","journal-title":"J Clin Invest"},{"key":"BFleu2016211_CR15","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/sj.leu.2403822","volume":"19","author":"S Barrena","year":"2005","unstructured":"Barrena S, Almeida J, Yunta M, Lopez A, Fernandez-Mosteirin N, Giralt M et al. Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation. Leukemia 2005; 19: 1376\u20131383.","journal-title":"Leukemia"},{"key":"BFleu2016211_CR16","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/sj.leu.2404284","volume":"20","author":"BG Durie","year":"2006","unstructured":"Durie BG, Harousseau JL, Miguel JS, Blade J, Barlogie B, Anderson K et al. International uniform response criteria for multiple myeloma. Leukemia 2006; 20: 1467\u20131473.","journal-title":"Leukemia"},{"key":"BFleu2016211_CR17","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1038\/leu.2012.120","volume":"26","author":"JJ van Dongen","year":"2012","unstructured":"van Dongen JJ, Lhermitte L, Bottcher S, Almeida J, van der Velden VH, Flores-Montero J et al. EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. Leukemia 2012; 26: 1908\u20131975.","journal-title":"Leukemia"},{"issue":"Suppl 1","key":"BFleu2016211_CR18","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1002\/cyto.b.20547","volume":"78","author":"M Perez-Andres","year":"2010","unstructured":"Perez-Andres M, Paiva B, Nieto WG, Caraux A, Schmitz A, Almeida J et al. Human peripheral blood B-cell compartments: a crossroad in B-cell traffic. Cytometry B Clin Cytom 2010; 78 (Suppl 1): S47\u2013S60.","journal-title":"Cytometry B Clin Cytom"},{"key":"BFleu2016211_CR19","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1182\/blood-2011-04-345579","volume":"118","author":"MA Berkowska","year":"2011","unstructured":"Berkowska MA, Driessen GJ, Bikos V, Grosserichter-Wagener C, Stamatopoulos K, Cerutti A et al. Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways. Blood 2011; 118: 2150\u20132158.","journal-title":"Blood"},{"key":"BFleu2016211_CR20","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1084\/jem.20060964","volume":"204","author":"MC van Zelm","year":"2007","unstructured":"van Zelm MC, Szczepanski T, van der Burg M, van Dongen JJ . Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion. J Exp Med 2007; 204: 645\u2013655.","journal-title":"J Exp Med"},{"key":"BFleu2016211_CR21","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.1182\/blood-2013-06-510453","volume":"122","author":"B Paiva","year":"2013","unstructured":"Paiva B, Paino T, Sayagues JM, Garayoa M, San-Segundo L, Martin M et al. Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile. Blood 2013; 122: 3591\u20133598.","journal-title":"Blood"},{"key":"BFleu2016211_CR22","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1182\/blood-2015-08-665679","volume":"127","author":"B Paiva","year":"2016","unstructured":"Paiva B, Corchete LA, Vidriales MB, Puig N, Maiso P, Rodriguez I et al. Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance. Blood 2016; 127: 1896\u20131906.","journal-title":"Blood"},{"key":"BFleu2016211_CR23","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1038\/leu.2014.321","volume":"29","author":"T Paino","year":"2015","unstructured":"Paino T, Paiva B, Sayagues JM, Mota I, Carvalheiro T, Corchete LA et al. Phenotypic identification of subclones in multiple myeloma with different chemoresistant, cytogenetic and clonogenic potential. Leukemia 2015; 29: 1186\u20131194.","journal-title":"Leukemia"},{"key":"BFleu2016211_CR24","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1182\/blood-2014-09-602565","volume":"125","author":"B Paiva","year":"2015","unstructured":"Paiva B, Corchete LA, Vidriales MB, Garcia-Sanz R, Perez JJ, Aires-Mejia I et al. The cellular origin and malignant transformation of Waldenstrom macroglobulinemia. Blood 2015; 125: 2370\u20132380.","journal-title":"Blood"},{"key":"BFleu2016211_CR25","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/leu.2012.160","volume":"27","author":"SZ Usmani","year":"2013","unstructured":"Usmani SZ, Crowley J, Hoering A, Mitchell A, Waheed S, Nair B et al. Improvement in long-term outcomes with successive Total Therapy trials for multiple myeloma: are patients now being cured? Leukemia 2013; 27: 226\u2013232.","journal-title":"Leukemia"},{"key":"BFleu2016211_CR26","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1101\/gr.180240.114","volume":"25","author":"X Agirre","year":"2015","unstructured":"Agirre X, Castellano G, Pascual M, Heath S, Kulis M, Segura V et al. Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers. Genome Res 2015; 25: 478\u2013487.","journal-title":"Genome Res"},{"key":"BFleu2016211_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/cytob.21134","volume":"86","author":"W Zeijlemaker","year":"2014","unstructured":"Zeijlemaker W, Gratama JW, Schuurhuis GJ . Tumor heterogeneity makes AML a \u2018moving target\u2019 for detection of residual disease. Cytometry B Clin Cytom 2014; 86: 3\u201314.","journal-title":"Cytometry B Clin Cytom"},{"key":"BFleu2016211_CR28","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ccr.2013.08.009","volume":"24","author":"C Leung-Hagesteijn","year":"2013","unstructured":"Leung-Hagesteijn C, Erdmann N, Cheung G, Keats JJ, Stewart AK, Reece DE et al. Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma. Cancer Cell 2013; 24: 289\u2013304.","journal-title":"Cancer Cell"},{"key":"BFleu2016211_CR29","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1056\/NEJMoa066092","volume":"357","author":"IJ Amanna","year":"2007","unstructured":"Amanna IJ, Carlson NE, Slifka MK . Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med 2007; 357: 1903\u20131915.","journal-title":"N Engl J Med"},{"key":"BFleu2016211_CR30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/40540","volume":"388","author":"RA Manz","year":"1997","unstructured":"Manz RA, Thiel A, Radbruch A . Lifetime of plasma cells in the bone marrow. Nature 1997; 388: 133\u2013134.","journal-title":"Nature"},{"key":"BFleu2016211_CR31","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s10875-015-0148-2","volume":"35","author":"F Vences-Catalan","year":"2015","unstructured":"Vences-Catalan F, Kuo CC, Sagi Y, Chen H, Kela-Madar N, van Zelm MC et al. A mutation in the human tetraspanin CD81 gene is expressed as a truncated protein but does not enable CD19 maturation and cell surface expression. J Clin Immunol 2015; 35: 254\u2013263.","journal-title":"J Clin Immunol"},{"key":"BFleu2016211_CR32","doi-asserted-by":"publisher","first-page":"31973","DOI":"10.1074\/jbc.M404410200","volume":"279","author":"A Cherukuri","year":"2004","unstructured":"Cherukuri A, Carter RH, Brooks S, Bornmann W, Finn R, Dowd CS et al. B cell signaling is regulated by induced palmitoylation of CD81. J Biol Chem 2004; 279: 31973\u201331982.","journal-title":"J Biol Chem"},{"key":"BFleu2016211_CR33","doi-asserted-by":"publisher","first-page":"370","DOI":"10.4049\/jimmunol.172.1.370","volume":"172","author":"A Cherukuri","year":"2004","unstructured":"Cherukuri A, Shoham T, Sohn HW, Levy S, Brooks S, Carter R et al. The tetraspanin CD81 is necessary for partitioning of coligated CD19\/CD21-B cell antigen receptor complexes into signaling-active lipid rafts. J Immunol 2004; 172: 370\u2013380.","journal-title":"J Immunol"},{"key":"BFleu2016211_CR34","doi-asserted-by":"publisher","first-page":"4062","DOI":"10.4049\/jimmunol.171.8.4062","volume":"171","author":"T Shoham","year":"2003","unstructured":"Shoham T, Rajapaksa R, Boucheix C, Rubinstein E, Poe JC, Tedder TF et al. The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. J Immunol 2003; 171: 4062\u20134072.","journal-title":"J Immunol"},{"key":"BFleu2016211_CR35","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nri2727","volume":"10","author":"K Tokoyoda","year":"2010","unstructured":"Tokoyoda K, Hauser AE, Nakayama T, Radbruch A . Organization of immunological memory by bone marrow stroma. Nat Rev Immunol 2010; 10: 193\u2013200.","journal-title":"Nat Rev Immunol"},{"key":"BFleu2016211_CR36","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.4049\/jimmunol.1402260","volume":"194","author":"CH Rozanski","year":"2015","unstructured":"Rozanski CH, Utley A, Carlson LM, Farren MR, Murray M, Russell LM et al. CD28 promotes plasma cell survival, sustained antibody responses, and BLIMP-1 upregulation through its distal PYAP proline motif. J Immunol 2015; 194: 4717\u20134728.","journal-title":"J Immunol"},{"key":"BFleu2016211_CR37","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.2443","volume":"44","author":"M Kulis","year":"2012","unstructured":"Kulis M, Heath S, Bibikova M, Queiros AC, Navarro A, Clot G et al. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet 2012; 44: 1236\u20131242.","journal-title":"Nat Genet"},{"key":"BFleu2016211_CR38","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nrg3230","volume":"13","author":"PA Jones","year":"2012","unstructured":"Jones PA . Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 2012; 13: 484\u2013492.","journal-title":"Nat Rev Genet"},{"key":"BFleu2016211_CR39","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1182\/blood-2012-06-436220","volume":"121","author":"A Chaidos","year":"2013","unstructured":"Chaidos A, Barnes CP, Cowan G, May PC, Melo V, Hatjiharissi E et al. Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma. Blood 2013; 121: 318\u2013328.","journal-title":"Blood"},{"key":"BFleu2016211_CR40","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1056\/NEJMoa1504542","volume":"373","author":"AL Garfall","year":"2015","unstructured":"Garfall AL, Maus MV, Hwang WT, Lacey SF, Mahnke YD, Melenhorst JJ et al. Chimeric antigen receptor T cells against CD19 for multiple myeloma. N Engl J Med 2015; 373: 1040\u20131047.","journal-title":"N Engl J Med"},{"key":"BFleu2016211_CR41","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1182\/blood-2003-09-3064","volume":"103","author":"W Matsui","year":"2004","unstructured":"Matsui W, Huff CA, Wang Q, Malehorn MT, Barber J, Tanhehco Y et al. Characterization of clonogenic multiple myeloma cells. Blood 2004; 103: 2332\u20132336.","journal-title":"Blood"},{"key":"BFleu2016211_CR42","doi-asserted-by":"publisher","first-page":"4048","DOI":"10.1073\/pnas.0611682104","volume":"104","author":"CD Peacock","year":"2007","unstructured":"Peacock CD, Wang Q, Gesell GS, Corcoran-Schwartz IM, Jones E, Kim J et al. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci USA 2007; 104: 4048\u20134053.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2016211_CR43","first-page":"391","volume":"28","author":"N Puig","year":"2014","unstructured":"Puig N, Sarasquete ME, Balanzategui A, Martinez J, Paiva B, Garcia H et al. Critical evaluation of ASO RQ-PCR for minimal residual disease evaluation in multiple myeloma. A comparative analysis with flow cytometry Blood 2014; 28: 391\u2013397.","journal-title":"A comparative analysis with flow cytometry"},{"key":"BFleu2016211_CR44","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1182\/blood-2011-07-370460","volume":"119","author":"B Paiva","year":"2012","unstructured":"Paiva B, Gutierrez NC, Rosinol L, Vidriales MB, Montalban MA, Martinez-Lopez J et al. High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma. Blood 2012; 119: 687\u2013691.","journal-title":"Blood"},{"key":"BFleu2016211_CR45","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1182\/blood-2014-01-550020","volume":"123","author":"J Martinez-Lopez","year":"2014","unstructured":"Martinez-Lopez J, Lahuerta JJ, Pepin F, Gonzalez M, Barrio S, Ayala R et al. Prognostic value of deep sequencing method for minimal residual disease detection in multiple myeloma. Blood 2014; 123: 3073\u20133079.","journal-title":"Blood"},{"key":"BFleu2016211_CR46","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1182\/blood-2014-07-590166","volume":"125","author":"AC Rawstron","year":"2015","unstructured":"Rawstron AC, Gregory WM, de Tute RM, Davies FE, Bell SE, Drayson MT et al. Minimal residual disease in myeloma by flow cytometry: independent prediction of survival benefit per log reduction. Blood 2015; 125: 1932\u20131935.","journal-title":"Blood"},{"key":"BFleu2016211_CR47","doi-asserted-by":"publisher","first-page":"7599","DOI":"10.1158\/1078-0432.CCR-05-0523","volume":"11","author":"S Yaccoby","year":"2005","unstructured":"Yaccoby S . The phenotypic plasticity of myeloma plasma cells as expressed by dedifferentiation into an immature, resilient, and apoptosis-resistant phenotype. Clin Cancer Res 2005; 11: 7599\u20137606.","journal-title":"Clin Cancer Res"},{"key":"BFleu2016211_CR48","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1182\/blood-2014-11-568907","volume":"125","author":"B Paiva","year":"2015","unstructured":"Paiva B, van Dongen JJ, Orfao A . New criteria for response assessment: role of minimal residual disease in multiple myeloma. Blood 2015; 125: 3059\u20133068.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2016211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2016211","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2016211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T10:33:48Z","timestamp":1749033228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2016211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["BFleu2016211"],"URL":"https:\/\/doi.org\/10.1038\/leu.2016.211","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,1]]},"assertion":[{"value":"3 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}