{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:11:38Z","timestamp":1790514698597,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/leu.2016.251","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T03:30:50Z","timestamp":1473305450000},"page":"720-727","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts"],"prefix":"10.1038","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-0462","authenticated-orcid":false,"given":"A","family":"Mupo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Seiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Sathiaseelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7063-8913","authenticated-orcid":false,"given":"F","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bautista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Pacharne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tzelepis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Manes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Papaemmanuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D G","family":"Kent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Buonamici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1018-5139","authenticated-orcid":false,"given":"N","family":"Bolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G S","family":"Vassiliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,8]]},"reference":[{"key":"BFleu2016251_CR1","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1056\/NEJMra0902908","volume":"361","author":"A Tefferi","year":"2009","unstructured":"Tefferi A, Vardiman JW . Myelodysplastic syndromes. N Engl J Med 2009; 361: 1872\u20131885.","journal-title":"N Engl J Med"},{"key":"BFleu2016251_CR2","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1056\/NEJMoa1103283","volume":"365","author":"E Papaemmanuil","year":"2011","unstructured":"Papaemmanuil E, Cazzola M, Boultwood J, Malcovati L, Vyas P, Bowen D et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med 2011; 365: 1384\u20131395.","journal-title":"N Engl J Med"},{"key":"BFleu2016251_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature10496","volume":"478","author":"K Yoshida","year":"2011","unstructured":"Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 2011; 478: 64\u201369.","journal-title":"Nature"},{"issue":"1-2","key":"BFleu2016251_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cbi.2009.10.009","volume":"184","author":"James W. Vardiman","year":"2010","unstructured":"Vardiman JW . The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: an overview with emphasis on the myeloid neoplasms. Chem Biol Interact 2010; 184 16\u201320.","journal-title":"Chemico-Biological Interactions"},{"key":"BFleu2016251_CR5","doi-asserted-by":"publisher","first-page":"6239","DOI":"10.1182\/blood-2011-09-377275","volume":"118","author":"L Malcovati","year":"2011","unstructured":"Malcovati L, Papaemmanuil E, Bowen DT, Boultwood J, Della Porta MG, Pascutto C et al. Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic\/myeloproliferative neoplasms. Blood 2011; 118: 6239\u20136246.","journal-title":"Blood"},{"key":"BFleu2016251_CR6","doi-asserted-by":"publisher","first-page":"10004","DOI":"10.1038\/ncomms10004","volume":"6","author":"SA Mian","year":"2015","unstructured":"Mian SA, Rouault-Pierre K, Smith AE, Seidl T, Pizzitola I, Kizilors A et al. SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment. Nat Commun 2015; 6: 10004.","journal-title":"Nat Commun"},{"key":"BFleu2016251_CR7","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1182\/blood-2013-08-518886","volume":"122","author":"E Papaemmanuil","year":"2013","unstructured":"Papaemmanuil E, Gerstung M, Malcovati L, Tauro S, Gundem G, Van Loo P et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood 2013; 122: 3616\u20133627, quiz 99.","journal-title":"Blood"},{"key":"BFleu2016251_CR8","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.celrep.2015.02.005","volume":"10","author":"T McKerrell","year":"2015","unstructured":"McKerrell T, Park N, Moreno T, Grove CS, Ponstingl H, Stephens J et al. Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. Cell Rep 2015; 10: 1239\u20131245.","journal-title":"Cell Rep"},{"key":"BFleu2016251_CR9","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/leu.2013.336","volume":"28","author":"T Haferlach","year":"2014","unstructured":"Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia 2014; 28: 241\u2013247.","journal-title":"Leukemia"},{"key":"BFleu2016251_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nrg.2015.3","volume":"17","author":"MM Scotti","year":"2016","unstructured":"Scotti MM, Swanson MS . RNA mis-splicing in disease. Nat Rev Genet 2016; 17: 19\u201332.","journal-title":"Nat Rev Genet"},{"key":"BFleu2016251_CR11","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/leu.2014.331","volume":"29","author":"H Dolatshad","year":"2015","unstructured":"Dolatshad H, Pellagatti A, Fernandez-Mercado M, Yip BH, Malcovati L, Attwood M et al. Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells. Leukemia 2015; 29: 1092\u20131103.","journal-title":"Leukemia"},{"key":"BFleu2016251_CR12","doi-asserted-by":"publisher","first-page":"5901","DOI":"10.1038\/ncomms6901","volume":"6","author":"M Gerstung","year":"2015","unstructured":"Gerstung M, Pellagatti A, Malcovati L, Giagounidis A, Porta MG, Jadersten M et al. Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes. Nat Commun 2015; 6: 5901.","journal-title":"Nat Commun"},{"key":"BFleu2016251_CR13","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.celrep.2015.09.053","volume":"13","author":"RB Darman","year":"2015","unstructured":"Darman RB, Seiler M, Agrawal AA, Lim KH, Peng S, Aird D et al. Cancer-associated SF3B1 hotspot mutations induce cryptic 3' splice site selection through use of a different branch point. Cell Rep 2015; 13: 1033\u20131045.","journal-title":"Cell Rep"},{"key":"BFleu2016251_CR14","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature10163","volume":"474","author":"WC Skarnes","year":"2011","unstructured":"Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature 2011; 474: 337\u2013342.","journal-title":"Nature"},{"key":"BFleu2016251_CR15","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1101\/gr.749203","volume":"13","author":"P Liu","year":"2003","unstructured":"Liu P, Jenkins NA, Copeland NG . A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res. 2003; 13: 476\u2013484.","journal-title":"Genome Res."},{"key":"BFleu2016251_CR16","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1182\/blood-2009-12-259747","volume":"116","author":"J Li","year":"2010","unstructured":"Li J, Spensberger D, Ahn JS, Anand S, Beer PA, Ghevaert C et al. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood 2010; 116: 1528\u20131538.","journal-title":"Blood"},{"key":"BFleu2016251_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 2013; 29: 15\u201321.","journal-title":"Bioinformatics"},{"key":"BFleu2016251_CR18","doi-asserted-by":"publisher","first-page":"Article3","DOI":"10.2202\/1544-6115.1027","volume":"3","author":"GK Smyth","year":"2004","unstructured":"Smyth GK . Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: Article3.","journal-title":"Stat Appl Genet Mol Biol"},{"key":"BFleu2016251_CR19","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/nbt.2862","volume":"32","author":"R Patro","year":"2014","unstructured":"Patro R, Mount SM, Kingsford C . Sailfish enables alignment-free isoform quantification from RNA-seq reads using lightweight algorithms. Nat Biotechnol 2014; 32: 462\u2013464.","journal-title":"Nat Biotechnol"},{"key":"BFleu2016251_CR20","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK . edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 2010; 26: 139\u2013140.","journal-title":"Bioinformatics"},{"key":"BFleu2016251_CR21","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nmeth.1342","volume":"6","author":"SJ Pettitt","year":"2009","unstructured":"Pettitt SJ, Liang Q, Rairdan XY, Moran JL, Prosser HM, Beier DR et al. Agouti C57BL\/6N embryonic stem cells for mouse genetic resources. Nat Methods 2009; 6: 493\u2013495.","journal-title":"Nat Methods"},{"key":"BFleu2016251_CR22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<106::AID-GENE30>3.0.CO;2-T","volume":"28","author":"FW Farley","year":"2000","unstructured":"Farley FW, Soriano P, Steffen LS, Dymecki SM . Widespread recombinase expression using FLPeR (flipper) mice. Genesis 2000; 28: 106\u2013110.","journal-title":"Genesis"},{"key":"BFleu2016251_CR23","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.7660125","volume":"269","author":"R Kuhn","year":"1995","unstructured":"Kuhn R, Schwenk F, Aguet M, Rajewsky K . Inducible gene targeting in mice. Science 1995; 269: 1427\u20131429.","journal-title":"Science"},{"key":"BFleu2016251_CR24","doi-asserted-by":"publisher","first-page":"17413","DOI":"10.1073\/pnas.0909296106","volume":"106","author":"K Chen","year":"2009","unstructured":"Chen K, Liu J, Heck S, Chasis JA, An X, Mohandas N . Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis. Proc Natl Acad Sci USA 2009; 106: 17413\u201317418.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2016251_CR25","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/bjh.13610","volume":"171","author":"S Conte","year":"2015","unstructured":"Conte S, Katayama S, Vesterlund L, Karimi M, Dimitriou M, Jansson M et al. Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts. Br J Haematol. 2015; 171: 478\u2013490.","journal-title":"Br J Haematol."},{"key":"BFleu2016251_CR26","doi-asserted-by":"publisher","first-page":"306fs38","DOI":"10.1126\/scitranslmed.aac4428","volume":"7","author":"T McKerrell","year":"2015","unstructured":"McKerrell T, Vassiliou GS . Aging as a driver of leukemogenesis. Sci Transl Med 2015; 7: 306fs38.","journal-title":"Sci Transl Med"},{"key":"BFleu2016251_CR27","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/leu.2014.28","volume":"28","author":"D Gentien","year":"2014","unstructured":"Gentien D, Kosmider O, Nguyen-Khac F, Albaud B, Rapinat A, Dumont AG et al. A common alternative splicing signature is associated with SF3B1 mutations in malignancies from different cell lineages. Leukemia 2014; 28: 1355\u20131357.","journal-title":"Leukemia"},{"key":"BFleu2016251_CR28","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/leu.2012.298","volume":"27","author":"M Nikpour","year":"2013","unstructured":"Nikpour M, Scharenberg C, Liu A, Conte S, Karimi M, Mortera-Blanco T et al. The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts. Leukemia 2013; 27: 889\u2013896.","journal-title":"Leukemia"},{"issue":"12","key":"BFleu2016251_CR29","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1038\/leu.2016.149","volume":"30","author":"H Dolatshad","year":"2016","unstructured":"Dolatshad H, Pellagatti A, Liberante FG, Llorian M, Repapi E, Steeples V et al. Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes. Leukemia 2016; e-pub ahead of print 17 June 2016 doi:10.1038\/leu.2016.149.","journal-title":"Leukemia"},{"key":"BFleu2016251_CR30","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1182\/blood-2012-05-430876","volume":"120","author":"V Visconte","year":"2012","unstructured":"Visconte V, Rogers HJ, Singh J, Barnard J, Bupathi M, Traina F et al. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes. Blood 2012; 120: 3173\u20133186.","journal-title":"Blood"},{"key":"BFleu2016251_CR31","doi-asserted-by":"publisher","first-page":"10615","DOI":"10.1038\/ncomms10615","volume":"7","author":"S Alsafadi","year":"2016","unstructured":"Alsafadi S, Houy A, Battistella A, Popova T, Wassef M, Henry E et al. Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage. Nat Commun 2016; 7: 10615.","journal-title":"Nat Commun"},{"key":"BFleu2016251_CR32","doi-asserted-by":"publisher","first-page":"e1004105","DOI":"10.1371\/journal.pcbi.1004105","volume":"11","author":"C DeBoever","year":"2015","unstructured":"DeBoever C, Ghia EM, Shepard PJ, Rassenti L, Barrett CL, Jepsen K et al. Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers. PLoS Comput Biol 2015; 11: e1004105.","journal-title":"PLoS Comput Biol"},{"key":"BFleu2016251_CR33","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ccell.2015.04.008","volume":"27","author":"CL Shirai","year":"2015","unstructured":"Shirai CL, Ley JN, White BS, Kim S, Tibbitts J, Shao J et al. Mutant U2AF1 expression alters hematopoiesis and pre-mRNA splicing in vivo. Cancer Cell 2015; 27: 631\u2013643.","journal-title":"Cancer Cell"},{"key":"BFleu2016251_CR34","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.ccell.2015.04.006","volume":"27","author":"E Kim","year":"2015","unstructured":"Kim E, Ilagan JO, Liang Y, Daubner GM, Lee SC, Ramakrishnan A et al. SRSF2 mutations contribute to myelodysplasia by mutant-specific effects on exon recognition. Cancer Cell. 2015; 27: 617\u2013630.","journal-title":"Cancer Cell."},{"key":"BFleu2016251_CR35","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nature04512","volume":"440","author":"GC Shaw","year":"2006","unstructured":"Shaw GC, Cope JJ, Li L, Corson K, Hersey C, Ackermann GE et al. Mitoferrin is essential for erythroid iron assimilation. Nature 2006; 440: 96\u2013100.","journal-title":"Nature"},{"key":"BFleu2016251_CR36","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1182\/blood-2002-01-0309","volume":"101","author":"H Harigae","year":"2003","unstructured":"Harigae H, Nakajima O, Suwabe N, Yokoyama H, Furuyama K, Sasaki T et al. Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts. Blood 2003; 101: 1188\u20131193.","journal-title":"Blood"},{"key":"BFleu2016251_CR37","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.1182\/blood-2006-04-015768","volume":"109","author":"C Pondarre","year":"2007","unstructured":"Pondarre C, Campagna DR, Antiochos B, Sikorski L, Mulhern H, Fleming MD . Abcb7 the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood 2007; 109: 3567\u20133569.","journal-title":"Blood"},{"key":"BFleu2016251_CR38","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.tibs.2008.06.001","volume":"33","author":"NJ McGlincy","year":"2008","unstructured":"McGlincy NJ, Smith CW . Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense? Trends Biochem Sci 2008; 33: 385\u2013393.","journal-title":"Trends Biochem Sci"},{"key":"BFleu2016251_CR39","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1084\/jem.20131141","volume":"210","author":"O Abdel-Wahab","year":"2013","unstructured":"Abdel-Wahab O, Gao J, Adli M, Dey A, Trimarchi T, Chung YR et al. Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med 2013; 210: 2641\u20132659.","journal-title":"J Exp Med"},{"key":"BFleu2016251_CR40","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","volume":"371","author":"G Genovese","year":"2014","unstructured":"Genovese G, Kahler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med 2014; 371: 2477\u20132487.","journal-title":"N Engl J Med"},{"key":"BFleu2016251_CR41","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","volume":"371","author":"S Jaiswal","year":"2014","unstructured":"Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med 2014; 371: 2488\u20132498.","journal-title":"N Engl J Med"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/leu2016251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/leu2016251","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/leu2016251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:06:03Z","timestamp":1684418763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2016251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,8]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["BFleu2016251"],"URL":"https:\/\/doi.org\/10.1038\/leu.2016.251","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726720651.793549674","asserted-by":"object"}]},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,8]]},"assertion":[{"value":"15 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}