{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:33:45Z","timestamp":1792506825082,"version":"4.5.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1038\/leu.2017.15","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T02:41:58Z","timestamp":1484534518000},"page":"788-797","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Proposed diagnostic criteria and classification of basophilic leukemias and related disorders"],"prefix":"10.1038","volume":"31","author":[{"given":"P","family":"Valent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Sotlar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Blatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Sadovnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W R","family":"Sperr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bettelheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T I","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7409-4204","authenticated-orcid":false,"given":"E","family":"Hadzijusufovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Gotlib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F-X","family":"Mahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D D","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H-P","family":"Horny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Arock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,16]]},"reference":[{"key":"BFleu201715_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0065-2776(08)60879-2","volume":"52","author":"P Valent","year":"1992","unstructured":"Valent P, Bettelheim P . Cell surface structures on human basophils and mast cells: biochemical and functional characterization. Adv Immunol 1992; 52: 333\u2013423.","journal-title":"Adv Immunol"},{"key":"BFleu201715_CR2","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.4049\/jimmunol.151.8.4221","volume":"151","author":"H Agis","year":"1993","unstructured":"Agis H, Willheim M, Sperr WR, Wilfing A, Kr\u00f6mer E, Kabrna E et al. Monocytes do not make mast cells when cultured in the presence of SCF. Characterization of the circulating mast cell progenitor as a c-kit+, CD34+, Ly\u2212, CD14\u2212, CD17\u2212, colony-forming cell. J Immunol 1993; 151: 4221\u20134227.","journal-title":"J Immunol"},{"key":"BFleu201715_CR3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1046\/j.1365-2567.1996.493578.x","volume":"87","author":"H Agis","year":"1996","unstructured":"Agis H, F\u00fcreder W, Bankl HC, Kundi M, Sperr WR, Willheim M et al. Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. Immunology 1996; 87: 535\u2013543.","journal-title":"Immunology"},{"key":"BFleu201715_CR4","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1182\/blood.V93.10.3338.410k05_3338_3346","volume":"93","author":"D Kempuraj","year":"1999","unstructured":"Kempuraj D, Saito H, Kaneko A, Fukagawa K, Nakayama M, Toru H et al. Characterization of mast cell-committed progenitors present in human umbilical cord blood. Blood 1999; 93: 3338\u20133346.","journal-title":"Blood"},{"key":"BFleu201715_CR5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1182\/blood.V61.4.775.775","volume":"61","author":"JA Denburg","year":"1983","unstructured":"Denburg JA, Richardson M, Telizyn S, Bienenstock J . Basophil\/mast cell precursors in human peripheral blood. Blood 1983; 61: 775\u2013780.","journal-title":"Blood"},{"key":"BFleu201715_CR6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1182\/blood.V64.1.78.78","volume":"64","author":"AG Leary","year":"1984","unstructured":"Leary AG, Ogawa M . Identification of pure and mixed basophil colonies in culture of human peripheral blood and marrow cells. Blood 1984; 64: 78\u201383.","journal-title":"Blood"},{"key":"BFleu201715_CR7","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/0091-6749(85)90728-6","volume":"76","author":"JA Denburg","year":"1985","unstructured":"Denburg JA, Telizyn S, Belda A, Dolovich J, Bienenstock J . Increased numbers of circulating basophil progenitors in atopic patients. J Allergy Clin Immunol 1985; 76: 466\u2013472.","journal-title":"J Allergy Clin Immunol"},{"key":"BFleu201715_CR8","first-page":"757","volume":"133","author":"H Otsuka","year":"1986","unstructured":"Otsuka H, Dolovich J, Befus D, Bienenstock J, Denburg J . Peripheral blood basophils, basophil progenitors, and nasal metachromatic cells in allergic rhinitis. Am Rev Respir Dis 1986; 133: 757\u2013762.","journal-title":"Am Rev Respir Dis"},{"key":"BFleu201715_CR9","first-page":"293","volume":"18","author":"F Arnalich","year":"1987","unstructured":"Arnalich F, Lahoz C, Larrocha C, Zamorano AF, Jimenez C, Gasalla R et al. Incidence and clinical significance of peripheral and bone marrow basophilia. J Med 1987; 18: 293\u2013303.","journal-title":"J Med"},{"key":"BFleu201715_CR10","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1164\/ajrccm\/143.2.331","volume":"143","author":"PG Gibson","year":"1991","unstructured":"Gibson PG, Manning PJ, O'Byrne PM, Girgis-Gabardo A, Dolovich J, Denburg JA et al. Allergen-induced asthmatic responses. Relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils, and their progenitors. Am Rev Respir Dis 1991; 143: 331\u2013335.","journal-title":"Am Rev Respir Dis"},{"key":"BFleu201715_CR11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1182\/blood.V60.1.113.113","volume":"60","author":"JA Denburg","year":"1982","unstructured":"Denburg JA, Wilson WE, Bienenstock J . Basophil production in myeloproliferative disorders: increases during acute blastic transformation of chronic myeloid leukemia. Blood 1982; 60: 113\u2013120.","journal-title":"Blood"},{"key":"BFleu201715_CR12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/ajh.2830270208","volume":"27","author":"JA Denburg","year":"1988","unstructured":"Denburg JA, Browman G . Prognostic implications of basophil differentiation in chronic myeloid leukemia. Am J Hematol 1988; 27: 110\u2013114.","journal-title":"Am J Hematol"},{"key":"BFleu201715_CR13","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1093\/jnci\/90.11.850","volume":"90","author":"J Hasford","year":"1998","unstructured":"Hasford J, Pfirrmann M, Hehlmann R, Allan NC, Baccarani M, Kluin-Nelemans JC et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Writing Committee for the Collaborative CML Prognostic Project Group. J Natl Cancer Inst 1998; 90: 850\u2013858.","journal-title":"J Natl Cancer Inst"},{"key":"BFleu201715_CR14","first-page":"978","volume":"84","author":"JL Steegmann","year":"1999","unstructured":"Steegmann JL, Odriozola J, Rodriguez-Salvan\u00e9s F, Giraldo P, Garc\u00eda-Lara\u00f1a J, Ferro MT et al. Stage, percentage of basophils at diagnosis, hematologic response within six months, cytogenetic response in the first year: the main prognostic variables affecting outcome in patients with chronic myeloid leukemia in chronic phase treated with interferon-alpha. Results of the CML89 trial of the Spanish Collaborative Group on interferon-alpha2a and CML. Haematologica 1999; 84: 978\u2013987.","journal-title":"Haematologica"},{"key":"BFleu201715_CR15","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1182\/blood-2010-12-319038","volume":"118","author":"J Hasford","year":"2011","unstructured":"Hasford J, Baccarani M, Hoffmann V, Guilhot J, Saussele S, Rosti G et al. Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score. Blood 2011; 118: 686\u2013692.","journal-title":"Blood"},{"key":"BFleu201715_CR16","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1097\/00007611-198010000-00008","volume":"73","author":"MJ Nissenblatt","year":"1980","unstructured":"Nissenblatt MJ . Basophilic transformation of chronic myelogenous leukemia. South Med J 1980; 73: 1316\u20131319.","journal-title":"South Med J"},{"key":"BFleu201715_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2169\/internalmedicine1962.28.67","volume":"28","author":"M Ozaki","year":"1989","unstructured":"Ozaki M, Kanemitsu N, Yasukawa M, Fujita S . Basophilic crisis of chronic myelogenous leukemia. Jpn J Med 1989; 28: 67\u201371.","journal-title":"Jpn J Med"},{"key":"BFleu201715_CR18","doi-asserted-by":"publisher","first-page":"334","DOI":"10.2169\/internalmedicine1962.29.334","volume":"29","author":"K Yamauchi","year":"1990","unstructured":"Yamauchi K, Arimori S . Basophilic crisis in chronic myelogenous leukemia: case report and literature review in Japan. Jpn J Med 1990; 29: 334\u2013340.","journal-title":"Jpn J Med"},{"key":"BFleu201715_CR19","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0165-4608(91)90134-G","volume":"51","author":"YQ Xue","year":"1991","unstructured":"Xue YQ, Guo Y, Lu DR, Gu J, Lu DW, Gong JX et al. A case of basophilic leukemia bearing simultaneous translocations t(8;21) and t(9;22). Cancer Genet Cytogenet 1991; 51: 215\u2013221.","journal-title":"Cancer Genet Cytogenet"},{"key":"BFleu201715_CR20","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cancergencyto.2007.12.009","volume":"182","author":"J Pidala","year":"2008","unstructured":"Pidala J, Pinilla-Ibarz J, Cualing HD . A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). Cancer Genet Cytogenet 2008; 182: 46\u201349.","journal-title":"Cancer Genet Cytogenet"},{"key":"BFleu201715_CR21","first-page":"269491","volume":"2011","author":"A Rojas-Atencio","year":"2011","unstructured":"Rojas-Atencio A, Urdaneta K, Soto-Quintana M, Alvarez Nava F, Ca\u00f1izales J, Solis E . Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. Case Rep Pathol 2011; 2011: 269491.","journal-title":"Case Rep Pathol"},{"key":"BFleu201715_CR22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1532\/IJH97.03153","volume":"80","author":"N Sugimoto","year":"2004","unstructured":"Sugimoto N, Ishikawa T, Gotoh S, Shinzato I, Matsushita A, Nagai K et al. Primary myelofibrosis terminated in basophilic leukemia and successful allogeneic bone marrow transplantation. Int J Hematol 2004; 80: 183\u2013185.","journal-title":"Int J Hematol"},{"key":"BFleu201715_CR23","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/ajh.10446","volume":"76","author":"R Gupta","year":"2004","unstructured":"Gupta R, Jain P, Anand M . Acute basophilic leukemia: case report. Am J Hematol 2004; 76: 134\u2013138.","journal-title":"Am J Hematol"},{"key":"BFleu201715_CR24","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/j.1365-2362.2008.01950.x","volume":"38","author":"F Wimazal","year":"2008","unstructured":"Wimazal F, Baumgartner C, Sonneck K, Zauner C, Geissler P, Schur S et al. Mixed-lineage eosinophil\/basophil crisis in MDS: a rare form of progression. Eur J Clin Invest 2008; 38: 447\u2013455.","journal-title":"Eur J Clin Invest"},{"key":"BFleu201715_CR25","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.humpath.2009.02.011","volume":"40","author":"G Tang","year":"2009","unstructured":"Tang G, Woods LJ, Wang SA, Brettler D, Andersen M, Miron PM et al. Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm. Hum Pathol 2009; 40: 1194\u20131199.","journal-title":"Hum Pathol"},{"key":"BFleu201715_CR26","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3109\/08880018.2014.883655","volume":"31","author":"M Servitzoglou","year":"2014","unstructured":"Servitzoglou M, Grenzelia M, Baka M, Harisi M, Pourtsidis A, Bouhoutsou D et al. A novel karyotype in acute myeloid leukemia with basophilia. Pediatr Hematol Oncol 2014; 31: 149\u2013156.","journal-title":"Pediatr Hematol Oncol"},{"key":"BFleu201715_CR27","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.cancergencyto.2006.09.016","volume":"172","author":"SY Shin","year":"2007","unstructured":"Shin SY, Koo SH, Kwon KC, Park JW, Ko CS, Jo DY . Monosomy 7 as the sole abnormality of an acute basophilic leukemia. Cancer Genet Cytogenet 2007; 172: 168\u2013171.","journal-title":"Cancer Genet Cytogenet"},{"key":"BFleu201715_CR28","doi-asserted-by":"publisher","first-page":"e623","DOI":"10.1200\/JCO.2010.34.5710","volume":"29","author":"A Kritharis","year":"2011","unstructured":"Kritharis A, Brody J, Koduru P, Teichberg S, Allen SL . Acute basophilic leukemia associated with loss of gene ETV6 and protean complications. J Clin Oncol 2011; 29: e623\u2013e626.","journal-title":"J Clin Oncol"},{"key":"BFleu201715_CR29","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1073\/pnas.85.7.2288","volume":"85","author":"H Saito","year":"1988","unstructured":"Saito H, Hatake K, Dvorak AM, Leiferman KM, Donnenberg AD, Arai N et al. Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins. Proc Natl Acad Sci USA 1988; 85: 2288\u20132292.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu201715_CR30","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1182\/blood.V73.7.1763.1763","volume":"73","author":"P Valent","year":"1989","unstructured":"Valent P, Schmidt G, Besemer J, Mayer P, Zenke G, Liehl E et al. Interleukin-3 is a differentiation factor for human basophils. Blood 1989; 73: 1763\u20131769.","journal-title":"Blood"},{"key":"BFleu201715_CR31","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1182\/blood.V74.2.613.613","volume":"74","author":"P Mayer","year":"1989","unstructured":"Mayer P, Valent P, Schmidt G, Liehl E, Bettelheim P . The in vivo effects of recombinant human interleukin-3: demonstration of basophil differentiation factor, histamine-producing activity, and priming of GM-CSF-responsive progenitors in nonhuman primates. Blood 1989; 74: 613\u2013621.","journal-title":"Blood"},{"key":"BFleu201715_CR32","doi-asserted-by":"publisher","first-page":"5542","DOI":"10.1073\/pnas.86.14.5542","volume":"86","author":"P Valent","year":"1989","unstructured":"Valent P, Besemer J, Muhm M, Majdic O, Lechner K, Bettelheim P . Interleukin 3 activates human blood basophils via high-affinity binding sites. Proc Natl Acad Sci USA 1989; 86: 5542\u20135546.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu201715_CR33","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1084\/jem.170.2.467","volume":"170","author":"Y Kurimoto","year":"1989","unstructured":"Kurimoto Y, de Weck AL, Dahinden CA . Interleukin 3-dependent mediator release in basophils triggered by C5a. J Exp Med 1989; 170: 467\u2013479.","journal-title":"J Exp Med"},{"key":"BFleu201715_CR34","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1182\/blood.V77.7.1462.1462","volume":"77","author":"JA Denburg","year":"1991","unstructured":"Denburg JA, Silver JE, Abrams JS . Interleukin-5 is a human basophilopoietin: induction of histamine content and basophilic differentiation of HL-60 cells and of peripheral blood basophil-eosinophil progenitors. Blood 1991; 77: 1462\u20131468.","journal-title":"Blood"},{"key":"BFleu201715_CR35","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1182\/blood.V80.3.634.634","volume":"80","author":"C Sillaber","year":"1992","unstructured":"Sillaber C, Geissler K, Scherrer R, Kaltenbrunner R, Bettelheim P, Lechner K et al. Type beta transforming growth factors promote interleukin-3 (IL-3)-dependent differentiation of human basophils but inhibit IL-3-dependent differentiation of human eosinophils. Blood 1992; 80: 634\u2013641.","journal-title":"Blood"},{"key":"BFleu201715_CR36","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/nature10329","volume":"477","author":"MC Siracusa","year":"2011","unstructured":"Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature 2011; 477: 229\u2013233.","journal-title":"Nature"},{"key":"BFleu201715_CR37","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/1040-8428(90)90009-H","volume":"10","author":"P Valent","year":"1990","unstructured":"Valent P, Bettelheim P . The human basophil. Crit Rev Oncol Hematol 1990; 10: 327\u2013352.","journal-title":"Crit Rev Oncol Hematol"},{"key":"BFleu201715_CR38","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/0091-6749(94)90326-3","volume":"94","author":"BS Bochner","year":"1994","unstructured":"Bochner BS, Sterbinsky SA, Knol EF, Katz BJ, Lichtenstein LM, MacGlashan DW Jr et al. Function and expression of adhesion molecules on human basophils. J Allergy Clin Immunol 1994; 94: 1157\u20131162.","journal-title":"J Allergy Clin Immunol"},{"key":"BFleu201715_CR39","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1034\/j.1600-065X.2001.790101.x","volume":"179","author":"BS Bochner","year":"2001","unstructured":"Bochner BS, Schleimer RP . Mast cells, basophils, and eosinophils: distinct but overlapping pathways for recruitment. Immunol Rev. 2001; 179: 5\u201315.","journal-title":"Immunol Rev."},{"key":"BFleu201715_CR40","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1182\/blood.V96.13.4028","volume":"96","author":"FH Falcone","year":"2000","unstructured":"Falcone FH, Haas H, Gibbs BF . The human basophil: a new appreciation of its role in immune responses. Blood 2000; 96: 4028\u20134038.","journal-title":"Blood"},{"key":"BFleu201715_CR41","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1189\/jlb.71.4.557","volume":"71","author":"M Arock","year":"2002","unstructured":"Arock M, Schneider E, Boissan M, Tricottet V, Dy M . Differentiation of human basophils: an overview of recent advances and pending questions. J Leukoc Biol 2002; 71: 557\u2013564.","journal-title":"J Leukoc Biol"},{"key":"BFleu201715_CR42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/00043426-198721000-00006","volume":"9","author":"H Kurosawa","year":"1987","unstructured":"Kurosawa H, Eguchi M, Sakakibara H, Takahashi H, Furukawa T . Ultrastructural cytochemistry of congenital basophilic leukemia. Am J Pediatr Hematol Oncol 1987; 9: 27\u201332.","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"BFleu201715_CR43","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3109\/10428199609051750","volume":"22","author":"H Agis","year":"1996","unstructured":"Agis H, Beil WJ, Bankl HC, F\u00fcreder W, Sperr WR, Ghannadan M et al. Mast cell-lineage versus basophil lineage involvement in myeloproliferative and myelodysplastic syndromes: diagnostic role of cell-immunophenotyping. Leuk Lymphoma 1996; 22: 187\u2013204.","journal-title":"Leuk Lymphoma"},{"key":"BFleu201715_CR44","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3109\/10428199909167387","volume":"32","author":"E Duchayne","year":"1999","unstructured":"Duchayne E, Demur C, Rubie H, Robert A, Dastugue N . Diagnosis of acute basophilic leukemia. Leuk Lymphoma 1999; 32: 269\u2013278.","journal-title":"Leuk Lymphoma"},{"key":"BFleu201715_CR45","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1046\/j.1365-2141.2003.04167.x","volume":"120","author":"L Shvidel","year":"2003","unstructured":"Shvidel L, Shaft D, Stark B, Shtalrid M, Berrebi A, Resnitzky P . Acute basophilic leukaemia: eight unsuspected new cases diagnosed by electron microscopy. Br J Haematol 2003; 120: 774\u2013781.","journal-title":"Br J Haematol"},{"key":"BFleu201715_CR46","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0145-2126(01)00041-8","volume":"25","author":"WR Sperr","year":"2001","unstructured":"Sperr WR, Escribano L, Jordan JH, Schernthaner GH, Kundi M, Horny HP et al. Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis. Leuk Res 2001; 25: 529\u2013536.","journal-title":"Leuk Res"},{"key":"BFleu201715_CR47","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1309\/M9FQMQGF66167N2X","volume":"125","author":"H Agis","year":"2006","unstructured":"Agis H, Krauth MT, B\u00f6hm A, Mosberger I, M\u00fcllauer L, Simonitsch-Klupp I et al. Identification of basogranulin (BB1) as a novel immunohistochemical marker of basophils in normal bone marrow and patients with myeloproliferative disorders. Am J Clin Pathol 2006; 125: 273\u2013281.","journal-title":"Am J Clin Pathol"},{"key":"BFleu201715_CR48","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1136\/jcp.2005.029215","volume":"59","author":"H Agis","year":"2006","unstructured":"Agis H, Krauth MT, Mosberger I, M\u00fcllauer L, Simonitsch-Klupp I, Schwartz LB et al. Enumeration and immunohistochemical characterisation of bone marrow basophils in myeloproliferative disorders using the basophil specific monoclonal antibody 2D7. J Clin Pathol 2006; 59: 396\u2013402.","journal-title":"J Clin Pathol"},{"key":"BFleu201715_CR49","doi-asserted-by":"crossref","first-page":"483","DOI":"10.18632\/oncotarget.185","volume":"1","author":"P Valent","year":"2010","unstructured":"Valent P, Orazi A, B\u00fcsche G, Schmitt-Gr\u00e4ff A, George TI, Sotlar K et al. Standards and impact of hematopathology in myelodysplastic syndromes (MDS). Oncotarget 2010; 1: 483\u2013496.","journal-title":"Oncotarget"},{"key":"BFleu201715_CR50","first-page":"392","volume":"23","author":"MA Idoate","year":"2013","unstructured":"Idoate MA, Echeveste J, Gil P, Sanz ML, Ferrer M . Expression of the basophil-specific antibodies 2D7 and BB1 in patients with cutaneous Mastocytosis. J Investig Allergol Clin Immunol 2013; 23: 392\u2013397.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"BFleu201715_CR51","first-page":"521","volume":"140","author":"H Noguchi","year":"1992","unstructured":"Noguchi H, Kephart GM, Colby TV, Gleich GJ . Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis. Am J Pathol 1992; 140: 521\u2013528.","journal-title":"Am J Pathol"},{"key":"BFleu201715_CR52","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1365-2141.1987.tb02348.x","volume":"67","author":"MP Bodger","year":"1987","unstructured":"Bodger MP, Newton LA . The purification of human basophils: their immunophenotype and cytochemistry. Br J Haematol 1987; 67: 281\u2013284.","journal-title":"Br J Haematol"},{"key":"BFleu201715_CR53","first-page":"34","volume":"61","author":"P Valent","year":"1995","unstructured":"Valent P . Immunophenotypic characterization of human basophils and mast cells. Chem Immunol 1995; 61: 34\u201348.","journal-title":"Chem Immunol"},{"key":"BFleu201715_CR54","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1182\/blood.V94.2.832","volume":"94","author":"HJ B\u00fchring","year":"1999","unstructured":"B\u00fchring HJ, Simmons PJ, Pudney M, M\u00fcller R, Jarrossay D, van Agthoven A et al. The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors. Blood 1999; 94: 2343\u20132356.","journal-title":"Blood"},{"key":"BFleu201715_CR55","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1177\/039463200802100404","volume":"21","author":"AW Hauswirth","year":"2008","unstructured":"Hauswirth AW, Escribano L, Prados A, Nu\u00f1ez R, Mirkina I, Kneidinger M et al. CD203c is overexpressed on neoplastic mast cells in systemic mastocytosis and is upregulated upon IgE receptor cross-linking. Int J Immunopathol Pharmacol 2008; 21: 797\u2013806.","journal-title":"Int J Immunopathol Pharmacol"},{"key":"BFleu201715_CR56","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1067\/mai.2002.121454","volume":"109","author":"B Foster","year":"2002","unstructured":"Foster B, Schwartz LB, Devouassoux G, Metcalfe DD, Prussin C . Characterization of mast-cell tryptase-expressing peripheral blood cells as basophils. J Allergy Clin Immunol 2002; 109: 287\u2013293.","journal-title":"J Allergy Clin Immunol"},{"key":"BFleu201715_CR57","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1182\/blood.V98.8.2580","volume":"98","author":"P Samorapoompichit","year":"2001","unstructured":"Samorapoompichit P, Kiener HP, Schernthaner GH, Jordan JH, Agis H, Wimazal F et al. Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid neoplasms. Blood 2001; 98: 2580\u20132583.","journal-title":"Blood"},{"key":"BFleu201715_CR58","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1172\/JCI118337","volume":"96","author":"LB Schwartz","year":"1995","unstructured":"Schwartz LB, Sakai K, Bradford TR, Ren S, Zweiman B, Worobec AS et al. The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis. J Clin Invest 1995; 96: 2702\u20132710.","journal-title":"J Clin Invest"},{"key":"BFleu201715_CR59","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000059404","volume":"128","author":"WR Sperr","year":"2002","unstructured":"Sperr WR, Jordan JH, Fiegl M, Escribano L, Bellas C, Dirnhofer S et al. Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for defining the category of disease. Int Arch Allergy Immunol 2002; 128: 136\u2013141.","journal-title":"Int Arch Allergy Immunol"},{"key":"BFleu201715_CR60","first-page":"354","volume":"5","author":"WR Sperr","year":"2014","unstructured":"Sperr WR, Pfeiffer T, Hoermann G, Herndlhofer S, Sillaber C, Mannhalter C et al. Serum-tryptase at diagnosis: a novel biomarker improving prognostication in Ph(+) CML. Am J Cancer Res 2014; 5: 354\u2013362.","journal-title":"Am J Cancer Res"},{"key":"BFleu201715_CR61","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1182\/blood.V73.3.777.777","volume":"73","author":"MP Bodger","year":"1989","unstructured":"Bodger MP, Morris CM, Kennedy MA, Bowen JA, Hilton JM, Fitzgerald PH . Basophils (Bsp-1+) derive from the leukemic clone in human myeloid leukemias involving the chromosome breakpoint 9q34. Blood 1989; 73: 777\u2013781.","journal-title":"Blood"},{"key":"BFleu201715_CR62","doi-asserted-by":"publisher","first-page":"5719","DOI":"10.1182\/blood-2011-01-333013","volume":"117","author":"C Quelen","year":"2011","unstructured":"Quelen C, Lippert E, Struski S, Demur C, Soler G, Prade N et al. Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. Blood 2011; 117: 5719\u20135722.","journal-title":"Blood"},{"key":"BFleu201715_CR63","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3324\/haematol.11836","volume":"93","author":"I Lahortiga","year":"2008","unstructured":"Lahortiga I, Akin C, Cools J, Wilson TM, Mentens N, Arthur DC et al. Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion. Haematologica 2008; 93: 49\u201356.","journal-title":"Haematologica"},{"key":"BFleu201715_CR64","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1182\/blood-2014-06-581173","volume":"125","author":"PA Beer","year":"2015","unstructured":"Beer PA, Knapp DJ, Miller PH, Kannan N, Sloma I, Heel K et al. Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression. Blood 2015; 125: 504\u2013515.","journal-title":"Blood"},{"key":"BFleu201715_CR65","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.leukres.2006.11.013","volume":"31","author":"Y Takasaki","year":"2007","unstructured":"Takasaki Y, Iwanaga M, Tsukasaki K, Kusano M, Sugahara K, Yamada Y et al. Impact of visceral involvements and blood cell count abnormalities on survival in adult T-cell leukemia\/lymphoma (ATLL). Leuk Res 2007; 31: 751\u2013757.","journal-title":"Leuk Res"},{"key":"BFleu201715_CR66","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1182\/blood-2002-03-0947","volume":"101","author":"T Matsushima","year":"2003","unstructured":"Matsushima T, Handa H, Yokohama A, Nagasaki J, Koiso H, Kin Y et al. Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia. Blood 2003; 101: 3386\u20133390.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu201715.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu201715","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu201715.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:25:17Z","timestamp":1692631517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu201715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,16]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["BFleu201715"],"URL":"https:\/\/doi.org\/10.1038\/leu.2017.15","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,16]]},"assertion":[{"value":"29 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}