{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:18:06Z","timestamp":1791850686419,"version":"4.3.4"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1038\/leu.2017.177","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T06:40:52Z","timestamp":1496731252000},"page":"332-342","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups"],"prefix":"10.1038","volume":"32","author":[{"given":"A","family":"Burns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Alsolami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Becq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Stamatopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Timbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Robbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Vavoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Clifford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cabes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Dreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J L","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Mansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Beekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Mart\u00edn-Subero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R S","family":"Houlston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K E","family":"Ridout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Schuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"BFleu2017177_CR1","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. World Health Organization: Geneva, Switzerland, 2008."},{"key":"BFleu2017177_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.20138","volume":"62","author":"R Siegel","year":"2012","unstructured":"Siegel R, Naishadham D, Jemal A . Cancer statistics, 2012. CA Cancer J Clin 2012; 62: 10\u201329.","journal-title":"CA Cancer J Clin"},{"key":"BFleu2017177_CR3","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1056\/NEJM200012283432602","volume":"343","author":"H D\u00f6hner","year":"2000","unstructured":"D\u00f6hner H, Stilgenbauer S, Benner A, Leupolt E, Kr\u00f6ber A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910\u20131916.","journal-title":"N Engl J Med"},{"key":"BFleu2017177_CR4","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1053\/j.seminoncol.2006.01.017","volume":"33","author":"T Seiler","year":"2006","unstructured":"Seiler T, D\u00f6hner H, Stilgenbauer S . Risk stratification in chronic lymphocytic leukemia. Semin Oncol 2006; 33: 186\u2013194.","journal-title":"Semin Oncol"},{"key":"BFleu2017177_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature10113","volume":"475","author":"XS Puente","year":"2011","unstructured":"Puente XS, Pinyol M, Quesada V, Conde L, Ord\u00f3\u00f1ez GR, Villamor N et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 2011; 475: 101\u2013105.","journal-title":"Nature"},{"key":"BFleu2017177_CR6","doi-asserted-by":"publisher","first-page":"4191","DOI":"10.1182\/blood-2012-05-433540","volume":"120","author":"A Schuh","year":"2012","unstructured":"Schuh A, Becq J, Humphray S, Alexa A, Burns A, Clifford R et al. Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns. Blood 2012; 120: 4191\u20134196.","journal-title":"Blood"},{"key":"BFleu2017177_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/ng.1032","volume":"44","author":"V Quesada","year":"2012","unstructured":"Quesada V, Conde L, Villamor N, Ordonez GR, Jares P, Bassaganyas L et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet 2012; 44: 47\u201352.","journal-title":"Nat Genet"},{"key":"BFleu2017177_CR8","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1038\/leu.2010.208","volume":"24","author":"T Zenz","year":"2010","unstructured":"Zenz T, Vollmer D, Trbusek M, Smardova J, Benner A, Soussi T et al. TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations. Leukemia 2010; 24: 2072\u20132079.","journal-title":"Leukemia"},{"key":"BFleu2017177_CR9","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1080\/10428190902763533","volume":"50","author":"T Zenz","year":"2009","unstructured":"Zenz T, Mohr J, Edelmann J, Sarno A, Hoth P, Heuberger M et al. Treatment resistance in chronic lymphocytic leukemia: the role of the p53 pathway. Leuk Lymphoma 2009; 50: 510\u2013513.","journal-title":"Leuk Lymphoma"},{"key":"BFleu2017177_CR10","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.1182\/blood-2008-04-154070","volume":"112","author":"T Zenz","year":"2008","unstructured":"Zenz T, Kr\u00f6ber A, Scherer K, H\u00e4be S, B\u00fchler A, Benner A et al. Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood 2008; 112: 3322\u20133329.","journal-title":"Blood"},{"key":"BFleu2017177_CR11","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.1182\/blood-2011-08-373159","volume":"118","author":"D Rossi","year":"2011","unstructured":"Rossi D, Bruscaggin A, Spina V, Rasi S, Khiabanian H, Messina M et al. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood 2011; 118: 6904\u20136908.","journal-title":"Blood"},{"key":"BFleu2017177_CR12","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1056\/NEJMoa1109016","volume":"365","author":"L Wang","year":"2011","unstructured":"Wang L, Lawrence MS, Wan Y, Stojanov P, Sougnez C, Stevenson K et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med 2011; 365: 2497\u20132506.","journal-title":"N Engl J Med"},{"key":"BFleu2017177_CR13","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1182\/blood-2011-09-379966","volume":"119","author":"D Rossi","year":"2011","unstructured":"Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, Forconi F et al. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 2011; 119: 521\u2013529.","journal-title":"Blood"},{"key":"BFleu2017177_CR14","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1084\/jem.20110921","volume":"208","author":"G Fabbri","year":"2011","unstructured":"Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, Ma J et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med 2011; 208: 1389\u20131401.","journal-title":"J Exp Med"},{"key":"BFleu2017177_CR15","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/j.1365-2141.2012.09155.x","volume":"158","author":"D Rossi","year":"2012","unstructured":"Rossi D, Rasi S, Spina V, Fangazio M, Monti S, Greco M et al. Different impact of NOTCH1 and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome. Br J Haematol 2012; 158: 426\u2013429.","journal-title":"Br J Haematol"},{"key":"BFleu2017177_CR16","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature15395","volume":"526","author":"DA Landau","year":"2015","unstructured":"Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J et al. Mutations driving CLL and their evolution in progression and relapse. Nature 2015; 526: 525\u2013530.","journal-title":"Nature"},{"key":"BFleu2017177_CR17","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1182\/blood-2013-04-490847","volume":"123","author":"R Clifford","year":"2014","unstructured":"Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs AT et al. SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood 2014; 123: 1021\u20131031.","journal-title":"Blood"},{"key":"BFleu2017177_CR18","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nature14666","volume":"526","author":"XS Puente","year":"2015","unstructured":"Puente XS, Be\u00e0 S, Vald\u00e9s-Mas R, Villamor N, Guti\u00e9rrez-Abril J, Mart\u00edn-Subero JI et al. Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature 2015; 526: 519\u2013524.","journal-title":"Nature"},{"key":"BFleu2017177_CR19","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/leu.2016.298","volume":"31","author":"M Larrayoz","year":"2016","unstructured":"Larrayoz M, Rose-Zerilli MJJ, Kadalayil L, Parker H, Blakemore S, Forster J et al. Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial. Leukemia 2016; 31: 510\u2013514.","journal-title":"Leukemia"},{"key":"BFleu2017177_CR20","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","volume":"94","author":"TJ Hamblin","year":"1999","unstructured":"Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK . Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848\u20131854.","journal-title":"Blood"},{"key":"BFleu2017177_CR21","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1182\/blood-2014-06-583765","volume":"124","author":"CS Tam","year":"2014","unstructured":"Tam CS, O\u2019Brien S, Plunkett W, Wierda W, Ferrajoli A, Wang X et al. Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab). Blood 2014; 124: 3059\u20133064.","journal-title":"Blood"},{"key":"BFleu2017177_CR22","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1182\/blood-2015-06-651125","volume":"127","author":"K Fischer","year":"2016","unstructured":"Fischer K, Bahlo J, Fink AM, Goede V, Herling CD, Cramer P et al. Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial. Blood 2016; 127: 208\u2013215.","journal-title":"Blood"},{"key":"BFleu2017177_CR23","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/leu.2016.307","volume":"31","author":"B Stamatopoulos","year":"2016","unstructured":"Stamatopoulos B, Timbs A, Bruce D, Smith T, Clifford R, Robbe P et al. Targeted deep sequencing reveals clinically relevant subclonal IgHV rearrangements in chronic lymphocytic leukemia. Leukemia 2016; 31: 837\u2013845.","journal-title":"Leukemia"},{"key":"BFleu2017177_CR24","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1084\/jem.194.11.1639","volume":"194","author":"A Rosenwald","year":"2001","unstructured":"Rosenwald A, Alizadeh AA, Widhopf G, Simon R, Davis RE, Yu X et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001; 194: 1639\u20131647.","journal-title":"J Exp Med"},{"key":"BFleu2017177_CR25","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1084\/jem.194.11.1625","volume":"194","author":"U Klein","year":"2001","unstructured":"Klein U, Tu Y, Stolovitzky GA, Mattioli M, Cattoretti G, Husson H et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 2001; 194: 1625\u20131638.","journal-title":"J Exp Med"},{"key":"BFleu2017177_CR26","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/ng.3488","volume":"48","author":"CC Oakes","year":"2016","unstructured":"Oakes CC, Seifert M, Assenov Y, Gu L, Przekopowitz M, Ruppert AS et al. DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia. Nat Genet 2016; 48: 253\u2013264.","journal-title":"Nat Genet"},{"key":"BFleu2017177_CR27","doi-asserted-by":"publisher","first-page":"4313","DOI":"10.1182\/blood-2011-06-338855","volume":"118","author":"FK Stevenson","year":"2011","unstructured":"Stevenson FK, Krysov S, Davies AJ, Steele AJ, Packham G . B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2011; 118: 4313\u20134320.","journal-title":"Blood"},{"key":"BFleu2017177_CR28","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nature11309","volume":"489","author":"MD Minden","year":"2012","unstructured":"Minden MD, \u00dcbelhart R, Schneider D, Wossning T, Bach MP, Buchner M et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 2012; 489: 309\u2013312.","journal-title":"Nature"},{"key":"BFleu2017177_CR29","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature12477","volume":"500","author":"LB Alexandrov","year":"2013","unstructured":"Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SAJR, Behjati S, Biankin AV et al. Signatures of mutational processes in human cancer. Nature 2013; 500: 415\u2013421.","journal-title":"Nature"},{"key":"BFleu2017177_CR30","doi-asserted-by":"publisher","first-page":"11383","DOI":"10.1038\/ncomms11383","volume":"7","author":"S Morganella","year":"2016","unstructured":"Morganella S, Alexandrov LB, Glodzik D, Zou X, Davies H, Staaf J et al. The topography of mutational processes in breast cancer genomes. Nat Commun 2016; 7: 11383.","journal-title":"Nat Commun"},{"key":"BFleu2017177_CR31","doi-asserted-by":"publisher","first-page":"4802","DOI":"10.1182\/blood-2012-08-449744","volume":"120","author":"PEM Patten","year":"2012","unstructured":"Patten PEM, Chu CC, Albesiano E, Damle RN, Yan X-J, Kim D et al. IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions. Blood 2012; 120: 4802\u20134811.","journal-title":"Blood"},{"key":"BFleu2017177_CR32","doi-asserted-by":"publisher","first-page":"8866","DOI":"10.1038\/ncomms9866","volume":"6","author":"S Kasar","year":"2015","unstructured":"Kasar S, Kim J, Improgo R, Tiao G, Polak P, Haradhvala N et al. Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. Nat Commun 2015; 6: 8866.","journal-title":"Nat Commun"},{"key":"BFleu2017177_CR33","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1126\/science.1105136","volume":"306","author":"ENCODE Project Consortium EP","year":"2004","unstructured":"ENCODE Project Consortium EP. The ENCODE (ENCyclopedia Of DNA Elements) Project. Science 2004; 306: 636\u2013640.","journal-title":"Science"},{"key":"BFleu2017177_CR34","doi-asserted-by":"publisher","first-page":"baw001","DOI":"10.1093\/database\/baw001","volume":"2016","author":"EL Hong","year":"2016","unstructured":"Hong EL, Sloan CA, Chan ET, Davidson JM, Malladi VS, Strattan JS et al. Principles of metadata organization at the ENCODE data coordination center. Database 2016; 2016: baw001.","journal-title":"Database"},{"key":"BFleu2017177_CR35","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1182\/blood-2005-06-2227","volume":"107","author":"M Thors\u00e9lius","year":"2006","unstructured":"Thors\u00e9lius M, Kr\u00f6ber A, Murray F, Thunberg U, Tobin G, B\u00fchler A et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status. Blood 2006; 107: 2889\u20132894.","journal-title":"Blood"},{"key":"BFleu2017177_CR36","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1093\/bioinformatics\/btt314","volume":"29","author":"C Raczy","year":"2013","unstructured":"Raczy C, Petrovski R, Saunders CT, Chorny I, Kruglyak S, Margulies EH et al. Isaac: ultra-fast whole-genome secondary analysis on Illumina sequencing platforms. Bioinformatics 2013; 29: 2041\u20132043.","journal-title":"Bioinformatics"},{"key":"BFleu2017177_CR37","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1093\/bioinformatics\/bts271","volume":"28","author":"CT Saunders","year":"2012","unstructured":"Saunders CT, Wong WSW, Swamy S, Becq J, Murray LJ, Cheetham RK . Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs. Bioinformatics 2012; 28: 1811\u20131817.","journal-title":"Bioinformatics"},{"key":"BFleu2017177_CR38","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nmeth.1906","volume":"9","author":"J Ernst","year":"2012","unstructured":"Ernst J, Kellis M . ChromHMM: automating chromatin-state discovery and characterization. Nat Methods 2012; 9: 215\u2013216.","journal-title":"Nat Methods"},{"key":"BFleu2017177_CR39","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell C, Pachter L, Salzberg SL . TopHat: discovering splice junctions with RNA-seq. Bioinformatics 2009; 25: 1105\u20131111.","journal-title":"Bioinformatics"},{"key":"BFleu2017177_CR40","doi-asserted-by":"publisher","first-page":"i333","DOI":"10.1093\/bioinformatics\/bts378","volume":"28","author":"T Rausch","year":"2012","unstructured":"Rausch T, Zichner T, Schlattl A, St\u00fctz AM, Benes V, Korbel JO . DELLY: structural variant discovery by integrated paired-end and split-read analysis. Bioinformatics 2012; 28: i333\u2013i339.","journal-title":"Bioinformatics"},{"key":"BFleu2017177_CR41","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature12213","volume":"499","author":"MS Lawrence","year":"2013","unstructured":"Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 2013; 499: 214\u2013218.","journal-title":"Nature"},{"key":"BFleu2017177_CR42","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.cell.2012.04.024","volume":"149","author":"S Nik-Zainal","year":"2012","unstructured":"Nik-Zainal S, Alexandrov LB, Wedge DC, Van Loo P, Greenman CD, Raine K et al. Mutational processes molding the genomes of 21 breast cancers. Cell 2012; 149: 979\u2013993.","journal-title":"Cell"},{"key":"BFleu2017177_CR43","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.celrep.2012.12.008","volume":"3","author":"LB Alexandrov","year":"2013","unstructured":"Alexandrov LB, Nik-Zainal S, Wedge DC, Campbell PJ, Stratton MR . Deciphering signatures of mutational processes operative in human cancer. Cell Rep 2013; 3: 246\u2013259.","journal-title":"Cell Rep"},{"key":"BFleu2017177_CR44","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.cell.2013.01.019","volume":"152","author":"DA Landau","year":"2013","unstructured":"Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, Lawrence MS et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 2013; 152: 714\u2013726.","journal-title":"Cell"},{"key":"BFleu2017177_CR45","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.leukres.2009.03.042","volume":"34","author":"E Chapiro","year":"2010","unstructured":"Chapiro E, Leporrier N, Radford-Weiss I, Bastard C, Mossafa H, Leroux D et al. Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages. Leuk Res 2010; 34: 63\u201368.","journal-title":"Leuk Res"},{"key":"BFleu2017177_CR46","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2141.2008.07373.x","volume":"143","author":"F Forconi","year":"2008","unstructured":"Forconi F, Rinaldi A, Kwee I, Sozzi E, Raspadori D, Rancoita PMV et al. Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion. Br J Haematol 2008; 143: 532\u2013536.","journal-title":"Br J Haematol"},{"key":"BFleu2017177_CR47","doi-asserted-by":"publisher","first-page":"3791","DOI":"10.1158\/1078-0432.CCR-11-2342","volume":"18","author":"JR Brown","year":"2012","unstructured":"Brown JR, Hanna M, Tesar B, Werner L, Pochet N, Asara JM et al. Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemia. Clin Cancer Res 2012; 18: 3791\u20133802.","journal-title":"Clin Cancer Res"},{"key":"BFleu2017177_CR48","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1182\/blood-2013-10-534271","volume":"123","author":"M Messina","year":"2014","unstructured":"Messina M, Del Giudice I, Khiabanian H, Rossi D, Chiaretti S, Rasi S et al. Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness. Blood 2014; 123: 2378\u20132388.","journal-title":"Blood"},{"key":"BFleu2017177_CR49","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/1741-7015-11-124","volume":"11","author":"V Quesada","year":"2013","unstructured":"Quesada V, Ramsay AJ, Rodr\u00edguez D, Puente XS, Campo E, L\u00f3pez-Ot\u00edn C . The genomic landscape of chronic lymphocytic leukemia: clinical implications. BMC Med 2013; 11: 124.","journal-title":"BMC Med"},{"key":"BFleu2017177_CR50","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S0140-6736(98)10117-4","volume":"353","author":"T Stankovic","year":"1999","unstructured":"Stankovic T, Weber P, Stewart G, Bedenham T, Murray J, Byrd PJ et al. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. Lancet (London, England) 1999; 353: 26\u201329.","journal-title":"Lancet (London, England)"},{"key":"BFleu2017177_CR51","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1182\/blood.V94.2.748","volume":"94","author":"C Schaffner","year":"1999","unstructured":"Schaffner C, Stilgenbauer S, Rappold GA, D\u00f6hner H, Lichter P . Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. Blood 1999; 94: 748\u2013753.","journal-title":"Blood"},{"key":"BFleu2017177_CR52","doi-asserted-by":"publisher","first-page":"6997","DOI":"10.1038\/ncomms7997","volume":"6","author":"BA Walker","year":"2015","unstructured":"Walker BA, Wardell CP, Murison A, Boyle EM, Begum DB, Dahir NM et al. APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma. Nat Commun 2015; 6: 6997.","journal-title":"Nat Commun"},{"key":"BFleu2017177_CR53","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.18632\/oncotarget.653","volume":"3","author":"AH Khodabakhshi","year":"2012","unstructured":"Khodabakhshi AH, Morin RD, Fejes AP, Mungall AJ, Mungall KL, Bolger-Munro M et al. Recurrent targets of aberrant somatic hypermutation in lymphoma. Oncotarget 2012; 3: 1308\u20131319.","journal-title":"Oncotarget"},{"key":"BFleu2017177_CR54","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/35085588","volume":"412","author":"L Pasqualucci","year":"2001","unstructured":"Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, K\u00fcppers R et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 2001; 412: 341\u2013346.","journal-title":"Nature"},{"key":"BFleu2017177_CR55","doi-asserted-by":"publisher","first-page":"e85113","DOI":"10.1371\/journal.pone.0085113","volume":"9","author":"H Ma","year":"2014","unstructured":"Ma H, Cheng L, Hao K, Li Y, Song X, Zhou H et al. Reversal effect of ST6GAL 1 on multidrug resistance in human leukemia by regulating the PI3K\/Akt pathway and the expression of P-gp and MRP1. PLoS One 2014; 9: e85113.","journal-title":"PLoS One"},{"key":"BFleu2017177_CR56","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/leu.2016.10","volume":"30","author":"MJJ Rose-Zerilli","year":"2016","unstructured":"Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H et al. Longitudinal copy number, whole exome and targeted deep sequencing of \u2018good risk\u2019 IGHV-mutated CLL patients with progressive disease. Leukemia 2016; 30: 1301\u20131310.","journal-title":"Leukemia"},{"key":"BFleu2017177_CR57","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nature17676","volume":"534","author":"S Nik-Zainal","year":"2016","unstructured":"Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X et al. Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature 2016; 534: 47\u201354.","journal-title":"Nature"},{"key":"BFleu2017177_CR58","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.cell.2005.10.023","volume":"123","author":"MJ Carrozza","year":"2005","unstructured":"Carrozza MJ, Li B, Florens L, Suganuma T, Swanson SK, Lee KK et al. Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 2005; 123: 581\u2013592.","journal-title":"Cell"},{"key":"BFleu2017177_CR59","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cell.2010.10.012","volume":"143","author":"T Bartke","year":"2010","unstructured":"Bartke T, Vermeulen M, Xhemalce B, Robson SC, Mann M, Kouzarides T . Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 2010; 143: 470\u2013484.","journal-title":"Cell"},{"key":"BFleu2017177_CR60","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3324\/haematol.2012.070623","volume":"98","author":"A Garding","year":"2013","unstructured":"Garding A, Bhattacharya N, Haebe S, M\u00fcller F, Weichenhan D, Idler I et al. TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q. Haematologica 2013; 98: 269\u2013273.","journal-title":"Haematologica"},{"key":"BFleu2017177_CR61","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/gcc.1099","volume":"30","author":"MR Yuille","year":"2001","unstructured":"Yuille MR, Condie A, Stone EM, Wilsher J, Bradshaw PS, Brooks L et al. TCL1 is activated by chromosomal rearrangement or by hypomethylation. Genes Chromosomes Cancer 2001; 30: 336\u2013341.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2017177_CR62","doi-asserted-by":"publisher","first-page":"11590","DOI":"10.1158\/0008-5472.CAN-06-3613","volume":"66","author":"Y Pekarsky","year":"2006","unstructured":"Pekarsky Y, Santanam U, Cimmino A, Palamarchuk A, Efanov A, Maximov V et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res 2006; 66: 11590\u201311593.","journal-title":"Cancer Res"},{"key":"BFleu2017177_CR63","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1182\/blood-2010-09-307140","volume":"117","author":"K Billot","year":"2011","unstructured":"Billot K, Soeur J, Chereau F, Arrouss I, Merle-Beral H, Huang M-E et al. Deregulation of Aiolos expression in chronic lymphocytic leukemia is associated with epigenetic modifications. Blood 2011; 117: 1917\u20131927.","journal-title":"Blood"},{"key":"BFleu2017177_CR64","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/leu.2015.199","volume":"30","author":"JM Boer","year":"2016","unstructured":"Boer JM, van der Veer A, Rizopoulos D, Fiocco M, Sonneveld E, de Groot-Kruseman HA et al. Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study. Leukemia 2016; 30: 32\u201338.","journal-title":"Leukemia"},{"key":"BFleu2017177_CR65","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1182\/blood-2011-12-395673","volume":"119","author":"D Rossi","year":"2012","unstructured":"Rossi D, Fangazio M, Rasi S, Vaisitti T, Monti S, Cresta S et al. Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood 2012; 119: 2854\u20132862.","journal-title":"Blood"}],"updated-by":[{"DOI":"10.1038\/s41375-019-0515-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000}},{"DOI":"10.1038\/leu.2017.311","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000}}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/leu2017177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/leu2017177","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/leu.2017.177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/leu2017177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T15:47:58Z","timestamp":1719244078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2017177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,6]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["BFleu2017177"],"URL":"https:\/\/doi.org\/10.1038\/leu.2017.177","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/leu.2017.311","asserted-by":"object"}],"correction":[{"id-type":"doi","id":"10.1038\/s41375-019-0515-8","asserted-by":"object"}]},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,6]]},"assertion":[{"value":"9 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2017","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been corrected since Advance Online Publication and a corrigendum is also printed in this issue","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JB and DB are employees of Illumina Inc., a public company that develops and markets systems for genetic analysis. The other authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}