{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:06:30Z","timestamp":1790417190082,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1038\/leu.2017.252","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T02:40:35Z","timestamp":1502678435000},"page":"774-787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling"],"prefix":"10.1038","volume":"32","author":[{"given":"E I","family":"Andersson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"P\u00fctzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Dufva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-401X","authenticated-orcid":false,"given":"L","family":"Sellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Schrader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Crispatzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ole\u015b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Adnan-Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lagstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bellanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Mpindi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5056-4750","authenticated-orcid":false,"given":"S","family":"Eldfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Pemovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Pietarinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lauhio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tomska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Cuesta-Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Faber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Koschmieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T H","family":"Br\u00fcmmendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kyt\u00f6l\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E-R","family":"Savolainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Siitonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ellonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-0332","authenticated-orcid":false,"given":"O","family":"Kallioniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Wennerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-H","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0474-2218","authenticated-orcid":false,"given":"W","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3986-9892","authenticated-orcid":false,"given":"S","family":"Anders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Aittokallio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Zenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Herling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mustjoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"BFleu2017252_CR1","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1182\/blood-2004-01-0002","volume":"104","author":"M Herling","year":"2004","unstructured":"Herling M, Khoury JD, Washington LT, Duvic M, Keating MJ, Jones D . A systematic approach to diagnosis of mature T-cell leukemias reveals heterogeneity among WHO categories. Blood 2004; 104: 328\u2013335.","journal-title":"Blood"},{"key":"BFleu2017252_CR2","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1182\/blood-2007-07-101519","volume":"111","author":"M Herling","year":"2008","unstructured":"Herling M, Patel KA, Teitell MA, Konopleva M, Ravandi F, Kobayashi R et al. High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia. Blood 2008; 111: 328\u2013337.","journal-title":"Blood"},{"key":"BFleu2017252_CR3","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1182\/blood-2012-01-380139","volume":"120","author":"C Dearden","year":"2012","unstructured":"Dearden C . How I treat prolymphocytic leukemia. Blood 2012; 120: 538\u2013551.","journal-title":"Blood"},{"key":"BFleu2017252_CR4","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1002\/cncr.27972","volume":"119","author":"G Hopfinger","year":"2013","unstructured":"Hopfinger G, Busch R, Pflug N, Weit N, Westermann A, Fink AM et al. Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-cell prolymphocytic leukemia. Cancer 2013; 119: 2258\u20132267.","journal-title":"Cancer"},{"key":"BFleu2017252_CR5","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1111\/j.1365-2141.2010.08134.x","volume":"149","author":"B Krishnan","year":"2010","unstructured":"Krishnan B, Else M, Tjonnfjord GE, Cazin B, Carney D, Carter J et al. Stem cell transplantation after alemtuzumab in T-cell prolymphocytic leukaemia results in longer survival than after alemtuzumab alone: a multicentre retrospective study. Br J Haematol 2010; 149: 907\u2013910.","journal-title":"Br J Haematol"},{"key":"BFleu2017252_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/ejh.12462","volume":"94","author":"M Herling","year":"2015","unstructured":"Herling M . Are we improving the outcome for patients with T-cell prolymphocytic leukemia by allogeneic stem cell transplantation? Eur J Haematol 2015; 94: 191\u2013192.","journal-title":"Eur J Haematol"},{"key":"BFleu2017252_CR7","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/leu.2011.304","volume":"26","author":"W Wiktor-Jedrzejczak","year":"2012","unstructured":"Wiktor-Jedrzejczak W, Dearden C, de Wreede L, van Biezen A, Brinch L, Leblond V et al. Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium. Leukemia 2012; 26: 972\u2013976.","journal-title":"Leukemia"},{"key":"BFleu2017252_CR8","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/gcc.22313","volume":"55","author":"A Stengel","year":"2016","unstructured":"Stengel A, Kern W, Zenger M, Perglerova K, Schnittger S, Haferlach T et al. Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker. Genes Chromosomes Cancer 2016; 55: 82\u201394.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2017252_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s12185-011-0986-5","volume":"95","author":"A Yokohama","year":"2012","unstructured":"Yokohama A, Saitoh A, Nakahashi H, Mitsui T, Koiso H, Kim Y et al. TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients. Int J Hematol 2012; 95: 77\u201385.","journal-title":"Int J Hematol"},{"key":"BFleu2017252_CR10","first-page":"2475","volume":"8","author":"MH Stern","year":"1993","unstructured":"Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A et al. MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha\/delta locus in mature T cell proliferations. Oncogene 1993; 8: 2475\u20132483.","journal-title":"Oncogene"},{"key":"BFleu2017252_CR11","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1073\/pnas.95.7.3885","volume":"95","author":"L Virgilio","year":"1998","unstructured":"Virgilio L, Lazzeri C, Bichi R, Nibu K, Narducci MG, Russo G et al. Deregulated expression of TCL1 causes T cell leukemia in mice. Proc Natl Acad Sci USA 1998; 95: 3885\u20133889.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2017252_CR12","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.V92.2.368","volume":"92","author":"C Gritti","year":"1998","unstructured":"Gritti C, Dastot H, Soulier J, Janin A, Daniel MT, Madani A et al. Transgenic mice for MTCP1 develop T-cell prolymphocytic leukemia. Blood 1998; 92: 368\u2013373.","journal-title":"Blood"},{"key":"BFleu2017252_CR13","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1182\/blood-2014-03-559542","volume":"124","author":"MJ Kiel","year":"2014","unstructured":"Kiel MJ, Velusamy T, Rolland D, Sahasrabuddhe AA, Chung F, Bailey NG et al. Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia. Blood 2014; 124: 1460\u20131472.","journal-title":"Blood"},{"key":"BFleu2017252_CR14","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/ajh.24679","volume":"92","author":"Z Hu","year":"2017","unstructured":"Hu Z, Medeiros LJ, Fang L, Sun Y, Tang Z, Tang G et al. Prognostic significance of cytogenetic abnormalities in T-cell prolymphocytic leukemia. Am J Hematol 2017; 92: 441\u2013447.","journal-title":"Am J Hematol"},{"key":"BFleu2017252_CR15","first-page":"193","volume":"38","author":"P Delgado","year":"2012","unstructured":"Delgado P, Starshak P, Rao N, Tirado CA . A comprehensive update on molecular and cytogenetic abnormalities in T-cell prolymphocytic leukemia (T-PLL). J Assoc Genet Technol 2012; 38: 193\u2013198.","journal-title":"J Assoc Genet Technol"},{"key":"BFleu2017252_CR16","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1038\/sj.leu.2404877","volume":"21","author":"J Durig","year":"2007","unstructured":"Durig J, Bug S, Klein-Hitpass L, Boes T, Jons T, Martin-Subero JI et al. Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32). Leukemia 2007; 21: 2153\u20132163.","journal-title":"Leukemia"},{"key":"BFleu2017252_CR17","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1182\/blood-2011-08-374561","volume":"119","author":"E Gaudio","year":"2012","unstructured":"Gaudio E, Spizzo R, Paduano F, Luo Z, Efanov A, Palamarchuk A et al. Tcl1 interacts with Atm and enhances NF-kappaB activation in hematologic malignancies. Blood 2012; 119: 180\u2013187.","journal-title":"Blood"},{"key":"BFleu2017252_CR18","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/leu.2013.271","volume":"28","author":"D Bellanger","year":"2014","unstructured":"Bellanger D, Jacquemin V, Chopin M, Pierron G, Bernard OA, Ghysdael J et al. Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia. Leukemia 2014; 28: 417\u2013419.","journal-title":"Leukemia"},{"key":"BFleu2017252_CR19","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1158\/2159-8290.CD-13-0350","volume":"3","author":"T Pemovska","year":"2013","unstructured":"Pemovska T, Kontro M, Yadav B, Edgren H, Eldfors S, Szwajda A et al. Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. Cancer Discov 2013; 3: 1416\u20131429.","journal-title":"Cancer Discov"},{"key":"BFleu2017252_CR20","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 2016; 127: 2375\u20132390.","journal-title":"Blood"},{"key":"BFleu2017252_CR21","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1056\/NEJMoa1114885","volume":"366","author":"HL Koskela","year":"2012","unstructured":"Koskela HL, Eldfors S, Ellonen P, van Adrichem AJ, Kuusanmaki H, Andersson EI et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med 2012; 366: 1905\u20131913.","journal-title":"N Engl J Med"},{"key":"BFleu2017252_CR22","doi-asserted-by":"publisher","first-page":"R6","DOI":"10.1186\/gb-2011-12-1-r6","volume":"12","author":"H Edgren","year":"2011","unstructured":"Edgren H, Murumagi A, Kangaspeska S, Nicorici D, Hongisto V, Kleivi K et al. Identification of fusion genes in breast cancer by paired-end RNA-sequencing. Genome Biol 2011; 12: R6.","journal-title":"Genome Biol"},{"key":"BFleu2017252_CR23","first-page":"1694","volume":"9","author":"SH Maljaie","year":"1995","unstructured":"Maljaie SH, Brito-Babapulle V, Matutes E, Hiorns LR, De Schouwer PJ, Catovsky D . Expression of c-myc oncoprotein in chronic T cell leukemias. Leukemia 1995; 9: 1694\u20131699.","journal-title":"Leukemia"},{"key":"BFleu2017252_CR24","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature12831","volume":"504","author":"B Haibe-Kains","year":"2013","unstructured":"Haibe-Kains B, El-Hachem N, Birkbak NJ, Jin AC, Beck AH, Aerts HJ et al. Inconsistency in large pharmacogenomic studies. Nature 2013; 504: 389\u2013393.","journal-title":"Nature"},{"key":"BFleu2017252_CR25","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature17987","volume":"533","author":"PM Haverty","year":"2016","unstructured":"Haverty PM, Lin E, Tan J, Yu Y, Lam B, Lianoglou S et al. Reproducible pharmacogenomic profiling of cancer cell line panels. Nature 2016; 533: 333\u2013337.","journal-title":"Nature"},{"key":"BFleu2017252_CR26","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1073\/pnas.1315752111","volume":"111","author":"M Dose","year":"2014","unstructured":"Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K et al. beta-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci USA 2014; 111: 391\u2013396.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2017252_CR27","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1038\/sj.onc.1204527","volume":"20","author":"KE Keating","year":"2001","unstructured":"Keating KE, Gueven N, Watters D, Rodemann HP, Lavin MF . Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein. Oncogene 2001; 20: 4281\u20134290.","journal-title":"Oncogene"},{"key":"BFleu2017252_CR28","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1182\/blood-2008-12-190256","volume":"113","author":"R Chen","year":"2009","unstructured":"Chen R, Wierda WG, Chubb S, Hawtin RE, Fox JA, Keating MJ et al. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood 2009; 113: 4637\u20134645.","journal-title":"Blood"},{"key":"BFleu2017252_CR29","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1038\/leu.2015.99","volume":"29","author":"L Li","year":"2015","unstructured":"Li L, Pongtornpipat P, Tiutan T, Kendrick SL, Park S, Persky DO et al. Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1. Leukemia 2015; 29: 1702\u20131712.","journal-title":"Leukemia"},{"key":"BFleu2017252_CR30","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1101\/gad.244368.114","volume":"28","author":"CH Huang","year":"2014","unstructured":"Huang CH, Lujambio A, Zuber J, Tschaharganeh DF, Doran MG, Evans MJ et al. CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. Genes Dev 2014; 28: 1800\u20131814.","journal-title":"Genes Dev"},{"key":"BFleu2017252_CR31","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s11899-013-0165-2","volume":"8","author":"K Warner","year":"2013","unstructured":"Warner K, Weit N, Crispatzu G, Admirand J, Jones D, Herling M . T-cell receptor signaling in peripheral T-cell lymphoma - a review of patterns of alterations in a central growth regulatory pathway. Curr Hematol Malig Rep 2013; 8: 163\u2013172.","journal-title":"Curr Hematol Malig Rep"},{"key":"BFleu2017252_CR32","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/gcc.22141","volume":"53","author":"AK Bergmann","year":"2014","unstructured":"Bergmann AK, Schneppenheim S, Seifert M, Betts MJ, Haake A, Lopez C et al. Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia. Genes Chromosomes Cancer 2014; 53: 309\u2013316.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFleu2017252_CR33","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/bjh.13952","volume":"173","author":"C Lopez","year":"2016","unstructured":"Lopez C, Bergmann AK, Paul U, Murga Penas EM, Nagel I, Betts MJ et al. Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia. Br J Haematol 2016; 173: 265\u2013273.","journal-title":"Br J Haematol"},{"key":"BFleu2017252_CR34","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1002\/eji.201041295","volume":"42","author":"CY Huang","year":"2012","unstructured":"Huang CY, Lin YC, Hsiao WY, Liao FH, Huang PY, Tan TH . DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development. Eur J Immunol 2012; 42: 476\u2013488.","journal-title":"Eur J Immunol"},{"key":"BFleu2017252_CR35","doi-asserted-by":"publisher","first-page":"e0145880","DOI":"10.1371\/journal.pone.0145880","volume":"10","author":"WY Hsiao","year":"2015","unstructured":"Hsiao WY, Lin YC, Liao FH, Chan YC, Huang CY . Dual-specificity phosphatase 4 regulates STAT5 protein stability and helper T cell polarization. PLoS One 2015; 10: e0145880.","journal-title":"PLoS One"},{"key":"BFleu2017252_CR36","doi-asserted-by":"publisher","first-page":"6025","DOI":"10.1038\/ncomms7025","volume":"6","author":"C Kucuk","year":"2015","unstructured":"Kucuk C, Jiang B, Hu X, Zhang W, Chan JK, Xiao W et al. Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells. Nat Commun 2015; 6: 6025.","journal-title":"Nat Commun"},{"key":"BFleu2017252_CR37","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.1182\/blood-2009-03-208256","volume":"114","author":"M Herling","year":"2009","unstructured":"Herling M, Patel KA, Weit N, Lilienthal N, Hallek M, Keating MJ et al. High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia. Blood 2009; 114: 4675\u20134686.","journal-title":"Blood"},{"key":"BFleu2017252_CR38","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s10637-007-9090-3","volume":"26","author":"EI Heath","year":"2008","unstructured":"Heath EI, Bible K, Martell RE, Adelman DC, Lorusso PM . A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors. Invest New Drugs 2008; 26: 59\u201365.","journal-title":"Invest New Drugs"},{"key":"BFleu2017252_CR39","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1182\/blood-2007-06-095570","volume":"111","author":"E Le Toriellec","year":"2008","unstructured":"Le Toriellec E, Despouy G, Pierron G, Gaye N, Joiner M, Bellanger D et al. Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia. Blood 2008; 111: 2321\u20132328.","journal-title":"Blood"},{"key":"BFleu2017252_CR40","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1200\/JCO.2009.26.1347","volume":"28","author":"WG Tong","year":"2010","unstructured":"Tong WG, Chen R, Plunkett W, Siegel D, Sinha R, Harvey RD et al. Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. J Clin Oncol 2010; 28: 3015\u20133022.","journal-title":"J Clin Oncol"},{"key":"BFleu2017252_CR41","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1046\/j.1365-2141.2000.02174.x","volume":"110","author":"V Brito-Babapulle","year":"2000","unstructured":"Brito-Babapulle V, Hamoudi R, Matutes E, Watson S, Kaczmarek P, Maljaie H et al. p53 allele deletion and protein accumulation occurs in the absence of p53 gene mutation in T-prolymphocytic leukaemia and Sezary syndrome. Br J Haematol 2000; 110: 180\u2013187.","journal-title":"Br J Haematol"},{"key":"BFleu2017252_CR42","doi-asserted-by":"publisher","first-page":"293ra102","DOI":"10.1126\/scitranslmed.aaa5079","volume":"7","author":"ZS Hasanali","year":"2015","unstructured":"Hasanali ZS, Saroya BS, Stuart A, Shimko S, Evans J, Vinod Shah M et al. Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia. Sci Transl Med 2015; 7: 293ra102.","journal-title":"Sci Transl Med"},{"key":"BFleu2017252_CR43","doi-asserted-by":"publisher","first-page":"14290","DOI":"10.1038\/ncomms14290","volume":"8","author":"F Cayrol","year":"2017","unstructured":"Cayrol F, Praditsuktavorn P, Fernando TM, Kwiatkowski N, Marullo R, Calvo-Vidal MN et al. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors. Nat Commun 2017; 8: 14290.","journal-title":"Nat Commun"},{"key":"BFleu2017252_CR44","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nature14119","volume":"519","author":"T Pemovska","year":"2015","unstructured":"Pemovska T, Johnson E, Kontro M, Repasky GA, Chen J, Wells P et al. Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation. Nature 2015; 519: 102\u2013105.","journal-title":"Nature"},{"key":"BFleu2017252_CR45","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/mt.2013.67","volume":"21","author":"T Heinrich","year":"2013","unstructured":"Heinrich T, Rengstl B, Muik A, Petkova M, Schmid F, Wistinghausen R et al. Mature T-cell lymphomagenesis induced by retroviral insertional activation of Janus kinase 1. Mol Ther 2013; 21: 1160\u20131168.","journal-title":"Mol Ther"},{"key":"BFleu2017252_CR46","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/leu.2016.49","volume":"30","author":"S Spinner","year":"2016","unstructured":"Spinner S, Crispatzu G, Yi JH, Munkhbaatar E, Mayer P, Hockendorf U et al. Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance. Leukemia 2016; 30: 1520\u20131530.","journal-title":"Leukemia"},{"key":"BFleu2017252_CR47","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.critrevonc.2013.07.014","volume":"88","author":"K Warner","year":"2013","unstructured":"Warner K, Crispatzu G, Al-Ghaili N, Weit N, Florou V, You MJ et al. Models for mature T-cell lymphomas\u2014a critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts. Crit Rev Oncol Hematol 2013; 88: 680\u2013695.","journal-title":"Crit Rev Oncol Hematol"},{"key":"BFleu2017252_CR48","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1752-0509-6-29","volume":"6","author":"DC Kirouac","year":"2012","unstructured":"Kirouac DC, Saez-Rodriguez J, Swantek J, Burke JM, Lauffenburger DA, Sorger PK . Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. BMC Syst Biol 2012; 6: 29.","journal-title":"BMC Syst Biol"},{"key":"BFleu2017252_CR49","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.celrep.2013.08.028","volume":"5","author":"N Zaman","year":"2013","unstructured":"Zaman N, Li L, Jaramillo ML, Sun Z, Tibiche C, Banville M et al. Signaling network assessment of mutations and copy number variations predict breast cancer subtype-specific drug targets. Cell Rep 2013; 5: 216\u2013223.","journal-title":"Cell Rep"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/leu2017252.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/leu2017252","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/leu.2017.252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/leu2017252.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:09:03Z","timestamp":1684418943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2017252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,14]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["BFleu2017252"],"URL":"https:\/\/doi.org\/10.1038\/leu.2017.252","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,14]]},"assertion":[{"value":"26 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Labcyte, Inc. and FIMM\/University of Helsinki have a collaboration agreement on the utilization of Labcyte\u2019s acoustic dispensing technologies. CC-M is an employee of IMMED.S.L. SM has received honoraria and research funding from Novartis, Pfizer and Bristol-Myers Squibb (not related to this study). KW has received honoraria and research funding from Novartis and Pfizer (not related to this study). The other authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}