{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:29:25Z","timestamp":1791008965483,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":5080,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1038\/mi.2007.18","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T10:58:33Z","timestamp":1199876313000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Persistence of Entamoeba histolytica infection in CBA mice owes to intestinal IL-4 production and inhibition of protective IFN-\u03b3"],"prefix":"10.1016","volume":"1","author":[{"given":"X","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S E","family":"Stroup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E R","family":"Houpt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2007.18_bib1","first-page":"97","article-title":"Amoebiasis","volume":"72","author":"WHO","year":"1997","journal-title":"WHO Weekly Epidemiologic Record"},{"key":"10.1038\/mi.2007.18_bib2","first-page":"669","article-title":"A longitudinal study of asymptomatic carriers of pathogenic zymodemes of Entamoeba histolytica","volume":"72","author":"Gathiram","year":"1987","journal-title":"S. Afr. Med. J."},{"key":"10.1038\/mi.2007.18_bib3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/IAI.68.1.400-402.2000","article-title":"Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease","volume":"68","author":"Seydel","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2007.18_bib4","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1128\/iai.57.6.1750-1756.1989","article-title":"Cytokine activation of murine macrophages for in vitro killing of Entamoeba histolytica trophozoites","volume":"57","author":"Denis","year":"1989","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2007.18_bib5","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1128\/iai.62.5.1534-1541.1994","article-title":"Tumor necrosis factor alpha augments nitric oxide-dependent macrophage cytotoxicity against Entamoeba histolytica by enhanced expression of the nitric oxide synthase gene","volume":"62","author":"Lin","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2007.18_bib6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1128\/IAI.74.1.118-124.2006","article-title":"Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease","volume":"74","author":"Lotter","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2007.18_bib7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4269\/ajtmh.2007.76.340","article-title":"Correlation of interferon-gamma production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis","volume":"76","author":"Haque","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1038\/mi.2007.18_bib8","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.4049\/jimmunol.177.2.1208","article-title":"Resistance of C57BL\/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production","volume":"177","author":"Hamano","year":"2006","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib9","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.4049\/jimmunol.169.8.4496","article-title":"The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells","volume":"169","author":"Houpt","year":"2002","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib10","doi-asserted-by":"crossref","first-page":"4522","DOI":"10.1128\/IAI.73.8.4522-4529.2005","article-title":"Resistance to intestinal Entamoeba histolytica infection is conferred by innate immunity and Gr-1+ cells","volume":"73","author":"Asgharpour","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2007.18_bib11","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.4049\/jimmunol.160.11.5347","article-title":"Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase\/arginase balance: competitive regulation by CD4+T cells correlates with TH1\/TH2 phenotype","volume":"160","author":"Munder","year":"1998","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1084\/jem.187.3.307","article-title":"Endogenous interleukin 4 is required for development of protective CD4+T helper type 1 cell responses to Candida albicans","volume":"187","author":"Mencacci","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2007.18_bib13","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1002\/eji.1830231147","article-title":"Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo","volume":"23","author":"Powrie","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/mi.2007.18_bib14","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.4049\/jimmunol.145.11.3796","article-title":"IL-4 directs the development of Th2-like helper effectors","volume":"145","author":"Swain","year":"1990","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib15","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1084\/jem.176.4.1091","article-title":"The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+T cells from T cell receptor transgenic mice","volume":"176","author":"Seder","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2007.18_bib16","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.4049\/jimmunol.159.11.5474","article-title":"IL-4-induced STAT6 suppresses IFN-\u03b3-stimulated STAT1-dependent transcription in mouse macrophages","volume":"159","author":"Ohmori","year":"1997","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib17","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1074-7613(00)80671-8","article-title":"Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism","volume":"9","author":"Ouyang","year":"1998","journal-title":"Immunity"},{"key":"10.1038\/mi.2007.18_bib18","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/clim.1999.4718","article-title":"GATA-3 significantly downregulates IFN-\u03b3 production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels","volume":"91","author":"Ferber","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1038\/mi.2007.18_bib19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1084\/jem.185.5.817","article-title":"Regulation of the interleukin (IL)-12R \u03b22 subunit expression in developing T helper 1 (Th1) and Th2 cells","volume":"185","author":"Szabo","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2007.18_bib20","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1002\/eji.200636290","article-title":"NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion","volume":"36","author":"Morandi","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/mi.2007.18_bib21","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jhep.2006.05.018","article-title":"Interferon-gamma produced by interleukin-12-activated tumor infiltrating CD8+T cells directly induces apoptosis of mouse hepatocellular carcinoma","volume":"45","author":"Komita","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1038\/mi.2007.18_bib22","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1002\/eji.200636889","article-title":"Gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malaria","volume":"37","author":"D'Ombrain","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/mi.2007.18_bib23","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1128\/iai.65.8.3074-3079.1997","article-title":"Gut intraepithelial lymphocytes induce immunity against Cryptosporidium infection through a mechanism involving gamma interferon production","volume":"65","author":"Culshaw","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2007.18_bib24","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.120.3.785","article-title":"Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion","volume":"120","author":"Colgan","year":"1993","journal-title":"J. Cell. Biol."},{"key":"10.1038\/mi.2007.18_bib25","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1128\/IAI.01375-06","article-title":"An increase in epithelial cell apoptosis is associated with chronic intestinal nematode infection","volume":"75","author":"Cliffe","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2007.18_bib26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/expr.1999.4407","article-title":"Trichuris muris: host intestinal epithelial cell hyperproliferation during chronic infection is regulated by interferon gamma","volume":"92","author":"Artis","year":"1999","journal-title":"Exp. Parasitol."},{"key":"10.1038\/mi.2007.18_bib27","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.4049\/jimmunol.150.6.2356","article-title":"IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding","volume":"150","author":"Adams","year":"1993","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib28","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1365-3083.2003.01342.x","article-title":"Interferon-gamma tempers the expression of carcinoembryonic antigen family molecules in human colon cells: a possible role in innate mucosal defence","volume":"58","author":"Fahlgren","year":"2003","journal-title":"Scand. J. Immunol."},{"key":"10.1038\/mi.2007.18_bib29","doi-asserted-by":"crossref","first-page":"C433","DOI":"10.1152\/ajpcell.00135.2005","article-title":"Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells","volume":"290","author":"Kuwano","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1038\/mi.2007.18_bib30","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.4049\/jimmunol.148.12.3999","article-title":"Macrophage cytotoxicity against Entamoeba histolytica trophozoites is mediated by nitric oxide from L-arginine","volume":"148","author":"Lin","year":"1992","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4049\/jimmunol.159.1.7","article-title":"IL-4 secretion by CD4+NK1+T cells induces monocyte chemoattractant protein-1 in early listeriosis","volume":"159","author":"Flesch","year":"1997","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.4049\/jimmunol.162.2.1003","article-title":"Activated eosinophils are the major source of Th2-associated cytokines in the schistosome granuloma","volume":"162","author":"Rumbley","year":"1999","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0952-7915(95)80094-8","article-title":"Induction of Th2 responses in infectious diseases","volume":"7","author":"Pearce","year":"1995","journal-title":"Curr. Opin. Immunol."},{"key":"10.1038\/mi.2007.18_bib34","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.4049\/jimmunol.165.7.3620","article-title":"Conventional, naive CD4+T cells provide an initial source of IL-4 during Th2 differentiation","volume":"165","author":"Noben-Trauth","year":"2000","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib35","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1084\/jem.168.5.1675","article-title":"Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens","volume":"168","author":"Scott","year":"1988","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2007.18_bib36","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.146.4.1322","article-title":"Egg deposition is the major stimulus for the production of Th2 cytokines in murine Schistosomiasis mansoni","volume":"146","author":"Grzych","year":"1991","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1084\/jem.173.1.159","article-title":"Downregulation of TH1 cytokine production accompanies induction of TH2 responses by a parasitic helminth, Schistosoma mansoni","volume":"173","author":"Pearce","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2007.18_bib38","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4049\/jimmunol.167.1.442","article-title":"Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing TH2-type response","volume":"167","author":"Okano","year":"2001","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib39","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.179.2.1080","article-title":"TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells","volume":"179","author":"Kato","year":"2007","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2007.18_bib40","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/eji.200324680","article-title":"Interleukin-5 participates in the pathogenesis of ileitis in SAMP1\/Yit mice","volume":"34","author":"Takedatsu","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/mi.2007.18_bib41","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1074-7613(02)00453-3","article-title":"Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells","volume":"17","author":"Heller","year":"2002","journal-title":"Immunity"},{"key":"10.1038\/mi.2007.18_bib42","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.micinf.2005.09.006","article-title":"Induction of chronic colitis in IL-10 deficient mice requires IL-4","volume":"8","author":"Spechta","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1038\/mi.2007.18_bib43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/MOG.0b013e3281c55eb2","article-title":"Immunopathogenesis of inflammatory bowel disease: current concepts","volume":"23","author":"Bamias","year":"2007","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1038\/mi.2007.18_bib44","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1084\/jem.20061082","article-title":"IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis","volume":"203","author":"Kullberg","year":"2006","journal-title":"J. Exp. Med."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi200718.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi200718","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922016646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922016646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi200718.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:29:16Z","timestamp":1761830956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922016646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S1933021922016646"],"URL":"https:\/\/doi.org\/10.1038\/mi.2007.18","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistence of Entamoeba histolytica infection in CBA mice owes to intestinal IL-4 production and inhibition of protective IFN-\u03b3","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2007.18","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/mi.2007.21","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}