{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:01:02Z","timestamp":1791036062311,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":4593,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1038\/mi.2009.16","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T10:02:29Z","timestamp":1240999349000},"page":"331-339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Cholera toxin B suppresses allergic inflammation through induction of secretory IgA"],"prefix":"10.1016","volume":"2","author":[{"given":"H H","family":"Smits","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A K","family":"Gloudemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"van Nimwegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Willart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Soulli\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Muskens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pilette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F-E","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H C","family":"Hoogsteden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B N","family":"Lambrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2009.16_bib1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/eji.200322919","article-title":"IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy","volume":"33,","author":"Jutel","year":"2003","journal-title":"Eur. J. Immunol"},{"key":"10.1038\/mi.2009.16_bib2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1399-3038.2007.00527.x","article-title":"Comparison of Der p1-specific antibody levels in children with allergic airway disease and healthy controls","volume":"18,","author":"Aydogan","year":"2007","journal-title":"Pediatr. Allergy Immunol"},{"key":"10.1038\/mi.2009.16_bib3","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/eji.1830200717","article-title":"Comparison of diversity and function of house dust mite-specific T lymphocyte clones from atopic and non-atopic donors","volume":"20,","author":"Wierenga","year":"1990","journal-title":"Eur. J. Immunol"},{"key":"10.1038\/mi.2009.16_bib4","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0140-6736(04)15592-X","article-title":"Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease","volume":"363,","author":"Ling","year":"2004","journal-title":"Lancet"},{"key":"10.1038\/mi.2009.16_bib5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1398-9995.2004.00587.x","article-title":"Genes of tolerance","volume":"59,","author":"Akdis","year":"2004","journal-title":"Allergy"},{"key":"10.1038\/mi.2009.16_bib6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ni0802-715","article-title":"Asthma: an epidemic of dysregulated immunity","volume":"3,","author":"Umetsu","year":"2002","journal-title":"Nat. Immunol"},{"key":"10.1038\/mi.2009.16_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nri2275","article-title":"Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma","volume":"8,","author":"Hammad","year":"2008","journal-title":"Nat. Rev. Immunol"},{"key":"10.1038\/mi.2009.16_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0369-8114(03)00099-3","article-title":"Regulation of dendritic cell function by microbial stimuli","volume":"51,","author":"Reis e Sousa Diebold","year":"2003","journal-title":"Pathol. Biol. (Paris)"},{"key":"10.1038\/mi.2009.16_bib9","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.4049\/jimmunol.170.3.1586","article-title":"Transcutaneous immunization with cholera toxin B subunit adjuvant suppresses IgE antibody responses via selective induction of Th1 immune responses","volume":"170,","author":"Anjuere","year":"2003","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2009.16_bib10","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.4049\/jimmunol.173.8.5103","article-title":"In vivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera toxin","volume":"173,","author":"Anjuere","year":"2004","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2009.16_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.imlet.2004.12.008","article-title":"From toxin to adjuvant: basic mechanisms for the control of mucosal IgA immunity and tolerance","volume":"97,","author":"Lycke","year":"2005","journal-title":"Immunol. Lett"},{"key":"10.1038\/mi.2009.16_bib12","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1038\/nm1213","article-title":"Mucosal immunity and vaccines","volume":"11,","author":"Holmgren","year":"2005","journal-title":"Nat. Med"},{"key":"10.1038\/mi.2009.16_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-3083.2006.01823.x","article-title":"Sublingual tolerance induction with antigen conjugated to cholera toxin B subunit induces Foxp3+CD25+CD4+ regulatory T cells and suppresses delayed-type hypersensitivity reactions","volume":"64,","author":"Sun","year":"2006","journal-title":"Scand. J. Immunol"},{"key":"10.1038\/mi.2009.16_bib14","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.4049\/jimmunol.177.11.7634","article-title":"Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-","volume":"177,","author":"Sun","year":"2006","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2009.16_bib15","doi-asserted-by":"crossref","first-page":"10795","DOI":"10.1073\/pnas.91.23.10795","article-title":"Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance","volume":"91,","author":"Sun","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2009.16_bib16","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/intimm\/11.10.1717","article-title":"Suppressive versus stimulatory effects of allergen\/cholera toxoid (CTB) conjugates depending on the nature of the allergen in a murine model of type I allergy","volume":"11,","author":"Wiedermann","year":"1999","journal-title":"Int. Immunol"},{"key":"10.1038\/mi.2009.16_bib17","doi-asserted-by":"crossref","first-page":"8395","DOI":"10.1016\/j.vaccine.2007.10.003","article-title":"Use of a genetic cholera toxin B subunit\/allergen fusion molecule as mucosal delivery system with immunosuppressive activity against Th2 immune responses","volume":"25,","author":"Bublin","year":"2007","journal-title":"Vaccine"},{"key":"10.1038\/mi.2009.16_bib18","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.4049\/jimmunol.171.5.2384","article-title":"Cholera toxin promotes the induction of regulatory T cells specific for bystander antigens by modulating dendritic cell activation","volume":"171,","author":"Lavelle","year":"2003","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2009.16_bib19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.imlet.2004.11.009","article-title":"Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA","volume":"97,","author":"Holmgren","year":"2005","journal-title":"Immunol. Lett"},{"key":"10.1038\/mi.2009.16_bib20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1172\/JCI8107","article-title":"Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation","volume":"106,","author":"Lambrecht","year":"2000","journal-title":"J. Clin. Invest"},{"key":"10.1038\/mi.2009.16_bib21","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.4049\/jimmunol.160.3.1198","article-title":"Cholera toxin and cholera toxin B subunit induce IgA switching through the action of TGF-beta 1","volume":"160,","author":"Kim","year":"1998","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2009.16_bib22","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1132742","article-title":"Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells","volume":"314,","author":"Mora","year":"2006","journal-title":"Science"},{"key":"10.1038\/mi.2009.16_bib23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1164\/ajrccm.158.2.9801014","article-title":"Antigen-specific immunoglobulin-A prevents increased airway responsiveness and lung eosinophilia after airway challenge in sensitized mice","volume":"158,","author":"Schwarze","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1038\/mi.2009.16_bib24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.190.7.915","article-title":"Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor\/secretory component-deficient mice","volume":"190,","author":"Johansen","year":"1999","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2009.16_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1084\/jem.20040035","article-title":"Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen","volume":"200,","author":"de Heer","year":"2004","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2009.16_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/mi.2007.7","article-title":"Cholera toxin, E. coli heat-labile toxin, non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer\u2032s patches","volume":"1,","author":"Anosova","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1038\/mi.2009.16_bib27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/bj2710285","article-title":"The structure and function of human IgA","volume":"271,","author":"Kerr","year":"1990","journal-title":"Biochem. J"},{"key":"10.1038\/mi.2009.16_bib28","doi-asserted-by":"crossref","first-page":"781S","DOI":"10.1093\/jn\/137.3.781S","article-title":"Cross-talk between probiotic bacteria and the host immune system","volume":"137,","author":"Corthesy","year":"2007","journal-title":"J. Nutr"},{"key":"10.1038\/mi.2009.16_bib29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1513\/pats.2306032","article-title":"Mucosal immunity in asthma and chronic obstructive pulmonary disease: a role for immunoglobulin A?","volume":"1,","author":"Pilette","year":"2004","journal-title":"Proc. Am. Thorac. Soc"},{"key":"10.1038\/mi.2009.16_bib30","first-page":"15","article-title":"IgA deficiency","volume":"3,","author":"Schaffer","year":"1991","journal-title":"Immunodefic. Rev"},{"key":"10.1038\/mi.2009.16_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0091-6749(98)70392-6","article-title":"Ragweed-specific antibodies in bronchoalveolar lavage fluids and serum before and after segmental lung challenge: IgE and IgA associated with eosinophil degranulation","volume":"101,","author":"Peebles","year":"1998","journal-title":"J. Allergy Clin. Immunol"},{"key":"10.1038\/mi.2009.16_bib32","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.4049\/jimmunol.178.7.4658","article-title":"Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-beta expression","volume":"178,","author":"Pilette","year":"2007","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2009.16_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1399-3038.2006.00489.x","article-title":"Casein-specific immunoglobulins in cow\u2032s milk allergic patient subgroups reveal a shift to IgA dominance in tolerant patients","volume":"18,","author":"Sletten","year":"2007","journal-title":"Pediatr. Allergy Immunol"},{"key":"10.1038\/mi.2009.16_bib34","first-page":"31","article-title":"Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM","volume":"22,","author":"Pasquier","year":"2005","journal-title":"Immunity"},{"key":"10.1038\/mi.2009.16_bib35","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1084\/jem.20042311","article-title":"In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma","volume":"201,","author":"van Rijt","year":"2005","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2009.16_bib36","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1172\/JCI28295","article-title":"Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function","volume":"116,","author":"Idzko","year":"2006","journal-title":"J. Clin. Invest"},{"key":"10.1038\/mi.2009.16_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jim.2004.03.004","article-title":"A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma","volume":"288,","author":"van Rijt","year":"2004","journal-title":"J. Immunol. Methods"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi200916.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi200916","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922015513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922015513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi200916.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:28:50Z","timestamp":1761830930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922015513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S1933021922015513"],"URL":"https:\/\/doi.org\/10.1038\/mi.2009.16","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholera toxin B suppresses allergic inflammation through induction of secretory IgA","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2009.16","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/mi.2009.88","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}