{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:15:02Z","timestamp":1790403302289,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":3924,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1038\/mi.2010.75","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T11:16:03Z","timestamp":1289387763000},"page":"304-313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Immunoregulatory mechanisms of macrophage PPAR-\u03b3 in mice with experimental inflammatory bowel disease"],"prefix":"10.1016","volume":"4","author":[{"given":"R","family":"Hontecillas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W T","family":"Horne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Climent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Guri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B W","family":"Sobral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bassaganya-Riera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2010.75_bib1","first-page":"81","article-title":"The state of the art in the management of inflammatory bowel disease","volume":"3,","author":"Hanauer","year":"2003","journal-title":"Rev. Gastroenterol. Disord"},{"key":"10.1038\/mi.2010.75_bib2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1053\/j.gastro.2004.06.049","article-title":"Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease","volume":"127,","author":"Bassaganya-Riera","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1038\/mi.2010.75_bib3","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/ibd.20765","article-title":"PPARgamma agonists as a new class of effective treatment for ulcerative colitis","volume":"15,","author":"Desreumaux","year":"2009","journal-title":"Inflamm. Bowel. Dis"},{"key":"10.1038\/mi.2010.75_bib4","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1053\/j.gastro.2007.12.012","article-title":"Rosiglitazone for active ulcerative colitis: a randomized placebo-controlled trial","volume":"134,","author":"Lewis","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1038\/mi.2010.75_bib5","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1345\/aph.1E072","article-title":"Second-generation thiazolidinediones and hepatotoxicity","volume":"38,","author":"Marcy","year":"2004","journal-title":"Ann. Pharmacother"},{"key":"10.1038\/mi.2010.75_bib6","first-page":"649","article-title":"Peroxisome proliferator-activated receptors: nuclear control of metabolism","volume":"20,","author":"Desvergne","year":"1999","journal-title":"Endocr. Rev"},{"key":"10.1038\/mi.2010.75_bib7","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1093\/jn\/133.10.3204","article-title":"Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression","volume":"133,","author":"Bassaganya-Riera","year":"2003","journal-title":"J. Nutr"},{"key":"10.1038\/mi.2010.75_bib8","doi-asserted-by":"crossref","unstructured":"Guri, A.J., Hontecillas, R. & Bassaganya-Riera, J. Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration. Clin. Nutr. e-pub ahead of print 15 March 2010.","DOI":"10.1016\/j.clnu.2010.02.009"},{"key":"10.1038\/mi.2010.75_bib9","doi-asserted-by":"crossref","unstructured":"Guri, A.J., Evans, N.P., Hontecillas, R. & Bassaganya-Riera, J. T cell PPAR gamma is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD. J. Nutr. Biochem. (in press) (2010).","DOI":"10.1016\/j.jnutbio.2010.06.011"},{"key":"10.1038\/mi.2010.75_bib10","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/jn\/132.7.2019","article-title":"Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid","volume":"132,","author":"Hontecillas","year":"2002","journal-title":"J. Nutr"},{"key":"10.1038\/mi.2010.75_bib11","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.clnu.2005.12.008","article-title":"CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD","volume":"25,","author":"Bassaganya-Riera","year":"2006","journal-title":"Clin. Nutr"},{"key":"10.1038\/mi.2010.75_bib12","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.4049\/jimmunol.178.5.2940","article-title":"Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis","volume":"178,","author":"Hontecillas","year":"2007","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2010.75_bib13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3945\/jn.109.115642","article-title":"Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma","volume":"140,","author":"Evans","year":"2010","journal-title":"J. Nutr"},{"key":"10.1038\/mi.2010.75_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-230X-10-60","article-title":"The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease","volume":"10,","author":"Guri","year":"2010","journal-title":"BMC Gastroenterol"},{"key":"10.1038\/mi.2010.75_bib15","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/gut.2005.081745","article-title":"Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease","volume":"55,","author":"Adachi","year":"2006","journal-title":"Gut"},{"key":"10.1038\/mi.2010.75_bib16","doi-asserted-by":"crossref","first-page":"e10215","DOI":"10.1371\/journal.pone.0010215","article-title":"Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease","volume":"5,","author":"Mohapatra","year":"2010","journal-title":"PLoS One"},{"key":"10.1038\/mi.2010.75_bib17","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.jtbi.2010.03.027","article-title":"Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease","volume":"264,","author":"Wendelsdorf","year":"2010","journal-title":"J. Theor. Biol"},{"key":"10.1038\/mi.2010.75_bib18","doi-asserted-by":"crossref","first-page":"G657","DOI":"10.1152\/ajpgi.00381.2006","article-title":"Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis","volume":"292,","author":"Shah","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"10.1038\/mi.2010.75_bib19","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1126\/science.7973709","article-title":"Modulation of epithelial cell growth by intraepithelial gamma delta T cells","volume":"266,","author":"Boismenu","year":"1994","journal-title":"Science"},{"key":"10.1038\/mi.2010.75_bib20","first-page":"569","article-title":"Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease","volume":"13,","author":"Bassaganya-Riera","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1038\/mi.2010.75_bib21","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1053\/j.gastro.2006.12.027","article-title":"CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon","volume":"132,","author":"Vowinkel","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1038\/mi.2010.75_bib22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1462-5822.2005.00629.x","article-title":"Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides","volume":"8,","author":"Lapaque","year":"2006","journal-title":"Cell. Microbiol"},{"key":"10.1038\/mi.2010.75_bib23","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0016-5085(03)00271-3","article-title":"Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis","volume":"124,","author":"Dubuquoy","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1038\/mi.2010.75_bib24","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nature05894","article-title":"Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance","volume":"447,","author":"Odegaard","year":"2007","journal-title":"Nature"},{"key":"10.1038\/mi.2010.75_bib25","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nature03988","article-title":"A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma","volume":"437,","author":"Pascual","year":"2005","journal-title":"Nature"},{"key":"10.1038\/mi.2010.75_bib26","doi-asserted-by":"crossref","first-page":"7614","DOI":"10.1073\/pnas.95.13.7614","article-title":"Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein","volume":"95,","author":"Ricote","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2010.75_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation","volume":"391,","author":"Ricote","year":"1998","journal-title":"Nature"},{"key":"10.1038\/mi.2010.75_bib28","first-page":"3323","article-title":"An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis","volume":"96,","author":"Lewis","year":"2001","journal-title":"Am. J. Gastroenterol"},{"key":"10.1038\/mi.2010.75_bib29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijdevneu.2008.01.009","article-title":"Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats","volume":"26,","author":"Sun","year":"2008","journal-title":"Int. J. Dev. Neurosci"},{"key":"10.1038\/mi.2010.75_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1089\/hum.2007.0142","article-title":"Peroxisome proliferator-activated receptor-gamma1 gene therapy attenuates atherosclerosis and stabilizes plaques in apolipoprotein E-deficient mice","volume":"19,","author":"Hu","year":"2008","journal-title":"Hum. Gene Ther"},{"key":"10.1038\/mi.2010.75_bib31","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1159\/000094735","article-title":"Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2)","volume":"26,","author":"Zhang","year":"2006","journal-title":"Am. J. Nephrol"},{"key":"10.1038\/mi.2010.75_bib32","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.4049\/jimmunol.163.7.4049","article-title":"Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production","volume":"163,","author":"Liu","year":"1999","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2010.75_bib33","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1111\/j.1572-0241.1999.01538.x","article-title":"Expression of CD40 and its ligand, CD40L, in intestinal lesions of Crohn's disease","volume":"94,","author":"Battaglia","year":"1999","journal-title":"Am. J. Gastroenterol"},{"key":"10.1038\/mi.2010.75_bib34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00042737-200203000-00006","article-title":"The role of CD40 in ulcerative colitis: histochemical analysis and clinical correlation","volume":"14,","author":"Polese","year":"2002","journal-title":"Eur. J. Gastroenterol. Hepatol"},{"key":"10.1038\/mi.2010.75_bib35","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/01.mib.0000234135.43336.72","article-title":"The proportion of CD40+ mucosal macrophages is increased in inflammatory bowel disease whereas CD40 ligand (CD154)+ T cells are relatively decreased, suggesting differential modulation of these costimulatory molecules in human gut lamina propria","volume":"12,","author":"Carlsen","year":"2006","journal-title":"Inflamm. Bowel. Dis"},{"key":"10.1038\/mi.2010.75_bib36","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.2353\/ajpath.2010.090461","article-title":"The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease","volume":"176,","author":"Borcherding","year":"2010","journal-title":"Am. J. Pathol"},{"key":"10.1038\/mi.2010.75_bib37","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cyto.2004.12.019","article-title":"Mouse genetic background influences severity of immune responses following trauma-hemorrhage","volume":"30,","author":"Matsutani","year":"2005","journal-title":"Cytokine"},{"key":"10.1038\/mi.2010.75_bib38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cellimm.2009.04.003","article-title":"PPAR gamma is highly expressed in F4\/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation","volume":"258,","author":"Bassaganya-Riera","year":"2009","journal-title":"Cell. Immunol"},{"key":"10.1038\/mi.2010.75_bib39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy\u2014analysis of Affymetrix GeneChip data at the probe level","volume":"20,","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1038\/mi.2010.75_bib40","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5,","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"10.1038\/mi.2010.75_bib41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/eji.200838391","article-title":"Phenotype and function of neonatal DC","volume":"39,","author":"Willems","year":"2009","journal-title":"Eur. J. Immunol"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201075","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922013885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922013885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:25:45Z","timestamp":1761830745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922013885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S1933021922013885"],"URL":"https:\/\/doi.org\/10.1038\/mi.2010.75","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoregulatory mechanisms of macrophage PPAR-\u03b3 in mice with experimental inflammatory bowel disease","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2010.75","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}