{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:23:26Z","timestamp":1791181406969,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T00:00:00Z","timestamp":1314748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1038\/mi.2011.34","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T14:31:26Z","timestamp":1314801086000},"page":"671-681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Enhanced HIV-1 replication in ex vivo ectocervical tissues from post-menopausal women correlates with increased inflammatory responses"],"prefix":"10.1016","volume":"4","author":[{"given":"C","family":"Rollenhagen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S N","family":"Asin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2011.34_bib1","unstructured":"UNAIDS\/WHO. Report on Global AIDS Epidemic ( UNAIDS, Geneva, 2008 )."},{"key":"10.1038\/mi.2011.34_bib2","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1097\/00002030-199611000-00019","article-title":"Age of wife as a major determinant of male-to-female transmission of HIV-2 infection: a community study from rural West Africa","volume":"10,","author":"Aaby","year":"1996","journal-title":"AIDS"},{"key":"10.1038\/mi.2011.34_bib3","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/bmj.304.6830.809","article-title":"Comparison of female-to-male and male-to-female transmission of HIV in 563 stable couples","volume":"304,","author":"European Study Group on Heterosexual transmission of HIV","year":"1992","journal-title":"Br. Med. J"},{"key":"10.1038\/mi.2011.34_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1210\/er.2009-0018","article-title":"Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection","volume":"31,","author":"Hel","year":"2010","journal-title":"Endocr. Rev"},{"key":"10.1038\/mi.2011.34_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2007-0001","article-title":"The complex role of estrogens in inflammation","volume":"28,","author":"Straub","year":"2007","journal-title":"Endocr. Rev"},{"key":"10.1038\/mi.2011.34_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0165-5728(02)00016-4","article-title":"Regulatory effects of estriol on T cell migration and cytokine profile: inhibition of transcription factor NF-kappa B","volume":"124,","author":"Zang","year":"2002","journal-title":"J. Neuroimmunol"},{"key":"10.1038\/mi.2011.34_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/rmv.369","article-title":"The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages","volume":"13,","author":"Kedzierska","year":"2003","journal-title":"Rev. Med. Virol"},{"key":"10.1038\/mi.2011.34_bib8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2174\/138955705774933383","article-title":"Modulation of HIV-1 transcription by cytokines and chemokines","volume":"5,","author":"Copeland","year":"2005","journal-title":"Mini Rev. Med. Chem"},{"key":"10.1038\/mi.2011.34_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2174\/1570162054368057","article-title":"HIV and inflammation","volume":"3,","author":"Decrion","year":"2005","journal-title":"Curr. HIV Res"},{"key":"10.1038\/mi.2011.34_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4690-6-118","article-title":"Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage","volume":"6,","author":"Kilareski","year":"2009","journal-title":"Retrovirology"},{"key":"10.1038\/mi.2011.34_bib11","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1128\/JVI.01844-08","article-title":"Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection in contrast to more modest and delayed responses in acute hepatitis B and C virus infection","volume":"83,","author":"Stacey","year":"2009","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1089\/aid.2006.22.757","article-title":"Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV type 1 infection","volume":"22,","author":"Norris","year":"2006","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1038\/mi.2011.34_bib13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1086\/520935","article-title":"Elevated serum levels of Interferon-gamma-inducible-protein-10 in patients co-infected with hepatitis C virus and HIV","volume":"196,","author":"Roe","year":"2007","journal-title":"J. Infect. Dis"},{"key":"10.1038\/mi.2011.34_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/157016209787048537","article-title":"Multiple roles for chemokines in the pathogenesis of SIV infection","volume":"7,","author":"Reinhart","year":"2009","journal-title":"Curr. HIV Res"},{"key":"10.1038\/mi.2011.34_bib15","doi-asserted-by":"crossref","first-page":"12164","DOI":"10.1128\/JVI.79.19.12164-12172.2005","article-title":"Temporal and anatomic relationship between virus replication and cytokine gene expression after vaginal simian immunodeficiency virus infection","volume":"79,","author":"Abel","year":"2005","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib16","doi-asserted-by":"crossref","first-page":"14355","DOI":"10.1128\/JVI.79.22.14355-14370.2005","article-title":"The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques","volume":"79,","author":"Wang","year":"2005","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib17","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1172\/JCI23006","article-title":"Anti-inflammatory profiles during primary HIV infection in African green monkeys are associated with protection against AIDS","volume":"115,","author":"Kornfeld","year":"2005","journal-title":"J. Clin. Invest"},{"key":"10.1038\/mi.2011.34_bib18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S1074-7613(03)00060-8","article-title":"Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia","volume":"18,","author":"Silvestri","year":"2003","journal-title":"Immunity"},{"key":"10.1038\/mi.2011.34_bib19","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1182\/blood-2002-06-1644","article-title":"Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers and T cell turnover in different organs of rhesus monkeys","volume":"101,","author":"Sopper","year":"2003","journal-title":"Blood"},{"key":"10.1038\/mi.2011.34_bib20","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1086\/590503","article-title":"Relationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection","volume":"198,","author":"Bebell","year":"2008","journal-title":"J. Infect. Dis"},{"key":"10.1038\/mi.2011.34_bib21","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1128\/JVI.00182-09","article-title":"HIV-1-specific CD8+ T cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells","volume":"83,","author":"Streeck","year":"2009","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157016208783572008","article-title":"Human immunodeficiency virus interactions with CD8+ T lymphocytes","volume":"6,","author":"Saksena","year":"2008","journal-title":"Curr. HIV Res"},{"key":"10.1038\/mi.2011.34_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11904-006-0006-1","article-title":"Studies of HIV-associated immune responses in lymphoid compartments","volume":"3,","author":"Grundstr\u00f6m","year":"2006","journal-title":"Curr. HIV\/AIDS Rep"},{"key":"10.1038\/mi.2011.34_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/COH.0b013e3282f310ae","article-title":"Antibody responses in primary HIV-1 infection","volume":"3,","author":"Frost","year":"2008","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1038\/mi.2011.34_bib25","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1128\/JVI.79.14.9228-9235.2005","article-title":"CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: too late and too little","volume":"79,","author":"Reynolds","year":"2005","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib26","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1128\/JVI.00183-08","article-title":"Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection","volume":"82,","author":"Gumbi","year":"2008","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib27","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1086\/605412","article-title":"HIV-1 in women: increased transcription of HIV-1 in ectocervical tissue explants","volume":"200,","author":"Asin","year":"2009","journal-title":"J. Infect. Dis"},{"key":"10.1038\/mi.2011.34_bib28","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1,","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"10.1038\/mi.2011.34_bib29","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/infdis\/jiq085","article-title":"Sex, race, and geographic region influence clinical outcomes following primary HIV-1 infection","volume":"203,","author":"Meditz","year":"2011","journal-title":"J. Infect. Dis"},{"key":"10.1038\/mi.2011.34_bib30","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1086\/600398","article-title":"Treatment responses in antiretroviral treatment-naive premenopausal and postmenopausal HIV-1-infected women: an analysis from AIDS Clinical Trials Group Studies","volume":"49,","author":"Patterson","year":"2009","journal-title":"Clin. Infect. Dis"},{"key":"10.1038\/mi.2011.34_bib31","first-page":"1","article-title":"Macrophage signaling in HIV-1 infection","volume":"7,","author":"Herbein","year":"2010","journal-title":"Retrovirology"},{"key":"10.1038\/mi.2011.34_bib32","first-page":"992","article-title":"Secretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract","volume":"174,","author":"Fahey","year":"2005","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2011.34_bib33","first-page":"1","article-title":"Cervicovaginal shedding of HIV type 1 is related to genital tract inflammation independent of changes in vaginal microbiota","volume":"26,","author":"Mitchell","year":"2010","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1038\/mi.2011.34_bib34","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1089\/aid.2008.0004","article-title":"Positive association between HIV RNA and IL-6 in the Genital Tract of Rwandan Women","volume":"24,","author":"Spear","year":"2008","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1038\/mi.2011.34_bib35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1086\/315713","article-title":"High levels of tumor necrosis factor-alpha and interleukin-1beta in bacterial vaginosis may increase susceptibility to human immunodeficiency virus","volume":"182,","author":"Sturm-Ramirez","year":"2000","journal-title":"J. Infect. Dis"},{"key":"10.1038\/mi.2011.34_bib36","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/intimm\/dxl078","article-title":"Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1(HIV-1) infected individuals","volume":"18,","author":"Ansari","year":"2006","journal-title":"Int. Immunol"},{"key":"10.1038\/mi.2011.34_bib37","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1128\/JVI.75.13.5812-5822.2001","article-title":"Human immunodeficiency virus type 1 (HIV-1)-induced GRO-alpha production stimulates HIV-1 replication in macrophages and T lymphocytes","volume":"75,","author":"Lane","year":"2001","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib38","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/QAI.0b013e3181e5e12c","article-title":"IL-8 decreases HIV-1 transcription in peripheral blood lymphocytes and ectocervical tissue explants","volume":"54,","author":"Rollenhagen","year":"2010","journal-title":"J. Acquir. Immune Defic. Syndr"},{"key":"10.1038\/mi.2011.34_bib39","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/CMR.14.4.753-777.2001","article-title":"Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection","volume":"14,","author":"Lawn","year":"2001","journal-title":"Clin. Microbiol. Rev"},{"key":"10.1038\/mi.2011.34_bib40","first-page":"2","article-title":"Pathogenesis of HIV infection: total CD4+ T-cell pool, immune activation, and inflammation","volume":"18,","author":"Lane","year":"2010","journal-title":"Top HIV Med"},{"key":"10.1038\/mi.2011.34_bib41","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jri.2009.07.005","article-title":"Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection","volume":"83,","author":"Mestecky","year":"2009","journal-title":"J. Reprod. Immunol"},{"key":"10.1038\/mi.2011.34_bib42","doi-asserted-by":"crossref","first-page":"11179","DOI":"10.1128\/JVI.79.17.11179-11186.2005","article-title":"The nonnucleoside revere transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type I infection of human cervical tissue and dissemination by migratory cells","volume":"79,","author":"Fletcher","year":"2005","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib43","doi-asserted-by":"crossref","first-page":"9175","DOI":"10.1128\/JVI.00820-09","article-title":"Human immunodeficiency virus type 1 nucleocapsid inhibitors impede trans infection in cellular and explant models and protect nonhuman primates from infection","volume":"83,","author":"Wallace","year":"2009","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib44","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/aje\/153.9.865","article-title":"Factors associated with age at natural menopause in a multiethnic sample of midlife women","volume":"153,","author":"Gold","year":"2001","journal-title":"Am. J. Epidemiol"},{"key":"10.1038\/mi.2011.34_bib45","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/aje\/kwn046","article-title":"Predictors of the timing of natural menopause in the Multiethnic Cohort Study","volume":"167,","author":"Henderson","year":"2008","journal-title":"Am. J. Epidemiol"},{"key":"10.1038\/mi.2011.34_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-5122(92)90003-M","article-title":"The normal menopause transition","volume":"14,","author":"McKinlay","year":"1992","journal-title":"Maturitas"},{"key":"10.1038\/mi.2011.34_bib47","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1128\/JVI.74.12.5577-5586.2000","article-title":"Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides","volume":"74,","author":"Greenhead","year":"2000","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib48","doi-asserted-by":"crossref","first-page":"10346","DOI":"10.1128\/JVI.73.12.10346-10358.1999","article-title":"Use of a gp120 binding assay to dissect the requirements and kinetics of human immunodeficiency virus fusion events","volume":"73,","author":"Doranz","year":"1999","journal-title":"J. Virol"},{"key":"10.1038\/mi.2011.34_bib49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.antiviral.2005.03.007","article-title":"Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)","volume":"67,","author":"Polianova","year":"2005","journal-title":"Antiviral Res"},{"key":"10.1038\/mi.2011.34_bib50","first-page":"139","article-title":"Alu-LTR real -time nested PCR assay for quantifying integrated HIV-1 DNA","volume":"304,","author":"Brussel","year":"2005","journal-title":"Methods Mol. Biol"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201134","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922014337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922014337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:26:52Z","timestamp":1761830812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922014337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S1933021922014337"],"URL":"https:\/\/doi.org\/10.1038\/mi.2011.34","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced HIV-1 replication in ex vivo ectocervical tissues from post-menopausal women correlates with increased inflammatory responses","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2011.34","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/mi.2011.43","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}