{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:53:39Z","timestamp":1790380419568,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T00:00:00Z","timestamp":1337731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1038\/mi.2012.35","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T11:02:46Z","timestamp":1337770966000},"page":"610-622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Role of novel type I interferon epsilon in viral infection and mucosal immunity"],"prefix":"10.1016","volume":"5","author":[{"given":"Yang","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charani","family":"Ranasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2012.35_bib1","first-page":"7","article-title":"The biology of interferon actions","volume":"56,","author":"Huber","year":"1988","journal-title":"Blut"},{"key":"10.1038\/mi.2012.35_bib2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1098\/rspb.1957.0048","article-title":"Virus interference. I. The interferon","volume":"147,","author":"Isaacs","year":"1957","journal-title":"Proc. R Soc. Lond. B Biol. Sci"},{"key":"10.1038\/mi.2012.35_bib3","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/CMR.14.4.778-809.2001","article-title":"Antiviral actions of interferons","volume":"14,","author":"Samuel","year":"2001","journal-title":"Clin. Microbiol. Rev"},{"key":"10.1038\/mi.2012.35_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/mrd.1080390216","article-title":"Role of interferons in the regulation of cell proliferation, differentiation, and development","volume":"39,","author":"Hertzog","year":"1994","journal-title":"Mol. Reprod. Dev"},{"key":"10.1038\/mi.2012.35_bib5","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1111\/j.1572-0241.1999.01300.x","article-title":"Long-term results with interferon therapy in chronic type B hepatitis: a prospective randomized trial","volume":"94,","author":"Mazzella","year":"1999","journal-title":"Am. J. Gastroenterol"},{"key":"10.1038\/mi.2012.35_bib6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/hep.1840210307","article-title":"Breakthrough during recombinant interferon alfa therapy in patients with chronic hepatitis C virus infection: prevalence, etiology, and management","volume":"21,","author":"Roffi","year":"1995","journal-title":"Hepatology"},{"key":"10.1038\/mi.2012.35_bib7","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nrd2422","article-title":"Interferons at age 50: past, current and future impact on biomedicine","volume":"6,","author":"Borden","year":"2007","journal-title":"Nat. Rev. Drug Discov"},{"key":"10.1038\/mi.2012.35_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2004.00204.x","article-title":"Interferons, interferon-like cytokines, and their receptors","volume":"202,","author":"Pestka","year":"2004","journal-title":"Immunol. Rev"},{"key":"10.1038\/mi.2012.35_bib9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.bi.56.070187.003455","article-title":"Interferons and their actions","volume":"56,","author":"Pestka","year":"1987","journal-title":"Annu. Rev. Biochem"},{"key":"10.1038\/mi.2012.35_bib10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ni875","article-title":"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex","volume":"4,","author":"Kotenko","year":"2003","journal-title":"Nat. Immunol"},{"key":"10.1038\/mi.2012.35_bib11","first-page":"51","article-title":"Potential role of interferon-lambda in the treatment of inflammation and cancer: an update International Journal of Interferon","volume":"3,","author":"Dornhoff","year":"2011","journal-title":"Cytokine Mediator Res"},{"key":"10.1038\/mi.2012.35_bib12","first-page":"71","article-title":"The receptor of the type I interferon family","volume":"316,","author":"Uze","year":"2007","journal-title":"Curr. Top Microbiol. Immunol"},{"key":"10.1038\/mi.2012.35_bib13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ygeno.2004.03.003","article-title":"Characterization of the type I interferon locus and identification of novel genes","volume":"84,","author":"Hardy","year":"2004","journal-title":"Genomics"},{"key":"10.1038\/mi.2012.35_bib14","series-title":"Genentech Inc","author":"Chen","year":"2003"},{"key":"10.1038\/mi.2012.35_bib15","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.pep.2006.12.013","article-title":"Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes","volume":"53,","author":"Peng","year":"2007","journal-title":"Protein Expr. Purif"},{"key":"10.1038\/mi.2012.35_bib16","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.4049\/jimmunol.179.7.4542","article-title":"IFN-epsilon mediates TNF-alpha-induced STAT1 phosphorylation and induction of retinoic acid-inducible gene-I in human cervical cancer cells","volume":"179,","author":"Matsumiya","year":"2007","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.35_bib17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/molehr\/gam028","article-title":"Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells","volume":"13,","author":"Sharkey","year":"2007","journal-title":"Mol. Hum. Reprod"},{"key":"10.1038\/mi.2012.35_bib18","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.4049\/jimmunol.180.11.7158","article-title":"Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy","volume":"180,","author":"Day","year":"2008","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.35_bib19","series-title":"John Curtin School of Medical Research","author":"Day","year":"2008"},{"key":"10.1038\/mi.2012.35_bib20","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1128\/CMR.14.2.430-445.2001","article-title":"Vaccination strategies for mucosal immune responses","volume":"14,","author":"Ogra","year":"2001","journal-title":"Clin. Microbiol. Rev"},{"key":"10.1038\/mi.2012.35_bib21","doi-asserted-by":"crossref","unstructured":"Wijesundara, D.K., Jackson, R.J., Ramshaw, I.A. & Ranasinghe, C. Human immunodeficiency virus-1 vaccine design: where do we go now? Immunol. Cell Biol. 89, 367\u2013374.","DOI":"10.1038\/icb.2010.118"},{"key":"10.1038\/mi.2012.35_bib22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1126\/science.280.5362.427","article-title":"Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection","volume":"280,","author":"Veazey","year":"1998","journal-title":"Science"},{"key":"10.1038\/mi.2012.35_bib23","first-page":"171","article-title":"Prime-boost strategies in DNA vaccines","volume":"127,","author":"Dale","year":"2006","journal-title":"Methods Mol. Med"},{"key":"10.1038\/mi.2012.35_bib24","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.1016\/j.vaccine.2006.06.007","article-title":"4-1BBL coexpression enhances HIV-specific CD8T cell memory in a poxvirus prime-boost vaccine","volume":"24,","author":"Harrison","year":"2006","journal-title":"Vaccine"},{"key":"10.1038\/mi.2012.35_bib25","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0264-410X(96)00238-1","article-title":"Diversified prime and boost protocols using recombinant vaccinia virus and recombinant non-replicating avian pox virus to enhance T-cell immunity and antitumor responses","volume":"15,","author":"Hodge","year":"1997","journal-title":"Vaccine"},{"key":"10.1038\/mi.2012.35_bib26","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1016\/j.vaccine.2006.04.023","article-title":"Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1","volume":"24,","author":"Ranasinghe","year":"2006","journal-title":"Vaccine"},{"key":"10.1038\/mi.2012.35_bib27","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1586\/erv.09.86","article-title":"Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity","volume":"8,","author":"Ranasinghe","year":"2009","journal-title":"Expert Rev. Vaccines"},{"key":"10.1038\/mi.2012.35_bib28","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/eji.200838995","article-title":"Immunisation route-dependent expression of IL-4\/IL-13 can modulate HIV-specific CD8(+) CTL avidity","volume":"39,","author":"Ranasinghe","year":"2009","journal-title":"Eur. J. Immunol"},{"key":"10.1038\/mi.2012.35_bib29","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.4049\/jimmunol.178.4.2370","article-title":"Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine\/granzyme B profiles","volume":"178,","author":"Ranasinghe","year":"2007","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.35_bib30","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1016\/j.vaccine.2011.01.106","article-title":"A comparative analysis of HIV-specific mucosal\/systemic T cell immunity and avidity following rDNA\/rFPV and poxvirus-poxvirus prime boost immunisations","volume":"29,","author":"Ranasinghe","year":"2011","journal-title":"Vaccine"},{"key":"10.1038\/mi.2012.35_bib31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cellimm.2008.08.007","article-title":"Relationship between CD107a expression and cytotoxic activity","volume":"254,","author":"Aktas","year":"2009","journal-title":"Cell Immunol"},{"key":"10.1038\/mi.2012.35_bib32","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1182\/blood-2003-12-4395","article-title":"Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions","volume":"104,","author":"Nascimbeni","year":"2004","journal-title":"Blood"},{"key":"10.1038\/mi.2012.35_bib33","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/eji.200535520","article-title":"Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines","volume":"36,","author":"Pahar","year":"2006","journal-title":"Eur. J. Immunol"},{"key":"10.1038\/mi.2012.35_bib34","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1086\/515674","article-title":"Persistent expansion, in a human immunodeficiency virus-infected person, of V beta-restricted CD4+CD8+ T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-gamma and tumor necrosis factor-alpha","volume":"178,","author":"Weiss","year":"1998","journal-title":"J. Infect. Dis"},{"key":"10.1038\/mi.2012.35_bib35","doi-asserted-by":"crossref","first-page":"e1294","DOI":"10.1371\/journal.pntd.0001294","article-title":"Increased CD4+\/CD8+ double-positive T cells in chronic Chagasic patients","volume":"5,","author":"Giraldo","year":"2011","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1038\/mi.2012.35_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cellimm.2009.06.011","article-title":"Peripheral CD4+CD8+cells are the activated T cells expressed granzyme B (GrB), Foxp3, interleukin 17 (IL-17), at higher levels in Th1\/Th2 cytokines","volume":"259,","author":"Xie","year":"2009","journal-title":"Cell Immunol"},{"key":"10.1038\/mi.2012.35_bib37","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1016\/j.vaccine.2005.05.032","article-title":"Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3","volume":"23,","author":"Kent","year":"2005","journal-title":"Vaccine"},{"key":"10.1038\/mi.2012.35_bib38","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.imbio.2008.01.005","article-title":"CXCR6 identifies a putative population of retained human lung T cells characterised by co-expression of activation markers","volume":"213,","author":"Morgan","year":"2008","journal-title":"Immunobiology"},{"key":"10.1038\/mi.2012.35_bib39","unstructured":"Lee, Y.T. et al. Environmental and antigen-receptor derived signals support sustained surveillance of the lungs by pathogen-specific CTL. J. Virol."},{"key":"10.1038\/mi.2012.35_bib40","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/QAI.0b013e31819aa8c4","article-title":"Phenotypic and functional characterization of HIV-1-specific CD4+CD8+ double-positive T cells in early and chronic HIV-1 infection","volume":"50,","author":"Howe","year":"2009","journal-title":"J. Acquir. Immune Defic. Syndr"},{"key":"10.1038\/mi.2012.35_bib41","doi-asserted-by":"crossref","first-page":"7633","DOI":"10.1128\/JVI.73.9.7633-7640.1999","article-title":"Respiratory mucosal immunization with reovirus serotype 1\/L stimulates virus-specific humoral and cellular immune responses, including double-positive (CD4(+)\/CD8(+)) T cells","volume":"73,","author":"Periwal","year":"1999","journal-title":"J. Virol"},{"key":"10.1038\/mi.2012.35_bib42","first-page":"500","article-title":"Functional and phenotypic analysis of porcine peripheral blood CD4\/CD8 double-positive T cells","volume":"87,","author":"Zuckermann","year":"1996","journal-title":"Immunology"},{"key":"10.1038\/mi.2012.35_bib43","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1006\/bbrc.1993.1260","article-title":"Cytofluorimetric identification of two populations of double positive (CD4+,CD8+) T lymphocytes in human peripheral blood","volume":"191,","author":"Ortolani","year":"1993","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1038\/mi.2012.35_bib44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.autrev.2003.09.001","article-title":"CD4+ CD8+ double positive (DP) T cells in health and disease","volume":"3,","author":"Parel","year":"2004","journal-title":"Autoimmun. Rev"},{"key":"10.1038\/mi.2012.35_bib45","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1128\/IAI.66.7.3290-3294.1998","article-title":"Expansion of a novel pulmonary CD3(\u2212) CD4(+) CD8(+) cell population in mice during Chlamydia pneumoniae infection","volume":"66,","author":"Penttila","year":"1998","journal-title":"Infect. Immun"},{"key":"10.1038\/mi.2012.35_bib46","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401,","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"10.1038\/mi.2012.35_bib47","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.4049\/jimmunol.181.6.4188","article-title":"Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination","volume":"181,","author":"Kaufman","year":"2008","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.35_bib48","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.4049\/jimmunol.0990002","article-title":"Comment on \u2018trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination","volume":"182,","author":"Belyakov","year":"2009","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.35_bib50","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.vaccine.2005.09.044","article-title":"Fowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials","volume":"24,","author":"Coupar","year":"2006","journal-title":"Vaccine"},{"key":"10.1038\/mi.2012.35_bib51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01378632","article-title":"Infectious bursal disease virus structural protein VP2 expressed by a fowlpox virus recombinant confers protection against disease in chickens","volume":"131,","author":"Heine","year":"1993","journal-title":"Arch. Virol"},{"key":"10.1038\/mi.2012.35_bib49","first-page":"1","article-title":"Interferon epsilon regulates reproductive tract immunity to Chlamydia infection","volume":"86,","author":"Fung","year":"2010","journal-title":"J. Reprod. Immunol. (Poster Abstracts)"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201235","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922013423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922013423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:26:02Z","timestamp":1761830762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922013423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1933021922013423"],"URL":"https:\/\/doi.org\/10.1038\/mi.2012.35","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of novel type I interferon epsilon in viral infection and mucosal immunity","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2012.35","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/mi.2012.94","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}