{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T05:25:42Z","timestamp":1793510742450,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":3374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1038\/mi.2012.38","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T08:22:27Z","timestamp":1338366147000},"page":"646-657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":192,"title":["Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection"],"prefix":"10.1016","volume":"5","author":[{"given":"N R","family":"Klatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J D","family":"Estes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Barber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L D","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Cervasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L K","family":"Yokomizo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C L","family":"Vinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Tabb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L A","family":"Canary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V M","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Belkaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J D","family":"Lifson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J D","family":"Milner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Paiardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E K","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Brenchley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2012.38_bib1","doi-asserted-by":"crossref","first-page":"e1001052","DOI":"10.1371\/journal.ppat.1001052","article-title":"Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections","volume":"6,","author":"Estes","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1038\/mi.2012.38_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/mi.2007.1","article-title":"HIV infection and the gastrointestinal immune system","volume":"1,","author":"Brenchley","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1038\/mi.2012.38_bib3","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nm1511","article-title":"Microbial translocation is a cause of systemic immune activation in chronic HIV infection","volume":"12,","author":"Brenchley","year":"2006","journal-title":"Nat. Med"},{"key":"10.1038\/mi.2012.38_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ni1316","article-title":"HIV disease: fallout from a mucosal catastrophe?","volume":"7,","author":"Brenchley","year":"2006","journal-title":"Nat. Immunol"},{"key":"10.1038\/mi.2012.38_bib5","doi-asserted-by":"crossref","first-page":"e2516","DOI":"10.1371\/journal.pone.0002516","article-title":"Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients","volume":"3,","author":"Ancuta","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1038\/mi.2012.38_bib6","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1097\/QAD.0b013e3283112d29","article-title":"Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy","volume":"22,","author":"Marchetti","year":"2008","journal-title":"AIDS"},{"key":"10.1038\/mi.2012.38_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jcv.2009.09.011","article-title":"Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50copies\/ml HIV-1 RNA","volume":"46,","author":"Baroncelli","year":"2009","journal-title":"J. Clin. Virol"},{"key":"10.1038\/mi.2012.38_bib8","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1086\/597476","article-title":"Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection","volume":"199,","author":"Jiang","year":"2009","journal-title":"J. Infect. Dis"},{"key":"10.1038\/mi.2012.38_bib9","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1182\/blood-2008-05-159301","article-title":"Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections","volume":"112,","author":"Brenchley","year":"2008","journal-title":"Blood"},{"key":"10.1038\/mi.2012.38_bib10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/mi.2008.14","article-title":"Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques","volume":"1,","author":"Cecchinato","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1038\/mi.2012.38_bib11","doi-asserted-by":"crossref","first-page":"e1000296","DOI":"10.1371\/journal.ppat.1000296","article-title":"Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization","volume":"5,","author":"Lederer","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1038\/mi.2012.38_bib12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/COH.0b013e328335c161","article-title":"Th17 cells in natural SIV hosts","volume":"5,","author":"Paiardini","year":"2010","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1038\/mi.2012.38_bib13","doi-asserted-by":"crossref","first-page":"e1000295","DOI":"10.1371\/journal.ppat.1000295","article-title":"Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection","volume":"5,","author":"Favre","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1038\/mi.2012.38_bib14","doi-asserted-by":"crossref","unstructured":"Nigam, P., Kwa, S., Velu, V. & Amara, R.R. Loss of IL-17-producing CD8T cells during late chronic stage of pathogenic SIV infection. J. Immunol. (2010).","DOI":"10.4049\/jimmunol.1002807"},{"key":"10.1038\/mi.2012.38_bib15","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.4049\/jimmunol.1001801","article-title":"Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals","volume":"185,","author":"Gordon","year":"2010","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.38_bib16","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1182\/blood-2011-04-347260","article-title":"Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection","volume":"118,","author":"Reeves","year":"2011","journal-title":"Blood"},{"key":"10.1038\/mi.2012.38_bib17","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1086\/422329","article-title":"Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice","volume":"190,","author":"Huang","year":"2004","journal-title":"J. Infect. Dis"},{"key":"10.1038\/mi.2012.38_bib18","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.4049\/jimmunol.170.4.1958","article-title":"CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism","volume":"170,","author":"Chung","year":"2003","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.38_bib19","doi-asserted-by":"crossref","first-page":"G827","DOI":"10.1152\/ajpgi.00513.2005","article-title":"IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration","volume":"290,","author":"Brand","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"10.1038\/mi.2012.38_bib20","first-page":"534","article-title":"IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis","volume":"118,","author":"Sugimoto","year":"2008","journal-title":"J. Clin. Invest"},{"key":"10.1038\/mi.2012.38_bib21","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1074\/jbc.M210429200","article-title":"Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine\/autocrine loop","volume":"278,","author":"Chen","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1038\/mi.2012.38_bib22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1084\/jem.20091509","article-title":"Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells","volume":"207,","author":"Crellin","year":"2010","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2012.38_bib23","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity","volume":"457,","author":"Cella","year":"2009","journal-title":"Nature"},{"key":"10.1038\/mi.2012.38_bib24","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.1005641107","article-title":"Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity","volume":"107,","author":"Cella","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/mi.2012.38_bib25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ni.1962","article-title":"The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling","volume":"12,","author":"Spits","year":"2010","journal-title":"Nat. Immunol"},{"key":"10.1038\/mi.2012.38_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1084\/jem.20100052","article-title":"Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells","volume":"208,","author":"Lochner","year":"2010","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2012.38_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/ni0109-11","article-title":"Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes","volume":"10,","author":"Malmberg","year":"2009","journal-title":"Nat. Immunol"},{"key":"10.1038\/mi.2012.38_bib28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.0105-2896.2009.00866.x","article-title":"Subsets of migrating intestinal dendritic cells","volume":"234,","author":"Simon","year":"2010","journal-title":"Immunol. Rev"},{"key":"10.1038\/mi.2012.38_bib29","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1084\/jem.20091844","article-title":"GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization","volume":"207,","author":"King","year":"2010","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2012.38_bib30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.0105-2896.2009.00866.x","article-title":"Subsets of migrating intestinal dendritic cells","volume":"234,","author":"Milling","year":"2010","journal-title":"Immunol. Rev"},{"key":"10.1038\/mi.2012.38_bib31","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1084\/jem.20091925","article-title":"Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions","volume":"206,","author":"Schulz","year":"2009","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2012.38_bib32","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.20070590","article-title":"A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism","volume":"204,","author":"Coombes","year":"2007","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2012.38_bib33","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1084\/jem.20080414","article-title":"Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans","volume":"205,","author":"Jaensson","year":"2008","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2012.38_bib34","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/intimm\/dxn106","article-title":"The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation","volume":"20,","author":"Annunziato","year":"2008","journal-title":"Int. Immunol"},{"key":"10.1038\/mi.2012.38_bib35","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.4049\/jimmunol.0902944","article-title":"Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid","volume":"184,","author":"Cha","year":"2010","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.38_bib36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.immuni.2011.03.003","article-title":"Essential role for retinoic acid in the promotion of CD4+ T Cell effector responses via retinoic acid receptor alpha","volume":"34,","author":"Hall","year":"2011","journal-title":"Immunity"},{"key":"10.1038\/mi.2012.38_bib37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.immuni.2004.08.011","article-title":"Retinoic acid imprints gut-homing specificity on T cells","volume":"21,","author":"Iwata","year":"2004","journal-title":"Immunity"},{"key":"10.1038\/mi.2012.38_bib38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/mi.2007.4","article-title":"Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8+ T cells","volume":"1,","author":"Svensson","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1038\/mi.2012.38_bib39","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.4049\/jimmunol.0903942","article-title":"Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine","volume":"184,","author":"Wang","year":"2010","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.38_bib40","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/mi.2010.91","article-title":"Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells","volume":"4,","author":"Jaensson-Gyllenback","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1038\/mi.2012.38_bib41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1194597","article-title":"Lineage relationship analysis of RORgammat+ innate lymphoid cells","volume":"330,","author":"Sawa","year":"2010","journal-title":"Science"},{"key":"10.1038\/mi.2012.38_bib42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/COH.0b013e3283364846","article-title":"Th17 cell dynamics in HIV infection","volume":"5,","author":"Klatt","year":"2010","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1038\/mi.2012.38_bib43","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1182\/blood-2010-01-265595","article-title":"CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection","volume":"115,","author":"Reeves","year":"2010","journal-title":"Blood"},{"key":"10.1038\/mi.2012.38_bib44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/mi.2010.14","article-title":"Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection","volume":"3,","author":"Klatt","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1038\/mi.2012.38_bib45","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2567.2011.03410.x","article-title":"Control of epithelial cell function by interleukin-22-producing RORgammat+ innate lymphoid cells","volume":"132,","author":"Sanos","year":"2011","journal-title":"Immunology"},{"key":"10.1038\/mi.2012.38_bib46","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1182\/blood.V97.1.39","article-title":"The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium","volume":"97,","author":"Haque","year":"2001","journal-title":"Blood"},{"key":"10.1038\/mi.2012.38_bib47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1196\/annals.1326.036","article-title":"CCR6 and CCL20: partners in intestinal immunity and lymphorganogenesis","volume":"1072,","author":"Williams","year":"2006","journal-title":"Ann. NY Acad. Sci"},{"key":"10.1038\/mi.2012.38_bib48","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/1044-5323(95)90014-4","article-title":"The beta 7 integrins in mucosal homing and retention","volume":"7,","author":"Shaw","year":"1995","journal-title":"Semin. Immunol"},{"key":"10.1038\/mi.2012.38_bib49","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.20091618","article-title":"OX40 is required for regulatory T cell-mediated control of colitis","volume":"207,","author":"Griseri","year":"2010","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2012.38_bib50","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.4049\/jimmunol.0901514","article-title":"The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals","volume":"183,","author":"Withers","year":"2009","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.38_bib51","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126,","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1038\/mi.2012.38_bib52","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","article-title":"Phenotypic and functional features of human Th17 cells","volume":"204,","author":"Annunziato","year":"2007","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2012.38_bib53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF02981951","article-title":"Role of Jak kinases and STATs in cytokine signal transduction","volume":"73,","author":"Leonard","year":"2001","journal-title":"Int. J. Hematol"},{"key":"10.1038\/mi.2012.38_bib54","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.1073\/pnas.101579798","article-title":"c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity","volume":"98,","author":"Pessah","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/mi.2012.38_bib55","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.4049\/jimmunol.0900986","article-title":"IDO activates regulatory T cells and blocks their conversion into Th17-like T cells","volume":"183,","author":"Baban","year":"2009","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.38_bib56","doi-asserted-by":"crossref","first-page":"733","DOI":"10.4049\/jimmunol.1002701","article-title":"Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell\/APC ratio, source of mouse strain, and regional localization","volume":"187,","author":"Denning","year":"2011","journal-title":"J. Immunol"},{"key":"10.1038\/mi.2012.38_bib57","doi-asserted-by":"crossref","first-page":"Article 3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3,","author":"Smyth","year":"2004","journal-title":"Stat. Appl. Genet. Mol. Biol"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201238","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922013459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922013459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:25:41Z","timestamp":1761830741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922013459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1933021922013459"],"URL":"https:\/\/doi.org\/10.1038\/mi.2012.38","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.716947856.793153161","asserted-by":"object"}]},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2012.38","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/mi.2012.39","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}