{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:34:22Z","timestamp":1790004862712,"version":"4.0.1"},"reference-count":112,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":2767,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1038\/mi.2014.25","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T08:39:51Z","timestamp":1397032791000},"page":"744-752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii"],"prefix":"10.1016","volume":"7","author":[{"given":"S B","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Y","family":"Denkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2014.25_bib1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/intimm\/dxs094","article-title":"Regulation of intestinal homeostasis by innate and adaptive immunity","volume":"24","author":"Kayama","year":"2012","journal-title":"Int. Immunol."},{"key":"10.1038\/mi.2014.25_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.coi.2012.04.009","article-title":"T cell tolerance and immunity to commensal bacteria","volume":"24","author":"Nutsch","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1038\/mi.2014.25_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/mi.2010.77","article-title":"To be or not to be a pathogen: that is the mucosally relevant question","volume":"4","author":"Sansonetti","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1038\/mi.2014.25_bib4","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1136\/gutjnl-2012-303955","article-title":"Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation","volume":"62","author":"Cader","year":"2013","journal-title":"Gut"},{"key":"10.1038\/mi.2014.25_bib5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","article-title":"Inflammatory bowel disease","volume":"28","author":"Kaser","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/mi.2014.25_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"10.1038\/mi.2014.25_bib7","unstructured":"McLeod, R., Van Tubbergen, C., Montoya, J.G. & Petersen, E. In Toxoplasma gondii Weiss L.M., Kim K., 100\u2013162 Academic Press: Amsterdam, (2014)."},{"key":"10.1038\/mi.2014.25_bib8","doi-asserted-by":"crossref","unstructured":"Dubey, J.P. In Toxoplasma gondii Weiss L.M., Kim K., 1\u201320 Academic Press: Amsterdam, (2014).","DOI":"10.1016\/B978-0-12-396481-6.00001-5"},{"key":"10.1038\/mi.2014.25_bib9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/CMR.11.4.569","article-title":"Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection","volume":"11","author":"Denkers","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1038\/mi.2014.25_bib10","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00281-012-0339-3","article-title":"Immune response and immunopathology during toxoplasmosis","volume":"34","author":"Dupont","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"10.1038\/mi.2014.25_bib11","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/icb.2011.93","article-title":"Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger","volume":"90","author":"Egan","year":"2012","journal-title":"Immunol. Cell Biol."},{"key":"10.1038\/mi.2014.25_bib12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1462-5822.2005.00486.x","article-title":"Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2","volume":"7","author":"Barragan","year":"2005","journal-title":"Cell Microbiol."},{"key":"10.1038\/mi.2014.25_bib13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1749-6632.2012.06534.x","article-title":"The protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium","volume":"1258","author":"Weight","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1038\/mi.2014.25_bib14","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1084\/jem.20020258","article-title":"Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence","volume":"195","author":"Barragan","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0966-842X(03)00205-1","article-title":"Migration of Toxoplasma gondii across biological barriers","volume":"11","author":"Barragan","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1038\/mi.2014.25_bib16","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1128\/IAI.01126-12","article-title":"Replication and distribution of Toxoplasma gondii in the small intestine after oral infection with tissue cysts","volume":"81","author":"Gregg","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2014.25_bib17","doi-asserted-by":"crossref","first-page":"E1913","DOI":"10.1073\/pnas.1220272110","article-title":"Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread","volume":"110","author":"Coombes","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/mi.2014.25_bib18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.chom.2013.08.003","article-title":"Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis","volume":"14","author":"Molloy","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1038\/mi.2014.25_bib19","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.4049\/jimmunol.181.12.8485","article-title":"Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection","volume":"181","author":"Bierly","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1182\/blood-2005-02-0666","article-title":"CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain","volume":"107","author":"Courret","year":"2006","journal-title":"Blood"},{"key":"10.1038\/mi.2014.25_bib21","doi-asserted-by":"crossref","first-page":"e1003051","DOI":"10.1371\/journal.ppat.1003051","article-title":"GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii","volume":"8","author":"Fuks","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2014.25_bib22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijpara.2013.09.006","article-title":"Tightly regulated migratory subversion of immune cells promotes the dissemination of Toxoplasma gondii","volume":"44","author":"Weidner","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1038\/mi.2014.25_bib23","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1111\/j.1462-5822.2006.00735.x","article-title":"Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination","volume":"8","author":"Lambert","year":"2006","journal-title":"Cell Microbiol."},{"key":"10.1038\/mi.2014.25_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4049\/jimmunol.177.1.31","article-title":"Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice","volume":"177","author":"Liu","year":"2006","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib25","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.4049\/jimmunol.163.4.2081","article-title":"Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-gamma-independent IL-12","volume":"163","author":"Bliss","year":"1999","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1073\/pnas.1011549108","article-title":"Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors","volume":"108","author":"Hou","year":"2011","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/mi.2014.25_bib27","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.4049\/jimmunol.180.9.6229","article-title":"Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines","volume":"180","author":"Pepper","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib28","doi-asserted-by":"crossref","first-page":"e1003706","DOI":"10.1371\/journal.ppat.1003706","article-title":"CXCR3-dependent CD4+ T cells are required to activate inflammatory monocytes for defense against intestinal infection","volume":"9","author":"Cohen","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2014.25_bib29","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1128\/IAI.00472-09","article-title":"Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice","volume":"78","author":"Dunay","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2014.25_bib30","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20112675","article-title":"Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage","volume":"209","author":"Meredith","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.immuni.2008.05.019","article-title":"Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii","volume":"29","author":"Dunay","year":"2008","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib32","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20091627","article-title":"Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells","volume":"207","author":"Edelson","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib33","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.4049\/jimmunol.1203541","article-title":"Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8\u03b1+ dendritic cell development","volume":"191","author":"Jaiswal","year":"2013","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.immuni.2011.08.008","article-title":"CD8\u03b1(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites","volume":"35","author":"Mashayekhi","year":"2011","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib35","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.chom.2009.06.005","article-title":"Gut commensal bacteria direct a protective immune response against Toxoplasma gondii","volume":"6","author":"Benson","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1038\/mi.2014.25_bib36","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1145697","article-title":"Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid","volume":"317","author":"Mucida","year":"2007","journal-title":"Science"},{"key":"10.1038\/mi.2014.25_bib37","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.20070590","article-title":"A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism","volume":"204","author":"Coombes","year":"2007","journal-title":"J. Exp. Med"},{"key":"10.1038\/mi.2014.25_bib38","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1084\/jem.20070602","article-title":"Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid","volume":"204","author":"Sun","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.immuni.2011.03.003","article-title":"Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha","volume":"34","author":"Hall","year":"2011","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/737125","article-title":"Toll-like receptor initiated host defense against Toxoplasma gondii","volume":"2010","author":"Denkers","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1038\/mi.2014.25_bib41","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nri1978","article-title":"Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism","volume":"6","author":"Gazzinelli","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/mi.2014.25_bib42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.imlet.2008.05.007","article-title":"Toll-like receptors and their role in host resistance to Toxoplasma gondii","volume":"119","author":"Yarovinsky","year":"2008","journal-title":"Immunol. Lett."},{"key":"10.1038\/mi.2014.25_bib43","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1128\/IAI.00328-12","article-title":"Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii","volume":"80","author":"B\u00e9la","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2014.25_bib44","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.4049\/jimmunol.168.12.5997","article-title":"Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells","volume":"168","author":"Scanga","year":"2002","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib45","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.4049\/jimmunol.181.5.3464","article-title":"TLR adaptor MyD88 is essential for pathogen control during oral Toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite","volume":"181","author":"Sukhumavasi","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib46","doi-asserted-by":"crossref","first-page":"e1001071","DOI":"10.1371\/journal.ppat.1001071","article-title":"UNC93B1 mediates host resistance to infection with Toxoplasma gondii","volume":"6","author":"Melo","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2014.25_bib47","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1074\/jbc.M110.171025","article-title":"UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii","volume":"286","author":"Pifer","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1038\/mi.2014.25_bib48","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.1109893","article-title":"TLR11 activation of dendritic cells by a protozoan profilin-like protein","volume":"308","author":"Yarovinsky","year":"2005","journal-title":"Science"},{"key":"10.1038\/mi.2014.25_bib49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.chom.2012.12.003","article-title":"Combined action of nucleic acid-sensing Toll-like receptors and TLR11\/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice","volume":"13","author":"Andrade","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1038\/mi.2014.25_bib50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.immuni.2012.09.016","article-title":"Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii","volume":"38","author":"Koblansky","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib51","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.4049\/jimmunol.1301301","article-title":"Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin","volume":"191","author":"Raetz","year":"2013","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib52","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chom.2008.01.001","article-title":"Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response","volume":"3","author":"Plattner","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"Pt 1","key":"10.1038\/mi.2014.25_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/SQB.1989.054.01.003","article-title":"Approaching the asymptote? Evolution and revolution in immunology","volume":"54","author":"Janeway","year":"1989","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1038\/mi.2014.25_bib54","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pt.2011.03.009","article-title":"Innate responses to Toxoplasma gondii in mice and humans","volume":"27","author":"Pifer","year":"2011","journal-title":"Trends Parasitol."},{"key":"10.1038\/mi.2014.25_bib55","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.4049\/jimmunol.179.2.1129","article-title":"Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii","volume":"179","author":"Debierre-Grockiego","year":"2007","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib56","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/1753425908099936","article-title":"Toxoplasma gondii glycosylphosphatidylinositols up-regulate major histocompatibility complex (MHC) molecule expression on primary murine macrophages","volume":"15","author":"Debierre-Grockiego","year":"2009","journal-title":"Innate Immun."},{"key":"10.1038\/mi.2014.25_bib57","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1084\/jem.20100717","article-title":"Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein","volume":"208","author":"Rosowski","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib58","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.4049\/jimmunol.177.4.2584","article-title":"Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages","volume":"177","author":"Kim","year":"2006","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib59","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.pt.2011.08.001","article-title":"Toxoplasma gondii effectors are master regulators of the inflammatory response","volume":"27","author":"Melo","year":"2011","journal-title":"Trends Parasitol."},{"key":"10.1038\/mi.2014.25_bib60","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1220961","article-title":"Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses","volume":"337","author":"Hand","year":"2012","journal-title":"Science"},{"key":"10.1038\/mi.2014.25_bib61","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1086\/653738","article-title":"Interleukin 17 receptor signaling is deleterious during Toxoplasma gondii infection in susceptible BL6 mice","volume":"202","author":"Guiton","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2014.25_bib62","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/IAI.73.1.617-621.2005","article-title":"Interleukin-17\/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection","volume":"73","author":"Kelly","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2014.25_bib63","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1084\/jem.20090900","article-title":"Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17","volume":"206","author":"Mu\u00f1oz","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib64","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-3024.1999.00237.x","article-title":"TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii","volume":"21","author":"Liesenfeld","year":"1999","journal-title":"Parasite Immunol."},{"issue":"Suppl 1","key":"10.1038\/mi.2014.25_bib65","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1086\/338006","article-title":"Oral infection of C57BL\/6 mice with Toxoplasma gondii: a new model of inflammatory bowel disease?","volume":"185","author":"Liesenfeld","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2014.25_bib66","doi-asserted-by":"crossref","first-page":"e41594","DOI":"10.1371\/journal.pone.0041594","article-title":"Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease","volume":"7","author":"Craven","year":"2012","journal-title":"PLoS One"},{"key":"10.1038\/mi.2014.25_bib67","doi-asserted-by":"crossref","first-page":"8785","DOI":"10.4049\/jimmunol.177.12.8785","article-title":"Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii","volume":"177","author":"Heimesaat","year":"2006","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib68","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1136\/gut.2006.104497","article-title":"Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli","volume":"56","author":"Heimesaat","year":"2007","journal-title":"Gut"},{"key":"10.1038\/mi.2014.25_bib69","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/mi.2011.31","article-title":"Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection","volume":"4","author":"Egan","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1038\/mi.2014.25_bib70","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev-physiol-030212-183744","article-title":"Paneth cells: maestros of the small intestinal crypts","volume":"75","author":"Clevers","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1038\/mi.2014.25_bib71","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.4049\/jimmunol.0901642","article-title":"TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii","volume":"184","author":"Foureau","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib72","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.2508","article-title":"Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-\u03b3-dependent elimination of Paneth cells","volume":"14","author":"Raetz","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2014.25_bib73","doi-asserted-by":"crossref","first-page":"18129","DOI":"10.1073\/pnas.0505256102","article-title":"Reduced Paneth cell alpha-defensins in ileal Crohn's disease","volume":"102","author":"Wehkamp","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/mi.2014.25_bib74","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/mi.2014.25_bib75","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib76","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2014.25_bib77","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2012.05.013","article-title":"Interleukin-15-dependent NKp46+ innate lymphoid cells control intestinal inflammation by recruiting inflammatory monocytes","volume":"37","author":"Schulthess","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib78","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.4049\/jimmunol.166.3.1930","article-title":"Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infection","volume":"166","author":"Khan","year":"2001","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib79","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.immuni.2012.03.026","article-title":"NK cell-derived interferon-\u03b3 orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection","volume":"36","author":"Goldszmid","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib80","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens","volume":"26","author":"Serbina","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/mi.2014.25_bib81","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.185.7.1261","article-title":"Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii","volume":"185","author":"Scharton-Kersten","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib82","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.4049\/jimmunol.157.9.4045","article-title":"In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection","volume":"157","author":"Scharton-Kersten","year":"1996","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib83","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.mib.2011.07.002","article-title":"The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii","volume":"14","author":"Howard","year":"2011","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1038\/mi.2014.25_bib84","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1462-5822.2010.01443.x","article-title":"Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole","volume":"12","author":"Khaminets","year":"2010","journal-title":"Cell Microbiol."},{"key":"10.1038\/mi.2014.25_bib85","doi-asserted-by":"crossref","first-page":"e1000288","DOI":"10.1371\/journal.ppat.1000288","article-title":"Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death","volume":"5","author":"Zhao","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2014.25_bib86","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1371\/journal.ppat.0010024","article-title":"Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases","volume":"1","author":"Martens","year":"2005","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2014.25_bib87","doi-asserted-by":"crossref","first-page":"e20568","DOI":"10.1371\/journal.pone.0020568","article-title":"The IFN-\u03b3-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens","volume":"6","author":"Liesenfeld","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1038\/mi.2014.25_bib88","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.immuni.2012.06.009","article-title":"A cluster of interferon-\u03b3-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii","volume":"37","author":"Yamamoto","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib89","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm.3189","article-title":"Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection","volume":"19","author":"Grainger","year":"2013","journal-title":"Nat. Med."},{"key":"10.1038\/mi.2014.25_bib90","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1101029","article-title":"Regulation of immune responses by prostaglandin E2","volume":"188","author":"Kalinski","year":"2012","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib91","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-065X.2006.00475.x","article-title":"Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine","volume":"215","author":"Kunisawa","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1038\/mi.2014.25_bib92","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nri3007","article-title":"The light and dark sides of intestinal intraepithelial lymphocytes","volume":"11","author":"Cheroutre","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/mi.2014.25_bib93","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1053\/j.gastro.2006.06.003","article-title":"Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection","volume":"131","author":"Dalton","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1038\/mi.2014.25_bib94","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.4049\/jimmunol.153.10.4596","article-title":"Toxoplasma gondii oral infection induces specific cytotoxic CD8 alpha\/beta+ Thy-1+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes","volume":"153","author":"Chard\u00e8s","year":"1994","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib95","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1053\/gast.2001.22432a","article-title":"Murine ileitis after intracellular parasite infection is controlled by TGF-beta-producing intraepithelial lymphocytes","volume":"120","author":"Buzoni-Gatel","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1038\/mi.2014.25_bib96","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.4049\/jimmunol.162.10.5846","article-title":"Intraepithelial lymphocytes traffic to the intestine and enhance resistance to Toxoplasma gondii oral infection","volume":"162","author":"Buzoni-Gatel","year":"1999","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib97","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0016-5085(03)00903-X","article-title":"CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells","volume":"125","author":"Luangsay","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1038\/mi.2014.25_bib98","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.4049\/jimmunol.161.9.4902","article-title":"Gut-derived intraepithelial lymphocytes induce long term immunity against Toxoplasma gondii","volume":"161","author":"Lepage","year":"1998","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib99","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.4049\/jimmunol.168.6.2988","article-title":"Lamina propria CD4+ T lymphocytes synergize with murine intestinal epithelial cells to enhance proinflammatory response against an intracellular pathogen","volume":"168","author":"Mennechet","year":"2002","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib100","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/eji.200324416","article-title":"Intestinal intraepithelial lymphocytes prevent pathogen-driven inflammation and regulate the Smad\/T-bet pathway of lamina propria CD4+ T cells","volume":"34","author":"Mennechet","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/mi.2014.25_bib101","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/mi.2009.105","article-title":"CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection","volume":"2","author":"Egan","year":"2009","journal-title":"Mucosal Immunol."},{"key":"10.1038\/mi.2014.25_bib102","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.184.2.597","article-title":"Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii","volume":"184","author":"Liesenfeld","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib103","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.immuni.2012.06.014","article-title":"The cytokines interleukin 27 and interferon-\u03b3 promote distinct Treg cell populations required to limit infection-induced pathology","volume":"37","author":"Hall","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib104","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.smim.2013.09.002","article-title":"Controlling the frontier: regulatory T-cells and intestinal homeostasis","volume":"25","author":"Bollrath","year":"2013","journal-title":"Semin. Immunol."},{"key":"10.1038\/mi.2014.25_bib105","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4049\/jimmunol.157.2.798","article-title":"In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha","volume":"157","author":"Gazzinelli","year":"1996","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib106","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.4049\/jimmunol.164.10.5375","article-title":"IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB\/c and susceptible C57BL\/6 mice following peroral infection with Toxoplasma gondii","volume":"164","author":"Suzuki","year":"2000","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib107","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.immuni.2009.10.001","article-title":"Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection","volume":"31","author":"Oldenhove","year":"2009","journal-title":"Immunity"},{"key":"10.1038\/mi.2014.25_bib108","doi-asserted-by":"crossref","first-page":"800","DOI":"10.4049\/jimmunol.1100769","article-title":"Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism","volume":"188","author":"Benson","year":"2012","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib109","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1084\/jem.20041789","article-title":"T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation","volume":"200","author":"Roers","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1084\/jem.20062175","article-title":"Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection","volume":"204","author":"Jankovic","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2014.25_bib111","doi-asserted-by":"crossref","first-page":"899","DOI":"10.4049\/jimmunol.175.2.899","article-title":"NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii","volume":"175","author":"Ronet","year":"2005","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.25_bib112","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.chom.2009.11.003","article-title":"Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells","volume":"6","author":"Perona-Wright","year":"2009","journal-title":"Cell Host Microbe"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/mi201425.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mi201425","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922010893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922010893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mi201425.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:23:27Z","timestamp":1761830607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922010893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":112,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1933021922010893"],"URL":"https:\/\/doi.org\/10.1038\/mi.2014.25","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2014.25","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/mi.2014.48","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}