{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:59:05Z","timestamp":1774925945866,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1038\/mi.2014.3","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T08:27:13Z","timestamp":1391588833000},"page":"1165-1174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Herpes simplex virus type-2 stimulates HIV-1 replication in cervical tissues: implications for HIV-1 transmission and efficacy of anti-HIV-1 microbicides"],"prefix":"10.1016","volume":"7","author":[{"given":"C","family":"Rollenhagen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Lathrop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Macura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G F","family":"Doncel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S N","family":"Asin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2014.3_bib1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/1756-0500-5-451","article-title":"Deciphering the epidemic synergy of herpes simplex virus type 2 (HSV-2) on human immunodeficiency virus type 1 (HIV-1) infection among women in sub-Saharan Africa","volume":"5","author":"Ghebremichael","year":"2012","journal-title":"BMC Res. Notes"},{"key":"10.1038\/mi.2014.3_bib2","first-page":"28","article-title":"Herpes simplex virus type-2 and human immunodeficiency virus infections in a rural population in Kilimanjaro Tanzania","volume":"8","author":"Mmbaga","year":"2011","journal-title":"East Afr. J. Public Health"},{"key":"10.1038\/mi.2014.3_bib3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1258\/ijsa.2010.010385","article-title":"The relative contribution of viral and bacterial sexually transmitted infections on HIV acquisition in southern African women in the Methods for Improving Reproductive Health in Africa study","volume":"22","author":"Venkatesh","year":"2011","journal-title":"Int. J. STD AIDS"},{"key":"10.1038\/mi.2014.3_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1086\/338231","article-title":"Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis","volume":"185","author":"Wald","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2014.3_bib5","doi-asserted-by":"crossref","first-page":"e22638","DOI":"10.1371\/journal.pone.0022638","article-title":"Herpes simplex virus-induced epithelial damage and susceptibility to human immunodeficiency virus type 1 infection in human cervical organ culture","volume":"6","author":"Horbul","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1038\/mi.2014.3_bib6","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nm.2006","article-title":"Persistence of HIV receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV acquisition","volume":"15","author":"Zhu","year":"2009","journal-title":"Nat. Med."},{"key":"10.1038\/mi.2014.3_bib7","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.1128\/JVI.02243-12","article-title":"Antiviral activity of trappin-2 and elafin in vitroin vivo against genital herpes","volume":"87","author":"Drannik","year":"2013","journal-title":"J. Virol."},{"key":"10.1038\/mi.2014.3_bib8","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1128\/JVI.00603-08","article-title":"Herpes simplex virus downregulates secretory leukocyte protease inhibitor: a novel immune evasion","volume":"82","author":"Fakioglu","year":"2008","journal-title":"J. Virol."},{"key":"10.1038\/mi.2014.3_bib9","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1086\/587697","article-title":"Coinfection with herpes simplex virus type 2 is associated with reduced HIV-specific T cell responses and systemic immune activation","volume":"197","author":"Sheth","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2014.3_bib10","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.bbrc.2008.12.150","article-title":"HSV-2 induces TLRs and NF-kappaB-dependent cytokines in cervical epithelial cells","volume":"379","author":"Li","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1038\/mi.2014.3_bib11","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1128\/JVI.77.13.7261-7280.2003","article-title":"NF-kappa B is required for apoptosis prevention during herpes simplex virus type 1 infection","volume":"77","author":"Goodkin","year":"2003","journal-title":"J. Virol."},{"key":"10.1038\/mi.2014.3_bib12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1086\/605412","article-title":"HIV type 1 infection in women: increased transcription of HIV type 1 in ectocervical tissue explants","volume":"200","author":"Asin","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2014.3_bib13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/QAI.0b013e3181e5e12c","article-title":"IL-8 decreases HIV-1 transmission in peripheral blood lymphocytes and ectocervical tissue explants","volume":"54","author":"Rollenhagen","year":"2010","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1038\/mi.2014.3_bib14","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/mi.2011.34","article-title":"Enhanced HIV-1 replication in ex vivo ectocervical tissues from post-menopausal women correlates with increased inflammatory responses","volume":"4","author":"Rollenhagen","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1038\/mi.2014.3_bib15","doi-asserted-by":"crossref","first-page":"e70308","DOI":"10.1371\/journal.pone.0070308","article-title":"HSV-2 regulates monocyte inflammatory response via the Fas\/FasL pathway","volume":"8","author":"Krzyzowska","year":"2013","journal-title":"PLoS One"},{"key":"10.1038\/mi.2014.3_bib16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1073\/pnas.1005201108","article-title":"Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue","volume":"108","author":"Iijima","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2014.3_bib17","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nature08511","article-title":"CD8 (+) T lymphocyte mobilization to virus-infected tissue requires CD4 (+) T-cell help","volume":"462","author":"Nakanishi","year":"2009","journal-title":"Nature"},{"key":"10.1038\/mi.2014.3_bib18","doi-asserted-by":"crossref","first-page":"7510","DOI":"10.4049\/jimmunol.177.11.7510","article-title":"Cutting edge: plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ","volume":"177","author":"Lund","year":"2006","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.3_bib19","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1086\/315749","article-title":"Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection","volume":"182","author":"Koelle","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2014.3_bib20","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1182\/blood-2007-05-088435","article-title":"HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo","volume":"111","author":"Biancotto","year":"2008","journal-title":"Blood"},{"key":"10.1038\/mi.2014.3_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/COH.0b013e3283504941","article-title":"Quality and quantity: mucosal CD4+ T cells and HIV susceptibility","volume":"7","author":"McKinnon","year":"2012","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1038\/mi.2014.3_bib22","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/infdis\/jir591","article-title":"Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding","volume":"204","author":"Jaspan","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2014.3_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4149\/av_2010_04_261","article-title":"Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection","volume":"54","author":"Shao","year":"2010","journal-title":"Acta Virol."},{"key":"10.1038\/mi.2014.3_bib24","first-page":"47","article-title":"Herpes simplex virus and the chemokines that mediate the inflammation","volume":"30","author":"Carr","year":"2006","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1038\/mi.2014.3_bib25","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1258\/ijsa.2012.011356","article-title":"Herpes simplex virus and HIV: genital infection synergy and novel approaches to dual prevention","volume":"23","author":"Thurman","year":"2012","journal-title":"Int. J. STD AIDS"},{"key":"10.1038\/mi.2014.3_bib26","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.1193748","article-title":"Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women","volume":"333","author":"Abdool Karim","year":"2010","journal-title":"Science"},{"key":"10.1038\/mi.2014.3_bib27","doi-asserted-by":"crossref","first-page":"e1003432","DOI":"10.1371\/journal.ppat.1003432","article-title":"Single cell analysis of lymph node tissues from HIV-1 infected patients reveals that the majority of CD4+ T-cells contain one HIV-1 DNA molecule","volume":"9","author":"Josefsson","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2014.3_bib28","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/mi.2010.2","article-title":"HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model","volume":"3","author":"Saba","year":"2010","journal-title":"Mucosal Immunol."},{"key":"10.1038\/mi.2014.3_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11904-010-0069-x","article-title":"Coreceptors and HIV pathogenesis","volume":"8","author":"Gorry","year":"2011","journal-title":"Curr. HIV\/AIDS Rep."},{"issue":"Suppl 1","key":"10.1038\/mi.2014.3_bib30","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1479-5876-9-S1-S6","article-title":"Selective transmission of R5 HIV-1 variants: where is the gatekeeper?","volume":"9","author":"Grivel","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1038\/mi.2014.3_bib31","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1097\/QAD.0b013e3281864667","article-title":"HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1","volume":"21","author":"Grivel","year":"2007","journal-title":"AIDS"},{"key":"10.1038\/mi.2014.3_bib32","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nrmicro1387","article-title":"Selective transmission of CCR5-utilizing HIV-1: the \u201cgatekeeper\u201d problem resolved?","volume":"4","author":"Margolis","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1038\/mi.2014.3_bib33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.chom.2011.08.015","article-title":"Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication","volume":"10","author":"Andrei","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1038\/mi.2014.3_bib34","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1089\/aid.2012.0078","article-title":"Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection","volume":"28","author":"Vibholm","year":"2012","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1038\/mi.2014.3_bib35","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nprot.2008.245","article-title":"Use of human tissue explants to study human infectious agents","volume":"4","author":"Grivel","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1038\/mi.2014.3_bib36","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2174\/157016212800618156","article-title":"Infectious co-factors in HIV-1 transmission herpes simplex virus type-2 and HIV-1: new insights and interventions","volume":"10","author":"Barnabas","year":"2012","journal-title":"Curr. HIV Res."},{"key":"10.1038\/mi.2014.3_bib37","first-page":"50","article-title":"Molecular basis of the interactions between herpes simplex viruses and HIV-1","volume":"8","author":"Pal\u00f9","year":"2001","journal-title":"Herpes"},{"issue":"Suppl 1","key":"10.1038\/mi.2014.3_bib38","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1086\/505359","article-title":"The cycle of human herpes simplex virus infection: virus transport and immune control","volume":"194","author":"Cunningham","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2014.3_bib39","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.4049\/jimmunol.1103706","article-title":"Herpes simplex virus type 2 infection of human epithelial cells induces CXCL9 expression and CD4+ T cell migration via activation of p38-CCAAT\/enhancer-binding protein-\u03b2 pathway","volume":"188","author":"Huang","year":"2012","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2014.3_bib40","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1517\/17425255.2.3.459","article-title":"Tenofovir disoproxil fumarate for the treatment of HIV infection","volume":"2","author":"Pham","year":"2006","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1038\/mi.2014.3_bib41","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/JVI.05842-11","article-title":"Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue","volume":"86","author":"Dobard","year":"2012","journal-title":"J. Virol."},{"key":"10.1038\/mi.2014.3_bib42","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1097\/QAD.0b013e328355ce08","article-title":"Declining adherence is a more likely explanation than frailty of the apparent decline in efficacy in the CAPRISA 004 trial","volume":"26","author":"Grobler","year":"2012","journal-title":"AIDS"},{"key":"10.1038\/mi.2014.3_bib43","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/infdis\/jis465","article-title":"Innate immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel","volume":"206","author":"Naranbhai","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2014.3_bib44","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1592\/phco.23.6.695.32189","article-title":"Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells","volume":"23","author":"Robbins","year":"2003","journal-title":"Pharmacotherapy"},{"key":"10.1038\/mi.2014.3_bib45","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1097\/00002030-200211080-00008","article-title":"Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells","volume":"16","author":"Balzarini","year":"2002","journal-title":"AIDS"},{"key":"10.1038\/mi.2014.3_bib46","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/QAD.0b013e32833676eb","article-title":"Abacavir and tenofovir disoproxil fumarate co-administration results in a nonadditive antiviral effect in HIV-1-infected patients","volume":"24","author":"Goicoechea","year":"2010","journal-title":"AIDS"},{"key":"10.1038\/mi.2014.3_bib47","doi-asserted-by":"crossref","first-page":"e1003456","DOI":"10.1371\/journal.ppat.1003456","article-title":"A Multi-targeted drug candidate with dual anti-HIV and anti-HSV activity","volume":"9","author":"Ballzarini","year":"2013","journal-title":"PloS Pathog."},{"key":"10.1038\/mi.2014.3_bib48","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.1128\/AAC.01431-12","article-title":"A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis","volume":"56","author":"Johnson","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1038\/mi.2014.3_bib49","doi-asserted-by":"crossref","first-page":"16145","DOI":"10.1073\/pnas.1311355110","article-title":"Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges","volume":"110","author":"Smith","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2014.3_bib50","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1089\/aid.2007.0108","article-title":"Estradiol and progesterone regulate HIV type 1 replication in peripheral blood cells","volume":"24","author":"Asin","year":"2008","journal-title":"AIDS Res. Hum. Retroviruses"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi20143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi20143","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922011266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922011266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi20143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:24:57Z","timestamp":1761830697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922011266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S1933021922011266"],"URL":"https:\/\/doi.org\/10.1038\/mi.2014.3","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Herpes simplex virus type-2 stimulates HIV-1 replication in cervical tissues: implications for HIV-1 transmission and efficacy of anti-HIV-1 microbicides","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2014.3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}