{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:52:54Z","timestamp":1789667574571,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":2279,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1038\/mi.2015.14","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T09:14:27Z","timestamp":1426065267000},"page":"1237-1247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4+ T-cell priming"],"prefix":"10.1016","volume":"8","author":[{"given":"A S","family":"McKee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D G","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A P","family":"Fontenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2015.14_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1034\/j.1398-9995.2000.00107.x","article-title":"Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview","volume":"55","author":"Budinger","year":"2000","journal-title":"Allergy"},{"key":"10.1038\/mi.2015.14_bib2","first-page":"197","article-title":"Delayed chemical pneumonitis occurring in workers exposed to beryllium compounds","volume":"28","author":"Hardy","year":"1946","journal-title":"J. Ind. Hyg. Toxicol."},{"key":"10.1038\/mi.2015.14_bib3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.it.2005.08.004","article-title":"Genetic susceptibility and immune-mediated destruction in beryllium-induced disease","volume":"26","author":"Fontenot","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1038\/mi.2015.14_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s004200100237","article-title":"Beryllium sensitization and disease among long-term and short-term workers in a beryllium ceramics plant","volume":"74","author":"Henneberger","year":"2001","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1038\/mi.2015.14_bib5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/0272-4332.00009","article-title":"Risk estimation and value-of-information analysis for three proposed genetic screening programs for chronic beryllium disease prevention","volume":"20","author":"Bartell","year":"2000","journal-title":"Risk Anal."},{"key":"10.1038\/mi.2015.14_bib6","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jaci.2005.01.019","article-title":"Frequency of beryllium-specific, TH1-type cytokine-expressing CD4+ T cells in patients with beryllium-induced disease","volume":"115","author":"Pott","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/mi.2015.14_bib7","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1172\/JCI0215846","article-title":"Target organ localization of memory CD4(+) T cells in patients with chronic beryllium disease","volume":"110","author":"Fontenot","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1038\/mi.2015.14_bib8","doi-asserted-by":"crossref","first-page":"8553","DOI":"10.1073\/pnas.1408048111","article-title":"Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease","volume":"111","author":"Mack","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2015.14_bib9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.8105536","article-title":"HLA-DPB1 glutamate 69: a genetic marker of beryllium disease","volume":"262","author":"Richeldi","year":"1993","journal-title":"Science"},{"key":"10.1038\/mi.2015.14_bib10","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1084\/jem.20122426","article-title":"Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease","volume":"210","author":"Falta","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2015.14_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.04.048","article-title":"Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity","volume":"158","author":"Clayton","year":"2014","journal-title":"Cell"},{"key":"10.1038\/mi.2015.14_bib12","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4049\/jimmunol.163.2.1019","article-title":"Identification of pathogenic T cells in patients with beryllium-induced lung disease","volume":"163","author":"Fontenot","year":"1999","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.14_bib13","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1038\/mi.2015.14_bib14","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/eji.201343862","article-title":"Regulation of the tolerogenic function of steady-state DCs","volume":"44","author":"Probst","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/mi.2015.14_bib15","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/mi.2015.14_bib16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1084\/jem.194.6.769","article-title":"Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo","volume":"194","author":"Hawiger","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2015.14_bib17","doi-asserted-by":"crossref","first-page":"E1122","DOI":"10.1073\/pnas.1300392110","article-title":"Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells","volume":"110","author":"McKee","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2015.14_bib18","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.4049\/jimmunol.181.6.3755","article-title":"Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome","volume":"181","author":"Kool","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.14_bib19","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.4049\/jimmunol.134.4.2047","article-title":"The effects of beryllium and other adjuvants on Ia expression by macrophages","volume":"134","author":"Behbehani","year":"1985","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.14_bib20","first-page":"105","article-title":"Studies on the adjuvant action of beryllium. I. Effects on individual lymph nodes","volume":"53","author":"Hall","year":"1984","journal-title":"Immunology"},{"key":"10.1038\/mi.2015.14_bib21","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1128\/IAI.68.7.4032-4039.2000","article-title":"Beryllium, an adjuvant that promotes gamma interferon production","volume":"68","author":"Lee","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2015.14_bib22","doi-asserted-by":"crossref","first-page":"8194","DOI":"10.4049\/jimmunol.181.12.8194","article-title":"Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells","volume":"181","author":"Eigenbrod","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.14_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1165\/rcmb.2004-0090OC","article-title":"Beryllium-ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium disease","volume":"31","author":"Sawyer","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2015.14_bib24","doi-asserted-by":"crossref","first-page":"15942","DOI":"10.1074\/jbc.M114.557561","article-title":"Release of interleukin-1alpha or interleukin-1beta depends on mechanism of cell death","volume":"289","author":"England","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1038\/mi.2015.14_bib25","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nm1603","article-title":"Identification of a key pathway required for the sterile inflammatory response triggered by dying cells","volume":"13","author":"Chen","year":"2007","journal-title":"Nat. Med."},{"key":"10.1038\/mi.2015.14_bib26","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1073\/pnas.86.14.5227","article-title":"Identification of a monocyte specific pre-interleukin 1 beta convertase activity","volume":"86","author":"Kostura","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2015.14_bib27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1038\/mi.2015.14_bib28","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2015.14_bib29","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"key":"10.1038\/mi.2015.14_bib30","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF01487040","article-title":"Interleukin-1 stimulates rapid release of cytokine-induced neutrophil chemoattractant (CINC) in rat lungs","volume":"20","author":"Hybertson","year":"1996","journal-title":"Inflammation"},{"key":"10.1038\/mi.2015.14_bib31","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1182\/blood-2010-03-275529","article-title":"Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo","volume":"116","author":"Munks","year":"2010","journal-title":"Blood"},{"key":"10.1038\/mi.2015.14_bib32","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/mi.2015.14_bib33","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1084\/jem.20110538","article-title":"CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen","volume":"208","author":"Desch","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2015.14_bib34","doi-asserted-by":"crossref","first-page":"14521","DOI":"10.1073\/pnas.0807449105","article-title":"CD4 memory T cells divide poorly in response to antigen because of their cytokine profile","volume":"105","author":"MacLeod","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2015.14_bib35","doi-asserted-by":"crossref","first-page":"12063","DOI":"10.1073\/pnas.0605130103","article-title":"CD8 T cell competition for dendritic cells in vivo is an early event in activation","volume":"103","author":"Willis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2015.14_bib36","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.4049\/jimmunol.174.10.6129","article-title":"Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways","volume":"174","author":"Yasuda","year":"2005","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.14_bib37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/ar1469","article-title":"Toll-like receptor downstream signaling","volume":"7","author":"Kawai","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1038\/mi.2015.14_bib38","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.4049\/jimmunol.1102048","article-title":"IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation","volume":"187","author":"Rider","year":"2011","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.14_bib39","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.4049\/jimmunol.1100001","article-title":"Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection","volume":"186","author":"Blomgran","year":"2011","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.14_bib40","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1165\/rcmb.2012-0479OC","article-title":"Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice","volume":"48","author":"Bauer","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2015.14_bib41","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.humimm.2014.10.010","article-title":"p38 mitogen-activated protein kinase in beryllium-induced dendritic cell activation","volume":"75","author":"Li","year":"2014","journal-title":"Hum. Immunol."},{"key":"10.1038\/mi.2015.14_bib42","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1055\/s-0028-1101276","article-title":"Metal-induced diffuse lung disease","volume":"29","author":"Fontenot","year":"2008","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1038\/mi.2015.14_bib43","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nm.2403","article-title":"DNA released from dying host cells mediates aluminum adjuvant activity","volume":"17","author":"Marichal","year":"2011","journal-title":"Nat. Med."},{"key":"10.1038\/mi.2015.14_bib44","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.4049\/jimmunol.178.8.5271","article-title":"Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release","volume":"178","author":"Li","year":"2007","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.14_bib45","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4049\/jimmunol.1102744","article-title":"CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization","volume":"188","author":"Langlet","year":"2012","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.14_bib46","first-page":"45","article-title":"Lymph circulation: physiology, pharmacology, and biomechanics","volume":"14","author":"Reddy","year":"1986","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"10.1038\/mi.2015.14_bib47","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/eji.1830260915","article-title":"In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to freund's complete adjuvant, but continues to induce T helper 2 cytokine production","volume":"26","author":"Brewer","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/mi.2015.14_bib48","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1126\/science.1135299","article-title":"Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling","volume":"314","author":"Gavin","year":"2006","journal-title":"Science"},{"key":"10.1038\/mi.2015.14_bib49","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.immuni.2008.01.008","article-title":"Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules","volume":"28","author":"Dai","year":"2008","journal-title":"Immunity"},{"key":"10.1038\/mi.2015.14_bib50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-61779-527-5_7","article-title":"Isolation of human and mouse neutrophils ex vivoin vitro","volume":"844","author":"Hu","year":"2012","journal-title":"Methods Mol. Biol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201514.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201514","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922010030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922010030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201514.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:22:25Z","timestamp":1761830545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922010030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S1933021922010030"],"URL":"https:\/\/doi.org\/10.1038\/mi.2015.14","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4+ T-cell priming","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2015.14","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}