{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:43:02Z","timestamp":1787812982613,"version":"build-2784847793"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1038\/mi.2015.35","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T08:25:56Z","timestamp":1430295956000},"page":"56-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage"],"prefix":"10.1016","volume":"9","author":[{"given":"S","family":"Glennie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"Gritzfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H","family":"Pennington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Garner-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Coombes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C F","family":"Vadesilho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E N","family":"Miyaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S B","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2015.35_bib1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1086\/591708","article-title":"Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness","volume":"198","author":"Morens","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2015.35_bib2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1086\/656333","article-title":"Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets","volume":"202","author":"McCullers","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2015.35_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/INF.0b013e3181f111a2","article-title":"Association between nasopharyngeal load of Streptococcus pneumoniae, viral coinfection, and radiologically confirmed pneumonia in Vietnamese children","volume":"30","author":"Vu","year":"2011","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1038\/mi.2015.35_bib4","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1093\/infdis\/jir618","article-title":"Influenza virus induces bacterial and nonbacterial otitis media","volume":"204","author":"Short","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2015.35_bib5","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1172\/JCI57762","article-title":"Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice","volume":"121","author":"Nakamura","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1038\/mi.2015.35_bib6","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/infdis\/142.6.923","article-title":"Epidemiologic studies of Streptococcus pneumoniae in infants: acquisition, carriage, and infection during the first 24 months of life","volume":"142","author":"Gray","year":"1980","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2015.35_bib7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","article-title":"Streptococcus pneumoniae colonisation: the key to pneumococcal disease","volume":"4","author":"Bogaert","year":"2004","journal-title":"Lancet Infect. Dis."},{"key":"10.1038\/mi.2015.35_bib8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1084\/jem.20070891","article-title":"Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection","volume":"205","author":"Didierlaurent","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2015.35_bib9","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S1473-3099(10)70067-0","article-title":"Structured regulation of inflammation during respiratory viral infection","volume":"10","author":"Hussell","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"10.1038\/mi.2015.35_bib10","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1165\/rcmb.2007-0417OC","article-title":"Influenza virus infection decreases tracheal mucociliary velocity and clearance of Streptococcus pneumoniae","volume":"42","author":"Pittet","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2015.35_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.coviro.2011.05.013","article-title":"Innate immunity modulation in virus entry","volume":"1","author":"Faure","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"10.1038\/mi.2015.35_bib12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1128\/CMR.00014-10","article-title":"The airway epithelium: soldier in the fight against respiratory viruses","volume":"24","author":"Vareille","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1038\/mi.2015.35_bib13","first-page":"50115","article-title":"Experimental human pneumococcal carriage","volume":"72","author":"Gritzfeld","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1038\/mi.2015.35_bib14","doi-asserted-by":"crossref","first-page":"e1003274","DOI":"10.1371\/journal.ppat.1003274","article-title":"Experimental human pneumococcal carriage augments IL-17A-dependent T-cell defence of the lung","volume":"9","author":"Wright","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2015.35_bib15","doi-asserted-by":"crossref","first-page":"e1002622","DOI":"10.1371\/journal.ppat.1002622","article-title":"Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriage","volume":"8","author":"Wright","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2015.35_bib16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tim.2011.06.003","article-title":"Experimental human pneumococcal carriage models for vaccine research","volume":"19","author":"Ferreira","year":"2011","journal-title":"Trends Microbiol."},{"key":"10.1038\/mi.2015.35_bib17","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1164\/rccm.201212-2277OC","article-title":"Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults","volume":"187","author":"Ferreira","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1038\/mi.2015.35_bib18","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.168.4.1886","article-title":"Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8-11 of factor H","volume":"168","author":"Jarva","year":"2002","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.35_bib19","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1128\/IAI.69.5.3435-3437.2001","article-title":"PspC, a pneumococcal surface protein, binds human factor H","volume":"69","author":"Dave","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2015.35_bib20","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.4049\/jimmunol.178.9.5848","article-title":"The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells","volume":"178","author":"Hammerschmidt","year":"2007","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.35_bib21","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4049\/jimmunol.173.1.471","article-title":"Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H","volume":"173","author":"Dave","year":"2004","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.35_bib22","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1128\/IAI.70.5.2526-2534.2002","article-title":"Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae","volume":"70","author":"Balachandran","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2015.35_bib23","doi-asserted-by":"crossref","first-page":"23486","DOI":"10.1074\/jbc.M110.142703","article-title":"Complement regulator Factor H mediates a two-step uptake of Streptococcus pneumoniae by human cells","volume":"285","author":"Agarwal","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1038\/mi.2015.35_bib24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/mi.2013.41","article-title":"Pneumococcal IgA1 protease subverts specific protection by human IgA1","volume":"7","author":"Janoff","year":"2013","journal-title":"Mucosal Immunol."},{"key":"10.1038\/mi.2015.35_bib25","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.4049\/jimmunol.181.10.7138","article-title":"Species-specific interaction of Streptococcus pneumoniae with human complement factor H","volume":"181","author":"Lu","year":"2008","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.35_bib26","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1046\/j.1365-2958.2000.01897.x","article-title":"Species-specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif","volume":"36","author":"Hammerschmidt","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1038\/mi.2015.35_bib27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1574-6968.2006.00439.x","article-title":"Interaction of clinical isolates of Streptococcus pneumoniae with human complement factor H","volume":"264","author":"Quin","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1038\/mi.2015.35_bib28","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1093\/infdis\/jiu326","article-title":"High nasopharyngeal pneumococcal density, increased by viral co-infection, is associated with invasive pneumococcal pneumonia","volume":"210","author":"Wolter","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2015.35_bib29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/1471-2164-14-378","article-title":"Transcriptional adaptation of pneumococci and human pharyngeal cells in the presence of a virus infection","volume":"14","author":"Kimaro Mlacha","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1038\/mi.2015.35_bib30","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrmicro1871","article-title":"The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease","volume":"6","author":"Kadioglu","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1038\/mi.2015.35_bib31","doi-asserted-by":"crossref","first-page":"15614","DOI":"10.1074\/jbc.M112.443507","article-title":"The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin","volume":"288","author":"Voss","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1038\/mi.2015.35_bib32","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1128\/CVI.00395-08","article-title":"Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in mice","volume":"16","author":"Ferreira","year":"2009","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1038\/mi.2015.35_bib33","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1574-695X.2011.00809.x","article-title":"Nasal immunization of mice with Lactobacillus casei expressing the pneumococcal surface protein C primes the immune system and decreases pneumococcal nasopharyngeal colonization in mice","volume":"62","author":"Hernani Mde","year":"2011","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1038\/mi.2015.35_bib34","doi-asserted-by":"crossref","first-page":"6533","DOI":"10.1128\/IAI.67.12.6533-6542.1999","article-title":"The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia","volume":"67","author":"Brooks-Walter","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2015.35_bib35","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.1016\/j.vaccine.2012.10.004","article-title":"Development of cross-reactive antibodies to the proline-rich region of pneumococcal surface protein A in children","volume":"30","author":"Melin","year":"2012","journal-title":"Vaccine"},{"key":"10.1038\/mi.2015.35_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1128\/IAI.00541-09","article-title":"The effects of PspC on complement-mediated immunity to Streptococcus pneumoniae vary with strain background and capsular serotype","volume":"78","author":"Yuste","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2015.35_bib37","doi-asserted-by":"crossref","first-page":"23486","DOI":"10.1074\/jbc.M110.142703","article-title":"Complement regulator Factor H mediates a two-step uptake of Streptococcus pneumoniae by human cells","volume":"285","author":"Agarwal","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1038\/mi.2015.35_bib38","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1128\/IAI.00474-07","article-title":"Factor H binding to PspC of Streptococcus pneumoniae increases adherence to human cell lines in vitro and enhances invasion of mouse lungs in vivo","volume":"75","author":"Quin","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1038\/mi.2015.35_bib39","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/infdis\/jit008","article-title":"Effect of the 2009 influenza A(H1N1) pandemic on invasive pneumococcal pneumonia","volume":"207","author":"Fleming-Dutra","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2015.35_bib40","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1086\/533501","article-title":"Host polymorphisms in interleukin 4, complement factor H, and C-reactive protein associated with nasal carriage of Staphylococcus aureus and occurrence of boils","volume":"197","author":"Emonts","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2015.35_bib41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4049\/jimmunol.177.1.501","article-title":"The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance","volume":"177","author":"Madico","year":"2006","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.35_bib42","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1097\/INF.0b013e3181f59f6d","article-title":"Immunogenicity of two investigational serogroup B meningococcal vaccines in the first year of life: a randomized comparative trial","volume":"29","author":"Snape","year":"2010","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1038\/mi.2015.35_bib43","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0140-6736(11)61713-3","article-title":"Immunogenicity and tolerability of a multicomponent meningococcal serogroup B (4CMenB) vaccine in healthy adolescents in Chile: a phase 2b\/3 randomised, observer-blind, placebo-controlled study","volume":"379","author":"Santolaya","year":"2012","journal-title":"Lancet"},{"key":"10.1038\/mi.2015.35_bib44","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0140-6736(14)60226-9","article-title":"Group B meningococcal vaccine: recommendations for UK use","volume":"383","author":"Pollard","year":"2014","journal-title":"Lancet"},{"key":"10.1038\/mi.2015.35_bib45","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.4049\/jimmunol.1003470","article-title":"A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination","volume":"186","author":"Beernink","year":"2011","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2015.35_bib46","doi-asserted-by":"crossref","first-page":"e18928","DOI":"10.1371\/journal.pone.0018928","article-title":"Viral and atypical bacterial detection in acute respiratory infection in children under five years","volume":"6","author":"Bezerra","year":"2011","journal-title":"PLoS One"},{"key":"10.1038\/mi.2015.35_bib47","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1750-2659.2010.00178.x","article-title":"Using the full spectral capacity (six channels) of a real-time PCR instrument can simplify diagnostic laboratory screening and typing protocols for pandemic H1N1 influenza","volume":"5","author":"Hopkins","year":"2011","journal-title":"Influenza Other Resp. Viruses"},{"key":"10.1038\/mi.2015.35_bib48","doi-asserted-by":"crossref","first-page":"e8902","DOI":"10.1371\/journal.pone.0008902","article-title":"C3b\/iC3b deposition on Streptococcus pneumoniae is not affected by HIV infection","volume":"5","author":"Hyams","year":"2010","journal-title":"PLoS One"},{"key":"10.1038\/mi.2015.35_bib49","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1128\/CVI.00239-14","article-title":"Mapping of epitopes recognized by antibodies induced by immunization of mice with PspA and PspC","volume":"21","author":"Vadesilho","year":"2014","journal-title":"Clin. Vaccine Immunol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201535.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201535","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193302192200842X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193302192200842X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201535.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:20:12Z","timestamp":1761830412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193302192200842X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S193302192200842X"],"URL":"https:\/\/doi.org\/10.1038\/mi.2015.35","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2015.35","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 The authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}