{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:37:46Z","timestamp":1789331866690,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":2218,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1038\/mi.2015.53","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T08:21:47Z","timestamp":1435738907000},"page":"206-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Interaction of IFN-\u03b3 with cholinergic agonists to modulate rat and human goblet cell function"],"prefix":"10.1016","volume":"9","author":[{"given":"L","family":"Garc\u00eda-Posadas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R R","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Shatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Storr-Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Diebold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Dartt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2015.53_bib1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1042\/BST0370877","article-title":"Regulation of mucin expression in respiratory diseases","volume":"37","author":"Turner","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.1038\/mi.2015.53_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11894-010-0131-2","article-title":"Intestinal goblet cells and mucins in health and disease: recent insights and progress","volume":"12","author":"Kim","year":"2010","journal-title":"Curr. Gastroenterol. Rep"},{"key":"10.1038\/mi.2015.53_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exer.2003.10.005","article-title":"Control of mucin production by ocular surface epithelial cells","volume":"78","author":"Dartt","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1038\/mi.2015.53_bib4","doi-asserted-by":"crossref","first-page":"e50704","DOI":"10.1371\/journal.pone.0050704","article-title":"Mucin deficiency causes functional and structural changes of the ocular surface","volume":"7","author":"Floyd","year":"2012","journal-title":"PLoS One"},{"key":"10.1038\/mi.2015.53_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/exer.2001.1045","article-title":"Epithelial mucins of the ocular surface: structure, biosynthesis and function","volume":"73","author":"Argueso","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1038\/mi.2015.53_bib6","first-page":"1004","article-title":"Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome","volume":"43","author":"Argueso","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1034\/j.1600-0420.2003.00019.x","article-title":"Amniotic membrane transplantation elicits goblet cell repopulation after conjunctival reconstruction in a case of severe ocular cicatricial pemphigoid","volume":"81","author":"Barabino","year":"2003","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1038\/mi.2015.53_bib8","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1001\/archopht.120.3.330","article-title":"Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine","volume":"120","author":"Kunert","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1038\/mi.2015.53_bib9","series-title":"The Dry Eye: A Comprehensive Guide","first-page":"101","article-title":"Basic principles and classifications of dry eye disorders","author":"Lemp","year":"1992"},{"key":"10.1038\/mi.2015.53_bib10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.exer.2007.08.019","article-title":"Effect of protein kinase C and Ca(2+) on p42\/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells","volume":"85","author":"Hodges","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1038\/mi.2015.53_bib11","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.bbamcr.2012.12.016","article-title":"IP3, a small molecule with a powerful message","volume":"1833","author":"Decrock","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1038\/mi.2015.53_bib12","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1006\/exer.2000.0915","article-title":"Regulation of conjunctival goblet cell secretion by Ca(2+)and protein kinase C","volume":"71","author":"Dartt","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1038\/mi.2015.53_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fendo.2013.00129","article-title":"Regulated mucin secretion from airway epithelial cells","volume":"4","author":"Adler","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1038\/mi.2015.53_bib14","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.15.1.749","article-title":"Cellular responses to interferon-gamma","volume":"15","author":"Boehm","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/mi.2015.53_bib15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1146\/annurev.iy.11.040193.003035","article-title":"The molecular cell biology of interferon-gamma and its receptor","volume":"11","author":"Farrar","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/mi.2015.53_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cytogfr.2008.08.004","article-title":"IFNgamma signaling-does it mean JAK-STAT?","volume":"19","author":"Gough","year":"2008","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1038\/mi.2015.53_bib17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.immuni.2009.09.002","article-title":"Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases","volume":"31","author":"Hu","year":"2009","journal-title":"Immunity"},{"key":"10.1038\/mi.2015.53_bib18","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1167\/iovs.10-7081","article-title":"Interferon-gamma exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways","volume":"52","author":"Zhang","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/BF00266749","article-title":"Heterogeneity in the immunolocalization of cytokeratin specific monoclonal antibodies in the rat eye: evaluation of unusual epithelial tissue entities","volume":"95","author":"Kasper","year":"1991","journal-title":"Histochemistry"},{"key":"10.1038\/mi.2015.53_bib20","first-page":"142","article-title":"Cytokeratin expression in normal human bulbar conjunctiva obtained by impression cytology","volume":"38","author":"Krenzer","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib21","first-page":"1102","article-title":"Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion","volume":"40","author":"Rios","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ceca.2007.01.011","article-title":"Recent breakthroughs in the molecular mechanism of capacitative calcium entry (with thoughts on how we got here)","volume":"42","author":"Putney","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1038\/mi.2015.53_bib23","doi-asserted-by":"crossref","first-page":"C988","DOI":"10.1152\/ajpcell.00582.2001","article-title":"Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion","volume":"284","author":"Kanno","year":"2003","journal-title":"Am. J. Physiol. Cell. Physiol"},{"key":"10.1038\/mi.2015.53_bib24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.exer.2012.08.010","article-title":"Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion","volume":"103","author":"Hodges","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1038\/mi.2015.53_bib25","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1167\/iovs.11-8748","article-title":"Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion","volume":"53","author":"Hayashi","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib26","first-page":"299","article-title":"Conjunctival goblet cell density in normal subjects and in dry eye syndromes","volume":"14","author":"Ralph","year":"1975","journal-title":"Invest. Ophthalmol"},{"key":"10.1038\/mi.2015.53_bib27","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1189\/jlb.1110611","article-title":"Interferon-gamma-secreting NK cells promote induction of dry eye disease","volume":"89","author":"Chen","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"10.1038\/mi.2015.53_bib28","first-page":"28","article-title":"Regulation of human leukocyte antigen expression in human conjunctival epithelium","volume":"40","author":"Tsubota","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/08830185.2012.748052","article-title":"Dry eye as a mucosal autoimmune disease","volume":"32","author":"Stern","year":"2013","journal-title":"Int. Rev. Immunol."},{"key":"10.1038\/mi.2015.53_bib30","doi-asserted-by":"crossref","unstructured":"The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul. Surf.5, 75\u201392 (2007).","DOI":"10.1016\/S1542-0124(12)70081-2"},{"key":"10.1038\/mi.2015.53_bib31","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.1093\/emboj\/19.21.5729","article-title":"The endoplasmic reticulum as one continuous Ca(2+) pool: visualization of rapid Ca(2+) movements and equilibration","volume":"19","author":"Park","year":"2000","journal-title":"EMBO J."},{"key":"10.1038\/mi.2015.53_bib32","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1111\/j.1582-4934.2010.01168.x","article-title":"Activation and regulation of store-operated calcium entry","volume":"14","author":"Smyth","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"10.1038\/mi.2015.53_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.immunol.021908.132550","article-title":"Molecular basis of calcium signaling in lymphocytes: STIM and ORAI","volume":"28","author":"Hogan","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1038\/mi.2015.53_bib34","doi-asserted-by":"crossref","first-page":"636812","DOI":"10.1155\/2013\/636812","article-title":"Modulation of conjunctival goblet cell function by inflammatory cytokines","volume":"2013","author":"Contreras-Ruiz","year":"2013","journal-title":"Mediators Inflamm."},{"key":"10.1038\/mi.2015.53_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exer.2013.11.011","article-title":"Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye","volume":"118","author":"Zhang","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1038\/mi.2015.53_bib36","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2174\/1566524011313020003","article-title":"The role of calcium stores in apoptosis and autophagy","volume":"13","author":"Smaili","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"10.1038\/mi.2015.53_bib37","first-page":"1455","article-title":"Isolation, characterization, and propagation of rat conjunctival goblet cells in vitro","volume":"42","author":"Shatos","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib38","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1167\/iovs.02-1117","article-title":"Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells","volume":"44","author":"Horikawa","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib39","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1167\/iovs.06-1226","article-title":"Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation","volume":"48","author":"Rios","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib40","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1167\/iovs.02-0550","article-title":"Isolation and characterization of cultured human conjunctival goblet cells","volume":"44","author":"Shatos","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1038\/mi.2015.53_bib41","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201553","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922008546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922008546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:19:56Z","timestamp":1761830396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922008546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1933021922008546"],"URL":"https:\/\/doi.org\/10.1038\/mi.2015.53","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction of IFN-\u03b3 with cholinergic agonists to modulate rat and human goblet cell function","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2015.53","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}