{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:43:58Z","timestamp":1790081038321,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":1671,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1038\/mi.2016.107","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T08:23:40Z","timestamp":1481703820000},"page":"1043-1055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia"],"prefix":"10.1016","volume":"10","author":[{"given":"T.","family":"Aoyagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Newstead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Kunkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.J.","family":"Standiford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2016.107_bib1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S1473-3099(12)70121-4","article-title":"Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study","volume":"12","author":"Dawood","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"10.1038\/mi.2016.107_bib2","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm1477","article-title":"Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia","volume":"12","author":"de Jong","year":"2006","journal-title":"Nat. Med."},{"key":"10.1038\/mi.2016.107_bib3","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1093\/infdis\/jit440","article-title":"Cytokine and chemokine levels in patients infected with the novel avian influenza A (H7N9) virus in China","volume":"208","author":"Chi","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2016.107_bib4","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1086\/650581","article-title":"Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection","volume":"50","author":"To","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1038\/mi.2016.107_bib5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1189\/jlb.3RI1014-495R","article-title":"Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions","volume":"97","author":"Gabay","year":"2015","journal-title":"J. Leuk. Biol."},{"key":"10.1038\/mi.2016.107_bib6","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1038\/jid.2011.234","article-title":"Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitroin vivo: implications in psoriasis pathogenesis","volume":"131","author":"Carrier","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1038\/mi.2016.107_bib7","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1182\/blood-2012-06-439026","article-title":"IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells","volume":"120","author":"Vigne","year":"2012","journal-title":"Blood"},{"key":"10.1038\/mi.2016.107_bib8","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.4049\/jimmunol.1003162","article-title":"IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression","volume":"186","author":"Johnston","year":"2011","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.107_bib9","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1056\/NEJMoa1013068","article-title":"Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis","volume":"365","author":"Marrakchi","year":"2011","journal-title":"N. Engl.J. Med."},{"key":"10.1038\/mi.2016.107_bib10","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1084\/jem.20070157","article-title":"Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation","volume":"204","author":"Blumberg","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2016.107_bib11","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1172\/JCI63451","article-title":"Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk","volume":"122","author":"Tortola","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1038\/mi.2016.107_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1165\/rcmb.2010-0075OC","article-title":"Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cells","volume":"45","author":"Chustz","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2016.107_bib13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1152\/physiolgenomics.00289.2004","article-title":"Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense","volume":"21","author":"Vos","year":"2005","journal-title":"Physiol. Genomics"},{"key":"10.1038\/mi.2016.107_bib14","doi-asserted-by":"crossref","first-page":"e45784","DOI":"10.1371\/journal.pone.0045784","article-title":"IL-36alpha exerts pro-inflammatory effects in the lungs of mice","volume":"7","author":"Ramadas","year":"2012","journal-title":"PLoS One"},{"key":"10.1038\/mi.2016.107_bib15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1165\/rcmb.2009-0315OC","article-title":"Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs","volume":"44","author":"Ramadas","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2016.107_bib16","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.4049\/jimmunol.0803301","article-title":"Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide\/ATP activation of transduced bone marrow macrophages","volume":"183","author":"Martin","year":"2009","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.107_bib17","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/jid.2011.482","article-title":"The double-stranded RNA analogue polyinosinic-polycytidylic acid induces keratinocyte pyroptosis and release of IL-36gamma","volume":"132","author":"Lian","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1038\/mi.2016.107_bib18","first-page":"414","article-title":"ATP release and purinergic signaling in NLRP3 inflammasome activation","volume":"3","author":"Gombault","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1038\/mi.2016.107_bib19","doi-asserted-by":"crossref","first-page":"e101087","DOI":"10.1371\/journal.pone.0101087","article-title":"Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma\/COPD","volume":"9","author":"Eltom","year":"2014","journal-title":"PLoS One"},{"key":"10.1038\/mi.2016.107_bib20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbrc.2013.01.135","article-title":"P2X4 receptor regulates P2X7 receptor-dependent IL-1beta and IL-18 release in mouse bone marrow-derived dendritic cells","volume":"432","author":"Sakaki","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1038\/mi.2016.107_bib21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/bja\/aes321","article-title":"Role of microparticles in sepsis","volume":"109","author":"Reid","year":"2012","journal-title":"Br. J. Anaesth."},{"key":"10.1038\/mi.2016.107_bib22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1189\/jlb.4A0315-087R","article-title":"IL-36gamma is secreted in microparticles and exosomes by lung macrophages in response to bacteria and bacterial components","volume":"100","author":"Kovach","year":"2016","journal-title":"J. Leuk. Biol."},{"key":"10.1038\/mi.2016.107_bib23","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1038\/mi.2016.107_bib24","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2016.107_bib25","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ccell.2015.07.014","article-title":"IL-36gamma transforms the tumor microenvironment and promotes type 1 lymphocyte-mediated antitumor immune responses","volume":"28","author":"Wang","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1038\/mi.2016.107_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1473-3099(13)70286-X","article-title":"Pathogenesis of influenza-induced acute respiratory distress syndrome","volume":"14","author":"Short","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1038\/mi.2016.107_bib27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nri3665","article-title":"Innate immunity to influenza virus infection","volume":"14","author":"Iwasaki","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/mi.2016.107_bib28","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1084\/jem.20080201","article-title":"Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand","volume":"205","author":"Herold","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2016.107_bib29","doi-asserted-by":"crossref","first-page":"e1003188","DOI":"10.1371\/journal.ppat.1003188","article-title":"Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia","volume":"9","author":"Hogner","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2016.107_bib30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol. Med."},{"key":"10.1038\/mi.2016.107_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ajpath.2011.03.013","article-title":"Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis","volume":"179","author":"Narasaraju","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1038\/mi.2016.107_bib32","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/eji.200635977","article-title":"An absence of reactive oxygen species improves the resolution of lung influenza infection","volume":"36","author":"Snelgrove","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1038\/mi.2016.107_bib33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1348-0421.2011.00424.x","article-title":"Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection","volume":"56","author":"Sugamata","year":"2012","journal-title":"Microbiol. Immunol."},{"key":"10.1038\/mi.2016.107_bib34","doi-asserted-by":"crossref","first-page":"R203","DOI":"10.1186\/cc9324","article-title":"Clinical aspects and cytokine response in severe H1N1 influenza A virus infection","volume":"14","author":"Hagau","year":"2010","journal-title":"Crit. Care"},{"key":"10.1038\/mi.2016.107_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1164\/rccm.201203-0508OC","article-title":"CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin","volume":"187","author":"Ichikawa","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1038\/mi.2016.107_bib36","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.4049\/jimmunol.179.6.4135","article-title":"IL-17 enhances chemokine gene expression through mRNA stabilization","volume":"179","author":"Hartupee","year":"2007","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.107_bib37","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"Khader","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2016.107_bib38","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.4049\/jimmunol.0900995","article-title":"Critical role of IL-17RA in immunopathology of influenza infection","volume":"183","author":"Crowe","year":"2009","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.107_bib39","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/cr.2011.165","article-title":"IL-17 response mediates acute lung injury induced by the 2009 pandemic influenza A (H1N1) virus","volume":"22","author":"Li","year":"2012","journal-title":"Cell Res."},{"key":"10.1038\/mi.2016.107_bib40","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/cr.2013.25","article-title":"Monoclonal antibody against CXCL-10\/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury","volume":"23","author":"Wang","year":"2013","journal-title":"Cell Res."},{"key":"10.1038\/mi.2016.107_bib41","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.4049\/jimmunol.0801814","article-title":"Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge","volume":"182","author":"Hamada","year":"2009","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.107_bib42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12974-015-0392-7","article-title":"Interleukin-36 gamma is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis","volume":"12","author":"Bozoyan","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1038\/mi.2016.107_bib43","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1126\/science.7667639","article-title":"Requirement of MIP-1 alpha for an inflammatory response to viral infection","volume":"269","author":"Cook","year":"1995","journal-title":"Science"},{"key":"10.1038\/mi.2016.107_bib44","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0002-9440(10)65068-7","article-title":"Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus","volume":"156","author":"Dawson","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1038\/mi.2016.107_bib45","doi-asserted-by":"crossref","first-page":"6878","DOI":"10.4049\/jimmunol.175.10.6878","article-title":"Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection","volume":"175","author":"Carey","year":"2005","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.107_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/intimm\/dxq460","article-title":"Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-gamma and TNF-alpha by Gr-1+ monocytes","volume":"23","author":"Aoyagi","year":"2011","journal-title":"Int. Immunol."},{"key":"10.1038\/mi.2016.107_bib47","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.4049\/jimmunol.0901709","article-title":"Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia","volume":"184","author":"Seki","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.107_bib48","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/01.shk.0000228791.10550.36","article-title":"Endothelium-derived microparticles induce endothelial dysfunction and acute lung injury","volume":"26","author":"Densmore","year":"2006","journal-title":"Shock"},{"key":"10.1038\/mi.2016.107_bib49","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.2217\/nnm.13.149","article-title":"Gateway to understanding microparticles: standardized isolation and identification of plasma membrane-derived vesicles","volume":"8","author":"Dinkla","year":"2013","journal-title":"Nanomedicine"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi2016107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi2016107","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922007127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922007127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/mi.2016.107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/mi2016107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:18:14Z","timestamp":1761830294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922007127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1933021922007127"],"URL":"https:\/\/doi.org\/10.1038\/mi.2016.107","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2016.107","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}