{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:20:40Z","timestamp":1771881640061,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":1793,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/mi.2016.52","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T13:43:27Z","timestamp":1465998207000},"page":"470-480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis"],"prefix":"10.1016","volume":"10","author":[{"given":"T.","family":"Zelante","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Y W","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mencarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Foo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zolezzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Poidinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ricciardi-Castagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 3","key":"10.1038\/mi.2016.52_bib1","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1002\/lt.22378","article-title":"Infections in immunocompromised hosts and organ transplant recipients: essentials","volume":"17","author":"Fishman","year":"2011","journal-title":"Liver Transpl."},{"key":"10.1038\/mi.2016.52_bib2","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1086\/651262","article-title":"Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET)","volume":"50","author":"Pappas","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1038\/mi.2016.52_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1399-3062.2008.00304.x","article-title":"Invasive aspergillosis and allogeneic hematopoietic stem cell transplantation in children: a 15-year experience","volume":"10","author":"Crassard","year":"2008","journal-title":"Transpl. Infect. Dis."},{"key":"10.1038\/mi.2016.52_bib4","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1086\/651263","article-title":"Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database","volume":"50","author":"Kontoyiannis","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1038\/mi.2016.52_bib5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1086\/510592","article-title":"Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality","volume":"44","author":"Upton","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"10.1038\/mi.2016.52_bib6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3324\/haematol.2009.012054","article-title":"Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study","volume":"95","author":"Pagano","year":"2010","journal-title":"Haematologica"},{"key":"10.1038\/mi.2016.52_bib7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/10245330500141390","article-title":"Complete resolution of hepatic aspergillosis after non-myeloablative hematopoietic stem cell transplantation in a patient with acute myeloid leukemia","volume":"10","author":"Marotta","year":"2005","journal-title":"Hematology"},{"key":"10.1038\/mi.2016.52_bib8","first-page":"643","article-title":"A new and clinically relevant murine model of solid-organ transplant aspergillosis","volume":"6","author":"Herbst","year":"2013","journal-title":"Dis. Model Mech."},{"key":"10.1038\/mi.2016.52_bib9","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/jac\/dku566","article-title":"Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany","volume":"70","author":"Steinmann","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1038\/mi.2016.52_bib10","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1182\/blood-2012-02-404475","article-title":"NFAT control of innate immunity","volume":"120","author":"Fric","year":"2012","journal-title":"Blood"},{"key":"10.1038\/mi.2016.52_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-811X-12-8","article-title":"Calcineurin\/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions","volume":"12","author":"Vandewalle","year":"2014","journal-title":"Cell Commun. Signal."},{"key":"10.1038\/mi.2016.52_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/mi.2016.52_bib13","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1084\/jem.20092531","article-title":"Calcineurin regulates innate antifungal immunity in neutrophils","volume":"207","author":"Greenblatt","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2016.52_bib14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.15252\/emmm.201404556","article-title":"Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus","volume":"7","author":"Herbst","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1038\/mi.2016.52_bib15","doi-asserted-by":"crossref","first-page":"e1003152","DOI":"10.1371\/journal.ppat.1003152","article-title":"Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients","volume":"9","author":"Tourneur","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1038\/mi.2016.52_bib16","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.4049\/jimmunol.179.7.4598","article-title":"Calcineurin negatively regulates TLR-mediated activation pathways","volume":"179","author":"Kang","year":"2007","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.52_bib17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/emmm.201100207","article-title":"Calcineurin\/NFAT signalling inhibits myeloid haematopoiesis","volume":"4","author":"Fric","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1038\/mi.2016.52_bib18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3389\/fimmu.2013.00513","article-title":"Phagocytosis of particulate antigens - all roads lead to calcineurin\/NFAT signaling pathway","volume":"4","author":"Fric","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1038\/mi.2016.52_bib19","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1002\/stem.1813","article-title":"Calcium and calcineurin-NFAT signaling regulate granulocyte-monocyte progenitor cell cycle via Flt3-L","volume":"32","author":"Fric","year":"2014","journal-title":"Stem Cells"},{"key":"10.1038\/mi.2016.52_bib20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1046\/j.1365-2141.2001.02747.x","article-title":"Older patients with high-risk fungal infections can be successfully allografted using non-myeloablative conditioning in combination with intensified supportive care regimens","volume":"113","author":"Hermann","year":"2001","journal-title":"Br. J. Haematol."},{"key":"10.1038\/mi.2016.52_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fimmu.2012.00161","article-title":"Interleukin-2 production by dendritic cells and its immuno-regulatory functions","volume":"3","author":"Zelante","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1038\/mi.2016.52_bib22","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.celrep.2015.08.030","article-title":"CD103(+) dendritic cells control Th17 cell function in the lung","volume":"12","author":"Zelante","year":"2015","journal-title":"Cell Rep."},{"key":"10.1038\/mi.2016.52_bib23","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.4049\/jimmunol.178.5.3107","article-title":"Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells","volume":"178","author":"Goodridge","year":"2007","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.52_bib24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature01195","article-title":"Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response","volume":"420","author":"Garlanda","year":"2002","journal-title":"Nature"},{"key":"10.1038\/mi.2016.52_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-065X.2008.00719.x","article-title":"The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity","volume":"227","author":"Bottazzi","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1038\/mi.2016.52_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fimmu.2013.00127","article-title":"Pentraxin 3: an immuno-regulator in the lungs","volume":"4","author":"Balhara","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1038\/mi.2016.52_bib27","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1182\/blood-2006-03-009266","article-title":"Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation","volume":"108","author":"Bozza","year":"2006","journal-title":"Blood"},{"key":"10.1038\/mi.2016.52_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00441-010-1018-0","article-title":"Pentraxins in innate immunity: lessons from PTX3","volume":"343","author":"Deban","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1038\/mi.2016.52_bib29","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ni.2987","article-title":"Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens","volume":"15","author":"Branzk","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2016.52_bib30","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1182\/blood-2009-12-258376","article-title":"Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus","volume":"116","author":"Moalli","year":"2010","journal-title":"Blood"},{"key":"10.1038\/mi.2016.52_bib31","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1056\/NEJMoa1211161","article-title":"Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation","volume":"370","author":"Cunha","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/mi.2016.52_bib32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00281-014-0468-y","article-title":"Host genetics of invasive Aspergillus and Candida infections","volume":"37","author":"Wojtowicz","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"10.1038\/mi.2016.52_bib33","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.20062648","article-title":"Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen","volume":"204","author":"Caton","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2016.52_bib34","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0092-8674(01)00585-2","article-title":"Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working\/episodic-like memory","volume":"107","author":"Zeng","year":"2001","journal-title":"Cell"},{"key":"10.1038\/mi.2016.52_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"10.1038\/mi.2016.52_bib36","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1086\/652768","article-title":"Factors associated with mortality in transplant patients with invasive aspergillosis","volume":"50","author":"Baddley","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1038\/mi.2016.52_bib37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00281-014-0467-z","article-title":"Antifungal innate immunity: recognition and inflammatory networks","volume":"37","author":"Becker","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"10.1038\/mi.2016.52_bib38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.immuni.2014.02.015","article-title":"The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection","volume":"40","author":"Jaillon","year":"2014","journal-title":"Immunity"},{"key":"10.1038\/mi.2016.52_bib39","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.4049\/jimmunol.1400814","article-title":"PTX3 binds MD-2 and promotes TRIF-dependent immune protection in Aspergillosis","volume":"193","author":"Bozza","year":"2014","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.52_bib40","doi-asserted-by":"crossref","first-page":"25584","DOI":"10.1074\/jbc.270.43.25584","article-title":"Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor\/interleukin-1-inducible pentraxin protein","volume":"270","author":"Altmeyer","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1038\/mi.2016.52_bib41","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1084\/jem.20061301","article-title":"The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps","volume":"204","author":"Jaillon","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1038\/mi.2016.52_bib42","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1128\/AAC.48.11.4414-4421.2004","article-title":"Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals","volume":"48","author":"Gaziano","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1038\/mi.2016.52_bib43","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1128\/AAC.00674-10","article-title":"Efficacy of PTX3 in a rat model of invasive aspergillosis","volume":"54","author":"Lo Giudice","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1038\/mi.2016.52_bib44","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1056\/NEJMoa0802629","article-title":"Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation","volume":"359","author":"Bochud","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/mi.2016.52_bib45","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1086\/526500","article-title":"Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis","volume":"197","author":"Carvalho","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2016.52_bib46","doi-asserted-by":"crossref","first-page":"e32273","DOI":"10.1371\/journal.pone.0032273","article-title":"Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection","volume":"7","author":"Sainz","year":"2012","journal-title":"PLoS One"},{"key":"10.1038\/mi.2016.52_bib47","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1182\/blood-2010-04-279307","article-title":"Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity","volume":"116","author":"Cunha","year":"2010","journal-title":"Blood"},{"key":"10.1038\/mi.2016.52_bib48","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/infdis\/jiq102","article-title":"The Y238X stop codon polymorphism in the human beta-glucan receptor dectin-1 and susceptibility to invasive aspergillosis","volume":"203","author":"Chai","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1038\/mi.2016.52_bib49","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.7660125","article-title":"Inducible gene targeting in mice","volume":"269","author":"Kuhn","year":"1995","journal-title":"Science"},{"key":"10.1038\/mi.2016.52_bib50","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4049\/jimmunol.168.3.1362","article-title":"Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus","volume":"168","author":"Bozza","year":"2002","journal-title":"J. Immunol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201652.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201652","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922006596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922006596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201652.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:18:09Z","timestamp":1761830289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922006596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S1933021922006596"],"URL":"https:\/\/doi.org\/10.1038\/mi.2016.52","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2016.52","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}