{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:00:22Z","timestamp":1790431222986,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":1793,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/mi.2016.61","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T08:25:13Z","timestamp":1469003113000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis"],"prefix":"10.1016","volume":"10","author":[{"given":"S.L.","family":"Ashley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Wilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.B.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2016.61_bib1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/mi.2008.85","article-title":"Pulmonary fibrosis: pathogenesis, etiology and regulation","volume":"2","author":"Wilson","year":"2009","journal-title":"Mucosal Immunol."},{"key":"10.1038\/mi.2016.61_bib2","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(11)60052-4","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"King","year":"2011","journal-title":"Lancet"},{"key":"10.1038\/mi.2016.61_bib3","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1513\/AnnalsATS.201404-145OC","article-title":"Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century","volume":"11","author":"Hutchinson","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1038\/mi.2016.61_bib4","doi-asserted-by":"crossref","first-page":"963","DOI":"10.7326\/0003-4819-142-12_Part_1-200506210-00005","article-title":"The clinical course of patients with idiopathic pulmonary fibrosis","volume":"142","author":"Martinez","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"10.1038\/mi.2016.61_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.pupt.2006.01.002","article-title":"Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis","volume":"20","author":"Antoniou","year":"2007","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1038\/mi.2016.61_bib6","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0140-6736(12)61144-1","article-title":"New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis","volume":"380","author":"Fernandez","year":"2012","journal-title":"Lancet"},{"key":"10.1038\/mi.2016.61_bib7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1164\/rccm.201306-1141WS","article-title":"Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report","volume":"189","author":"Blackwell","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1038\/mi.2016.61_bib8","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1378\/chest.06-2568","article-title":"Molecular targets in pulmonary fibrosis: the myofibroblast in focus","volume":"132","author":"Scotton","year":"2007","journal-title":"Chest"},{"key":"10.1038\/mi.2016.61_bib9","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial-mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1038\/mi.2016.61_bib10","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1038\/mi.2016.61_bib11","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"10.1038\/mi.2016.61_bib12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1513\/pats.200601-003TK","article-title":"Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers","volume":"3","author":"Selman","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1038\/mi.2016.61_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1165\/rcmb.2009-0031OC","article-title":"Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis","volume":"43","author":"Hashimoto","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2016.61_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2353\/ajpath.2010.090517","article-title":"Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis","volume":"176","author":"Humphreys","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1038\/mi.2016.61_bib15","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1164\/rccm.201212-2297OC","article-title":"Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis","volume":"188","author":"Hung","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1038\/mi.2016.61_bib16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nm.3218","article-title":"Origin and function of myofibroblasts in kidney fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat. Med."},{"key":"10.1038\/mi.2016.61_bib17","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.4049\/jimmunol.1200604","article-title":"Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury","volume":"190","author":"Osterholzer","year":"2013","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.61_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1586\/17476348.2014.862154","article-title":"Paracrine functions of fibrocytes to promote lung fibrosis","volume":"8","author":"Kleaveland","year":"2014","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1038\/mi.2016.61_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03403533","article-title":"Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair","volume":"1","author":"Bucala","year":"1994","journal-title":"Mol. Med."},{"key":"10.1038\/mi.2016.61_bib20","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.94.12.6307","article-title":"The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ","volume":"94","author":"Chesney","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1038\/mi.2016.61_bib21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4049\/jimmunol.160.1.419","article-title":"Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes","volume":"160","author":"Chesney","year":"1998","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.61_bib22","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1164\/rccm.201411-2013ED","article-title":"Fibrocytes and progression of fibrotic lung disease. Ready for showtime?","volume":"190","author":"Moore","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1038\/mi.2016.61_bib23","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0002-9440(10)62289-4","article-title":"CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury","volume":"166","author":"Moore","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1038\/mi.2016.61_bib24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1165\/rcmb.2005-0239OC","article-title":"The role of CCL12 in the recruitment of fibrocytes and lung fibrosis","volume":"35","author":"Moore","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2016.61_bib25","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI200420997","article-title":"Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis","volume":"114","author":"Phillips","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1038\/mi.2016.61_bib26","doi-asserted-by":"crossref","first-page":"26996","DOI":"10.1074\/jbc.M110.208033","article-title":"The non-phagocytic route of collagen uptake: a distinct degradation pathway","volume":"286","author":"Madsen","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1038\/mi.2016.61_bib27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1582-4934.2011.01344.x","article-title":"Extracellular matrix remodelling properties of human fibrocytes","volume":"16","author":"Bianchetti","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1038\/mi.2016.61_bib28","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.4049\/jimmunol.1400753","article-title":"Fibrocytes are not an essential source of type I collagen during lung fibrosis","volume":"193","author":"Kleaveland","year":"2014","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.61_bib29","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1177\/1535370215584933","article-title":"Bone marrow-derived fibrocytes contribute to liver fibrosis","volume":"240","author":"Xu","year":"2015","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1038\/mi.2016.61_bib30","first-page":"34","article-title":"Contribution of bone marrow-derived fibrocytes to liver fibrosis","volume":"4","author":"Xu","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1038\/mi.2016.61_bib31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1164\/rccm.201407-1334OC","article-title":"Fibrocytes contribute to inflammation and fibrosis in chronic hypersensitivity pneumonitis through paracrine effects","volume":"191","author":"Garcia de Alba","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1038\/mi.2016.61_bib32","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1165\/rcmb.2013-0042OC","article-title":"Bone marrow-derived stromal cells are invasive and hyperproliferative and alter transforming growth factor-alpha-induced pulmonary fibrosis","volume":"50","author":"Madala","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2016.61_bib33","doi-asserted-by":"crossref","first-page":"L1046","DOI":"10.1152\/ajplung.00139.2012","article-title":"Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis","volume":"303","author":"Naik","year":"2012","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1038\/mi.2016.61_bib34","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1007\/s00018-011-0784-5","article-title":"Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell","volume":"68","author":"Kudo","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"10.1038\/mi.2016.61_bib35","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1359\/jbmr.1999.14.7.1239","article-title":"Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta","volume":"14","author":"Horiuchi","year":"1999","journal-title":"J. Bone. Miner. Res."},{"key":"10.1038\/mi.2016.61_bib36","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1007\/s00018-009-0013-7","article-title":"The multifaceted role of periostin in tumorigenesis","volume":"66","author":"Ruan","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1038\/mi.2016.61_bib37","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1183\/09031936.00059810","article-title":"Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias","volume":"37","author":"Okamoto","year":"2011","journal-title":"Eur. Respir. J."},{"key":"10.1038\/mi.2016.61_bib38","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1164\/rccm.201510-2032PP","article-title":"Roles of Periostin in Respiratory Disorders","volume":"193","author":"Izuhara","year":"2016","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"10.1038\/mi.2016.61_bib39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0167-4781(94)00207-J","article-title":"Effect of the 3'-untranslated region on the expression levels and mRNA stability of alpha 1(I) collagen gene","volume":"1260","author":"Maatta","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1038\/mi.2016.61_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-1536-3-15","article-title":"Mesenchymal cell survival in airway and interstitial pulmonary fibrosis","volume":"3","author":"Bonner","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1038\/mi.2016.61_bib41","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast: one function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1038\/mi.2016.61_bib42","doi-asserted-by":"crossref","first-page":"286S","DOI":"10.1378\/chest.122.6_suppl.286S","article-title":"The myofibroblast in pulmonary fibrosis","volume":"122","author":"Phan","year":"2002","journal-title":"Chest"},{"key":"10.1038\/mi.2016.61_bib43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1165\/rcmb.2011-0115OC","article-title":"Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis","volume":"46","author":"Uchida","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2016.61_bib44","doi-asserted-by":"crossref","first-page":"7556","DOI":"10.4049\/jimmunol.166.12.7556","article-title":"Peripheral blood fibrocytes: differentiation pathway and migration to wound sites","volume":"166","author":"Abe","year":"2001","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.61_bib45","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4049\/jimmunol.171.1.380","article-title":"Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma","volume":"171","author":"Schmidt","year":"2003","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.61_bib46","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1165\/rcmb.2012-0224OC","article-title":"X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis","volume":"49","author":"Ajayi","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2016.61_bib47","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1165\/rcmb.2015-0148OC","article-title":"Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-induced Lung Fibrosis","volume":"54","author":"Ashley","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1038\/mi.2016.61_bib48","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.110.217737","article-title":"Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation","volume":"106","author":"Leask","year":"2010","journal-title":"Circ. Res."},{"key":"10.1038\/mi.2016.61_bib49","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1186\/1755-1536-5-S1-S24","article-title":"CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis","volume":"5","author":"Lipson","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1038\/mi.2016.61_bib50","doi-asserted-by":"crossref","first-page":"L786","DOI":"10.1152\/ajplung.00243.2013","article-title":"Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor","volume":"306","author":"Yang","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1038\/mi.2016.61_bib51","doi-asserted-by":"crossref","first-page":"13294","DOI":"10.1074\/jbc.M109.088864","article-title":"Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase","volume":"285","author":"Maruhashi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1038\/mi.2016.61_bib52","doi-asserted-by":"crossref","first-page":"288ra279","DOI":"10.1126\/scitranslmed.aaa5094","article-title":"The alphavbeta1 integrin plays a critical in vivo role in tissue fibrosis","volume":"7","author":"Reed","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1038\/mi.2016.61_bib53","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.4049\/jimmunol.167.8.4368","article-title":"Protection from pulmonary fibrosis in the absence of CCR2 signaling","volume":"167","author":"Moore","year":"2001","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2016.61_bib54","doi-asserted-by":"crossref","first-page":"L219","DOI":"10.1152\/ajplung.00300.2013","article-title":"gamma-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosis","volume":"307","author":"Ashley","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201661.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201661","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922006481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922006481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201661.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:16:10Z","timestamp":1761830170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922006481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S1933021922006481"],"URL":"https:\/\/doi.org\/10.1038\/mi.2016.61","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2016.61","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}