{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:33:23Z","timestamp":1790728403862,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":1487,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1038\/mi.2017.38","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T08:20:35Z","timestamp":1495009235000},"page":"50-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Jak3 deficiency blocks innate lymphoid cell development"],"prefix":"10.1016","volume":"11","author":[{"given":"M L","family":"Robinette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J B","family":"Telliez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T K","family":"Ulland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D","family":"Barrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Capuder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Gilfillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L-L","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L D","family":"Notarangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Colonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mi.2017.38_bib1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s10875-015-0201-1","article-title":"Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015","volume":"35","author":"Picard","year":"2015","journal-title":"J. Clin. Immunol."},{"key":"10.1038\/mi.2017.38_bib2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1056\/NEJMoa1401177","article-title":"Transplantation outcomes for severe combined immunodeficiency, 2000-2009","volume":"371","author":"Pai","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/mi.2017.38_bib3","first-page":"5","article-title":"Severe combined immunodeficiency (SCID): from molecular basis to clinical management","volume":"82","author":"Sponzilli","year":"2011","journal-title":"Acta Biomed."},{"key":"10.1038\/mi.2017.38_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.0105-2896.2004.00203.x","article-title":"Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways","volume":"202","author":"Kovanen","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1038\/mi.2017.38_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.immuni.2012.03.016","article-title":"Inborn errors of human JAKs and STATs","volume":"36","author":"Casanova","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/mi.2017.38_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/377065a0","article-title":"Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)","volume":"377","author":"Macchi","year":"1995","journal-title":"Nature"},{"key":"10.1038\/mi.2017.38_bib7","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1126\/science.270.5237.800","article-title":"Defective lymphoid development in mice lacking Jak3","volume":"270","author":"Nosaka","year":"1995","journal-title":"Science"},{"key":"10.1038\/mi.2017.38_bib8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.0105-2896.2005.00220.x","article-title":"Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs","volume":"203","author":"Pesu","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1038\/mi.2017.38_bib9","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.4049\/jimmunol.1003668","article-title":"Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)","volume":"186","author":"Ghoreschi","year":"2011","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2017.38_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1056\/NEJMoa1109071","article-title":"Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis","volume":"367","author":"Fleischmann","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1038\/mi.2017.38_bib11","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1021\/acschembio.6b00677","article-title":"Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition","volume":"11","author":"Telliez","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1038\/mi.2017.38_bib12","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1021\/acs.jmedchem.6b01694","article-title":"Design of a Janus Kinase 3 (JAK3) specific inhibitor 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop -2-en-1-one (PF-06651600) allowing for the Interrogation of JAK3 signaling in humans","volume":"60","author":"Thorarensen","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1038\/mi.2017.38_bib13","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jaci.2016.09.006","article-title":"Immune modules shared by innate lymphoid cells and T cells","volume":"138","author":"Robinette","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1038\/mi.2017.38_bib14","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/ni.3481","article-title":"Development of innate lymphoid cells","volume":"17","author":"Zook","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2017.38_bib15","doi-asserted-by":"crossref","first-page":"aaa6566","DOI":"10.1126\/science.aaa6566","article-title":"Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology","volume":"348","author":"Eberl","year":"2015","journal-title":"Science"},{"key":"10.1038\/mi.2017.38_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nri3855","article-title":"Transcriptional regulation of innate lymphoid cell fate","volume":"15","author":"Serafini","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1038\/mi.2017.38_bib17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ni.3448","article-title":"Innate lymphoid cells in defense, immunopathology and immunotherapy","volume":"17","author":"Cording","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2017.38_bib18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/ni.3368","article-title":"The heterogeneity of human CD127(+) innate lymphoid cells revealed by single-cell RNA sequencing","volume":"17","author":"Bjorklund","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2017.38_bib19","doi-asserted-by":"crossref","first-page":"14601","DOI":"10.1038\/ncomms14601","article-title":"IL-15 sustains IL-7R-independent ILC2 and ILC3 development","volume":"8","author":"Robinette","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1038\/mi.2017.38_bib20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.immuni.2014.09.006","article-title":"Innate lymphoid cells in inflammation and immunity","volume":"41","author":"McKenzie","year":"2014","journal-title":"Immunity"},{"key":"10.1038\/mi.2017.38_bib21","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nm.3892","article-title":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation","volume":"21","author":"Sonnenberg","year":"2015","journal-title":"Nat. Med."},{"key":"10.1038\/mi.2017.38_bib22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.imlet.2015.10.004","article-title":"Innate lymphoid cells in inflammatory bowel diseases","volume":"172","author":"Peters","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1038\/mi.2017.38_bib23","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ni.3489","article-title":"Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis","volume":"17","author":"Klose","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2017.38_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.coi.2015.11.005","article-title":"Differentiation of human innate lymphoid cells (ILCs)","volume":"38","author":"Juelke","year":"2016","journal-title":"Curr. Opin. Immunol."},{"key":"10.1038\/mi.2017.38_bib25","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ni.3094","article-title":"Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets","volume":"16","author":"Robinette","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2017.38_bib26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.immuni.2012.05.028","article-title":"Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease","volume":"37","author":"Hanash","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/mi.2017.38_bib27","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1126\/science.270.5237.794","article-title":"Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3","volume":"270","author":"Thomis","year":"1995","journal-title":"Science"},{"key":"10.1038\/mi.2017.38_bib28","doi-asserted-by":"crossref","first-page":"727","DOI":"10.4049\/jimmunol.166.2.727","article-title":"Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice","volume":"166","author":"Gozalo-Sanmillan","year":"2001","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2017.38_bib29","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/ni.3248","article-title":"TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow","volume":"16","author":"Yang","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2017.38_bib30","doi-asserted-by":"crossref","unstructured":"Yu, X. et al. The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. Elife3 (2014).","DOI":"10.7554\/eLife.04406"},{"key":"10.1038\/mi.2017.38_bib31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2014.03.030","article-title":"Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages","volume":"157","author":"Klose","year":"2014","journal-title":"Cell"},{"key":"10.1038\/mi.2017.38_bib32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nature13047","article-title":"A committed precursor to innate lymphoid cells","volume":"508","author":"Constantinides","year":"2014","journal-title":"Nature"},{"key":"10.1038\/mi.2017.38_bib33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature20105","article-title":"Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway","volume":"539","author":"Yu","year":"2016","journal-title":"Nature"},{"key":"10.1038\/mi.2017.38_bib34","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.immuni.2012.06.020","article-title":"The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells","volume":"37","author":"Hoyler","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/mi.2017.38_bib35","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.it.2013.07.005","article-title":"Location and cellular stages of natural killer cell development","volume":"34","author":"Yu","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1038\/mi.2017.38_bib36","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1073\/pnas.1423244112","article-title":"PLZF expression maps the early stages of ILC1 lineage development","volume":"112","author":"Constantinides","year":"2015","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/mi.2017.38_bib37","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/bjd.12517","article-title":"Effect of tofacitinib, a Janus kinase inhibitor, on haematological parameters during 12 weeks of psoriasis treatment","volume":"169","author":"Strober","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1038\/mi.2017.38_bib38","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.1005641107","article-title":"Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity","volume":"107","author":"Cella","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1038\/mi.2017.38_bib39","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.cell.2016.04.014","article-title":"Distinct gene regulatory pathways for human innate versus adaptive lymphoid cells","volume":"165","author":"Koues","year":"2016","journal-title":"Cell"},{"key":"10.1038\/mi.2017.38_bib40","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.immuni.2014.11.010","article-title":"Human RORgammat(+)CD34(+) cells are lineage-specified progenitors of group 3 RORgammat(+) innate lymphoid cells","volume":"41","author":"Montaldo","year":"2014","journal-title":"Immunity"},{"key":"10.1038\/mi.2017.38_bib41","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.4049\/jimmunol.1000665","article-title":"Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development","volume":"185","author":"Chappaz","year":"2010","journal-title":"J. Immunol."},{"key":"10.1038\/mi.2017.38_bib42","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/ni.3553","article-title":"Evidence of innate lymphoid cell redundancy in humans","volume":"17","author":"Vely","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1038\/mi.2017.38_bib43","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1021\/jm401490p","article-title":"Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases","volume":"57","author":"Clark","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1038\/mi.2017.38_bib44","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nm.3895","article-title":"IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases","volume":"21","author":"Teng","year":"2015","journal-title":"Nat. Med."},{"key":"10.1038\/mi.2017.38_bib45","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0140-6736(14)62113-9","article-title":"Tofacitinib versus etanercept or placebo in moderate-to-severe chronic plaque psoriasis: a phase 3 randomised non-inferiority trial","volume":"386","author":"Bachelez","year":"2015","journal-title":"Lancet"},{"key":"10.1038\/mi.2017.38_bib46","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1056\/NEJMoa1112168","article-title":"Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis","volume":"367","author":"Sandborn","year":"2012","journal-title":"N. Engl. J. Med."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mi201738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mi201738","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922004871?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021922004871?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/mi.2017.38","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/mi201738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:14:14Z","timestamp":1761830054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021922004871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1933021922004871"],"URL":"https:\/\/doi.org\/10.1038\/mi.2017.38","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jak3 deficiency blocks innate lymphoid cell development","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mi.2017.38","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 \u00a9 Society for Mucosal Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}