{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:39:11Z","timestamp":1790735951900,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5092,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1038\/modpathol.2008.148","type":"journal-article","created":{"date-parts":[[2008,9,26]],"date-time":"2008-09-26T12:07:32Z","timestamp":1222430852000},"page":"206-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["TCL1A expression delineates biological and clinical variability in B-cell lymphoma"],"prefix":"10.1016","volume":"22","author":[{"given":"Mohit","family":"Aggarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Villuendas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Socorro M","family":"Rodriguez-Pinilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Sanchez-Beato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca I","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Montes-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A","family":"Garcia-Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kimby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A","family":"Piris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2008.148_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/sj.leu.2404970","article-title":"Lymphoma microenvironment: culprit or innocent?","volume":"22","author":"Herreros","year":"2008","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.2008.148_bib2","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1182\/blood-2002-07-2009","article-title":"Cell cycle deregulation in B-cell lymphomas","volume":"101","author":"Sanchez-Beato","year":"2003","journal-title":"Blood"},{"key":"10.1038\/modpathol.2008.148_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0065-2776(05)87005-1","article-title":"The biology of human lymphoid malignancies revealed by gene expression profiling","volume":"87","author":"Staudt","year":"2005","journal-title":"Adv Immunol"},{"key":"10.1038\/modpathol.2008.148_bib4","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1073\/pnas.102181599","article-title":"Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression","volume":"99","author":"Bichi","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2008.148_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ccr.2005.03.037","article-title":"Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice","volume":"7","author":"Cattoretti","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1038\/modpathol.2008.148_bib6","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1073\/pnas.0611399104","article-title":"Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas","volume":"104","author":"Polo","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2008.148_bib7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrc1589","article-title":"Mechanisms of B-cell lymphoma pathogenesis","volume":"5","author":"Kuppers","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2008.148_bib8","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nrc1672","article-title":"The TCL1 family of oncoproteins: co-activators of transformation","volume":"5","author":"Teitell","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2008.148_bib9","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1158\/0008-5472.CAN-06-3613","article-title":"Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181","volume":"66","author":"Pekarsky","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2008.148_bib10","doi-asserted-by":"crossref","first-page":"11713","DOI":"10.1073\/pnas.0604564103","article-title":"B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia","volume":"103","author":"Yan","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2008.148_bib11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/sj.leu.2404017","article-title":"TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state","volume":"20","author":"Herling","year":"2006","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.2008.148_bib12","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1038\/sj.leu.2404853","article-title":"MicroRNA losses in the frequently deleted region of 7q in SMZL","volume":"21","author":"Ruiz-Ballesteros","year":"2007","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.2008.148_bib13","doi-asserted-by":"crossref","first-page":"10175","DOI":"10.1073\/pnas.0704170104","article-title":"TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation","volume":"104","author":"Kuraishy","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2008.148_bib14","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1182\/blood-2005-12-011213","article-title":"Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia","volume":"108","author":"Johnson","year":"2006","journal-title":"Blood"},{"key":"10.1038\/modpathol.2008.148_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/path.1768","article-title":"Expression of the NF-kappaB targets BCL2 and BIRC5\/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively","volume":"206","author":"Tracey","year":"2005","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2008.148_bib16","first-page":"8226","article-title":"The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival","volume":"63","author":"Martinez","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2008.148_bib17","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1158\/1078-0432.CCR-04-0753","article-title":"Variability in the degree of expression of phosphorylated IkappaBalpha in chronic lymphocytic leukemia cases with nodal involvement","volume":"10","author":"Rodriguez","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2008.148_bib18","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1182\/blood-2007-09-110601","article-title":"Lentiviral (HIV)-based RNA interference screen in human B-cell receptor regulatory networks reveals MCL1-induced oncogenic pathways","volume":"111","author":"Ruiz-Vela","year":"2008","journal-title":"Blood"},{"key":"10.1038\/modpathol.2008.148_bib19","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1182\/blood-2004-10-3898","article-title":"Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis","volume":"106","author":"Ruiz-Ballesteros","year":"2005","journal-title":"Blood"},{"key":"10.1038\/modpathol.2008.148_bib20","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"10.1038\/modpathol.2008.148_bib21","series-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe","year":"2001"},{"key":"10.1038\/modpathol.2008.148_bib22","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1038\/sj.leu.2404831","article-title":"Molecular heterogeneity in chronic lymphocytic leukemia is dependent on BCR signaling: clinical correlation","volume":"21","author":"Rodriguez","year":"2007","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.2008.148_bib23","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.3324\/haematol.12999","article-title":"Somatic hypermutation signature in B-cell low-grade lymphomas","volume":"93","author":"Tracey","year":"2008","journal-title":"Haematologica"},{"key":"10.1038\/modpathol.2008.148_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2006.09.006","article-title":"Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance","volume":"10","author":"Wei","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1038\/modpathol.2008.148_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.0105-2896.2006.00373.x","article-title":"A library of gene expression signatures to illuminate normal and pathological lymphoid biology","volume":"210","author":"Shaffer","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1038\/modpathol.2008.148_bib26","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ng1532","article-title":"Reverse engineering of regulatory networks in human B cells","volume":"37","author":"Basso","year":"2005","journal-title":"Nat Genet"},{"key":"10.1038\/modpathol.2008.148_bib27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/labinvest.3780264","article-title":"TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphoma","volume":"81","author":"Said","year":"2001","journal-title":"Lab Invest"},{"key":"10.1038\/modpathol.2008.148_bib28","first-page":"2095","article-title":"Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissues","volume":"60","author":"Narducci","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2008.148_bib29","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1056\/NEJMe068075","article-title":"Burkitt's lymphoma\u2014the message from microarrays","volume":"354","author":"Harris","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2008.148_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/PAS.0b013e3180959e09","article-title":"Characteristic expression patterns of TCL1, CD38, and CD44 identify aggressive lymphomas harboring a MYC translocation","volume":"32","author":"Rodig","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2008.148_bib31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/364645a0","article-title":"B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40","volume":"364","author":"Tsubata","year":"1993","journal-title":"Nature"},{"key":"10.1038\/modpathol.2008.148_bib32","doi-asserted-by":"crossref","first-page":"16600","DOI":"10.1073\/pnas.0407541101","article-title":"TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma\/chronic lymphocytic leukemia in transgenic mice","volume":"101","author":"Zapata","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2008.148_bib33","first-page":"151","article-title":"Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas","volume":"26","author":"Ramuz","year":"2005","journal-title":"Int J Oncol"},{"key":"10.1038\/modpathol.2008.148_bib34","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1158\/0008-5472.CAN-05-3426","article-title":"Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Emu-TCL1 transgenic mice","volume":"66","author":"Zanesi","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2008.148_bib35","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2008148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2008148","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222025637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222025637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2008148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:00:38Z","timestamp":1760230838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222025637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0893395222025637"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2008.148","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TCL1A expression delineates biological and clinical variability in B-cell lymphoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2008.148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}