{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:02:21Z","timestamp":1780408941997,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5154,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1038\/modpathol.2008.158","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T10:05:14Z","timestamp":1224237914000},"page":"1508-1516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Systemic mastocytosis involving the gastrointestinal tract: clinicopathologic and molecular study of five cases"],"prefix":"10.1016","volume":"21","author":[{"given":"Richard","family":"Kirsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Geboes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"de Hertogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nando","family":"Di Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Lebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugnius","family":"Mickys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H","family":"Riddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2008.158_bib1","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1182\/blood-2006-04-015545","article-title":"KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients","volume":"108","author":"Garcia-Montero","year":"2006","journal-title":"Blood"},{"key":"10.1038\/modpathol.2008.158_bib2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0889-8588(05)70298-7","article-title":"Gastrointestinal abnormalities and involvement in systemic mastocytosis","volume":"14","author":"Jensen","year":"2000","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1038\/modpathol.2008.158_bib3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1309\/2880LF7Q6XK3HA3Q","article-title":"Are gastrointestinal mucosal mast cells increased in patients with systemic mastocytosis?","volume":"122","author":"Siegert","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2008.158_bib4","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/0002-9343(80)90476-3","article-title":"The effect of cimetidine and propantheline on the symptoms of a patient with systemic mastocytosis","volume":"69","author":"Achord","year":"1980","journal-title":"Am J Med"},{"key":"10.1038\/modpathol.2008.158_bib5","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00004836-198508000-00017","article-title":"Bleeding after liver biopsy in a patient with systemic mastocytosis and malabsorption","volume":"7","author":"Adler","year":"1985","journal-title":"J Clin Gastroenterol"},{"key":"10.1038\/modpathol.2008.158_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/gut.17.2.107","article-title":"Gastrointestinal involvement in systemic mastocytosis","volume":"17","author":"Ammann","year":"1976","journal-title":"Gut"},{"key":"10.1038\/modpathol.2008.158_bib7","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1097\/01.pas.0000213310.51553.d7","article-title":"Systemic mastocytosis mimicking inflammatory bowel disease: a case report and discussion of gastrointestinal pathology in systemic mastocytosis","volume":"30","author":"Bedeir","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2008.158_bib8","first-page":"30","article-title":"Clinical, histological, and electron microscopic study of mast cell disease of the small bowel","volume":"80","author":"Braverman","year":"1985","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/modpathol.2008.158_bib9","first-page":"133","article-title":"Malabsorption and gastric hyperacidity in systemic mastocytosis. Results of cimetidine therapy","volume":"74","author":"Bredfeldt","year":"1980","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/modpathol.2008.158_bib10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0002-9343(70)90069-0","article-title":"Mastocytosis and intestinal malabsorption","volume":"48","author":"Broitman","year":"1970","journal-title":"Am J Med"},{"key":"10.1038\/modpathol.2008.158_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1365-2133.1988.tb03467.x","article-title":"Intestinal mucosal mast cells: enumeration in urticaria pigmentosa and systemic mastocytosis","volume":"119","author":"Ferguson","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1038\/modpathol.2008.158_bib12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2222.1991.tb00828.x","article-title":"Effects of tixocortol pivalate on gastrointestinal disease in systemic mastocytosis: a preliminary study","volume":"21","author":"Friedman","year":"1991","journal-title":"Clin Exp Allergy"},{"key":"10.1038\/modpathol.2008.158_bib13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000247526","article-title":"Systemic mastocytosis treated with histamine H1 and H2 receptor antagonists","volume":"184","author":"Gasior-Chrzan","year":"1992","journal-title":"Dermatology"},{"key":"10.1038\/modpathol.2008.158_bib14","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1097\/PAS.0b013e318078ce7a","article-title":"Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis","volume":"31","author":"Hahn","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2008.158_bib15","doi-asserted-by":"crossref","first-page":"769","DOI":"10.7326\/0003-4819-90-5-769","article-title":"Effect of cimetidine on gastric hypersecretion and diarrhea in systemic mastocytosis","volume":"90","author":"Hirschowitz","year":"1979","journal-title":"Ann Intern Med"},{"key":"10.1038\/modpathol.2008.158_bib16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/gut.8.1.64","article-title":"Mastocytosis (urticaria pigmentosa) of skin, stomach, and gut with malabsorption","volume":"8","author":"Jarnum","year":"1967","journal-title":"Gut"},{"key":"10.1038\/modpathol.2008.158_bib17","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/BF01295914","article-title":"Evaluation of anorectal physiology in patients with increased mast cells","volume":"38","author":"Libel","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1038\/modpathol.2008.158_bib18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2340\/0001555562264265","article-title":"Forty years of diarrhoea in a patient with urticaria pigmentosa","volume":"62","author":"Mahood","year":"1982","journal-title":"Acta Derm Venereol"},{"key":"10.1038\/modpathol.2008.158_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF01887793","article-title":"Bull's-eye lesions: a new gastrointestinal presentation of mastocytosis","volume":"9","author":"Quinn","year":"1984","journal-title":"Gastrointest Radiol"},{"key":"10.1038\/modpathol.2008.158_bib20","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/0002-9343(68)90178-2","article-title":"Systemic mast cell disease in a patient with unusual gastrointestinal and pulmonary abnormalities","volume":"45","author":"Roberts","year":"1968","journal-title":"Am J Med"},{"key":"10.1038\/modpathol.2008.158_bib21","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0016-5107(96)70019-6","article-title":"Endoscopic findings in systemic mastocytosis","volume":"44","author":"Scolapio","year":"1996","journal-title":"Gastrointest Endosc"},{"key":"10.1038\/modpathol.2008.158_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000017978","article-title":"Cutaneous mastocytosis in adults. Evaluation of 14 patients with respect to systemic disease manifestations","volume":"197","author":"Tebbe","year":"1998","journal-title":"Dermatology"},{"key":"10.1038\/modpathol.2008.158_bib23","first-page":"54","article-title":"Mastocytosis with malabsorption, myelofibrosis, and massive ascites","volume":"82","author":"Reisberg","year":"1987","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/modpathol.2008.158_bib24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.dld.2006.06.003","article-title":"Aggressive systemic mastocytosis complicated by protein-losing enteropathy","volume":"39","author":"Mickys","year":"2007","journal-title":"Dig Liver Dis"},{"key":"10.1038\/modpathol.2008.158_bib25","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1373\/clinchem.2006.068205","article-title":"Sensitive detection of KIT D816V in patients with mastocytosis","volume":"52","author":"Tan","year":"2006","journal-title":"Clin Chem"},{"key":"10.1038\/modpathol.2008.158_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00000478-198307000-00005","article-title":"Systemic mastocytosis. Extracutaneous manifestations","volume":"7","author":"Brunning","year":"1983","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2008.158_bib27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00005792-198811000-00001","article-title":"Systemic mast cell disease. Analysis of 58 cases and literature review","volume":"67","author":"Travis","year":"1988","journal-title":"Medicine (Baltimore)"},{"key":"10.1038\/modpathol.2008.158_bib28","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/1097-0142(19820301)49:5<927::AID-CNCR2820490517>3.0.CO;2-B","article-title":"Systemic mast cell disease: a clinical and hematopathologic study of 26 cases","volume":"49","author":"Webb","year":"1982","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2008.158_bib29","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0002-9343(86)90622-4","article-title":"Hepatic involvement in systemic mast cell disease","volume":"80","author":"Yam","year":"1986","journal-title":"Am J Med"},{"key":"10.1038\/modpathol.2008.158_bib30","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0016-5085(88)80012-X","article-title":"Gastrointestinal dysfunction in systemic mastocytosis. A prospective study","volume":"95","author":"Cherner","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.2008.158_bib31","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1001\/archinte.1975.00330110104014","article-title":"Tetany, malabsorption, and mastocytosis","volume":"135","author":"Dantzig","year":"1975","journal-title":"Arch Intern Med"},{"key":"10.1038\/modpathol.2008.158_bib32","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1111\/1523-1747.ep12468899","article-title":"Systemic mastocytosis: retrospective review of a decade\u2032s clinical experience at the Brigham and Women's Hospital","volume":"96","author":"Horan","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1038\/modpathol.2008.158_bib33","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1046\/j.1365-2133.2001.04123.x","article-title":"Mastocytosis: recent advances in defining the disease","volume":"144","author":"Hartmann","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1038\/modpathol.2008.158_bib34","first-page":"411","article-title":"[Gastrointestinal mastocytosis. Report of a case and review of the literature]","volume":"62","author":"Debray","year":"1973","journal-title":"Arch Fr Mal App Dig"},{"key":"10.1038\/modpathol.2008.158_bib35","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1259\/0007-1285-60-716-765","article-title":"Radiological features of systemic mast-cell disease","volume":"60","author":"Huang","year":"1987","journal-title":"Br J Radiol"},{"key":"10.1038\/modpathol.2008.158_bib36","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/00007611-198806000-00011","article-title":"Systemic mastocytosis and mastocytosis-like syndrome: radiologic features of gastrointestinal manifestations","volume":"81","author":"Johnson","year":"1988","journal-title":"South Med J"},{"key":"10.1038\/modpathol.2008.158_bib37","first-page":"1460","article-title":"[Colonic involvement in systemic mastocytosis (author's transl)]","volume":"58","author":"Legman","year":"1982","journal-title":"Sem Hop"},{"key":"10.1038\/modpathol.2008.158_bib38","doi-asserted-by":"crossref","first-page":"887","DOI":"10.7326\/0003-4819-59-6-887","article-title":"Systemic mast cell disease","volume":"59","author":"Mutter","year":"1963","journal-title":"Ann Intern Med"},{"key":"10.1038\/modpathol.2008.158_bib39","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0016-5085(19)34851-6","article-title":"Malabsorption in systemic mast cell disease","volume":"45","author":"Bank","year":"1963","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.2008.158_bib40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3748\/wjg.v10.i3.309","article-title":"Key role of mast cells and their major secretory products in inflammatory bowel disease","volume":"10","author":"He","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1038\/modpathol.2008.158_bib41","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/BF01307568","article-title":"Colonic mucosal mast cell distribution at line of demarcation of active ulcerative colitis","volume":"37","author":"King","year":"1992","journal-title":"Dig Dis Sci"},{"key":"10.1038\/modpathol.2008.158_bib42","doi-asserted-by":"crossref","first-page":"40S","DOI":"10.1111\/1523-1747.ep12469015","article-title":"The role of the mast cell in clinical gastrointestinal disease with special reference to systemic mastocytosis","volume":"96","author":"Miner","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1038\/modpathol.2008.158_bib43","doi-asserted-by":"crossref","first-page":"784","DOI":"10.5858\/2007-131-784-SMACCA","article-title":"Systemic mastocytosis: A concise clinical and laboratory review","volume":"131","author":"Patnaik","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.2008.158_bib44","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0002-9440(10)63870-9","article-title":"One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes","volume":"162","author":"Sotlar","year":"2003","journal-title":"Am J Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2008158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2008158","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222023699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222023699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2008158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:59:08Z","timestamp":1760230748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222023699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0893395222023699"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2008.158","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic mastocytosis involving the gastrointestinal tract: clinicopathologic and molecular study of five cases","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2008.158","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}