{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:02:14Z","timestamp":1785682934754,"version":"3.56.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5398,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1038\/modpathol.2008.8","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T10:32:06Z","timestamp":1201861926000},"page":"491-497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Malignant transformation of hepatic adenomas"],"prefix":"10.1016","volume":"21","author":[{"given":"Shien T L","family":"Micchelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perumal","family":"Vivekanandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K","family":"Boitnott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Choti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Torbenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2008.8_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jhep.2006.12.007","article-title":"Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update","volume":"46","author":"Bioulac-Sage","year":"2007","journal-title":"J Hepatol"},{"key":"10.1038\/modpathol.2008.8_bib2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng1001","article-title":"Bi-allelic inactivation of TCF1 in hepatic adenomas","volume":"32","author":"Bluteau","year":"2002","journal-title":"Nat Genet"},{"key":"10.1038\/modpathol.2008.8_bib3","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1053\/jhep.2002.36126","article-title":"P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia","volume":"36","author":"Chen","year":"2002","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.2008.8_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/modpathol.3880514","article-title":"Hepatic adenomas: analysis of sex steroid receptor status and the Wnt signaling pathway","volume":"15","author":"Torbenson","year":"2002","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2008.8_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.21068","article-title":"Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC","volume":"43","author":"Zucman-Rossi","year":"2006","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.2008.8_bib6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/1097-0142(19910715)68:2<341::AID-CNCR2820680223>3.0.CO;2-Q","article-title":"Oral contraceptive-associated liver cell adenoma and hepatocellular carcinoma. Cytomorphology and mechanism of malignant transformation","volume":"68","author":"Tao","year":"1991","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2008.8_bib7","first-page":"338","article-title":"Are oral contraceptive-associated liver cell adenomas premalignant?","volume":"36","author":"Tao","year":"1992","journal-title":"Acta Cytol"},{"key":"10.1038\/modpathol.2008.8_bib8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1309\/YH0H3FKYM4RMU1JF","article-title":"Concurrent evaluation of p53, beta-catenin, and alpha-fetoprotein expression in human hepatocellular carcinoma","volume":"122","author":"Torbenson","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2008.8_bib9","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0168-8278(96)80305-9","article-title":"Role of oral contraceptives in the growth of a multilobular adenoma associated with a hepatocellular carcinoma in a young woman","volume":"25","author":"Perret","year":"1996","journal-title":"J Hepatol"},{"key":"10.1038\/modpathol.2008.8_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00000478-199305000-00013","article-title":"Hepatocellular carcinoma arising in a focus of multilobular adenoma. A case report","volume":"17","author":"Ferrell","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2008.8_bib11","first-page":"296","article-title":"Hepatocellular adenoma. Its transformation to carcinoma in a user of oral contraceptives","volume":"105","author":"Tesluk","year":"1981","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.2008.8_bib12","first-page":"30","article-title":"Transformation of hepatic adenoma into hepatocellular carcinoma in patients with prolonged use of oral contraceptives","volume":"49","author":"Herman","year":"1994","journal-title":"Rev Hosp Clin Fac Med Sao Paulo"},{"key":"10.1038\/modpathol.2008.8_bib13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.7326\/0003-4819-105-4-547","article-title":"Resolution of a contraceptive-steroid-induced hepatic adenoma with subsequent evolution into hepatocellular carcinoma","volume":"105","author":"Gordon","year":"1986","journal-title":"Ann Intern Med"},{"key":"10.1038\/modpathol.2008.8_bib14","first-page":"416","article-title":"Hepatocellular carcinoma coexisting with hepatic adenoma. Incidental discovery after long-term oral contraceptive use","volume":"155","author":"Korula","year":"1991","journal-title":"West J Med"},{"key":"10.1038\/modpathol.2008.8_bib15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.7326\/0003-4819-110-6-489","article-title":"Transformation of hepatic cell adenoma to hepatocellular carcinoma due to oral contraceptive use","volume":"110","author":"Gyorffy","year":"1989","journal-title":"Ann Intern Med"},{"key":"10.1038\/modpathol.2008.8_bib16","first-page":"1382","article-title":"Retrospective analysis of 29 patients surgically treated for hepatocellular adenoma or focal nodular hyperplasia","volume":"47","author":"Closset","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"10.1038\/modpathol.2008.8_bib17","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/archsurg.1994.01420310044007","article-title":"The malignant transformation of liver cell adenomas","volume":"129","author":"Foster","year":"1994","journal-title":"Arch Surg"},{"key":"10.1038\/modpathol.2008.8_bib18","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.3748\/wjg.v9.i10.2379","article-title":"Liver cell adenoma with malignant transformation: a case report","volume":"9","author":"Ito","year":"2003","journal-title":"World J Gastroenterol"},{"key":"10.1038\/modpathol.2008.8_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1155\/1996\/59629","article-title":"Are hepatic adenomas premalignant?","volume":"10","author":"Nagorney","year":"1996","journal-title":"HPB Surg"},{"key":"10.1038\/modpathol.2008.8_bib20","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/modpathol.3800436","article-title":"The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma","volume":"18","author":"Yamauchi","year":"2005","journal-title":"Mod Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol20088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol20088","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222041540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222041540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol20088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:18:00Z","timestamp":1760231880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222041540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0893395222041540"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2008.8","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Malignant transformation of hepatic adenomas","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2008.8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}