{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:16:40Z","timestamp":1790072200324,"version":"4.0.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5276,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1038\/modpathol.2008.84","type":"journal-article","created":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T10:39:54Z","timestamp":1211539194000},"page":"943-949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":248,"title":["Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms"],"prefix":"10.1016","volume":"21","author":[{"given":"Joshua","family":"Weaver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinn","family":"Downs-Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Goldblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sondra","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sucheta","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond R","family":"Tubbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Skacel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2008.84_bib1","first-page":"263","article-title":"Dedifferentiated liposarcoma","volume":"18","author":"Nascimento","year":"2001","journal-title":"Semin Diagn Pathol"},{"key":"10.1038\/modpathol.2008.84_bib2","first-page":"258","article-title":"Well-differentiated liposarcoma (atypical lipomatous tumors)","volume":"18","author":"Laurino","year":"2001","journal-title":"Semin Diagn Pathol"},{"key":"10.1038\/modpathol.2008.84_bib3","series-title":"Enzinger and Weiss's Soft Tissue Tumors","first-page":"477","article-title":"Liposarcoma","author":"Weiss","year":"2008"},{"key":"10.1038\/modpathol.2008.84_bib4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00957030","article-title":"Liposarcoma. A study of 103 cases","volume":"335","author":"Enzinger","year":"1962","journal-title":"Virchows Arch Pathol Anat Physiol Klin Med"},{"key":"10.1038\/modpathol.2008.84_bib5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00000478-197912000-00004","article-title":"Liposarcoma: a study of 55 cases with a reassessment of its classification","volume":"3","author":"Evans","year":"1979","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2008.84_bib6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1001\/archsurg.1987.01400230043007","article-title":"Chromosomal changes in soft tissue sarcomas. A new diagnostic parameter","volume":"122","author":"Karakousis","year":"1987","journal-title":"Arch Surg"},{"key":"10.1038\/modpathol.2008.84_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0165-4608(93)90245-H","article-title":"Chromosome 12 origin in rings and giant markers in well-differentiated liposarcoma","volume":"66","author":"Pedeutour","year":"1993","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/modpathol.2008.84_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0165-4608(93)90001-3","article-title":"Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors","volume":"68","author":"Dal Cin","year":"1993","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/modpathol.2008.84_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/gcc.2870100203","article-title":"Complex composition and co-amplification of SAS and MDM2 in ring and giant rod marker chromosomes in well-differentiated liposarcoma","volume":"10","author":"Pedeutour","year":"1994","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2008.84_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/(SICI)1098-2264(199901)24:1<30::AID-GCC5>3.0.CO;2-P","article-title":"Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors","volume":"24","author":"Pedeutour","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2008.84_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(03)01001-7","article-title":"Mdm2: A regulator of cell growth and death","volume":"89","author":"Vargas","year":"2003","journal-title":"Adv Cancer Res"},{"key":"10.1038\/modpathol.2008.84_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00129039-200203000-00001","article-title":"Tissue microarrays: a powerful tool for high-throughput analysis of clinical specimens: a review of the method with validation data","volume":"10","author":"Skacel","year":"2002","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1038\/modpathol.2008.84_bib13","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1038\/modpathol.3800503","article-title":"Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma","volume":"18","author":"Patel","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2008.84_bib14","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1097\/01.pas.0000170343.09562.39","article-title":"MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data","volume":"29","author":"Binh","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2008.84_bib15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1309\/VMBP67QUNN6Q3J0E","article-title":"Reproducibility of MDM2 and CDK4 staining in soft tissue tumors","volume":"125","author":"Binh","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2008.84_bib16","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.humpath.2006.04.010","article-title":"The value of MDM2 and CDK4 amplification levels using real-time polymerase chain reaction for the differential diagnosis of liposarcomas and their histologic mimickers","volume":"37","author":"Shimada","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2008.84_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0165-4608(01)00516-7","article-title":"A well-differentiated liposarcoma with a new type of chromosome 12-derived markers","volume":"131","author":"Forus","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/modpathol.2008.84_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000064038","article-title":"Characterization of supernumerary rings and giant marker chromosomes in well-differentiated lipomatous tumors by a combination of G-banding, CGH, M-FISH, and chromosome- and locus-specific FISH","volume":"97","author":"Micci","year":"2002","journal-title":"Cytogenet Genome Res"},{"key":"10.1038\/modpathol.2008.84_bib19","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1054\/bjoc.1999.1090","article-title":"The expression of MDM2\/CDK4 gene product in the differential diagnosis of well-differentiated liposarcoma and large deep-seated lipoma","volume":"82","author":"Pilotti","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1038\/modpathol.2008.84_bib20","first-page":"13A","article-title":"Assessment of MDM2 amplification using fluorescence in situ hybridization on paraffin embedded tissues discriminates atypical lipomatous tumors from lipomas","volume":"19","author":"Jacob","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2008.84_bib21","first-page":"3977","article-title":"Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases","volume":"7","author":"Antonescu","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2008.84_bib22","series-title":"World Health Organization Classification of Tumours Pathology and Genetics Tumours of Soft Tissue and Bone","first-page":"120","article-title":"Pleomorphic malignant fibrous histiocytoma\/Undifferentiated high grade pleomorphic sarcoma","author":"Fletcher","year":"2002"},{"key":"10.1038\/modpathol.2008.84_bib23","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/path.1579","article-title":"Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity","volume":"203","author":"Coindre","year":"2004","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2008.84_bib24","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/01.MP.0000056983.78547.77","article-title":"Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma","volume":"16","author":"Coindre","year":"2003","journal-title":"Mod Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol200884.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol200884","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222022530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222022530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol200884.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:57:52Z","timestamp":1760230672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222022530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0893395222022530"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2008.84","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2008.84","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}