{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:47:48Z","timestamp":1773978468769,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4515,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1038\/modpathol.2010.101","type":"journal-article","created":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T10:10:41Z","timestamp":1274436641000},"page":"1209-1214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions"],"prefix":"10.1016","volume":"23","author":[{"given":"Limin","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W","family":"Harms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedram","family":"Pouryazdanparast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David SL","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linglei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R","family":"Fullen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2010.101_bib1","series-title":"Pathology and Genetics of Skin Tumours","author":"LeBoit","year":"2006"},{"key":"10.1038\/modpathol.2010.101_bib2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1080\/00313020412331283824","article-title":"The use and application of special techniques in assessing melanocytic tumours","volume":"36","author":"Busam","year":"2004","journal-title":"Pathology"},{"key":"10.1038\/modpathol.2010.101_bib3","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1038\/jid.2008.226","article-title":"Melanoma genetics and therapeutic approaches in the 21st century: moving from the benchside to the bedside","volume":"128","author":"Hocker","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/modpathol.2010.101_bib4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1146\/annurev.cellbio.19.041603.094522","article-title":"Nodal signaling in vertebrate development","volume":"19","author":"Schier","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1038\/modpathol.2010.101_bib5","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1242\/dev.01706","article-title":"TGFbeta\/activin\/Nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells","volume":"132","author":"James","year":"2005","journal-title":"Development"},{"key":"10.1038\/modpathol.2010.101_bib6","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1242\/jcs.02553","article-title":"Activin\/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells","volume":"118","author":"Vallier","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1038\/modpathol.2010.101_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ydbio.2004.08.031","article-title":"Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway","volume":"275","author":"Vallier","year":"2004","journal-title":"Dev Biol"},{"key":"10.1038\/modpathol.2010.101_bib8","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1128\/MCB.22.8.2586-2597.2002","article-title":"Cripto-1 activates Nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial cells","volume":"22","author":"Bianco","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1038\/modpathol.2010.101_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1755-148X.2008.00450.x","article-title":"Transforming growth factor-beta in cutaneous melanoma","volume":"21","author":"Javelaud","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1038\/modpathol.2010.101_bib10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1097-4652(199902)178:2<179::AID-JCP7>3.0.CO;2-5","article-title":"Desensitization of melanoma cells to autocrine TGF-beta isoforms","volume":"178","author":"Krasagakis","year":"1999","journal-title":"J Cell Physiol"},{"key":"10.1038\/modpathol.2010.101_bib11","first-page":"575","article-title":"Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells","volume":"54","author":"Rodeck","year":"1994","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2010.101_bib12","first-page":"2565","article-title":"Paracrine and autocrine regulation of human melanocyte and melanoma cell growth by transforming growth factor beta in vitro","volume":"14","author":"Krasagakis","year":"1994","journal-title":"Anticancer Res"},{"key":"10.1038\/modpathol.2010.101_bib13","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.1038\/sj.onc.1208900","article-title":"Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitroin vivo","volume":"24","author":"Javelaud","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2010.101_bib14","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1158\/0008-5472.CAN-06-3950","article-title":"Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis","volume":"67","author":"Javelaud","year":"2007","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2010.101_bib15","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nm1448","article-title":"Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness","volume":"12","author":"Topczewska","year":"2006","journal-title":"Nat Med"},{"key":"10.1038\/modpathol.2010.101_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ng1001-117","article-title":"TGF-beta signaling in tumor suppression and cancer progression","volume":"29","author":"Derynck","year":"2001","journal-title":"Nat Genet"},{"key":"10.1038\/modpathol.2010.101_bib17","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1073\/pnas.0800467105","article-title":"Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells","volume":"105","author":"Postovit","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2010.101_bib18","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1038\/jid.2008.166","article-title":"Melanoma, nevogenesis, and stem cell biology","volume":"128","author":"Grichnik","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/modpathol.2010.101_bib19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1440-0960.2009.00553_1.x","article-title":"Congenital melanocytic naevi","volume":"50","author":"Kovalyshyn","year":"2009","journal-title":"Australas J Dermatol"},{"key":"10.1038\/modpathol.2010.101_bib20","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.devcel.2008.11.009","article-title":"TGF-beta targets PAX3 to control melanocyte differentiation","volume":"15","author":"Moustakas","year":"2008","journal-title":"Dev Cell"},{"key":"10.1038\/modpathol.2010.101_bib21","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1755-148X.2008.00506.x","article-title":"The making of a melanocyte: the specification of melanoblasts from the neural crest","volume":"21","author":"Thomas","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1038\/modpathol.2010.101_bib22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1046\/j.0022-202x.2001.01696.x","article-title":"Transforming growth factor beta1 regulates melanocyte proliferation and differentiation in mouse neural crest cells via stem cell factor\/KIT signaling","volume":"118","author":"Kawakami","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1038\/modpathol.2010.101_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/01.pap.0000155071.86944.a6","article-title":"Cutaneous desmoplastic melanoma","volume":"12","author":"Busam","year":"2005","journal-title":"Adv Anat Pathol"},{"key":"10.1038\/modpathol.2010.101_bib24","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.0022-202X.2004.23600.x","article-title":"Distinction of desmoplastic melanoma from non-desmoplastic melanoma by gene expression profiling","volume":"124","author":"Busam","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/modpathol.2010.101_bib25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1038\/modpathol.2010.101_bib26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0092-8674(00)80720-5","article-title":"The EGF-CFC protein one-eyed pinhead is essential for Nodal signaling","volume":"97","author":"Gritsman","year":"1999","journal-title":"Cell"},{"key":"10.1038\/modpathol.2010.101_bib27","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1101\/gad.201801","article-title":"The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development","volume":"15","author":"Reissmann","year":"2001","journal-title":"Genes Dev"},{"key":"10.1038\/modpathol.2010.101_bib28","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1128\/MCB.22.13.4439-4449.2002","article-title":"Dual roles of Cripto as a ligand and coreceptor in the Nodal signaling pathway","volume":"22","author":"Yan","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1038\/modpathol.2010.101_bib29","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1097-2765(01)00249-0","article-title":"Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms","volume":"7","author":"Yeo","year":"2001","journal-title":"Mol Cell"},{"key":"10.1038\/modpathol.2010.101_bib30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.devcel.2006.07.005","article-title":"The Nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4","volume":"11","author":"Ben-Haim","year":"2006","journal-title":"Dev Cell"},{"key":"10.1038\/modpathol.2010.101_bib31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ydbio.2007.12.027","article-title":"Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo","volume":"315","author":"Liguori","year":"2008","journal-title":"Dev Biol"},{"key":"10.1038\/modpathol.2010.101_bib32","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.4161\/cc.7.13.6236","article-title":"Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma","volume":"7","author":"Strizzi","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1038\/modpathol.2010.101_bib33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1586\/17469872.4.1.67","article-title":"Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention","volume":"4","author":"Strizzi","year":"2009","journal-title":"Expert Rev Dermatol"},{"key":"10.1038\/modpathol.2010.101_bib34","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1101\/gad.1127703","article-title":"Tomoregulin-1 (TMEFF1) inhibits Nodal signaling through direct binding to the Nodal coreceptor Cripto","volume":"17","author":"Harms","year":"2003","journal-title":"Genes Dev"},{"key":"10.1038\/modpathol.2010.101_bib35","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.cub.2004.02.042","article-title":"Two modes by which Lefty proteins inhibit Nodal signaling","volume":"14","author":"Chen","year":"2004","journal-title":"Curr Biol"},{"key":"10.1038\/modpathol.2010.101_bib36","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/17820","article-title":"The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals","volume":"397","author":"Piccolo","year":"1999","journal-title":"Nature"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010101","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222026527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222026527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:02:19Z","timestamp":1760230939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222026527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0893395222026527"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2010.101","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2010.101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}