{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:47:23Z","timestamp":1790876843468,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4393,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1038\/modpathol.2010.155","type":"journal-article","created":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T10:22:10Z","timestamp":1282299730000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":204,"title":["International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 5: surgical margins"],"prefix":"10.1016","volume":"24","author":[{"given":"Puay Hoon","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Srigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore H","family":"van der Kwast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Montironi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Delahunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Egevad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan I","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2010.155_bib1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0090-4295(96)00092-1","article-title":"Positive surgical margins with radical prostatectomy: detailed pathological analysis and prognosis","volume":"48","author":"Watson","year":"1996","journal-title":"Urology"},{"key":"10.1038\/modpathol.2010.155_bib2","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/(SICI)1097-0142(19991101)86:9<1775::AID-CNCR20>3.0.CO;2-L","article-title":"Correlation of margin status and extraprostatic extension with progression of prostate carcinoma","volume":"86","author":"Cheng","year":"1999","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2010.155_bib3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/03008880510030932","article-title":"Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens","volume":"216","author":"Epstein","year":"2005","journal-title":"Scand J Urol Nephrol Suppl"},{"key":"10.1038\/modpathol.2010.155_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/01.ju.0000132160.68779.96","article-title":"Biochemical failure in men following radical retropubic prostatectomy: impact of surgical margin status and location","volume":"172","author":"Pettus","year":"2004","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/00365590802299585","article-title":"Are positive surgical margins in radical prostatectomy specimens an independent prognostic marker?","volume":"42","author":"Saether","year":"2008","journal-title":"Scand J Urol Nephrol"},{"key":"10.1038\/modpathol.2010.155_bib6","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0022-5347(01)67462-7","article-title":"Patterns of positive specimen margins and detectable prostate specific antigen after radical perineal prostatectomy","volume":"153","author":"Weldon","year":"1995","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0022-5347(01)62881-7","article-title":"Incidence, etiology, location, prevention and treatment of positive surgical margins after radical prostatectomy for prostate cancer","volume":"160","author":"Wieder","year":"1998","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1464-410X.2008.08006.x","article-title":"Pathological definition and difficulties in assessing positive margins in radical prostatectomy specimens","volume":"103","author":"Montironi","year":"2009","journal-title":"BJU Int"},{"key":"10.1038\/modpathol.2010.155_bib9","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00000478-199603000-00004","article-title":"Prediction of progression following radical prostatectomy. A multivariate analysis of 721 men with long-term follow-up","volume":"20","author":"Epstein","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2010.155_bib10","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/S0022-5347(01)66792-2","article-title":"Prognostic significance of positive surgical margins in radical prostatectomy specimens","volume":"154","author":"Ohori","year":"1995","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib11","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1200\/JCO.2000.18.15.2862","article-title":"Preoperative prediction of surgical margin status in patients with prostate cancer treated by radical prostatectomy","volume":"18","author":"Cheng","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2010.155_bib12","doi-asserted-by":"crossref","unstructured":"Egevad L, Srigley JR, Delahunt B . International Society of Urological Pathology (ISUP) consensus conference on handling and staging of radical prostatectomy specimens: rationale and organization. Mod Pathol 2010 (in press).","DOI":"10.1038\/modpathol.2010.159"},{"key":"10.1038\/modpathol.2010.155_bib13","doi-asserted-by":"crossref","unstructured":"Samaratunga H, Montironi R, True L, et al. International Society of Urological Pathologists (ISUP) consensus conference on handling and staging of radical prostatectomy specimens. Working group 1: specimen handling. Mod Pathol 2010 (in press).","DOI":"10.1038\/modpathol.2010.178"},{"key":"10.1038\/modpathol.2010.155_bib14","doi-asserted-by":"crossref","unstructured":"van der Kwast T, Amin MB, Billis A, et al. International Society of Urological Pathology (ISUP) consensus conference on handling and staging of radical prostatectomy specimens. Working group 2: T2 substaging and prostate cancer volume. Mod Pathol 2010 (in press).","DOI":"10.1038\/modpathol.2010.156"},{"key":"10.1038\/modpathol.2010.155_bib15","doi-asserted-by":"crossref","unstructured":"Magi-Galluzzi C, Evans A, Delahunt B, et al. International Society of Urological Pathology (ISUP) consensus conference on handling and staging of radical prostatectomy specimens. Working group 3: extraprostatic extension, lymphovascular invasion and locally advanced disease. Mod Pathol 2010 (in press).","DOI":"10.1038\/modpathol.2010.158"},{"key":"10.1038\/modpathol.2010.155_bib16","doi-asserted-by":"crossref","unstructured":"Berney D, Wheeler T, Grignon D, et al. International Society of Urological Pathology (ISUP) consensus conference on handling and staging of radical prostatectomy specimens. Working group 4: seminal vesicles and lymph nodes. Mod Pathol 2010 (in press).","DOI":"10.1038\/modpathol.2010.160"},{"key":"10.1038\/modpathol.2010.155_bib17","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.5858\/133.10.1568","article-title":"Protocol for the examination of specimens from patients with carcinoma of the prostate gland","volume":"133","author":"Srigley","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.2010.155_bib18","unstructured":"Kench J, Clouston D, Delahunt B, et al. Royal College of Pathologists of Australasia Prostate Cancer (Radical Prostatectomy) Structured Reporting Protocol. 2010, 54 pp. http:\/\/www.rcpa.edu.au\/Publications\/StructuredReporting\/CancerProtocols.htm."},{"key":"10.1038\/modpathol.2010.155_bib19","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/00000478-199007000-00003","article-title":"Evaluation of radical prostatectomy capsular margins of resection. The significance of margins designated as negative, closely approaching, and positive","volume":"14","author":"Epstein","year":"1990","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2010.155_bib20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/01.pas.0000146008.47191.76","article-title":"Closest distance between tumor and resection margin in radical prostatectomy specimens: lack of prognostic significance","volume":"29","author":"Emerson","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2010.155_bib21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0022-5347(01)65336-9","article-title":"Do close but negative margins in radical prostatectomy specimens increase the risk of postoperative progression?","volume":"157","author":"Epstein","year":"1997","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib22","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0090-4295(02)02255-0","article-title":"Location of positive surgical margins after retropubic, perineal, and laparoscopic radical prostatectomy for organ-confined prostate cancer","volume":"61","author":"Salomon","year":"2003","journal-title":"Urology"},{"key":"10.1038\/modpathol.2010.155_bib23","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1016\/j.juro.2007.08.008","article-title":"A comparison of the incidence and location of positive surgical margins in robotic assisted laparoscopic radical prostatectomy and open retropubic radical prostatectomy","volume":"178","author":"Smith","year":"2007","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib24","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0090-4295(99)00204-6","article-title":"Positive surgical margins with radical retropubic prostatectomy: anatomic site-specific pathologic analysis and impact on prognosis","volume":"54","author":"Obek","year":"1999","journal-title":"Urology"},{"key":"10.1038\/modpathol.2010.155_bib25","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.urology.2007.08.040","article-title":"Prognostic significance of location of positive margins in radical prostatectomy specimens","volume":"70","author":"Eastham","year":"2007","journal-title":"Urology"},{"key":"10.1038\/modpathol.2010.155_bib26","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1016\/S0022-5347(05)65003-3","article-title":"Positive surgical margins after radical retropubic prostatectomy: the influence of site and number on progression","volume":"167","author":"Sofer","year":"2002","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib27","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/cncr.20551","article-title":"Bladder neck invasion is an independent predictor of prostate-specific antigen recurrence","volume":"101","author":"Poulos","year":"2004","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2010.155_bib28","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.urology.2004.04.003","article-title":"Positive proximal (bladder neck) margin at radical prostatectomy confers greater risk of biochemical progression","volume":"64","author":"Aydin","year":"2004","journal-title":"Urology"},{"key":"10.1038\/modpathol.2010.155_bib29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/modpathol.2008.190","article-title":"Microscopic bladder neck involvement by prostate carcinoma in radical prostatectomy specimens is not a significant independent prognostic factor","volume":"22","author":"Zhou","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2010.155_bib30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.juro.2007.08.130","article-title":"Is a positive bladder neck margin truly a T4 lesion in the prostate specific antigen era? Results from the SEARCH Database","volume":"179","author":"Buschemeyer","year":"2008","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib31","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/1097-0142(20010415)91:8<1414::AID-CNCR1147>3.0.CO;2-G","article-title":"Analysis of clinicopathologic factors predicting outcome after radical prostatectomy","volume":"91","author":"Babaian","year":"2001","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2010.155_bib32","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.juro.2007.05.159","article-title":"The significance of positive surgical margin in areas of capsular incision in otherwise organ confined disease at radical prostatectomy","volume":"178","author":"Chuang","year":"2007","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib33","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.humpath.2007.01.006","article-title":"The relationship between the extent of surgical margin positivity and prostate specific antigen recurrence in radical prostatectomy specimens","volume":"38","author":"Marks","year":"2007","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2010.155_bib34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/01.ju.0000132137.02846.ec","article-title":"Adverse prognostic significance of capsular incision with radical retropubic prostatectomy","volume":"172","author":"Shuford","year":"2004","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2010.155_bib35","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1097\/PAS.0b013e318162a8bf","article-title":"Positive surgical margins in areas of capsular incision in otherwise organ-confined disease at radical prostatectomy: histologic features and pitfalls","volume":"32","author":"Chuang","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2010.155_bib36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/jcp.2004.024182","article-title":"The presence of benign prostatic glandular tissue at surgical margins does not predict PSA recurrence","volume":"58","author":"Kernek","year":"2005","journal-title":"J Clin Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010155","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222029301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222029301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:04:36Z","timestamp":1760231076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222029301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0893395222029301"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2010.155","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 5: surgical margins","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2010.155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}