{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:08:53Z","timestamp":1791119333949,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4424,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1038\/modpathol.2010.174","type":"journal-article","created":{"date-parts":[[2010,9,10]],"date-time":"2010-09-10T10:21:47Z","timestamp":1284114107000},"page":"1657-1666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases"],"prefix":"10.1016","volume":"23","author":[{"given":"Nad\u00e8ge","family":"Dreux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Marty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Chibon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"V\u00e9lasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Hostein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Ranch\u00e8re-Vince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Terrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Coindre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2010.174_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1432-1033.1991.tb16003.x","article-title":"Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein","volume":"198","author":"Giancotti","year":"1991","journal-title":"Eur J Biochem"},{"key":"10.1038\/modpathol.2010.174_bib2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0888-7543(92)90441-T","article-title":"Chromosomal localization of the murine gene and two related sequences encoding high-mobility-group I and Y proteins","volume":"12","author":"Johnson","year":"1992","journal-title":"Genomics"},{"key":"10.1038\/modpathol.2010.174_bib3","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/carcin\/22.10.1583","article-title":"Role of the high mobility group A proteins in human lipomas","volume":"22","author":"Fedele","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1038\/modpathol.2010.174_bib4","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nrc2271","article-title":"Roles of HMGA proteins in cancer","volume":"7","author":"Fusco","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2010.174_bib5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cell.2006.05.052","article-title":"A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation","volume":"126","author":"Narita","year":"2006","journal-title":"Cell"},{"key":"10.1038\/modpathol.2010.174_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-1119(01)00689-8","article-title":"Molecular biology of HMGA proteins: hubs of nuclear function","volume":"277","author":"Reeves","year":"2001","journal-title":"Gene"},{"key":"10.1038\/modpathol.2010.174_bib7","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1101\/gad.1540407","article-title":"The tumor suppressor microRNA let-7 represses the HMGA2 oncogene","volume":"21","author":"Lee","year":"2007","journal-title":"Genes Dev"},{"key":"10.1038\/modpathol.2010.174_bib8","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1137999","article-title":"Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation","volume":"315","author":"Mayr","year":"2007","journal-title":"Science"},{"key":"10.1038\/modpathol.2010.174_bib9","first-page":"2439","article-title":"High level expression of the HMGI (Y) gene during embryonic development","volume":"13","author":"Chiappetta","year":"1996","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2010.174_bib10","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/(SICI)1098-2264(199812)23:4<350::AID-GCC10>3.0.CO;2-E","article-title":"The expression pattern of the Hmgic gene during development","volume":"23","author":"Hirning-Folz","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2010.174_bib11","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1016\/j.febslet.2007.06.072","article-title":"DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells","volume":"581","author":"Li","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1038\/modpathol.2010.174_bib12","first-page":"775","article-title":"HMGI-C expression patterns in human tissues. Implications for the genesis of frequent mesenchymal tumors","volume":"149","author":"Rogalla","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.2010.174_bib13","first-page":"3117","article-title":"Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins","volume":"60","author":"Abe","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2010.174_bib14","first-page":"737","article-title":"HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer","volume":"14","author":"Fabjani","year":"2005","journal-title":"Oncol Rep"},{"key":"10.1038\/modpathol.2010.174_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/modpathol.2008.140","article-title":"HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma","volume":"22","author":"Hristov","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2010.174_bib16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/mc.20235","article-title":"HMGA2 overexpression in non-small cell lung cancer","volume":"46","author":"Meyer","year":"2007","journal-title":"Mol Carcinog"},{"key":"10.1038\/modpathol.2010.174_bib17","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1158\/1078-0432.CCR-07-4667","article-title":"Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family","volume":"14","author":"Motoyama","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2010.174_bib18","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1158\/0008-5472.CAN-03-1855","article-title":"Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity","volume":"64","author":"Miyazawa","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2010.174_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/ajcp\/109.3.251","article-title":"Chromosomal translocations in benign tumors: the HMGI proteins","volume":"109","author":"Hess","year":"1998","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2010.174_bib20","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1006\/geno.1995.9952","article-title":"A 6-Mb yeast artificial chromosome contig and long-range physical map encompassing the region on chromosome 12q15 frequently rearranged in a variety of benign solid tumors","volume":"29","author":"Schoenmakers","year":"1995","journal-title":"Genomics"},{"key":"10.1038\/modpathol.2010.174_bib21","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/01.MP.0000092954.42656.94","article-title":"Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas","volume":"16","author":"Dahlen","year":"2003","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2010.174_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mrfmmm.2006.07.007","article-title":"Identification and characterization of novel human transcripts embedded within HMGA2 in t(12;14)(q15;q24.1) uterine leiomyoma","volume":"602","author":"Ingraham","year":"2006","journal-title":"Mutat Res"},{"key":"10.1038\/modpathol.2010.174_bib23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s100380170059","article-title":"Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas","volume":"46","author":"Mine","year":"2001","journal-title":"J Hum Genet"},{"key":"10.1038\/modpathol.2010.174_bib24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0165-4608(03)00037-2","article-title":"HMGA2 is expressed in an allele-specific manner in human lipomas","volume":"143","author":"Ashar","year":"2003","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/modpathol.2010.174_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000087514","article-title":"Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32\u2013>q33 and 12q14\u2013>q15","volume":"112","author":"Nilsson","year":"2006","journal-title":"Cytogenet Genome Res"},{"key":"10.1038\/modpathol.2010.174_bib26","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1006\/geno.1999.5778","article-title":"LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes","volume":"57","author":"Petit","year":"1999","journal-title":"Genomics"},{"key":"10.1038\/modpathol.2010.174_bib27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1476-4598-8-36","article-title":"Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups","volume":"8","author":"Bartuma","year":"2009","journal-title":"Mol Cancer"},{"key":"10.1038\/modpathol.2010.174_bib28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/(SICI)1096-9896(200004)190:5<531::AID-PATH579>3.0.CO;2-W","article-title":"Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours","volume":"190","author":"Dei Tos","year":"2000","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2010.174_bib29","first-page":"37","article-title":"Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations","volume":"151","author":"Tallini","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.2010.174_bib30","doi-asserted-by":"crossref","first-page":"14394","DOI":"10.1074\/jbc.M000564200","article-title":"Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas","volume":"275","author":"Arlotta","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2010.174_bib31","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/gcc.20445","article-title":"Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype","volume":"46","author":"Bartuma","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2010.174_bib32","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1002\/ijc.23380","article-title":"HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon","volume":"122","author":"Italiano","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.2010.174_bib33","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1097\/PAS.0b013e3180581fff","article-title":"Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR","volume":"31","author":"Sirvent","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2010.174_bib34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00000372-200408000-00001","article-title":"Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity","volume":"26","author":"Li","year":"2004","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/modpathol.2010.174_bib35","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/376771a0","article-title":"Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C","volume":"376","author":"Zhou","year":"1995","journal-title":"Nature"},{"key":"10.1038\/modpathol.2010.174_bib36","first-page":"4793","article-title":"The expression of truncated HMGI-C gene induces gigantism associated with lipomatosis","volume":"59","author":"Battista","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2010.174_bib37","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng0895-436","article-title":"Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumors","volume":"10","author":"Schoenmakers","year":"1995","journal-title":"Nat Genet"},{"key":"10.1038\/modpathol.2010.174_bib38","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00125480-199909000-00001","article-title":"HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors","volume":"6","author":"Tallini","year":"1999","journal-title":"Adv Anat Pathol"},{"key":"10.1038\/modpathol.2010.174_bib39","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1038\/sj.onc.1202881","article-title":"Regulation of HMGIC expression : an architectural transcription factor involved in growth control and development","volume":"18","author":"Ayoubi","year":"1999","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2010.174_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/geno.1996.0619","article-title":"Fusion transcripts between the HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations","volume":"38","author":"Kazmierczak","year":"1996","journal-title":"Genomics"},{"key":"10.1038\/modpathol.2010.174_bib41","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF00193583","article-title":"Characteristic chromosome abnormalities, including rearrangements of 6p, del(7q), +12, and t(12;14), in 44 uterine leiomyomas","volume":"85","author":"Nilbert","year":"1990","journal-title":"Hum Genet"},{"key":"10.1038\/modpathol.2010.174_bib42","first-page":"923","article-title":"Cytogenetic abnormalities in uterine leiomyomata","volume":"77","author":"Rein","year":"1991","journal-title":"Obstet Gynecol"},{"key":"10.1038\/modpathol.2010.174_bib43","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/gcc.10240","article-title":"HMGA2 expression in uterine leiomyomata and myometrium: quantitative analysis and tissue culture studies","volume":"38","author":"Gross","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2010.174_bib44","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1158\/1541-7786.MCR-07-0370","article-title":"Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma","volume":"6","author":"Peng","year":"2008","journal-title":"Mol Cancer Res"},{"key":"10.1038\/modpathol.2010.174_bib45","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0165-4608(91)90436-X","article-title":"Aggressive angiomyxoma of the pelvis: cytogenetic findings in a single case","volume":"56","author":"Horsman","year":"1991","journal-title":"Cancer Genet and Cytogenet"},{"key":"10.1038\/modpathol.2010.174_bib46","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0165-4608(96)85316-7","article-title":"Cytogenetics findings in a case of angiomyxoma of the vaginal wall","volume":"84","author":"Betz","year":"1995","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/modpathol.2010.174_bib47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0165-4608(96)85279-4","article-title":"Involvement of the MAR genes in two rares benign mesenchymal tumors: a hamartoma of the breast and a aggressive angiomyxoma","volume":"84","author":"Kazmierczak","year":"1995","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/modpathol.2010.174_bib48","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/gcc.1179","article-title":"Chromosomal translocation t(8;12) Induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva","volume":"32","author":"Nucci","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2010.174_bib49","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/gcc.20483","article-title":"Frequency and characterization of HMGA2 and HMGA1 rearrangements in mesenchymal tumors of the lower genital tract","volume":"46","author":"Medeiros","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2010.174_bib50","first-page":"214A","article-title":"HMGA2 expression was a biomarker for aggressive angiomyxoma","volume":"21","author":"Medeiros","year":"2008","journal-title":"Mod Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010174","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222026217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222026217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:01:57Z","timestamp":1760230917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222026217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0893395222026217"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2010.174","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2010.174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}