{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:50:11Z","timestamp":1761519011140,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4303,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1038\/modpathol.2010.199","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T10:18:35Z","timestamp":1297419515000},"page":"502-511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["D2-40\/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients"],"prefix":"10.1016","volume":"24","author":[{"given":"Einar","family":"Gudlaugsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivar","family":"Skaland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erling","family":"Undersrud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiel AM","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5vard","family":"S\u00f8iland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan PA","family":"Baak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2010.199_bib1","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0140-6736(05)66544-0","article-title":"Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials","volume":"365","author":"Early Breast Cancer Trialists' Collaborative Group (EBCTG)","year":"2005","journal-title":"Lancet"},{"key":"10.1038\/modpathol.2010.199_bib2","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.1200\/JCO.2005.05.511","article-title":"Prospective multicenter validation of the independent prognostic value of the mitotic activity index in lymph node-negative breast cancer patients younger than 55 years","volume":"23","author":"Baak","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2010.199_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10549-008-9980-x","article-title":"Validating the prognostic value of proliferation measured by PPH3 (phosphohistone H3) in invasive lymph node-negative breast cancer patients less than 71 years of age","volume":"114","author":"Skaland","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1038\/modpathol.2010.199_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10549-008-0126-y","article-title":"Proliferation is the strongest prognosticator in node-negative breast cancer: significance, error sources, alternatives and comparison with molecular prognostic markers","volume":"115","author":"Baak","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1038\/modpathol.2010.199_bib5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/jnci\/djj052","article-title":"Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis","volume":"98","author":"Sotiriou","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/modpathol.2010.199_bib6","first-page":"1","article-title":"Identification of a gene signature in cell cycle pathway for breast cancer prognosis using gene expression profiling data","volume":"11","author":"Liu","year":"2008","journal-title":"BMC Med Genomics"},{"key":"10.1038\/modpathol.2010.199_bib7","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1093\/bioinformatics\/btn374","article-title":"A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gen beat them all?","volume":"24","author":"Haibe-Kains","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1038\/modpathol.2010.199_bib8","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1200\/JCO.1991.9.9.1650","article-title":"Prognosis in T2N0M0 stage I breast carcinoma: a 20-year follow-up study","volume":"9","author":"Rosen","year":"1991","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2010.199_bib9","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/1097-0142(19951115)76:10<1772::AID-CNCR2820761014>3.0.CO;2-O","article-title":"The prognostic value of lymphatic and blood vessel invasion in operable breast cancer","volume":"76","author":"Lauria","year":"1995","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2010.199_bib10","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1097\/PAS.0b013e31806841f6","article-title":"Improved methods of detection of lymphovascular invasion demonstrate that it is the predominant method of vascular invasion in breast cancer and has important clinical consequences","volume":"31","author":"Mohammed","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2010.199_bib11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/modpathol.3800728","article-title":"Significance of lymph vessel invasion identified by the endothelial lymphatic marker D2-40 in node negative breast cancer","volume":"20","author":"Arnaout-Alkarain","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2010.199_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.humpath.2007.06.018","article-title":"D2-40 expression by breast myoepithelium: potential pitfalls in distinguishing intralymphatic carcinoma from insitu carcinoma","volume":"39","author":"Rabban","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2010.199_bib13","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1309\/2HGNJ1GU57JMBJAQ","article-title":"Prognostic significance of intratumoral and peritumoral lymphatic density and blood vessel density in invasive breast carcinoma","volume":"129","author":"El-Gohary","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2010.199_bib14","first-page":"25","article-title":"Clinical significance of intra-tumoral sinusoidal structures showing lympho-endothelial immunoreactivity in breast cancer","volume":"20","author":"Tezuka","year":"2008","journal-title":"Oncol Rep"},{"key":"10.1038\/modpathol.2010.199_bib15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2325\/jbcs.14.381","article-title":"Significance of pathological evaluation for lymphatic vessel invasion in invasive breast cancer","volume":"14","author":"Ito","year":"2007","journal-title":"Breast Cancer"},{"key":"10.1038\/modpathol.2010.199_bib16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/01.sla.0000133355.48672.22","article-title":"Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer","volume":"240","author":"Schoppmann","year":"2004","journal-title":"Ann Surg"},{"key":"10.1038\/modpathol.2010.199_bib17","series-title":"Pathology and Genetics: Tumours of the Breast and Female Genital Tract Organs; WHO Classification Tumours Series","first-page":"9","author":"Tavassoli","year":"2003"},{"key":"10.1038\/modpathol.2010.199_bib18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","article-title":"Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with a long-term follow-up","volume":"19","author":"Elston","year":"1991","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2010.199_bib19","series-title":"Pathology and Genetics of the Female Genital Tract Organs","first-page":"18","article-title":"Invasive breast carcinoma","author":"Ellis","year":"2003"},{"key":"10.1038\/modpathol.2010.199_bib20","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0344-0338(89)80213-4","article-title":"The multicenter morphometric mammary carcinoma project (MMMCP). A nationwide prospective study on reproducibility and prognostic power of routine quantitative assessments in The Netherlands","volume":"185","author":"Baak","year":"1989","journal-title":"Pathol Res Pract"},{"key":"10.1038\/modpathol.2010.199_bib21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0046-8177(92)90313-R","article-title":"Reproducibility of mitoses counting in 2469 breast cancer specimens: results from the Multicenter Morphometric Mammary Carcinoma Project","volume":"23","author":"van Diest","year":"1992","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2010.199_bib22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-2559.1996.d01-509.x","article-title":"Heterogeneity of mitotic activity in breast cancer","volume":"29","author":"Jannink","year":"1996","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2010.199_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0046-8177(97)90286-0","article-title":"The influence of fixation delay on mitotic activity and flow cytometric cell cycle variables","volume":"28","author":"Bergers","year":"1997","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2010.199_bib24","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/modpathol.3800972","article-title":"Phosphohistone H3 expression has much stronger prognostic value than classical prognosticators in invasive lymph node-negative breast cancer patients less than 55 years of age","volume":"12","author":"Skaland","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2010.199_bib25","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/jcp.2005.030452","article-title":"Phosphohistone H3 labelling for histoprognostic grading of breast adenocarcinomas and computer-assisted determination of mitotic index","volume":"59","author":"Bossard","year":"2006","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.2010.199_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s004280050297","article-title":"Consistency achieved by 23 European pathologists from 12 countries in diagnosing breast disease and reporting prognostic features of carcinomas. European Commission Working Group on Breast Screening Pathology","volume":"434","author":"Sloane","year":"1999","journal-title":"Virchows Arch"},{"key":"10.1038\/modpathol.2010.199_bib27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejca.2006.10.001","article-title":"The prognostic value of proliferation in lymph-node-negative breast cancer patients is age dependent","volume":"43","author":"Baak","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1038\/modpathol.2010.199_bib28","doi-asserted-by":"crossref","first-page":"9067","DOI":"10.1200\/JCO.2004.01.0454","article-title":"Reporting recommendations for tumor marker studies","volume":"23","author":"McShane","year":"2005","journal-title":"J Clin Oncol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010199","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222028848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222028848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2010199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:04:57Z","timestamp":1760231097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222028848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0893395222028848"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2010.199","relation":{},"ISSN":["0893-3952"],"issn-type":[{"type":"print","value":"0893-3952"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"D2-40\/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2010.199","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}