{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:49:02Z","timestamp":1791301742811,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4273,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1038\/modpathol.2011.1","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T22:42:57Z","timestamp":1298068977000},"page":"729-738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Clinicopathological and molecular characterization of colorectal micropapillary carcinoma"],"prefix":"10.1016","volume":"24","author":[{"given":"Montse","family":"Verd\u00fa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e0lia","family":"Rod\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2011.1_bib1","first-page":"660","article-title":"Invasive micropapillary carcinoma of the breast","volume":"6","author":"Siriangkul","year":"1993","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.1_bib2","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1097\/00000478-199412000-00005","article-title":"Micropapillary variant of transitional cell carcinoma of the urinary bladder. Histologic pattern resembling ovarian papillary carcinoma","volume":"18","author":"Amin","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2011.1_bib3","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0046-8177(99)90168-5","article-title":"Invasive micropapillary carcinoma of the breast: a prognostic study","volume":"30","author":"Paterakos","year":"1999","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2011.1_bib4","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/modpathol.3880399","article-title":"Clinicopathologic analysis of invasive micropapillary differentiation in breast carcinoma","volume":"14","author":"Nassar","year":"2001","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.1_bib5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/00000478-200203000-00010","article-title":"Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance","volume":"26","author":"Amin","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2011.1_bib6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-2559.2004.01757.x","article-title":"Invasive micropapillary carcinoma of the breast: high incidence of lymph node metastasis with extranodal extension and its immunohistochemical profile compared with invasive ductal carcinoma","volume":"44","author":"Zekioglu","year":"2002","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2011.1_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/01.pap.0000138142.26882.fe","article-title":"Carcinomas with micropapillary morphology: clinical significance and current concepts","volume":"11","author":"Nassar","year":"2004","journal-title":"Adv Anat Pathol"},{"key":"10.1038\/modpathol.2011.1_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2559.2005.02241.x","article-title":"Primary invasive micropapillary carcinoma of the colon","volume":"47","author":"Sakamoto","year":"2005","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2011.1_bib9","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.humpath.2005.10.018","article-title":"Invasive colorectal micropapillary carcinoma: an aggressive variant of adenocarcinoma","volume":"37","author":"Kim","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2011.1_bib10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/modpathol.3800790","article-title":"Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis","volume":"20","author":"Haupt","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.1_bib11","first-page":"457","article-title":"Invasive micropapillary carcinoma of the sigmoid colon: distinct morphology and aggressive behavior","volume":"1","author":"Wen","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1038\/modpathol.2011.1_bib12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s00795-007-0353-z","article-title":"Invasive micropapillary carcinoma of the colon: an immunohistochemical study","volume":"40","author":"Kuroda","year":"2007","journal-title":"Med Mol Morphol"},{"key":"10.1038\/modpathol.2011.1_bib13","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1097\/PAS.0b013e3181a5387b","article-title":"Micropapillary component in colorectal carcinoma is associated with lymph node metastases in T1 and T2 stages and decreased survival time in TNM stages I and II","volume":"33","author":"Xu","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2011.1_bib14","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/modpathol.3800166","article-title":"Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein","volume":"17","author":"Nassar","year":"2004","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.1_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2325\/jbcs.13.58","article-title":"The reversed apical pattern of MUC1 expression is characteristics of invasive micropapillary carcinoma of the breast","volume":"13","author":"Li","year":"2006","journal-title":"Breast Cancer"},{"key":"10.1038\/modpathol.2011.1_bib16","series-title":"World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of the Digestive System","first-page":"103","author":"Hamilton","year":"2000"},{"key":"10.1038\/modpathol.2011.1_bib17","series-title":"TNM Classification of Malignant Tumors","author":"Sobin","year":"2002"},{"key":"10.1038\/modpathol.2011.1_bib18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.MP.0000062859.46942.93","article-title":"Colorectal carcinoma: diagnostic, prognostic, and molecular features","volume":"16","author":"Compton","year":"2003","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.1_bib19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1053\/j.gastro.2003.12.023","article-title":"Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer","volume":"126","author":"Carethers","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.2011.1_bib20","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/01.pai.0000155193.92167.6a","article-title":"Immunohistochemical mismatch repair proteins expression in colorectal cancer","volume":"14","author":"Valentini","year":"2006","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1038\/modpathol.2011.1_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1084\/jem.167.1.225","article-title":"Detection of human papillomavirus in paraffin-embedded tissue using the polymerase chain reaction","volume":"167","author":"Shibata","year":"1988","journal-title":"J Exp Med"},{"key":"10.1038\/modpathol.2011.1_bib22","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1001\/jama.1991.03460040048027","article-title":"Genital human papillomavirus infection in female university students as determined by a PCR-based method","volume":"265","author":"Bauer","year":"1991","journal-title":"JAMA"},{"key":"10.1038\/modpathol.2011.1_bib23","first-page":"5248","article-title":"A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer","volume":"58","author":"Boland","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2011.1_bib24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJM199407283310401","article-title":"Allelic loss of chromosome 18q and prognosis in colorectal cancer","volume":"331","author":"Jen","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2011.1_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/gcc.2870050113","article-title":"Detection of loss of heterozygosity at the human TP53 locus using a dinucleotide repeat polymorphism","volume":"5","author":"Jones","year":"1992","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2011.1_bib26","unstructured":"R Development Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria, 2006. ISBN 3-900051-07-0, URLhttp:\/\/www.R-project.org."},{"key":"10.1038\/modpathol.2011.1_bib27","unstructured":"Hothorn T, Hornik K . exactRankTests: Exact Distributions for Rank and Permutation Tests. 2010. R package version 0.8-17. http:\/\/CRAN.R-project.org\/package=exactRankTests."},{"key":"10.1038\/modpathol.2011.1_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2559.2010.03615.x","article-title":"Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer","volume":"57","author":"Karamitopoulou","year":"2010","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2011.1_bib29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/jjco\/hyp051","article-title":"Pedunculated polyp of early sigmoid colon cancer with invasive micropapillary carcinoma","volume":"39","author":"Sonoo","year":"2009","journal-title":"Jpn J Clin Oncol"},{"key":"10.1038\/modpathol.2011.1_bib30","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0959-8049(02)00008-4","article-title":"Cytokeratins 20 and 7 as biomarkers: usefulness in discriminating primary from metastatic adenocarcinoma","volume":"38","author":"Tot","year":"2002","journal-title":"Eur J Cancer"},{"key":"10.1038\/modpathol.2011.1_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/modpathol.3800260","article-title":"Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma","volume":"18","author":"Logani","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.1_bib32","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/00129039-200306000-00007","article-title":"The lack of p53 nuclear immunostaining is not indicative of absence of TP53 gene mutations in colorectal adenocarcinomas","volume":"11","author":"Colomer","year":"2003","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1038\/modpathol.2011.1_bib33","first-page":"4855","article-title":"Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis","volume":"54","author":"Greenblatt","year":"1994","journal-title":"Cancer Res"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol20111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol20111","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222028794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222028794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol20111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:03:58Z","timestamp":1760231038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222028794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0893395222028794"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2011.1","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathological and molecular characterization of colorectal micropapillary carcinoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2011.1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}