{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:44:30Z","timestamp":1792082670073,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4089,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1038\/modpathol.2011.103","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T13:16:13Z","timestamp":1308316573000},"page":"1433-1443","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Nuclear overexpression of lymphoid-enhancer-binding factor 1 identifies chronic lymphocytic leukemia\/small lymphocytic lymphoma in small B-cell lymphomas"],"prefix":"10.1016","volume":"24","author":[{"given":"Bevan","family":"Tandon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LoAnn","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juehua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2011.103_bib1","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","first-page":"180","article-title":"Chronic lymphocytic leukemia\/small lymphocytic lymphoma","author":"Muller-Hermelink","year":"2008"},{"key":"10.1038\/modpathol.2011.103_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.beha.2010.02.001","article-title":"Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells","volume":"23","author":"Damle","year":"2010","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1038\/modpathol.2011.103_bib3","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1073\/pnas.0308648100","article-title":"Activation of the Wnt signaling pathway in chronic lymphocytic leukemia","volume":"101","author":"Lu","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2011.103_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.leukres.2005.06.004","article-title":"Variation of LEF-1 mRNA expression in low-grade B-cell non-Hodgkin's lymphoma","volume":"30","author":"Howe","year":"2006","journal-title":"Leuk Res"},{"key":"10.1038\/modpathol.2011.103_bib5","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.3109\/10428190903331082","article-title":"Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia","volume":"50","author":"Memarian","year":"2009","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/modpathol.2011.103_bib6","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1182\/blood-2008-06-163303","article-title":"Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemia","volume":"113","author":"Wu","year":"2009","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.103_bib7","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1182\/blood-2010-02-269878","article-title":"LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis","volume":"116","author":"Gutierrez","year":"2010","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.103_bib8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s000180050449","article-title":"Signaling through beta-catenin and Lef\/Tcf","volume":"56","author":"Novak","year":"1999","journal-title":"Cell Mol Life Sci"},{"key":"10.1038\/modpathol.2011.103_bib9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0955-0674(99)80031-3","article-title":"Regulation of LEF-1\/TCF transcription factors by Wnt and other signals","volume":"11","author":"Eastman","year":"1999","journal-title":"Curr Opin Cell Biol"},{"key":"10.1038\/modpathol.2011.103_bib10","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg1427","article-title":"Wnt and \u03b2 catenin signaling: disease and therapies","volume":"5","author":"Moon","year":"2004","journal-title":"Nat Rev Genet"},{"key":"10.1038\/modpathol.2011.103_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1074-7613(00)00004-2","article-title":"Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism","volume":"13","author":"Reya","year":"2000","journal-title":"Immunity"},{"key":"10.1038\/modpathol.2011.103_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1101\/sqb.1999.64.133","article-title":"Control of lymphocyte differentiation by the LEF-1\/TCF family of transcription factors","volume":"64","author":"Reya","year":"1999","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1038\/modpathol.2011.103_bib13","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/eji.200738118","article-title":"The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis","volume":"38","author":"Staal","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1038\/modpathol.2011.103_bib14","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1084\/jem.20071875","article-title":"A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis","volume":"205","author":"Petropoulos","year":"2008","journal-title":"J Exp Med"},{"key":"10.1038\/modpathol.2011.103_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2172-7-13","article-title":"Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis","volume":"7","author":"Dosen","year":"2006","journal-title":"BMC Immunol"},{"key":"10.1038\/modpathol.2011.103_bib16","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1084\/jem.194.11.1625","article-title":"Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells","volume":"194","author":"Klein","year":"2001","journal-title":"J Exp Med"},{"key":"10.1038\/modpathol.2011.103_bib17","first-page":"346","article-title":"Identification of a global gene expression signature of B-chronic lymphocytic leukemia","volume":"1","author":"Jelinek","year":"2003","journal-title":"Mol Cancer Res"},{"key":"10.1038\/modpathol.2011.103_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/modpathol.2009.140","article-title":"Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms","volume":"23","author":"Chen","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.103_bib19","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1309\/AJCPV8LN5ENMZOVY","article-title":"Immunophenotypic variations in mantle cell lymphoma","volume":"132","author":"Gao","year":"2009","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2011.103_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1309\/AJCPPAG4VR4IPGHZ","article-title":"Small B-cell neoplasms with typical mantle cell lymphoma immunophenotypes often include chronic lymphocytic leukemias","volume":"131","author":"Ho","year":"2009","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2011.103_bib21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/jcp.2005.032896","article-title":"CD5-positive diffuse large B cell lymphoma arising from a CD5-positive follicular lymphoma","volume":"60","author":"Vassallo","year":"2007","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.2011.103_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1440-1827.2006.02063.x","article-title":"CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma of ocular adnexal origin: usefulness of fluorescence in situ hybridization for distinction between mantle cell lymphoma and MALT lymphoma","volume":"57","author":"Tasaki","year":"2007","journal-title":"Pathol Int"},{"issue":"Suppl 1","key":"10.1038\/modpathol.2011.103_bib23","first-page":"S35","article-title":"CD5-positive chronic B-cell lymphoproliferative disorders: diagnosis and prognosis of a heterogeneous disease entity","volume":"78","author":"Dronca","year":"2010","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1038\/modpathol.2011.103_bib24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3324\/haematol.2009.011049","article-title":"CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathological, cytogenetic and molecular study of 24 cases","volume":"95","author":"Baseggio","year":"2010","journal-title":"Haematologica"},{"key":"10.1038\/modpathol.2011.103_bib25","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1309\/4KEH-AGY7-UT5H-41XJ","article-title":"CD5+ follicular lymphoma: a clinicopathologic study of three cases","volume":"118","author":"Barry","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2011.103_bib26","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1309\/V6PJ-BDAP-F0LU-CB6T","article-title":"CD5+ follicle center lymphoma. Immunophenotyping detects a unique subset of \u2018floral\u2019 follicular lymphoma","volume":"114","author":"Tiesinga","year":"2000","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2011.103_bib27","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3324\/haematol.2009.010264","article-title":"SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype","volume":"94","author":"Mozos","year":"2009","journal-title":"Haematologica"},{"key":"10.1038\/modpathol.2011.103_bib28","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1038\/sj.onc.1210056","article-title":"Diversity of LEF\/TCF action in development and disease","volume":"25","author":"Arce","year":"2006","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2011.103_bib29","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/MCB.21.22.7537-7544.2001","article-title":"The notch intracellular domain can function as a coactivator for LEF-1","volume":"21","author":"Ross","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1038\/modpathol.2011.103_bib30","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1101\/gad.11.5.640","article-title":"ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function","volume":"11","author":"Bruhn","year":"1997","journal-title":"Genes Dev"},{"key":"10.1038\/modpathol.2011.103_bib31","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.4049\/jimmunol.0901912","article-title":"Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements","volume":"184","author":"Chen","year":"2010","journal-title":"J Immunol"},{"key":"10.1038\/modpathol.2011.103_bib32","doi-asserted-by":"crossref","first-page":"e8294","DOI":"10.1371\/journal.pone.0008294","article-title":"Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt\/beta-catenin pathway","volume":"4","author":"Lu","year":"2009","journal-title":"PLoS One"},{"key":"10.1038\/modpathol.2011.103_bib33","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1593\/neo.91972","article-title":"Small molecule inhibitors of Wnt\/\u03b2-catenin\/Lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitroin vivo","volume":"12","author":"Gandhirajan","year":"2010","journal-title":"Neoplasia"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011103","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222027958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222027958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:03:38Z","timestamp":1760231018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222027958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0893395222027958"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2011.103","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear overexpression of lymphoid-enhancer-binding factor 1 identifies chronic lymphocytic leukemia\/small lymphocytic lymphoma in small B-cell lymphomas","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2011.103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}