{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:28:27Z","timestamp":1775953707374,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4028,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1038\/modpathol.2011.128","type":"journal-article","created":{"date-parts":[[2011,8,12]],"date-time":"2011-08-12T08:44:15Z","timestamp":1313138655000},"page":"65-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities"],"prefix":"10.1016","volume":"25","author":[{"given":"Leonardo","family":"Boiocchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attilio","family":"Orazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed","family":"Ghanima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Arabadjief","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B","family":"Bussel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Turbiner","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2011.128_bib1","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood-2008-07-162503","article-title":"Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group","volume":"113","author":"Rodeghiero","year":"2009","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib2","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1182\/blood-2004-12-4598","article-title":"How I treat idiopathic thrombocytopenic purpura (ITP)","volume":"106","author":"Cines","year":"2005","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib3","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.hoc.2009.09.004","article-title":"Traditional and new approaches to the management of immune thrombocytopenia: issues of when and who to treat","volume":"23","author":"Bussel","year":"2009","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1038\/modpathol.2011.128_bib4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ajh.21512","article-title":"Repeated courses of rituximab in chronic ITP: three different regimens","volume":"84","author":"Hasan","year":"2009","journal-title":"Am J Hematol"},{"key":"10.1038\/modpathol.2011.128_bib5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12185-010-0635-4","article-title":"Rituximab in immune thrombocytopenia: transient responses, low rate of sustained remissions and poor response to further therapy in refractory patients","volume":"92","author":"Aleem","year":"2010","journal-title":"Int J Hematol"},{"key":"10.1038\/modpathol.2011.128_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jpeds.2004.09.004","article-title":"Chronic immune thrombocytopenic purpura in children: assessment of rituximab treatment","volume":"146","author":"Wang","year":"2005","journal-title":"J Pediatr"},{"key":"10.1038\/modpathol.2011.128_bib7","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1056\/NEJMoa054626","article-title":"AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP","volume":"355","author":"Bussel","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2011.128_bib8","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMoa073275","article-title":"Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura","volume":"357","author":"Bussel","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2011.128_bib9","first-page":"1040","article-title":"The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases","volume":"23","author":"Sattler","year":"1995","journal-title":"Exp Hematol"},{"key":"10.1038\/modpathol.2011.128_bib10","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1182\/blood.V94.4.1273","article-title":"Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis","volume":"94","author":"Rojnuckarin","year":"1999","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib11","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1074\/jbc.M002633200","article-title":"Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes","volume":"276","author":"Miyakawa","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2011.128_bib12","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1182\/blood-2008-04-150078","article-title":"Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP","volume":"113","author":"Bussel","year":"2009","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib13","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1182\/blood-2009-05-224766","article-title":"Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim","volume":"114","author":"Kuter","year":"2009","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/modpathol.2009.53","article-title":"The stromal composition of mast cell aggregates in systemic mastocytosis","volume":"22","author":"Chiu","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.128_bib15","first-page":"633","article-title":"Standardization of bone marrow features\u2014does it work in hematopathology for histological discrimination of different disease patterns?","volume":"20","author":"Thiele","year":"2005","journal-title":"Histol Histopathol"},{"key":"10.1038\/modpathol.2011.128_bib16","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1309\/09NP-3DFG-BLM9-E5LE","article-title":"Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders","volume":"117","author":"Douglas","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2011.128_bib17","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1309\/6BQ5K8LHVYAKUAF4","article-title":"The significance of bone marrow biopsy and JAK2V617F mutation in the differential diagnosis between the \u2018early' prepolycythemic phase of polycythemia vera and essential thrombocythemia","volume":"130","author":"Gianelli","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2011.128_bib18","first-page":"1128","article-title":"European consensus on grading bone marrow fibrosis and assessment of cellularity","volume":"90","author":"Thiele","year":"2005","journal-title":"Haematologica"},{"key":"10.1038\/modpathol.2011.128_bib19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1182\/blood.V88.2.402.bloodjournal882402","article-title":"A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation","volume":"88","author":"Yan","year":"1996","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib20","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1182\/blood.V90.11.4369","article-title":"High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice","volume":"90","author":"Villeval","year":"1997","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib21","doi-asserted-by":"crossref","first-page":"691","DOI":"10.4049\/jimmunol.160.2.691","article-title":"Adenovector-mediated expression of human thrombopoietin cDNA in immune-compromised mice: insights into the pathophysiology of osteomyelofibrosis","volume":"160","author":"Frey","year":"1998","journal-title":"J Immunol"},{"key":"10.1038\/modpathol.2011.128_bib22","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1182\/blood.V86.11.4025.bloodjournal86114025","article-title":"Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice","volume":"86","author":"Yan","year":"1995","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib23","first-page":"1241","article-title":"Normal reticulin level in iliac bone marrow","volume":"114","author":"Beckman","year":"1990","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.2011.128_bib24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ajcp\/56.1.24","article-title":"Quantitation of bone marrow reticulin\u2014a normal range","volume":"56","author":"Bauermeister","year":"1971","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2011.128_bib25","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/ajh.21885","article-title":"Bone marrow reticulin and collagen content in patients with adult chronic immune thrombocytopenic purpura: A Danish nationwide study","volume":"85","author":"Ettrup","year":"2010","journal-title":"Am J Hematol"},{"key":"10.1038\/modpathol.2011.128_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2141.2007.06807.x","article-title":"Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres","volume":"139","author":"Kuter","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.2011.128_bib27","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1182\/blood-2002-04-1133","article-title":"Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice","volume":"100","author":"Chagraoui","year":"2002","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib28","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1182\/blood-2006-12-064626","article-title":"Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis","volume":"110","author":"Ciurea","year":"2007","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2141.1992.tb08905.x","article-title":"Vascular architecture and collagen type IV in primary myelofibrosis and polycythaemia vera: an immunomorphometric study on trephine biopsies of the bone marrow","volume":"80","author":"Thiele","year":"1992","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.2011.128_bib30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1699-0463.1991.tb05135.x","article-title":"Bone marrow stroma in idiopathic myelofibrosis and other haematological diseases. An immunohistochemical study","volume":"99","author":"Lisse","year":"1991","journal-title":"APMIS"},{"key":"10.1038\/modpathol.2011.128_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/bcmd.1995.0011","article-title":"Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies","volume":"21","author":"Caneva","year":"1995","journal-title":"Blood Cells Mol Dis"},{"key":"10.1038\/modpathol.2011.128_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrc2210","article-title":"Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders","volume":"7","author":"Levine","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2011.128_bib33","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/369568a0","article-title":"Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin","volume":"369","author":"Kaushansky","year":"1994","journal-title":"Nature"},{"key":"10.1038\/modpathol.2011.128_bib34","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1182\/blood.V87.6.2162.bloodjournal8762162","article-title":"Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl","volume":"87","author":"Alexander","year":"1996","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib35","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1182\/blood.V87.12.4998.bloodjournal87124998","article-title":"The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells","volume":"87","author":"Sitnicka","year":"1996","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.128_bib36","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.exphem.2009.09.001","article-title":"Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL","volume":"37","author":"Nishino","year":"2009","journal-title":"Exp Hematol"},{"key":"10.1038\/modpathol.2011.128_bib37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.stem.2007.10.008","article-title":"Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells","volume":"1","author":"Qian","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1038\/modpathol.2011.128_bib38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1749-6632.2003.tb03230.x","article-title":"Thrombopoietin: accumulating evidence for an important biological effect on the hematopoietic stem cell","volume":"996","author":"Kaushansky","year":"2003","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/modpathol.2011.128_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/MOH.0b013e32832c6705","article-title":"Insights into signaling and function of hematopoietic stem cells at the single-cell level","volume":"16","author":"Yamazaki","year":"2009","journal-title":"Curr Opin Hematol"},{"key":"10.1038\/modpathol.2011.128_bib40","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.stem.2007.10.020","article-title":"Thrombopoietin\/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche","volume":"1","author":"Yoshihara","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1038\/modpathol.2011.128_bib41","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","article-title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","volume":"7","author":"Levine","year":"2005","journal-title":"Cancer Cell"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011128","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222020646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222020646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:56:37Z","timestamp":1760230597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222020646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0893395222020646"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2011.128","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2011.128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}