{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:13:30Z","timestamp":1771877610671,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4028,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1038\/modpathol.2011.158","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T10:59:28Z","timestamp":1321009168000},"page":"237-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Therapy-related myeloid neoplasms following fludarabine, cyclophosphamide, and rituximab (FCR) treatment in patients with chronic lymphocytic leukemia\/small lymphocytic lymphoma"],"prefix":"10.1016","volume":"25","author":[{"given":"Yi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Keating","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G","family":"Wierda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa A","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2011.158_bib1","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow","year":"2008"},{"key":"10.1038\/modpathol.2011.158_bib2","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1182\/blood-2003-04-1124","article-title":"Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma with the ACVBP regimen: a GELA cohort study on 2837 patients","volume":"103","author":"Andre","year":"2004","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.158_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/cncr.24005","article-title":"Therapy-related acute myelogenous leukemia and myelodysplastic syndrome in patients with acute lymphoblastic leukemia treated with the hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimens","volume":"115","author":"Verma","year":"2009","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2011.158_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1182\/blood-2002-11-3343","article-title":"Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series","volume":"102","author":"Smith","year":"2003","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.158_bib5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1182\/blood-2008-02-140582","article-title":"Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia","volume":"112","author":"Tam","year":"2008","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.158_bib6","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1200\/JCO.2005.12.051","article-title":"Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia","volume":"23","author":"Keating","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2011.158_bib7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/annonc\/mdp297","article-title":"The frequency, manifestations, and duration of prolonged cytopenias after first-line fludarabine combination chemotherapy","volume":"21","author":"Gill","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1038\/modpathol.2011.158_bib8","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/jcp.2008.061143","article-title":"Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia","volume":"62","author":"MacCallum","year":"2009","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.2011.158_bib9","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1365-2141.2007.06513.x","article-title":"Immune anaemias in patients with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab\u2014incidence and predictors","volume":"136","author":"Borthakur","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.2011.158_bib10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ajh.20621","article-title":"Another case of myelodysplasia with monosomy 7 following fludarabine-based chemotherapy","volume":"81","author":"Murphy","year":"2006","journal-title":"Am J Hematol"},{"key":"10.1038\/modpathol.2011.158_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.leukres.2007.03.030","article-title":"Treatment-related acute myeloid leukemia with 11q23 translocation following treatment with fludarabine, cyclophosphamide and rituximab","volume":"32","author":"Martin-Salces","year":"2008","journal-title":"Leuk Res"},{"key":"10.1038\/modpathol.2011.158_bib12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.leukres.2008.11.025","article-title":"Therapy-related myelodysplastic syndrome with der(17)t(12;17)(q13;p13) as a new recurrent cytogenetic abnormality after treatment for chronic lymphocytic leukemia","volume":"33","author":"Park","year":"2009","journal-title":"Leuk Res"},{"key":"10.1038\/modpathol.2011.158_bib13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1365-2141.2006.06158.x","article-title":"High incidence of therapy-related myelodysplasia and acute leukaemia in general haematology clinic patients treated with fludarabine and cyclophosphamide for indolent lymphoproliferative disorders","volume":"134","author":"Bowcock","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.2011.158_bib14","first-page":"1546","article-title":"Treatment-related myelodysplasia following fludarabine combination chemotherapy","volume":"91","author":"Tam","year":"2006","journal-title":"Haematologica"},{"key":"10.1038\/modpathol.2011.158_bib15","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1038\/leu.2010.218","article-title":"Therapy-related myelodysplastic syndrome and acute myeloid leukemia following fludarabine combination chemotherapy","volume":"24","author":"Carney","year":"2010","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.2011.158_bib16","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.3109\/10428194.2010.505675","article-title":"Therapy-related myelodysplastic syndrome\/acute myeloid leukemia following fludarabine therapy for non-Hodgkin lymphoma and chronic lymphocytic leukemia in Thai patients","volume":"51","author":"Niparuck","year":"2010","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/modpathol.2011.158_bib17","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","article-title":"Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines","volume":"111","author":"Hallek","year":"2008","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.158_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0145-2126(92)90122-N","article-title":"A hematological remission by clonal hematopoiesis after treatment with recombinant human granulocyte-macrophage colony-stimulating factor and erythropoietin in a patient with therapy-related myelodysplastic syndrome","volume":"16","author":"Bessho","year":"1992","journal-title":"Leuk Res"},{"key":"10.1038\/modpathol.2011.158_bib19","first-page":"429","article-title":"Myelodysplasia syndrome and acute myeloid leukemia in patients with congenital neutropenia receiving G-CSF therapy","volume":"96","author":"Freedman","year":"2000","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.158_bib20","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1200\/JCO.2006.09.2882","article-title":"Treatment-related myelodysplastic syndrome and acute myelogenous leukemia in patients treated with ibritumomab tiuxetan radioimmunotherapy","volume":"25","author":"Czuczman","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2011.158_bib21","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1182\/blood-2010-01-234120","article-title":"G-CSF and its receptor in myeloid malignancy","volume":"115","author":"Beekman","year":"2010","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.158_bib22","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1056\/NEJM200012143432402","article-title":"Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia","volume":"343","author":"Rai","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2011.158_bib23","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1182\/blood.V98.8.2319","article-title":"Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients","volume":"98","author":"Leporrier","year":"2001","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.158_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/leu.2008.302","volume":"23","author":"Herbert","year":"2009","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.2011.158_bib25","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.exphem.2009.07.011","article-title":"Efficacious but insidious: a retrospective analysis of fludarabine-induced myelotoxicity using long-term culture-initiating cells in 100 follicular lymphoma patients","volume":"37","author":"Janikova","year":"2009","journal-title":"Exp Hematol"},{"key":"10.1038\/modpathol.2011.158_bib26","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1200\/JCO.2002.08.128","article-title":"Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011","volume":"20","author":"Morrison","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2011.158_bib27","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood.V92.4.1165","article-title":"Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy","volume":"92","author":"Keating","year":"1998","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.158_bib28","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1182\/blood-2004-08-3035","article-title":"Myelodysplasia and acute myeloid leukemia following therapy for indolent lymphoma with fludarabine, mitoxantrone, and dexamethasone (FND) plus rituximab and interferon alpha","volume":"105","author":"McLaughlin","year":"2005","journal-title":"Blood"},{"key":"10.1038\/modpathol.2011.158_bib29","first-page":"3580","article-title":"DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2011.158_bib30","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1080\/10428190500096989","article-title":"Accelerated growth of skin carcinoma following fludarabine therapy for chronic lymphocytic leukemia","volume":"46","author":"Rashid","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/modpathol.2011.158_bib31","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s12185-010-0511-2","article-title":"A case of treatment-related myelodysplastic syndrome spontaneously resolved by drug discontinuance","volume":"91","author":"Nakagawa","year":"2010","journal-title":"Int J Hematol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011158","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222033221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222033221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:09:45Z","timestamp":1760231385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222033221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"alternative-id":["S0893395222033221"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2011.158","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapy-related myeloid neoplasms following fludarabine, cyclophosphamide, and rituximab (FCR) treatment in patients with chronic lymphocytic leukemia\/small lymphocytic lymphoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2011.158","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}