{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:03:03Z","timestamp":1792609383777,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":3937,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1038\/modpathol.2011.183","type":"journal-article","created":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T07:43:43Z","timestamp":1324626223000},"page":"625-636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":247,"title":["Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma"],"prefix":"10.1016","volume":"25","author":[{"given":"Robert A","family":"Soslow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay J","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuna","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narciso","family":"Olvera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Spriggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah D","family":"Kauff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2011.183_bib1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1086\/318787","article-title":"Prevalence and penetrance of germline BRCA1 BRCA2 mutations in a population series of 649 women with ovarian cancer","volume":"68","author":"Risch","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1038\/modpathol.2011.183_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2407-8-17","article-title":"Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities","volume":"8","author":"Press","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1038\/modpathol.2011.183_bib3","first-page":"1120","article-title":"BRCA1 up-regulation is associated with repair-mediated resistance to cis-diamminedichloroplatinum(II)","volume":"58","author":"Husain","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2011.183_bib4","first-page":"3547","article-title":"BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo","volume":"59","author":"Yuan","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2011.183_bib5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1200\/JCO.2002.20.2.463","article-title":"Effect of BRCA mutations on the length of survival in epithelial ovarian tumors","volume":"20","author":"Ben David","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2011.183_bib6","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1001\/jama.283.17.2260","article-title":"Clinicopathologic features of BRCA-linked and sporadic ovarian cancer","volume":"283","author":"Boyd","year":"2000","journal-title":"JAMA"},{"key":"10.1038\/modpathol.2011.183_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(10)60893-8","article-title":"Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial","volume":"376","author":"Audeh","year":"2010","journal-title":"Lancet"},{"key":"10.1038\/modpathol.2011.183_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0140-6736(10)60892-6","article-title":"Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial","volume":"376","author":"Tutt","year":"2010","journal-title":"Lancet"},{"key":"10.1038\/modpathol.2011.183_bib9","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1200\/JCO.2009.26.9589","article-title":"Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval","volume":"28","author":"Fong","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2011.183_bib10","doi-asserted-by":"crossref","first-page":"18538","DOI":"10.1073\/pnas.0509182102","article-title":"Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+\/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer","volume":"102","author":"Sato","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2011.183_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1056\/NEJMoa020177","article-title":"Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer","volume":"348","author":"Zhang","year":"2003","journal-title":"N Eng J Med"},{"key":"10.1038\/modpathol.2011.183_bib12","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1073\/pnas.0611533104","article-title":"Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer","volume":"104","author":"Hamanishi","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2011.183_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/modpathol.2008.191","article-title":"Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss","volume":"22","author":"Clarke","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.183_bib14","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/1097-0142(19890301)63:5<839::AID-CNCR2820630508>3.0.CO;2-U","article-title":"Transitional cell carcinoma in high-grade high-stage ovarian carcinoma. An indicator of favorable response to chemotherapy","volume":"63","author":"Robey","year":"1989","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2011.183_bib15","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/0002-9378(93)90365-P","article-title":"Transitional cell carcinoma of the ovary: a matched control study of advanced-stage patients treated with cisplatin-based chemotherapy","volume":"168","author":"Gershenson","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1038\/modpathol.2011.183_bib16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ygyno.2004.12.047","article-title":"Survival benefit for patients with advanced-stage transitional cell carcinomas vs. other subtypes of ovarian carcinoma after chemotherapy with platinum and paclitaxel","volume":"97","author":"Kommoss","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1038\/modpathol.2011.183_bib17","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4161\/cbt.2.5.511","article-title":"Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors","volume":"2","author":"Tisserand","year":"2003","journal-title":"Cancer Biol Ther"},{"key":"10.1038\/modpathol.2011.183_bib18","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1002\/(SICI)1097-0142(19981201)83:11<2335::AID-CNCR13>3.0.CO;2-N","article-title":"The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: a population-based study","volume":"83","author":"Armes","year":"1998","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2011.183_bib19","first-page":"782","article-title":"The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2","volume":"6","author":"Lakhani","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2011.183_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1158\/1940-6207.CAPR-10-0212","article-title":"Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer","volume":"4","author":"Wong","year":"2011","journal-title":"Cancer Prev Res"},{"key":"10.1038\/modpathol.2011.183_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"The Cancer Genome Atlas Research Network","year":"2011","journal-title":"Nature"},{"key":"10.1038\/modpathol.2011.183_bib22","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.humpath.2008.01.003","article-title":"Tumor cell type can be reproducibly diagnosed and is of independent prognostic significance in patients with maximally debulked ovarian carcinoma","volume":"39","author":"Gilks","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2011.183_bib23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00000478-200404000-00004","article-title":"Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis","volume":"28","author":"Eichhorn","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2011.183_bib24","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJM199611073351901","article-title":"Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1","volume":"335","author":"Rubin","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2011.183_bib25","first-page":"2998","article-title":"Mutation analysis of the BRCA1 gene in ovarian cancers","volume":"55","author":"Takahashi","year":"1995","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2011.183_bib26","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/modpathol.2010.119","article-title":"High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression","volume":"23","author":"Roh","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.183_bib27","first-page":"2738","article-title":"Mutations of the BRCA2 gene in ovarian carcinomas","volume":"56","author":"Takahashi","year":"1996","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2011.183_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/01.pgp.0000101083.35393.cd","article-title":"Histopathology, FIGO stage, and BRCA mutation status of ovarian cancers from the Gilda Radner Familial Ovarian Cancer Registry","volume":"23","author":"Werness","year":"2004","journal-title":"Int J Gynecol Pathol"},{"key":"10.1038\/modpathol.2011.183_bib29","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1158\/1078-0432.CCR-1029-3","article-title":"Pathology of ovarian cancers in BRCA1 BRCA2 carriers","volume":"10","author":"Lakhani","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2011.183_bib30","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1001\/jama.283.17.2260","article-title":"Clinicopathologic features of BRCA-linked and sporadic ovarian cancer","volume":"283","author":"Boyd","year":"2000","journal-title":"JAMA"},{"key":"10.1038\/modpathol.2011.183_bib31","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1097\/00000478-200311000-00005","article-title":"Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers: histogenetic and diagnostic implications","volume":"27","author":"Logani","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2011.183_bib32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ccr.2007.02.016","article-title":"Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt\/\u03b2-catenin and PI3K\/Pten signaling pathways","volume":"11","author":"Wu","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1038\/modpathol.2011.183_bib33","first-page":"161","article-title":"Histologic subtypes of ovarian carcinoma: an overview","volume":"27","author":"Soslow","year":"2008","journal-title":"Int J Gynecol Pathol"},{"key":"10.1038\/modpathol.2011.183_bib34","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/PAS.0b013e3181e1a3bb","article-title":"Diagnosis of ovarian carcinoma cell type is highly reproducible: a Trans-Canadian study","volume":"34","author":"K\u00f6bel","year":"2010","journal-title":"Am J Surg Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011183","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222032082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222032082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2011183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:08:47Z","timestamp":1760231327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222032082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0893395222032082"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2011.183","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2011.183","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}