{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:42:42Z","timestamp":1777513362498,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4242,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1038\/modpathol.2011.40","type":"journal-article","created":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T11:17:39Z","timestamp":1301051859000},"page":"855-865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role and predictive strength of transglutaminase type 2 expression in premalignant lesions of the cervix"],"prefix":"10.1016","volume":"24","author":[{"given":"Franca","family":"Del Nonno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pisani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Visca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Signore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Rosalba","family":"Grillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Baiocchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Rosa","family":"Garbuglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Piacentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Falasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2011.40_bib1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jcp.55.4.244","article-title":"The causal relation between human papillomavirus and cervical cancer","volume":"55","author":"Bosch","year":"2002","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.2011.40_bib2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"zur Hausen","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2011.40_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.virol.2004.03.033","article-title":"Classification of papillomaviruses","volume":"324","author":"de Villiers","year":"2004","journal-title":"Virology"},{"key":"10.1038\/modpathol.2011.40_bib4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/CS20050369","article-title":"Molecular biology of human papillomavirus infection and cervical cancer","volume":"110","author":"Doorbar","year":"2006","journal-title":"Clin Sci (Lond)"},{"key":"10.1038\/modpathol.2011.40_bib5","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1128\/jvi.63.10.4417-4421.1989","article-title":"The E6 and E7 genes of human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes","volume":"63","author":"M\u00fcnger","year":"1989","journal-title":"J Virol"},{"key":"10.1038\/modpathol.2011.40_bib6","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.2537532","article-title":"The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product","volume":"243","author":"Dyson","year":"1989","journal-title":"Science"},{"key":"10.1038\/modpathol.2011.40_bib7","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1096\/fj.03-1332fje","article-title":"High level HPV-16 E7 oncoprotein expression correlates with reduced pRb-levels in cervical biopsies","volume":"18","author":"Fiedler","year":"2004","journal-title":"FASEB J"},{"key":"10.1038\/modpathol.2011.40_bib8","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.2741\/1902","article-title":"Alteration of Rb binding to HPV 18 E7 modified by transglutaminase 2 with different type of polyamines","volume":"11","author":"Jeon","year":"2006","journal-title":"Front Biosci"},{"key":"10.1038\/modpathol.2011.40_bib9","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0968-0004(02)02182-5","article-title":"Transglutaminase 2: an enigmatic enzyme with diverse functions","volume":"27","author":"Piacentini","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"10.1038\/modpathol.2011.40_bib10","doi-asserted-by":"crossref","first-page":"18259","DOI":"10.1074\/jbc.M000583200","article-title":"GTP binding and signaling by Gh\/transglutaminase II involves distinct residues in a unique GTP-binding pocket","volume":"275","author":"Iismaa","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2011.40_bib11","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1042\/bj20021084","article-title":"A novel function of tissue-type transglutaminase: protein disulphide isomerase","volume":"373","author":"Hasegawa","year":"2003","journal-title":"Biochem J"},{"key":"10.1038\/modpathol.2011.40_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000084233","article-title":"Type 2 transglutaminase and cell death","volume":"38","author":"Piacentini","year":"2005","journal-title":"Prog Exp Tumor Res"},{"key":"10.1038\/modpathol.2011.40_bib13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrm1014","article-title":"Transglutaminases: crosslinking enzymes with pleiotropic functions","volume":"4","author":"Lorand","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/modpathol.2011.40_bib14","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.2741\/1921","article-title":"The role of transglutaminase-2 and its substrates in human diseases","volume":"11","author":"Facchiano","year":"2006","journal-title":"Front Biosci"},{"key":"10.1038\/modpathol.2011.40_bib15","doi-asserted-by":"crossref","first-page":"7330","DOI":"10.4049\/jimmunol.174.11.7330","article-title":"Transglutaminase type II is a key element in the regulation of the anti-inflammatory response elicited by apoptotic cell engulfment","volume":"174","author":"Falasca","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/modpathol.2011.40_bib16","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.4049\/jimmunol.180.4.2616","article-title":"Transglutaminase type II is involved in the pathogenesis of endotoxic shock","volume":"180","author":"Falasca","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/modpathol.2011.40_bib17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1749-6632.2001.tb03906.x","article-title":"\u2018Tissue\u2019 transglutaminase expression in HIV-infected cells: an enzyme with an antiviral effect?","volume":"946","author":"Amendola","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1038\/modpathol.2011.40_bib18","doi-asserted-by":"crossref","first-page":"47993","DOI":"10.1074\/jbc.M109674200","article-title":"Post-translational modification of the hepatitis C virus core protein by tissue transglutaminase","volume":"276","author":"Lu","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2011.40_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2741\/1793","article-title":"Role of protein modifications mediated by transglutaminase 2 in human viral diseases","volume":"11","author":"Jeon","year":"2006","journal-title":"Front Biosci"},{"key":"10.1038\/modpathol.2011.40_bib20","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1093\/emboj\/cdg495","article-title":"Transglutaminase 2 inhibits Rb binding of human papillomavirus E7 by incorporating polyamine","volume":"22","author":"Jeon","year":"2003","journal-title":"EMBO J"},{"key":"10.1038\/modpathol.2011.40_bib21","doi-asserted-by":"crossref","first-page":"20127","DOI":"10.1074\/jbc.C200147200","article-title":"Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb","volume":"277","author":"Boehm","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2011.40_bib22","doi-asserted-by":"crossref","first-page":"8715","DOI":"10.1074\/jbc.M308479200","article-title":"Intracellular localization and activity state of tissue transglutaminase differentially impacts cell death","volume":"279","author":"Milakovic","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2011.40_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00428-009-0860-5","article-title":"Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression","volume":"456","author":"Gupta","year":"2010","journal-title":"Virchows Arch"},{"key":"10.1038\/modpathol.2011.40_bib24","first-page":"155","article-title":"Prognostic and predictive factors in breast cancer by immunohistochemical analysis","volume":"11","author":"Allred","year":"1998","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2011.40_bib25","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.2999980","article-title":"Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia","volume":"230","author":"Saiki","year":"1985","journal-title":"Science"},{"key":"10.1038\/modpathol.2011.40_bib26","first-page":"209","article-title":"The use of polymerase chain reaction amplification for the detection of genital papillomaviruses","volume":"7","author":"Manos","year":"1989","journal-title":"Cancer Cells"},{"key":"10.1038\/modpathol.2011.40_bib27","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/infdis\/170.5.1077","article-title":"Identification and assessment of known and novel human papillomaviruses by polymerase chain reaction amplification, restriction fragment length polymorphisms, nucleotide sequence, and phylogenetic algorithms","volume":"170","author":"Bernard","year":"1994","journal-title":"J Infect Dis"},{"key":"10.1038\/modpathol.2011.40_bib28","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2174\/1874357900903010060","article-title":"Human papillomavirus (HPV) type distribution in females with abnormal cervical cytology. A correlation with histological study","volume":"3","author":"Cobo","year":"2009","journal-title":"Open Virol J"},{"key":"10.1038\/modpathol.2011.40_bib29","doi-asserted-by":"crossref","first-page":"19541","DOI":"10.1073\/pnas.0707947104","article-title":"Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification","volume":"104","author":"Moody","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"10.1038\/modpathol.2011.40_bib30","first-page":"249","article-title":"Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions","volume":"2","author":"Feng","year":"2009","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1038\/modpathol.2011.40_bib31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00726-008-0190-y","article-title":"Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications","volume":"36","author":"Collighan","year":"2009","journal-title":"Amino Acids"},{"key":"10.1038\/modpathol.2011.40_bib32","doi-asserted-by":"crossref","first-page":"11991","DOI":"10.1074\/jbc.273.20.11991","article-title":"J Distinct nuclear localization and activity of tissue transglutaminase","volume":"273","author":"Lesort","year":"1998","journal-title":"Biol Chem"},{"key":"10.1038\/modpathol.2011.40_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-5793(99)00018-6","article-title":"Interaction of tissue transglutaminase with nuclear transport protein importin-alpha3","volume":"446","author":"Peng","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1038\/modpathol.2011.40_bib34","doi-asserted-by":"crossref","first-page":"20127","DOI":"10.1074\/jbc.C200147200","article-title":"Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb","volume":"277","author":"Boehm","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2011.40_bib35","doi-asserted-by":"crossref","first-page":"18609","DOI":"10.1073\/pnas.0604844103","article-title":"Two isoforms of tissue transglutaminase mediate opposing cellular fates","volume":"103","author":"Antonyak","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2011.40_bib36","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/carcin\/bgn158","article-title":"Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling","volume":"29","author":"Cao","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1038\/modpathol.2011.40_bib37","doi-asserted-by":"crossref","first-page":"e6123","DOI":"10.1371\/journal.pone.0006123","article-title":"Intracellular localization and conformational state of transglutaminase 2: implications for cell death","volume":"4","author":"Gundemir","year":"2009","journal-title":"PLoS One"},{"key":"10.1038\/modpathol.2011.40_bib38","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1073\/pnas.92.12.5436","volume":"92","author":"Almasan","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2011.40_bib39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/j.1460-2075.1995.tb07022.x","article-title":"Inhibition of apoptosis by the retinoblastoma gene product","volume":"14","author":"Haas-Kogan","year":"1995","journal-title":"EMBO J"},{"key":"10.1038\/modpathol.2011.40_bib40","doi-asserted-by":"crossref","first-page":"18108","DOI":"10.1074\/jbc.M607413200","article-title":"Transglutaminase 2 kinase activity facilitates protein kinase A-induced phosphorylation of retinoblastoma protein","volume":"282","author":"Mishra","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2011.40_bib41","first-page":"669","article-title":"Both cell proliferation and apoptosis increase with lesion grade in cervical neoplasia but do not correlate with human papillomavirus type","volume":"56","author":"Isacson","year":"1996","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2011.40_bib42","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2353\/ajpath.2008.080280","article-title":"Koilocytosis: a cooperative interaction between the human papillomavirus E5 and E6 oncoproteins","volume":"173","author":"Krawczyk","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.2011.40_bib43","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1096\/fj.07-097709","article-title":"Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling","volume":"22","author":"Filiano","year":"2008","journal-title":"FASEB J"},{"key":"10.1038\/modpathol.2011.40_bib44","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/CEJ.0b013e328305a10b","article-title":"Oxidative damage and antioxidant status in patients with cervical intraepithelial neoplasia and carcinoma of the cervix","volume":"17","author":"Looi","year":"2008","journal-title":"Eur J Cancer Prev"},{"key":"10.1038\/modpathol.2011.40_bib45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.nbd.2010.04.018","article-title":"Transglutaminase 2 protects against ischemic stroke","volume":"39","author":"Filiano","year":"2010","journal-title":"Neurobiol Dis"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol201140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol201140","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222028642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222028642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol201140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:04:16Z","timestamp":1760231056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222028642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0893395222028642"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2011.40","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role and predictive strength of transglutaminase type 2 expression in premalignant lesions of the cervix","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2011.40","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}