{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:58:09Z","timestamp":1790917089180,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":3693,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1038\/modpathol.2012.118","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T07:55:38Z","timestamp":1342166138000},"page":"1644-1653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinoma"],"prefix":"10.1016","volume":"25","author":[{"given":"Brian D","family":"McMillen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita M","family":"Aponte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene B","family":"Helenowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M","family":"Scholtens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara M","family":"Buttin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2012.118_bib1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","article-title":"The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory","volume":"34","author":"Kurman","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2012.118_bib2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","article-title":"The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome","volume":"30","author":"Medeiros","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2012.118_bib3","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1200\/JCO.2008.18.1107","article-title":"New insights into the pathogenesis of serous ovarian cancer and its clinical impact","volume":"26","author":"Levanon","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2012.118_bib4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrc2946","article-title":"The genesis and evolution of high-grade serous ovarian cancer","volume":"10","author":"Bowtell","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2012.118_bib5","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/jnci\/djj465","article-title":"Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada","volume":"98","author":"Risch","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/modpathol.2012.118_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ygyno.2011.01.020","article-title":"Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer","volume":"121","author":"Zhang","year":"2011","journal-title":"Gynecol Oncol"},{"key":"10.1038\/modpathol.2012.118_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2407-8-17","article-title":"Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities","volume":"8","author":"Press","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1038\/modpathol.2012.118_bib8","doi-asserted-by":"crossref","first-page":"5864","DOI":"10.1038\/sj.onc.1209874","article-title":"The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability","volume":"25","author":"Gudmundsdottir","year":"2006","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2012.118_bib9","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1038\/sj.onc.1209872","article-title":"The role of BRCA1 in transcriptional regulation and cell cycle control","volume":"25","author":"Mullan","year":"2006","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2012.118_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molcel.2010.12.005","article-title":"miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors","volume":"41","author":"Moskwa","year":"2011","journal-title":"Mol Cell"},{"key":"10.1038\/modpathol.2012.118_bib11","doi-asserted-by":"crossref","unstructured":"Liu Z, Liu J, Segura MF, et al. MiR182 overexpression in tumorigenesis of high-grade ovarian papillary serous carcinoma. J Pathol 2012.","DOI":"10.1002\/path.4000"},{"key":"10.1038\/modpathol.2012.118_bib12","doi-asserted-by":"crossref","first-page":"23204","DOI":"10.1074\/jbc.M109.031427","article-title":"Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells","volume":"284","author":"Guttilla","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2012.118_bib13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1158\/0008-5472.CAN-09-1891","article-title":"Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer","volume":"70","author":"Myatt","year":"2010","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2012.118_bib14","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1073\/pnas.0808263106","article-title":"Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor","volume":"106","author":"Segura","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2012.118_bib15","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1093\/nar\/gkh968","article-title":"Substrate requirements for let-7 function in the developing zebrafish embryo","volume":"32","author":"Kloosterman","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/modpathol.2012.118_bib16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/modpathol.2010.49","article-title":"HMGA2: a biomarker significantly overexpressed in high-grade ovarian serous carcinoma","volume":"23","author":"Mahajan","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2012.118_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/PAS.0b013e3181be5d72","article-title":"HMGA2: a potential biomarker complement to P53 for detection of early-stage high-grade papillary serous carcinoma in fallopian tubes","volume":"34","author":"Wei","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2012.118_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/path.2091","article-title":"A candidate precursor to serous carcinoma that originates in the distal fallopian tube","volume":"211","author":"Lee","year":"2007","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2012.118_bib19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Cancer Genome Atlas Research Network","year":"2011","journal-title":"Nature"},{"key":"10.1038\/modpathol.2012.118_bib20","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/IGC.0b013e318227c990","article-title":"Loss of BRCA1 protein expression as indicator of the BRCAness phenotype is associated with favorable overall survival after complete resection of sporadic ovarian cancer","volume":"21","author":"Radosa","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"10.1038\/modpathol.2012.118_bib21","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ygyno.2011.08.017","article-title":"BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer","volume":"123","author":"Carser","year":"2011","journal-title":"Gynecol Oncol"},{"key":"10.1038\/modpathol.2012.118_bib22","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1093\/annonc\/mdq770","article-title":"Breast cancer 1 (BRCA1) protein expression as a prognostic marker in sporadic epithelial ovarian carcinoma: an NCIC CTG OV.16 correlative study","volume":"22","author":"Weberpals","year":"2011","journal-title":"Ann Oncol"},{"key":"10.1038\/modpathol.2012.118_bib23","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1111\/j.1582-4934.2010.01148.x","article-title":"miRNA profiling along tumor progression in ovarian carcinoma","volume":"15","author":"Vaksman","year":"2010","journal-title":"J Cell Mol Med"},{"key":"10.1038\/modpathol.2012.118_bib24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1158\/0008-5472.CAN-10-2550","article-title":"HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes","volume":"71","author":"Wu","year":"2011","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2012.118_bib25","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1074\/jbc.M109.062265","article-title":"Derepression of HMGA2 via removal of ZBRK1\/BRCA1\/CtIP complex enhances mammary tumorigenesis","volume":"285","author":"Ahmed","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.2012.118_bib26","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1137999","article-title":"Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation","volume":"315","author":"Mayr","year":"2007","journal-title":"Science"},{"key":"10.1038\/modpathol.2012.118_bib27","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/gcc.20415","article-title":"A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas","volume":"46","author":"Wang","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2012.118_bib28","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1677\/ERC-08-0153","article-title":"Forkhead box-O transcription factor: critical conductors of cancer's fate","volume":"15","author":"Weidinger","year":"2008","journal-title":"Endocr Relat Cancer"},{"key":"10.1038\/modpathol.2012.118_bib29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/07357900802146204","article-title":"Low expression of Foxo3a is associated with poor prognosis in ovarian cancer patients","volume":"27","author":"Fei","year":"2009","journal-title":"Cancer Invest"},{"key":"10.1038\/modpathol.2012.118_bib30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.neo.7900231","article-title":"MIM, a potential metastasis suppressor gene in bladder cancer","volume":"4","author":"Lee","year":"2002","journal-title":"Neoplasia"},{"key":"10.1038\/modpathol.2012.118_bib31","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.ejca.2009.02.019","article-title":"Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer","volume":"45","author":"Parr","year":"2009","journal-title":"Eur J Cancer"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2012118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2012118","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222029532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222029532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2012118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:05:28Z","timestamp":1760231128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222029532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0893395222029532"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2012.118","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2012.118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}